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P35407

- CXCR2_RAT

UniProt

P35407 - CXCR2_RAT

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Protein

C-X-C chemokine receptor type 2

Gene
Cxcr2, Il8rb
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2 By similarity.

GO - Molecular functioni

  1. interleukin-8 receptor activity Source: Ensembl

GO - Biological processi

  1. acute inflammatory response to antigenic stimulus Source: RGD
  2. cellular defense response Source: Ensembl
  3. metanephric tubule morphogenesis Source: RGD
  4. midbrain development Source: RGD
  5. negative regulation of apoptotic process Source: RGD
  6. negative regulation of neutrophil apoptotic process Source: RGD
  7. neutrophil activation Source: Ensembl
  8. neutrophil chemotaxis Source: RGD
  9. phospholipase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
  10. positive regulation of angiogenesis Source: RGD
  11. positive regulation of cardiac muscle cell apoptotic process Source: RGD
  12. positive regulation of cell proliferation Source: Ensembl
  13. positive regulation of cytosolic calcium ion concentration Source: RGD
  14. positive regulation of leukocyte chemotaxis Source: RGD
  15. positive regulation of neutrophil chemotaxis Source: RGD
  16. positive regulation of vascular permeability Source: RGD
  17. receptor internalization Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Chemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C chemokine receptor type 2
Short name:
CXC-R2
Short name:
CXCR-2
Alternative name(s):
GRO/MGSA receptor
High affinity interleukin-8 receptor B
Short name:
IL-8R B
CD_antigen: CD182
Gene namesi
Name:Cxcr2
Synonyms:Il8rb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 9

Organism-specific databases

RGDi2906. Cxcr2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4747Extracellular Reviewed predictionAdd
BLAST
Transmembranei48 – 7427Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini75 – 839Cytoplasmic Reviewed prediction
Transmembranei84 – 10421Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini105 – 11915Extracellular Reviewed predictionAdd
BLAST
Transmembranei120 – 14122Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini142 – 16221Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei163 – 18220Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini183 – 20725Extracellular Reviewed predictionAdd
BLAST
Transmembranei208 – 23023Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini231 – 25020Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei251 – 27222Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini273 – 29624Extracellular Reviewed predictionAdd
BLAST
Transmembranei297 – 31418Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini315 – 35945Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. mast cell granule Source: Ensembl
  4. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359C-X-C chemokine receptor type 2PRO_0000069342Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi8 – 81N-linked (GlcNAc...) Reviewed prediction
Glycosylationi23 – 231N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi118 ↔ 195 By similarity
Glycosylationi201 – 2011N-linked (GlcNAc...) Reviewed prediction
Glycosylationi202 – 2021N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Phosphorylated upon ligand binding; which is required for desensitization By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP35407.
PRIDEiP35407.

PTM databases

PhosphoSiteiP35407.

Expressioni

Gene expression databases

GenevestigatoriP35407.

Interactioni

Protein-protein interaction databases

IntActiP35407. 1 interaction.
MINTiMINT-271110.
STRINGi10116.ENSRNOP00000019109.

Structurei

3D structure databases

ProteinModelPortaliP35407.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146068.
GeneTreeiENSGT00730000110292.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP35407.
KOiK05050.
OMAiVITEDCK.
OrthoDBiEOG7ZPNK9.
PhylomeDBiP35407.
TreeFamiTF330966.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000057. Chemokine_CXCR2.
IPR000174. Chemokine_CXCR_1/2.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00427. INTRLEUKIN8R.
PR00573. INTRLEUKN8BR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35407-1 [UniParc]FASTAAdd to Basket

« Hide

MGEIRVDNFS LEDFFSGDID SYNYSSDPPF TLSDAAPCPS ANLDINRYAV    50
VVIYVLVTLL SLVGNSLVML VILYNRSTCS VTDVYLLNLA IADLFFALTL 100
PVWAASKVNG WIFGSFLCKV FSFLQEITFY SSVLLLACIS MDRYLAIVHA 150
TSTLIQKRHL VKFVCITMWF LSLVLSLPIF ILRTTVKANP STVVCYENIG 200
NNTSKWRVVL RILPQTYGFL LPLLIMLFCY GFTLRTLFKA HMGQKHRAMR 250
VIFAVVLVFL LCWLPYNIVL FTDTLMRTKL IKETCERQNE INKALEATEI 300
LGFLHSCLNP IIYAFIGQKF RHGLLKIMAN YGLVSKEFLA KEGRPSFVGS 350
SSANTSTTL 359
Length:359
Mass (Da):40,532
Last modified:February 1, 1996 - v2
Checksum:iEF547326A074ABDD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X77797 mRNA. Translation: CAA54824.1.
D63584 Genomic DNA. Translation: BAA09797.1.
U70988 Genomic DNA. Translation: AAC52961.1.
PIRiS42096.
RefSeqiNP_058879.1. NM_017183.1.
UniGeneiRn.90347.

Genome annotation databases

EnsembliENSRNOT00000019109; ENSRNOP00000019109; ENSRNOG00000014269.
GeneIDi29385.
KEGGirno:29385.
UCSCiRGD:2906. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X77797 mRNA. Translation: CAA54824.1 .
D63584 Genomic DNA. Translation: BAA09797.1 .
U70988 Genomic DNA. Translation: AAC52961.1 .
PIRi S42096.
RefSeqi NP_058879.1. NM_017183.1.
UniGenei Rn.90347.

3D structure databases

ProteinModelPortali P35407.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P35407. 1 interaction.
MINTi MINT-271110.
STRINGi 10116.ENSRNOP00000019109.

Chemistry

GuidetoPHARMACOLOGYi 69.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P35407.

Proteomic databases

PaxDbi P35407.
PRIDEi P35407.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000019109 ; ENSRNOP00000019109 ; ENSRNOG00000014269 .
GeneIDi 29385.
KEGGi rno:29385.
UCSCi RGD:2906. rat.

Organism-specific databases

CTDi 3579.
RGDi 2906. Cxcr2.

Phylogenomic databases

eggNOGi NOG146068.
GeneTreei ENSGT00730000110292.
HOGENOMi HOG000234122.
HOVERGENi HBG106917.
InParanoidi P35407.
KOi K05050.
OMAi VITEDCK.
OrthoDBi EOG7ZPNK9.
PhylomeDBi P35407.
TreeFami TF330966.

Miscellaneous databases

NextBioi 608983.
PROi P35407.

Gene expression databases

Genevestigatori P35407.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000057. Chemokine_CXCR2.
IPR000174. Chemokine_CXCR_1/2.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24227. PTHR24227. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00427. INTRLEUKIN8R.
PR00573. INTRLEUKN8BR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and characterization of a cDNA encoding the rat interleukin-8 receptor."
    Gobl A.E., Huang M.R., Wang S., Zhou Y., Oeberg K.
    Biochim. Biophys. Acta 1326:171-177(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Lung.
  2. Konishi K., Shibata F., Watanabe K., Tsurufuji S., Nakagawa H., Fujioka M.
    Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Wistar.
    Tissue: Liver.
  3. "Identification of two rat genes orthologous to the human interleukin-8 receptors."
    Dunstan C.-A.N., Salafranca M.N., Adhikari S., Xia Y., Feng L., Harrison J.K.
    J. Biol. Chem. 271:32770-32776(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Wistar.
    Tissue: Lung and Spleen.

Entry informationi

Entry nameiCXCR2_RAT
AccessioniPrimary (citable) accession number: P35407
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: February 1, 1996
Last modified: June 11, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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