P35405 (ADA2C_DIDVI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alpha-2C adrenergic receptor

Alternative name(s):
Alpha-2C adrenoreceptor
Short name=Alpha-2C adrenoceptor
Short name=Alpha-2CAR

Gene names

Name:

ADRA2C

Organism

Didelphis virginiana (North American opossum) (Didelphis marsupialis virginiana)

Taxonomic identifier

9267 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Metatheria › Didelphimorphia › Didelphidae › Didelphinae › Didelphis

Protein attributes

Sequence length	469 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2C sub-subfamily.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	alpha2-adrenergic receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 469	469	Alpha-2C adrenergic receptor		PRO_0000069104
Regions
	Topological domain	1 – 36	36	Extracellular By similarity
	Transmembrane	37 – 62	26	Helical; Name=1; By similarity
	Topological domain	63 – 73	11	Cytoplasmic By similarity
	Transmembrane	74 – 99	26	Helical; Name=2; By similarity
	Topological domain	100 – 109	10	Extracellular By similarity
	Transmembrane	110 – 132	23	Helical; Name=3; By similarity
	Topological domain	133 – 154	22	Cytoplasmic By similarity
	Transmembrane	155 – 175	21	Helical; Name=4; By similarity
	Topological domain	176 – 194	19	Extracellular By similarity
	Transmembrane	195 – 216	22	Helical; Name=5; By similarity
	Topological domain	217 – 386	170	Cytoplasmic By similarity
	Transmembrane	387 – 407	21	Helical; Name=6; By similarity
	Topological domain	408 – 427	20	Extracellular By similarity
	Transmembrane	428 – 448	21	Helical; Name=7; By similarity
	Topological domain	449 – 469	21	Cytoplasmic By similarity
	Compositional bias	274 – 293	20	His-rich (basic)
Sites
	Site	116	1	Implicated in ligand binding By similarity
	Site	199	1	Implicated in catechol agonist binding and receptor activation By similarity
	Site	203	1	Implicated in catechol agonist binding and receptor activation By similarity
Amino acid modifications
	Glycosylation	8	1	N-linked (GlcNAc...) Potential
	Glycosylation	20	1	N-linked (GlcNAc...) Potential
	Disulfide bond	109 ↔ 187		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P35405 [UniParc]. Last modified June 6, 2002. Version 2. Checksum: 6F97D3718CC15C18	FASTA	469	53,223
	10 20 30 40 50 60 MDLQLTTNST DSGDRGGSSN ESLQRQPPSQ YSPAEVAGLA AVVSFLIVFT IVGNVLVVIA 70 80 90 100 110 120 VLTSRALKAP QNLFQVSLAS ADILVATLVM PFSLANELMN YWYFGKVWCV IYLALDVLFC 130 140 150 160 170 180 TSSIVHLCAI SLDRYWSVTQ AVEYNLKRTP RRIKGIIVTV WLISAVISFP PLISLYRDPE 190 200 210 220 230 240 DDLYPQCELN DETWYILSSC IGSFFAPCII MVLVYVRIYR VAKLRTRTLS EKRTVPEGSS 250 260 270 280 290 300 QTENGLSRPP VGAGPSTAAA AAASLRLQAG ENGHYHLHHH HHHLHHHHHH HHHQLRKSAE 310 320 330 340 350 360 LEDIELEESS TSENRRRRRS REEAAARKGS RGFSFSFSST KGGQSAGAGS RLSRASNRSL 370 380 390 400 410 420 EFFSTHRRRK RSSLCRRKVT QAREKRFTFV LAVVMGVFVV CWFPFFFTYS LYGICREACQ 430 440 450 460 VPETLFKFFF WIGYCNSSLN PVIYTIFNQD FRRSFKHILF KKKKKTSLQ

References

[1]	"Cloning and expression of the alpha 2C-adrenergic receptor from the OK cell line." Blaxall H.S., Cerutis D., Hass N.A., Iversen L.J., Bylund D.B. Mol. Pharmacol. 45:176-181(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Kidney.
[2]	Bylund D.B. Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION TO 60; 75; 110; 143; 326-332; 365 AND 432.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U04310 mRNA. Translation: AAA17566.2.
3D structure databases
ProteinModelPortal	P35405.
SMR	P35405. Positions 121-152.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG106962.
Family and domain databases
InterPro	IPR000735. Adren_rcpt_A2C. IPR002233. Adrnrgc_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR01103. ADRENERGICR. PR00560. ADRENRGCA2CR. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P35405.

Entry information

Entry name

ADA2C_DIDVI

Accession

Primary (citable) accession number: P35405

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 6, 2002
Last modified:	April 3, 2013
This is version 71 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program