Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot P35407 (CXCR2_RAT)

Last modified June 16, 2009. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    High affinity interleukin-8 receptor B
      Short name=IL-8R B
Alternative name(s):
    CXCR-2
    GRO/MGSA receptor
    CD_antigen=CD182
Gene names
Name: Il8rb
Synonyms: Cxcr2
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2 By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Post-translational modification

Phosphorylated upon ligand binding; which is required for desensitization By similarity.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Mpp4Q9QYH11EBI-937591,EBI-937554

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 359359High affinity interleukin-8 receptor B
PRO_0000069342

Regions

Topological domain1 – 4747Extracellular Potential
Transmembrane48 – 74271 Potential
Topological domain75 – 839Cytoplasmic Potential
Transmembrane84 – 104212 Potential
Topological domain105 – 11915Extracellular Potential
Transmembrane120 – 141223 Potential
Topological domain142 – 16221Cytoplasmic Potential
Transmembrane163 – 182204 Potential
Topological domain183 – 20725Extracellular Potential
Transmembrane208 – 230235 Potential
Topological domain231 – 25020Cytoplasmic Potential
Transmembrane251 – 272226 Potential
Topological domain273 – 29624Extracellular Potential
Transmembrane297 – 314187 Potential
Topological domain315 – 35945Cytoplasmic Potential

Amino acid modifications

Modified residue3461Phosphoserine By similarity
Modified residue3501Phosphoserine By similarity
Modified residue3511Phosphoserine By similarity
Modified residue3521Phosphoserine By similarity
Glycosylation81N-linked (GlcNAc...) Potential
Glycosylation231N-linked (GlcNAc...) Potential
Glycosylation2011N-linked (GlcNAc...) Potential
Glycosylation2021N-linked (GlcNAc...) Potential
Disulfide bond118 ↔ 195 By similarity

Sequences

Sequence LengthMass (Da)Tools
P35407-1 [UniParc].

Last modified February 1, 1996. Version 2.
Checksum: EF547326A074ABDD

FASTA35940,532
        10         20         30         40         50         60 
MGEIRVDNFS LEDFFSGDID SYNYSSDPPF TLSDAAPCPS ANLDINRYAV VVIYVLVTLL 

        70         80         90        100        110        120 
SLVGNSLVML VILYNRSTCS VTDVYLLNLA IADLFFALTL PVWAASKVNG WIFGSFLCKV 

       130        140        150        160        170        180 
FSFLQEITFY SSVLLLACIS MDRYLAIVHA TSTLIQKRHL VKFVCITMWF LSLVLSLPIF 

       190        200        210        220        230        240 
ILRTTVKANP STVVCYENIG NNTSKWRVVL RILPQTYGFL LPLLIMLFCY GFTLRTLFKA 

       250        260        270        280        290        300 
HMGQKHRAMR VIFAVVLVFL LCWLPYNIVL FTDTLMRTKL IKETCERQNE INKALEATEI 

       310        320        330        340        350 
LGFLHSCLNP IIYAFIGQKF RHGLLKIMAN YGLVSKEFLA KEGRPSFVGS SSANTSTTL 

« Hide

References

[1]"Molecular cloning and characterization of a cDNA encoding the rat interleukin-8 receptor."
Gobl A.E., Huang M.R., Wang S., Zhou Y., Oeberg K.
Biochim. Biophys. Acta 1326:171-177(1997) [PubMed: 9218548] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Lung.
[2]Konishi K., Shibata F., Watanabe K., Tsurufuji S., Nakagawa H., Fujioka M.
Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Wistar.
Tissue: Liver.
[3]"Identification of two rat genes orthologous to the human interleukin-8 receptors."
Dunstan C.-A.N., Salafranca M.N., Adhikari S., Xia Y., Feng L., Harrison J.K.
J. Biol. Chem. 271:32770-32776(1996) [PubMed: 8955112] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Wistar.
Tissue: Lung and Spleen.

Cross-references

Sequence databases

X77797 mRNA. Translation: CAA54824.1.
D63584 Genomic DNA. Translation: BAA09797.1.
U70988 Genomic DNA. Translation: AAC52961.1.
IPIIPI00198588.
PIRS42096.
RefSeqNP_058879.1.
UniGeneRn.90347

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActP35407. 1 interaction.

Protein family/group databases

GPCRDBSearch...

Genome annotation databases

EnsemblENSRNOG00000014269. Rattus norvegicus. [Contig view]
GeneID29385.
KEGGrno:29385.

Organism-specific databases

RGD2906. Il8rb.

Phylogenomic databases

HOVERGENP35407.
OMAP35407. IVHATST.

Gene expression databases

ArrayExpressP35407.
GermOnlineENSRNOG00000014269. Rattus norvegicus.

Family and domain databases

InterProIPR000276. 7TM_GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_supfam.
IPR000174. IL8_rcpt.
IPR000057. IL8B_rcpt.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00427. INTRLEUKIN8R.
PR00573. INTRLEUKN8BR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio608983.

Entry information

Entry nameCXCR2_RAT
AccessionPrimary (citable) accession number: P35407
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: February 1, 1996
Last modified: June 16, 2009
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents