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Protein

C-X-C chemokine receptor type 2

Gene

Cxcr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • acute inflammatory response to antigenic stimulus Source: RGD
  • metanephric tubule morphogenesis Source: RGD
  • midbrain development Source: RGD
  • negative regulation of apoptotic process Source: RGD
  • negative regulation of neutrophil apoptotic process Source: RGD
  • neutrophil chemotaxis Source: RGD
  • positive regulation of angiogenesis Source: RGD
  • positive regulation of cardiac muscle cell apoptotic process Source: RGD
  • positive regulation of cytosolic calcium ion concentration Source: RGD
  • positive regulation of leukocyte chemotaxis Source: RGD
  • positive regulation of neutrophil chemotaxis Source: RGD
  • positive regulation of vascular permeability Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

ReactomeiREACT_278843. Chemokine receptors bind chemokines.
REACT_339234. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C chemokine receptor type 2
Short name:
CXC-R2
Short name:
CXCR-2
Alternative name(s):
GRO/MGSA receptor
High affinity interleukin-8 receptor B
Short name:
IL-8R B
CD_antigen: CD182
Gene namesi
Name:Cxcr2
Synonyms:Il8rb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi2906. Cxcr2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4747ExtracellularSequence AnalysisAdd
BLAST
Transmembranei48 – 7427Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini75 – 839CytoplasmicSequence Analysis
Transmembranei84 – 10421Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini105 – 11915ExtracellularSequence AnalysisAdd
BLAST
Transmembranei120 – 14122Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini142 – 16221CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei163 – 18220Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini183 – 20725ExtracellularSequence AnalysisAdd
BLAST
Transmembranei208 – 23023Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini231 – 25020CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei251 – 27222Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini273 – 29624ExtracellularSequence AnalysisAdd
BLAST
Transmembranei297 – 31418Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini315 – 35945CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • cytosol Source: GOC
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359C-X-C chemokine receptor type 2PRO_0000069342Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi8 – 81N-linked (GlcNAc...)Sequence Analysis
Glycosylationi23 – 231N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi118 ↔ 195PROSITE-ProRule annotation
Glycosylationi201 – 2011N-linked (GlcNAc...)Sequence Analysis
Glycosylationi202 – 2021N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Phosphorylated upon ligand binding; which is required for desensitization.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP35407.
PRIDEiP35407.

PTM databases

PhosphoSiteiP35407.

Expressioni

Gene expression databases

GenevisibleiP35407. RN.

Interactioni

Protein-protein interaction databases

IntActiP35407. 1 interaction.
MINTiMINT-271110.
STRINGi10116.ENSRNOP00000019109.

Structurei

3D structure databases

ProteinModelPortaliP35407.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146068.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP35407.
KOiK05050.
OMAiMRTKLIK.
OrthoDBiEOG7ZPNK9.
PhylomeDBiP35407.
TreeFamiTF330966.

Family and domain databases

InterProiIPR000057. Chemokine_CXCR2.
IPR000174. Chemokine_CXCR_1/2.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00427. INTRLEUKIN8R.
PR00573. INTRLEUKN8BR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35407-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEIRVDNFS LEDFFSGDID SYNYSSDPPF TLSDAAPCPS ANLDINRYAV
60 70 80 90 100
VVIYVLVTLL SLVGNSLVML VILYNRSTCS VTDVYLLNLA IADLFFALTL
110 120 130 140 150
PVWAASKVNG WIFGSFLCKV FSFLQEITFY SSVLLLACIS MDRYLAIVHA
160 170 180 190 200
TSTLIQKRHL VKFVCITMWF LSLVLSLPIF ILRTTVKANP STVVCYENIG
210 220 230 240 250
NNTSKWRVVL RILPQTYGFL LPLLIMLFCY GFTLRTLFKA HMGQKHRAMR
260 270 280 290 300
VIFAVVLVFL LCWLPYNIVL FTDTLMRTKL IKETCERQNE INKALEATEI
310 320 330 340 350
LGFLHSCLNP IIYAFIGQKF RHGLLKIMAN YGLVSKEFLA KEGRPSFVGS

SSANTSTTL
Length:359
Mass (Da):40,532
Last modified:February 1, 1996 - v2
Checksum:iEF547326A074ABDD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77797 mRNA. Translation: CAA54824.1.
D63584 Genomic DNA. Translation: BAA09797.1.
U70988 Genomic DNA. Translation: AAC52961.1.
PIRiS42096.
RefSeqiNP_058879.1. NM_017183.1.
XP_008765435.1. XM_008767213.1.
XP_008765436.1. XM_008767214.1.
XP_008765437.1. XM_008767215.1.
UniGeneiRn.90347.

Genome annotation databases

EnsembliENSRNOT00000019109; ENSRNOP00000019109; ENSRNOG00000014269.
GeneIDi29385.
KEGGirno:29385.
UCSCiRGD:2906. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77797 mRNA. Translation: CAA54824.1.
D63584 Genomic DNA. Translation: BAA09797.1.
U70988 Genomic DNA. Translation: AAC52961.1.
PIRiS42096.
RefSeqiNP_058879.1. NM_017183.1.
XP_008765435.1. XM_008767213.1.
XP_008765436.1. XM_008767214.1.
XP_008765437.1. XM_008767215.1.
UniGeneiRn.90347.

3D structure databases

ProteinModelPortaliP35407.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP35407. 1 interaction.
MINTiMINT-271110.
STRINGi10116.ENSRNOP00000019109.

Chemistry

GuidetoPHARMACOLOGYi69.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP35407.

Proteomic databases

PaxDbiP35407.
PRIDEiP35407.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000019109; ENSRNOP00000019109; ENSRNOG00000014269.
GeneIDi29385.
KEGGirno:29385.
UCSCiRGD:2906. rat.

Organism-specific databases

CTDi3579.
RGDi2906. Cxcr2.

Phylogenomic databases

eggNOGiNOG146068.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP35407.
KOiK05050.
OMAiMRTKLIK.
OrthoDBiEOG7ZPNK9.
PhylomeDBiP35407.
TreeFamiTF330966.

Enzyme and pathway databases

ReactomeiREACT_278843. Chemokine receptors bind chemokines.
REACT_339234. G alpha (i) signalling events.

Miscellaneous databases

NextBioi608983.
PROiP35407.

Gene expression databases

GenevisibleiP35407. RN.

Family and domain databases

InterProiIPR000057. Chemokine_CXCR2.
IPR000174. Chemokine_CXCR_1/2.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00427. INTRLEUKIN8R.
PR00573. INTRLEUKN8BR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and characterization of a cDNA encoding the rat interleukin-8 receptor."
    Gobl A.E., Huang M.R., Wang S., Zhou Y., Oeberg K.
    Biochim. Biophys. Acta 1326:171-177(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Lung.
  2. Konishi K., Shibata F., Watanabe K., Tsurufuji S., Nakagawa H., Fujioka M.
    Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Wistar.
    Tissue: Liver.
  3. "Identification of two rat genes orthologous to the human interleukin-8 receptors."
    Dunstan C.-A.N., Salafranca M.N., Adhikari S., Xia Y., Feng L., Harrison J.K.
    J. Biol. Chem. 271:32770-32776(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Wistar.
    Tissue: Lung and Spleen.

Entry informationi

Entry nameiCXCR2_RAT
AccessioniPrimary (citable) accession number: P35407
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: February 1, 1996
Last modified: July 22, 2015
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.