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P35400

- GRM7_RAT

UniProt

P35400 - GRM7_RAT

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Protein

Metabotropic glutamate receptor 7

Gene

Grm7

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei159 – 1591GlutamateBy similarity
Binding sitei230 – 2301GlutamateBy similarity
Binding sitei314 – 3141GlutamateBy similarity
Binding sitei407 – 4071GlutamateBy similarity

GO - Molecular functioni

  1. adenylate cyclase inhibiting G-protein coupled glutamate receptor activity Source: RGD
  2. calcium channel regulator activity Source: RefGenome
  3. calcium-dependent protein binding Source: RGD
  4. calmodulin binding Source: UniProtKB
  5. glutamate binding Source: RGD
  6. group III metabotropic glutamate receptor activity Source: RGD
  7. PDZ domain binding Source: RGD
  8. protein homodimerization activity Source: RGD

GO - Biological processi

  1. adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway Source: RGD
  2. learning or memory Source: UniProtKB
  3. negative regulation of glutamate secretion Source: RGD
  4. regulation of synaptic transmission, glutamatergic Source: RefGenome
  5. sensory perception of smell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Names & Taxonomyi

Protein namesi
Recommended name:
Metabotropic glutamate receptor 7
Short name:
mGluR7
Gene namesi
Name:Grm7
Synonyms:Gprc1g, Mglur7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi619857. Grm7.

Subcellular locationi

GO - Cellular componenti

  1. asymmetric synapse Source: RGD
  2. axon Source: RGD
  3. axon terminus Source: RGD
  4. cell surface Source: UniProtKB
  5. dendrite Source: RGD
  6. dendritic shaft Source: RGD
  7. Golgi apparatus Source: RGD
  8. integral component of plasma membrane Source: RefGenome
  9. membrane Source: RGD
  10. neuronal cell body Source: RGD
  11. postsynaptic membrane Source: UniProtKB
  12. presynaptic active zone Source: UniProtKB
  13. presynaptic membrane Source: RGD
  14. protein complex Source: RGD
  15. rough endoplasmic reticulum Source: RGD
  16. synapse Source: RGD
  17. terminal bouton Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434Sequence AnalysisAdd
BLAST
Chaini35 – 915881Metabotropic glutamate receptor 7PRO_0000012940Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi67 ↔ 1091 Publication
Glycosylationi98 – 981N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi249 ↔ 541By similarity
Disulfide bondi374 ↔ 3901 Publication
Disulfide bondi430 ↔ 4371 Publication
Glycosylationi458 – 4581N-linked (GlcNAc...)Sequence Analysis
Glycosylationi486 – 4861N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi523 ↔ 542By similarity
Disulfide bondi527 ↔ 545By similarity
Disulfide bondi548 ↔ 560By similarity
Disulfide bondi563 ↔ 576By similarity
Glycosylationi572 – 5721N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP35400.

PTM databases

PhosphoSiteiP35400.

Expressioni

Tissue specificityi

Widely distributed throughout the brain.2 Publications

Gene expression databases

GenevestigatoriP35400.

Interactioni

Subunit structurei

Interacts with PICK1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Grip1P978793EBI-6936416,EBI-936113
Pick1Q9EP802EBI-6936416,EBI-77728
Ppp1ccP630884EBI-6936416,EBI-80049

Protein-protein interaction databases

BioGridi249569. 10 interactions.
DIPiDIP-41145N.
IntActiP35400. 6 interactions.
MINTiMINT-146474.
STRINGi10116.ENSRNOP00000053411.

Structurei

Secondary structure

1
915
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi42 – 454
Beta strandi48 – 558
Beta strandi58 – 603
Beta strandi62 – 643
Beta strandi66 – 705
Helixi72 – 9120
Beta strandi93 – 986
Beta strandi101 – 1077
Helixi112 – 1187
Helixi119 – 1268
Beta strandi150 – 1545
Helixi159 – 1657
Helixi168 – 1714
Beta strandi176 – 1805
Helixi184 – 1874
Turni189 – 1924
Beta strandi193 – 1997
Helixi202 – 21514
Beta strandi221 – 2288
Helixi229 – 24416
Beta strandi250 – 2567
Helixi265 – 27410
Beta strandi282 – 2865
Helixi289 – 30113
Turni305 – 3073
Beta strandi308 – 3125
Turni314 – 3185
Helixi321 – 3233
Helixi327 – 3304
Beta strandi334 – 3396
Helixi344 – 3507
Turni355 – 3573
Helixi364 – 3718
Helixi394 – 3974
Helixi408 – 42922
Turni438 – 4436
Helixi445 – 4528
Beta strandi477 – 4837
Beta strandi491 – 50414
Beta strandi506 – 5083

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2E4ZX-ray3.30A33-521[»]
ProteinModelPortaliP35400.
SMRiP35400. Positions 40-511.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP35400.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini35 – 590556ExtracellularSequence AnalysisAdd
BLAST
Topological domaini616 – 62712CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini649 – 6546ExtracellularSequence Analysis
Topological domaini676 – 70227CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini724 – 75330ExtracellularSequence AnalysisAdd
BLAST
Topological domaini776 – 78813CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini811 – 82515ExtracellularSequence AnalysisAdd
BLAST
Topological domaini851 – 91565CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei591 – 61525Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei628 – 64821Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei655 – 67521Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei703 – 72321Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei754 – 77522Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei789 – 81022Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei826 – 85025Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni180 – 1823Glutamate bindingBy similarity

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG295200.
HOVERGENiHBG107965.
InParanoidiP35400.
KOiK04608.
PhylomeDBiP35400.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR000162. GPCR_3_mtglu_rcpt.
IPR001883. GPCR_3_mtglu_rcpt_7.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
PR01057. MTABOTROPC7R.
PR00593. MTABOTROPICR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35400 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVQLGKLLRV LTLMKFPCCV LEVLLCVLAA AARGQEMYAP HSIRIEGDVT
60 70 80 90 100
LGGLFPVHAK GPSGVPCGDI KRENGIHRLE AMLYALDQIN SDPNLLPNVT
110 120 130 140 150
LGARILDTCS RDTYALEQSL TFVQALIQKD TSDVRCTNGE PPVFVKPEKV
160 170 180 190 200
VGVIGASGSS VSIMVANILR LFQIPQISYA STAPELSDDR RYDFFSRVVP
210 220 230 240 250
PDSFQAQAMV DIVKALGWNY VSTLASEGSY GEKGVESFTQ ISKEAGGLCI
260 270 280 290 300
AQSVRIPQER KDRTIDFDRI IKQLLDTPNS RAVVIFANDE DIKQILAAAK
310 320 330 340 350
RADQVGHFLW VGSDSWGSKI NPLHQHEDIA EGAITIQPKR ATVEGFDAYF
360 370 380 390 400
TSRTLENNRR NVWFAEYWEE NFNCKLTISG SKKEDTDRKC TGQERIGKDS
410 420 430 440 450
NYEQEGKVQF VIDAVYAMAH ALHHMNKDLC ADYRGVCPEM EQAGGKKLLK
460 470 480 490 500
YIRHVNFNGS AGTPVMFNKN GDAPGRYDIF QYQTTNTTNP GYRLIGQWTD
510 520 530 540 550
ELQLNIEDMQ WGKGVREIPS SVCTLPCKPG QRKKTQKGTP CCWTCEPCDG
560 570 580 590 600
YQYQFDEMTC QHCPYDQRPN ENRTGCQNIP IIKLEWHSPW AVIPVFLAML
610 620 630 640 650
GIIATIFVMA TFIRYNDTPI VRASGRELSY VLLTGIFLCY IITFLMIAKP
660 670 680 690 700
DVAVCSFRRV FLGLGMCISY AALLTKTNRI YRIFEQGKKS VTAPRLISPT
710 720 730 740 750
SQLAITSSLI SVQLLGVFIW FGVDPPNIII DYDEHKTMNP EQARGVLKCD
760 770 780 790 800
ITDLQIICSL GYSILLMVTC TVYAIKTRGV PENFNEAKPI GFTMYTTCIV
810 820 830 840 850
WLAFIPIFFG TAQSAEKLYI QTTTLTISMN LSASVALGML YMPKVYIIIF
860 870 880 890 900
HPELNVQKRK RSFKAVVTAA TMSSRLSHKP SDRPNGEAKT ELCENVDPNS
910
PAAKKKYVSY NNLVI
Length:915
Mass (Da):102,232
Last modified:June 1, 1994 - v1
Checksum:iF28AFC4C6454A6C2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D16817 mRNA. Translation: BAA04092.1.
U06832 mRNA. Translation: AAA20655.1.
PIRiA49874.
RefSeqiNP_112302.1. NM_031040.1.
UniGeneiRn.10409.

Genome annotation databases

GeneIDi81672.
KEGGirno:81672.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D16817 mRNA. Translation: BAA04092.1 .
U06832 mRNA. Translation: AAA20655.1 .
PIRi A49874.
RefSeqi NP_112302.1. NM_031040.1.
UniGenei Rn.10409.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2E4Z X-ray 3.30 A 33-521 [» ]
ProteinModelPortali P35400.
SMRi P35400. Positions 40-511.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 249569. 10 interactions.
DIPi DIP-41145N.
IntActi P35400. 6 interactions.
MINTi MINT-146474.
STRINGi 10116.ENSRNOP00000053411.

Chemistry

BindingDBi P35400.
ChEMBLi CHEMBL2111335.
GuidetoPHARMACOLOGYi 295.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P35400.

Proteomic databases

PRIDEi P35400.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 81672.
KEGGi rno:81672.

Organism-specific databases

CTDi 2917.
RGDi 619857. Grm7.

Phylogenomic databases

eggNOGi NOG295200.
HOVERGENi HBG107965.
InParanoidi P35400.
KOi K04608.
PhylomeDBi P35400.

Miscellaneous databases

EvolutionaryTracei P35400.
NextBioi 615264.

Gene expression databases

Genevestigatori P35400.

Family and domain databases

InterProi IPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR000162. GPCR_3_mtglu_rcpt.
IPR001883. GPCR_3_mtglu_rcpt_7.
IPR028082. Peripla_BP_I.
[Graphical view ]
Pfami PF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view ]
PRINTSi PR00248. GPCRMGR.
PR01057. MTABOTROPC7R.
PR00593. MTABOTROPICR.
SUPFAMi SSF53822. SSF53822. 1 hit.
PROSITEi PS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction."
    Okamoto N., Hori S., Akazawa C., Hayashi Y., Shigemoto R., Mizuno N., Nakanishi S.
    J. Biol. Chem. 269:1231-1236(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
    Tissue: Brain.
  2. "Cloning and expression of a new member of the L-2-amino-4-phosphonobutyric acid-sensitive class of metabotropic glutamate receptors."
    Saugstad J.A., Kinzie J.M., Mulvihill E.R., Segerson T.P., Westbrook G.L.
    Mol. Pharmacol. 45:367-372(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
    Tissue: Olfactory bulb.
  3. "Interaction of the C-terminal tail region of the metabotropic glutamate receptor 7 with the protein kinase C substrate PICK1."
    El Far O., Airas J., Wischmeyer E., Nehring R.B., Karschin A., Betz H.
    Eur. J. Neurosci. 12:4215-4221(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PICK1.
  4. "Structures of the extracellular regions of the group II/III metabotropic glutamate receptors."
    Muto T., Tsuchiya D., Morikawa K., Jingami H.
    Proc. Natl. Acad. Sci. U.S.A. 104:3759-3764(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF 33-521, DISULFIDE BONDS.

Entry informationi

Entry nameiGRM7_RAT
AccessioniPrimary (citable) accession number: P35400
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: October 29, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3