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Protein

C-X-C chemokine receptor type 2

Gene

Cxcr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • acute inflammatory response to antigenic stimulus Source: RGD
  • cellular defense response Source: Ensembl
  • metanephric tubule morphogenesis Source: RGD
  • midbrain development Source: RGD
  • negative regulation of apoptotic process Source: RGD
  • negative regulation of neutrophil apoptotic process Source: RGD
  • neutrophil activation Source: Ensembl
  • neutrophil chemotaxis Source: RGD
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
  • positive regulation of angiogenesis Source: RGD
  • positive regulation of cardiac muscle cell apoptotic process Source: RGD
  • positive regulation of cell proliferation Source: Ensembl
  • positive regulation of cytosolic calcium ion concentration Source: RGD
  • positive regulation of leukocyte chemotaxis Source: RGD
  • positive regulation of neutrophil chemotaxis Source: RGD
  • positive regulation of vascular permeability Source: RGD
  • receptor internalization Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

ReactomeiR-RNO-380108. Chemokine receptors bind chemokines.
R-RNO-418594. G alpha (i) signalling events.
R-RNO-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C chemokine receptor type 2
Short name:
CXC-R2
Short name:
CXCR-2
Alternative name(s):
GRO/MGSA receptor
High affinity interleukin-8 receptor B
Short name:
IL-8R B
CD_antigen: CD182
Gene namesi
Name:Cxcr2
Synonyms:Il8rb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi2906. Cxcr2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 47ExtracellularSequence analysisAdd BLAST47
Transmembranei48 – 74Helical; Name=1Sequence analysisAdd BLAST27
Topological domaini75 – 83CytoplasmicSequence analysis9
Transmembranei84 – 104Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini105 – 119ExtracellularSequence analysisAdd BLAST15
Transmembranei120 – 141Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini142 – 162CytoplasmicSequence analysisAdd BLAST21
Transmembranei163 – 182Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini183 – 207ExtracellularSequence analysisAdd BLAST25
Transmembranei208 – 230Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini231 – 250CytoplasmicSequence analysisAdd BLAST20
Transmembranei251 – 272Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini273 – 296ExtracellularSequence analysisAdd BLAST24
Transmembranei297 – 314Helical; Name=7Sequence analysisAdd BLAST18
Topological domaini315 – 359CytoplasmicSequence analysisAdd BLAST45

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000693421 – 359C-X-C chemokine receptor type 2Add BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi8N-linked (GlcNAc...)Sequence analysis1
Glycosylationi23N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi118 ↔ 195PROSITE-ProRule annotation
Glycosylationi201N-linked (GlcNAc...)Sequence analysis1
Glycosylationi202N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Phosphorylated upon ligand binding; which is required for desensitization.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP35407.
PRIDEiP35407.

PTM databases

PhosphoSitePlusiP35407.

Expressioni

Gene expression databases

BgeeiENSRNOG00000014269.
ExpressionAtlasiP35407. baseline and differential.
GenevisibleiP35407. RN.

Interactioni

Protein-protein interaction databases

IntActiP35407. 1 interactor.
MINTiMINT-271110.
STRINGi10116.ENSRNOP00000019109.

Structurei

3D structure databases

ProteinModelPortaliP35407.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEHI. Eukaryota.
ENOG410Y9Y6. LUCA.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP35407.
KOiK05050.
OMAiMRTKLIK.
OrthoDBiEOG091G0C7W.
PhylomeDBiP35407.
TreeFamiTF330966.

Family and domain databases

InterProiIPR000057. Chemokine_CXCR2.
IPR000174. Chemokine_CXCR_1/2.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00427. INTRLEUKIN8R.
PR00573. INTRLEUKN8BR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35407-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEIRVDNFS LEDFFSGDID SYNYSSDPPF TLSDAAPCPS ANLDINRYAV
60 70 80 90 100
VVIYVLVTLL SLVGNSLVML VILYNRSTCS VTDVYLLNLA IADLFFALTL
110 120 130 140 150
PVWAASKVNG WIFGSFLCKV FSFLQEITFY SSVLLLACIS MDRYLAIVHA
160 170 180 190 200
TSTLIQKRHL VKFVCITMWF LSLVLSLPIF ILRTTVKANP STVVCYENIG
210 220 230 240 250
NNTSKWRVVL RILPQTYGFL LPLLIMLFCY GFTLRTLFKA HMGQKHRAMR
260 270 280 290 300
VIFAVVLVFL LCWLPYNIVL FTDTLMRTKL IKETCERQNE INKALEATEI
310 320 330 340 350
LGFLHSCLNP IIYAFIGQKF RHGLLKIMAN YGLVSKEFLA KEGRPSFVGS

SSANTSTTL
Length:359
Mass (Da):40,532
Last modified:February 1, 1996 - v2
Checksum:iEF547326A074ABDD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77797 mRNA. Translation: CAA54824.1.
D63584 Genomic DNA. Translation: BAA09797.1.
U70988 Genomic DNA. Translation: AAC52961.1.
PIRiS42096.
RefSeqiNP_058879.1. NM_017183.1.
XP_008765435.1. XM_008767213.2.
UniGeneiRn.90347.

Genome annotation databases

EnsembliENSRNOT00000019109; ENSRNOP00000019109; ENSRNOG00000014269.
GeneIDi29385.
KEGGirno:29385.
UCSCiRGD:2906. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77797 mRNA. Translation: CAA54824.1.
D63584 Genomic DNA. Translation: BAA09797.1.
U70988 Genomic DNA. Translation: AAC52961.1.
PIRiS42096.
RefSeqiNP_058879.1. NM_017183.1.
XP_008765435.1. XM_008767213.2.
UniGeneiRn.90347.

3D structure databases

ProteinModelPortaliP35407.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP35407. 1 interactor.
MINTiMINT-271110.
STRINGi10116.ENSRNOP00000019109.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP35407.

Proteomic databases

PaxDbiP35407.
PRIDEiP35407.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000019109; ENSRNOP00000019109; ENSRNOG00000014269.
GeneIDi29385.
KEGGirno:29385.
UCSCiRGD:2906. rat.

Organism-specific databases

CTDi3579.
RGDi2906. Cxcr2.

Phylogenomic databases

eggNOGiENOG410IEHI. Eukaryota.
ENOG410Y9Y6. LUCA.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP35407.
KOiK05050.
OMAiMRTKLIK.
OrthoDBiEOG091G0C7W.
PhylomeDBiP35407.
TreeFamiTF330966.

Enzyme and pathway databases

ReactomeiR-RNO-380108. Chemokine receptors bind chemokines.
R-RNO-418594. G alpha (i) signalling events.
R-RNO-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiP35407.

Gene expression databases

BgeeiENSRNOG00000014269.
ExpressionAtlasiP35407. baseline and differential.
GenevisibleiP35407. RN.

Family and domain databases

InterProiIPR000057. Chemokine_CXCR2.
IPR000174. Chemokine_CXCR_1/2.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00427. INTRLEUKIN8R.
PR00573. INTRLEUKN8BR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCXCR2_RAT
AccessioniPrimary (citable) accession number: P35407
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: February 1, 1996
Last modified: November 30, 2016
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.