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P35407

- CXCR2_RAT

UniProt

P35407 - CXCR2_RAT

Protein

C-X-C chemokine receptor type 2

Gene

Cxcr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 2 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2 By similarity.By similarity

    GO - Molecular functioni

    1. interleukin-8 receptor activity Source: Ensembl

    GO - Biological processi

    1. acute inflammatory response to antigenic stimulus Source: RGD
    2. cellular defense response Source: Ensembl
    3. metanephric tubule morphogenesis Source: RGD
    4. midbrain development Source: RGD
    5. negative regulation of apoptotic process Source: RGD
    6. negative regulation of neutrophil apoptotic process Source: RGD
    7. neutrophil activation Source: Ensembl
    8. neutrophil chemotaxis Source: RGD
    9. phospholipase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
    10. positive regulation of angiogenesis Source: RGD
    11. positive regulation of cardiac muscle cell apoptotic process Source: RGD
    12. positive regulation of cell proliferation Source: Ensembl
    13. positive regulation of cytosolic calcium ion concentration Source: RGD
    14. positive regulation of leukocyte chemotaxis Source: RGD
    15. positive regulation of neutrophil chemotaxis Source: RGD
    16. positive regulation of vascular permeability Source: RGD
    17. receptor internalization Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Chemotaxis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-X-C chemokine receptor type 2
    Short name:
    CXC-R2
    Short name:
    CXCR-2
    Alternative name(s):
    GRO/MGSA receptor
    High affinity interleukin-8 receptor B
    Short name:
    IL-8R B
    CD_antigen: CD182
    Gene namesi
    Name:Cxcr2
    Synonyms:Il8rb
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 9

    Organism-specific databases

    RGDi2906. Cxcr2.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW
    3. mast cell granule Source: Ensembl
    4. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 359359C-X-C chemokine receptor type 2PRO_0000069342Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi8 – 81N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi23 – 231N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi118 ↔ 195PROSITE-ProRule annotation
    Glycosylationi201 – 2011N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi202 – 2021N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Phosphorylated upon ligand binding; which is required for desensitization.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiP35407.
    PRIDEiP35407.

    PTM databases

    PhosphoSiteiP35407.

    Expressioni

    Gene expression databases

    GenevestigatoriP35407.

    Interactioni

    Protein-protein interaction databases

    IntActiP35407. 1 interaction.
    MINTiMINT-271110.
    STRINGi10116.ENSRNOP00000019109.

    Structurei

    3D structure databases

    ProteinModelPortaliP35407.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4747ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini75 – 839CytoplasmicSequence Analysis
    Topological domaini105 – 11915ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini142 – 16221CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini183 – 20725ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini231 – 25020CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini273 – 29624ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini315 – 35945CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei48 – 7427Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei84 – 10421Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei120 – 14122Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei163 – 18220Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei208 – 23023Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei251 – 27222Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei297 – 31418Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG146068.
    GeneTreeiENSGT00730000110292.
    HOGENOMiHOG000234122.
    HOVERGENiHBG106917.
    InParanoidiP35407.
    KOiK05050.
    OMAiVITEDCK.
    OrthoDBiEOG7ZPNK9.
    PhylomeDBiP35407.
    TreeFamiTF330966.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000057. Chemokine_CXCR2.
    IPR000174. Chemokine_CXCR_1/2.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24227. PTHR24227. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00427. INTRLEUKIN8R.
    PR00573. INTRLEUKN8BR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P35407-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGEIRVDNFS LEDFFSGDID SYNYSSDPPF TLSDAAPCPS ANLDINRYAV    50
    VVIYVLVTLL SLVGNSLVML VILYNRSTCS VTDVYLLNLA IADLFFALTL 100
    PVWAASKVNG WIFGSFLCKV FSFLQEITFY SSVLLLACIS MDRYLAIVHA 150
    TSTLIQKRHL VKFVCITMWF LSLVLSLPIF ILRTTVKANP STVVCYENIG 200
    NNTSKWRVVL RILPQTYGFL LPLLIMLFCY GFTLRTLFKA HMGQKHRAMR 250
    VIFAVVLVFL LCWLPYNIVL FTDTLMRTKL IKETCERQNE INKALEATEI 300
    LGFLHSCLNP IIYAFIGQKF RHGLLKIMAN YGLVSKEFLA KEGRPSFVGS 350
    SSANTSTTL 359
    Length:359
    Mass (Da):40,532
    Last modified:February 1, 1996 - v2
    Checksum:iEF547326A074ABDD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X77797 mRNA. Translation: CAA54824.1.
    D63584 Genomic DNA. Translation: BAA09797.1.
    U70988 Genomic DNA. Translation: AAC52961.1.
    PIRiS42096.
    RefSeqiNP_058879.1. NM_017183.1.
    UniGeneiRn.90347.

    Genome annotation databases

    EnsembliENSRNOT00000019109; ENSRNOP00000019109; ENSRNOG00000014269.
    GeneIDi29385.
    KEGGirno:29385.
    UCSCiRGD:2906. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X77797 mRNA. Translation: CAA54824.1 .
    D63584 Genomic DNA. Translation: BAA09797.1 .
    U70988 Genomic DNA. Translation: AAC52961.1 .
    PIRi S42096.
    RefSeqi NP_058879.1. NM_017183.1.
    UniGenei Rn.90347.

    3D structure databases

    ProteinModelPortali P35407.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P35407. 1 interaction.
    MINTi MINT-271110.
    STRINGi 10116.ENSRNOP00000019109.

    Chemistry

    GuidetoPHARMACOLOGYi 69.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P35407.

    Proteomic databases

    PaxDbi P35407.
    PRIDEi P35407.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000019109 ; ENSRNOP00000019109 ; ENSRNOG00000014269 .
    GeneIDi 29385.
    KEGGi rno:29385.
    UCSCi RGD:2906. rat.

    Organism-specific databases

    CTDi 3579.
    RGDi 2906. Cxcr2.

    Phylogenomic databases

    eggNOGi NOG146068.
    GeneTreei ENSGT00730000110292.
    HOGENOMi HOG000234122.
    HOVERGENi HBG106917.
    InParanoidi P35407.
    KOi K05050.
    OMAi VITEDCK.
    OrthoDBi EOG7ZPNK9.
    PhylomeDBi P35407.
    TreeFami TF330966.

    Miscellaneous databases

    NextBioi 608983.
    PROi P35407.

    Gene expression databases

    Genevestigatori P35407.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000057. Chemokine_CXCR2.
    IPR000174. Chemokine_CXCR_1/2.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24227. PTHR24227. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00427. INTRLEUKIN8R.
    PR00573. INTRLEUKN8BR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of a cDNA encoding the rat interleukin-8 receptor."
      Gobl A.E., Huang M.R., Wang S., Zhou Y., Oeberg K.
      Biochim. Biophys. Acta 1326:171-177(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Lung.
    2. Konishi K., Shibata F., Watanabe K., Tsurufuji S., Nakagawa H., Fujioka M.
      Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Wistar.
      Tissue: Liver.
    3. "Identification of two rat genes orthologous to the human interleukin-8 receptors."
      Dunstan C.-A.N., Salafranca M.N., Adhikari S., Xia Y., Feng L., Harrison J.K.
      J. Biol. Chem. 271:32770-32776(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Wistar.
      Tissue: Lung and Spleen.

    Entry informationi

    Entry nameiCXCR2_RAT
    AccessioniPrimary (citable) accession number: P35407
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 117 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3