P35404 (5HT1B_DIDVI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
5-hydroxytryptamine receptor 1B
Short name=5-HT-1B
Short name=5-HT1B

Alternative name(s):
Serotonin receptor 1B

Gene names

Name:

HTR1B

Organism

Didelphis virginiana (North American opossum) (Didelphis marsupialis virginiana)

Taxonomic identifier

9267 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Metatheria › Didelphimorphia › Didelphidae › Didelphinae › Didelphis

Protein attributes

Sequence length	388 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Post-translational modification	Phosphorylated By similarity. Palmitoylated By similarity.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate Phosphoprotein
Gene Ontology (GO)
Biological_process	serotonin receptor signaling pathway Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	serotonin receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 388	388	5-hydroxytryptamine receptor 1B		PRO_0000068913
Regions
	Topological domain	1 – 48	48	Extracellular By similarity
	Transmembrane	49 – 74	26	Helical; Name=1; By similarity
	Topological domain	75 – 85	11	Cytoplasmic By similarity
	Transmembrane	86 – 112	27	Helical; Name=2; By similarity
	Topological domain	113 – 122	10	Extracellular By similarity
	Transmembrane	123 – 144	22	Helical; Name=3; By similarity
	Topological domain	145 – 166	22	Cytoplasmic By similarity
	Transmembrane	167 – 186	20	Helical; Name=4; By similarity
	Topological domain	187 – 207	21	Extracellular By similarity
	Transmembrane	208 – 227	20	Helical; Name=5; By similarity
	Topological domain	228 – 313	86	Cytoplasmic By similarity
	Transmembrane	314 – 335	22	Helical; Name=6; By similarity
	Topological domain	336 – 348	13	Extracellular By similarity
	Transmembrane	349 – 371	23	Helical; Name=7; By similarity
	Topological domain	372 – 388	17	Cytoplasmic By similarity
Amino acid modifications
	Glycosylation	22	1	N-linked (GlcNAc...) Potential
	Glycosylation	30	1	N-linked (GlcNAc...) Potential
	Disulfide bond	121 ↔ 197		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P35404 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: DB5E8A033325615A	FASTA	388	43,111
	10 20 30 40 50 60 MEQPSRLCSP PASGSLTSSQ TNHSTFPNPN CSAPDLEPYQ DSIALPWKVL LATFLGLITL 70 80 90 100 110 120 GTTLSNAFVI ATVSRTRKLH TPANYLIASL AVTDLLVSIL VMPISTMYTV TGRWTLGQVV 130 140 150 160 170 180 CDFWLSSDIT CCTASILHLC VIALDRYWAI TDAVEYSAKR TPKRAAGMII MVWVFSVSIS 190 200 210 220 230 240 MPPLFWRQAK AEEVADCSVN TDHILYTVYS TVGAFYFPTL LLIALYGRIY VEARSRILKQ 250 260 270 280 290 300 TPNRTGKRLT RAQLITDSPG SSSSGTSINS RAPEGPSESG SPVYVNQVKV KVSDALLEKK 310 320 330 340 350 360 KLMAARERKA TRTLGIILGA FIVCWLPFFI ISLALPICDD ACWFHLAIFD FFNWLGYLNS 370 380 LINPIIYTKS NDDFKQAFQK LMRFRRTS

References

[1]	"The cloning and expression of an OK cell cDNA encoding a 5-hydroxytryptamine1B receptor." Cerutis D., Hass N.A., Iversen L.J., Bylund D.B. Mol. Pharmacol. 45:20-28(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U04311 mRNA. Translation: AAA17567.1.
3D structure databases
ProteinModelPortal	P35404.
SMR	P35404. Positions 133-164.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG106962.
Family and domain databases
InterPro	IPR002147. 5HT1B_rcpt. IPR002231. 5HT_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00513. 5HT1BRECEPTR. PR01101. 5HTRECEPTOR. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

5HT1B_DIDVI

Accession

Primary (citable) accession number: P35404

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	April 3, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program