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P35400

- GRM7_RAT

UniProt

P35400 - GRM7_RAT

Protein

Metabotropic glutamate receptor 7

Gene

Grm7

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.2 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei159 – 1591GlutamateBy similarity
    Binding sitei230 – 2301GlutamateBy similarity
    Binding sitei314 – 3141GlutamateBy similarity
    Binding sitei407 – 4071GlutamateBy similarity

    GO - Molecular functioni

    1. adenylate cyclase inhibiting G-protein coupled glutamate receptor activity Source: RGD
    2. calcium channel regulator activity Source: RefGenome
    3. calcium-dependent protein binding Source: RGD
    4. calmodulin binding Source: UniProtKB
    5. glutamate binding Source: RGD
    6. group III metabotropic glutamate receptor activity Source: RGD
    7. PDZ domain binding Source: RGD
    8. protein binding Source: IntAct
    9. protein homodimerization activity Source: RGD

    GO - Biological processi

    1. adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway Source: RGD
    2. learning or memory Source: UniProtKB
    3. negative regulation of glutamate secretion Source: RGD
    4. regulation of synaptic transmission, glutamatergic Source: RefGenome
    5. sensory perception of smell Source: UniProtKB-KW

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Metabotropic glutamate receptor 7
    Short name:
    mGluR7
    Gene namesi
    Name:Grm7
    Synonyms:Gprc1g, Mglur7
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi619857. Grm7.

    Subcellular locationi

    GO - Cellular componenti

    1. asymmetric synapse Source: RGD
    2. axon Source: RGD
    3. axon terminus Source: RGD
    4. cell surface Source: UniProtKB
    5. dendrite Source: RGD
    6. dendritic shaft Source: RGD
    7. Golgi apparatus Source: RGD
    8. integral component of plasma membrane Source: RefGenome
    9. membrane Source: RGD
    10. neuronal cell body Source: RGD
    11. postsynaptic membrane Source: UniProtKB
    12. presynaptic active zone Source: UniProtKB
    13. presynaptic membrane Source: RGD
    14. protein complex Source: RGD
    15. rough endoplasmic reticulum Source: RGD
    16. synapse Source: RGD
    17. terminal bouton Source: RGD

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3434Sequence AnalysisAdd
    BLAST
    Chaini35 – 915881Metabotropic glutamate receptor 7PRO_0000012940Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi67 ↔ 1091 Publication
    Glycosylationi98 – 981N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi249 ↔ 541By similarity
    Disulfide bondi374 ↔ 3901 Publication
    Disulfide bondi430 ↔ 4371 Publication
    Glycosylationi458 – 4581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi486 – 4861N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi523 ↔ 542By similarity
    Disulfide bondi527 ↔ 545By similarity
    Disulfide bondi548 ↔ 560By similarity
    Disulfide bondi563 ↔ 576By similarity
    Glycosylationi572 – 5721N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP35400.

    PTM databases

    PhosphoSiteiP35400.

    Expressioni

    Tissue specificityi

    Widely distributed throughout the brain.2 Publications

    Gene expression databases

    GenevestigatoriP35400.

    Interactioni

    Subunit structurei

    Interacts with PICK1.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Grip1P978793EBI-6936416,EBI-936113
    Pick1Q9EP802EBI-6936416,EBI-77728
    Ppp1ccP630884EBI-6936416,EBI-80049

    Protein-protein interaction databases

    BioGridi249569. 10 interactions.
    DIPiDIP-41145N.
    IntActiP35400. 6 interactions.
    MINTiMINT-146474.
    STRINGi10116.ENSRNOP00000053411.

    Structurei

    Secondary structure

    1
    915
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi42 – 454
    Beta strandi48 – 558
    Beta strandi58 – 603
    Beta strandi62 – 643
    Beta strandi66 – 705
    Helixi72 – 9120
    Beta strandi93 – 986
    Beta strandi101 – 1077
    Helixi112 – 1187
    Helixi119 – 1268
    Beta strandi150 – 1545
    Helixi159 – 1657
    Helixi168 – 1714
    Beta strandi176 – 1805
    Helixi184 – 1874
    Turni189 – 1924
    Beta strandi193 – 1997
    Helixi202 – 21514
    Beta strandi221 – 2288
    Helixi229 – 24416
    Beta strandi250 – 2567
    Helixi265 – 27410
    Beta strandi282 – 2865
    Helixi289 – 30113
    Turni305 – 3073
    Beta strandi308 – 3125
    Turni314 – 3185
    Helixi321 – 3233
    Helixi327 – 3304
    Beta strandi334 – 3396
    Helixi344 – 3507
    Turni355 – 3573
    Helixi364 – 3718
    Helixi394 – 3974
    Helixi408 – 42922
    Turni438 – 4436
    Helixi445 – 4528
    Beta strandi477 – 4837
    Beta strandi491 – 50414
    Beta strandi506 – 5083

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2E4ZX-ray3.30A33-521[»]
    ProteinModelPortaliP35400.
    SMRiP35400. Positions 40-511.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP35400.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini35 – 590556ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini616 – 62712CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini649 – 6546ExtracellularSequence Analysis
    Topological domaini676 – 70227CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini724 – 75330ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini776 – 78813CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini811 – 82515ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini851 – 91565CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei591 – 61525Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei628 – 64821Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei655 – 67521Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei703 – 72321Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei754 – 77522Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei789 – 81022Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei826 – 85025Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni180 – 1823Glutamate bindingBy similarity

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG295200.
    HOVERGENiHBG107965.
    KOiK04608.
    PhylomeDBiP35400.

    Family and domain databases

    InterProiIPR001828. ANF_lig-bd_rcpt.
    IPR000337. GPCR_3.
    IPR011500. GPCR_3_9-Cys_dom.
    IPR017978. GPCR_3_C.
    IPR017979. GPCR_3_CS.
    IPR000162. GPCR_3_mtglu_rcpt.
    IPR001883. GPCR_3_mtglu_rcpt_7.
    IPR028082. Peripla_BP_I.
    [Graphical view]
    PfamiPF00003. 7tm_3. 1 hit.
    PF01094. ANF_receptor. 1 hit.
    PF07562. NCD3G. 1 hit.
    [Graphical view]
    PRINTSiPR00248. GPCRMGR.
    PR01057. MTABOTROPC7R.
    PR00593. MTABOTROPICR.
    SUPFAMiSSF53822. SSF53822. 1 hit.
    PROSITEiPS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
    PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
    PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
    PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P35400-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVQLGKLLRV LTLMKFPCCV LEVLLCVLAA AARGQEMYAP HSIRIEGDVT    50
    LGGLFPVHAK GPSGVPCGDI KRENGIHRLE AMLYALDQIN SDPNLLPNVT 100
    LGARILDTCS RDTYALEQSL TFVQALIQKD TSDVRCTNGE PPVFVKPEKV 150
    VGVIGASGSS VSIMVANILR LFQIPQISYA STAPELSDDR RYDFFSRVVP 200
    PDSFQAQAMV DIVKALGWNY VSTLASEGSY GEKGVESFTQ ISKEAGGLCI 250
    AQSVRIPQER KDRTIDFDRI IKQLLDTPNS RAVVIFANDE DIKQILAAAK 300
    RADQVGHFLW VGSDSWGSKI NPLHQHEDIA EGAITIQPKR ATVEGFDAYF 350
    TSRTLENNRR NVWFAEYWEE NFNCKLTISG SKKEDTDRKC TGQERIGKDS 400
    NYEQEGKVQF VIDAVYAMAH ALHHMNKDLC ADYRGVCPEM EQAGGKKLLK 450
    YIRHVNFNGS AGTPVMFNKN GDAPGRYDIF QYQTTNTTNP GYRLIGQWTD 500
    ELQLNIEDMQ WGKGVREIPS SVCTLPCKPG QRKKTQKGTP CCWTCEPCDG 550
    YQYQFDEMTC QHCPYDQRPN ENRTGCQNIP IIKLEWHSPW AVIPVFLAML 600
    GIIATIFVMA TFIRYNDTPI VRASGRELSY VLLTGIFLCY IITFLMIAKP 650
    DVAVCSFRRV FLGLGMCISY AALLTKTNRI YRIFEQGKKS VTAPRLISPT 700
    SQLAITSSLI SVQLLGVFIW FGVDPPNIII DYDEHKTMNP EQARGVLKCD 750
    ITDLQIICSL GYSILLMVTC TVYAIKTRGV PENFNEAKPI GFTMYTTCIV 800
    WLAFIPIFFG TAQSAEKLYI QTTTLTISMN LSASVALGML YMPKVYIIIF 850
    HPELNVQKRK RSFKAVVTAA TMSSRLSHKP SDRPNGEAKT ELCENVDPNS 900
    PAAKKKYVSY NNLVI 915
    Length:915
    Mass (Da):102,232
    Last modified:June 1, 1994 - v1
    Checksum:iF28AFC4C6454A6C2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D16817 mRNA. Translation: BAA04092.1.
    U06832 mRNA. Translation: AAA20655.1.
    PIRiA49874.
    RefSeqiNP_112302.1. NM_031040.1.
    UniGeneiRn.10409.

    Genome annotation databases

    GeneIDi81672.
    KEGGirno:81672.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D16817 mRNA. Translation: BAA04092.1 .
    U06832 mRNA. Translation: AAA20655.1 .
    PIRi A49874.
    RefSeqi NP_112302.1. NM_031040.1.
    UniGenei Rn.10409.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2E4Z X-ray 3.30 A 33-521 [» ]
    ProteinModelPortali P35400.
    SMRi P35400. Positions 40-511.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 249569. 10 interactions.
    DIPi DIP-41145N.
    IntActi P35400. 6 interactions.
    MINTi MINT-146474.
    STRINGi 10116.ENSRNOP00000053411.

    Chemistry

    BindingDBi P35400.
    ChEMBLi CHEMBL3879.
    GuidetoPHARMACOLOGYi 295.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P35400.

    Proteomic databases

    PRIDEi P35400.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 81672.
    KEGGi rno:81672.

    Organism-specific databases

    CTDi 2917.
    RGDi 619857. Grm7.

    Phylogenomic databases

    eggNOGi NOG295200.
    HOVERGENi HBG107965.
    KOi K04608.
    PhylomeDBi P35400.

    Miscellaneous databases

    EvolutionaryTracei P35400.
    NextBioi 615264.

    Gene expression databases

    Genevestigatori P35400.

    Family and domain databases

    InterProi IPR001828. ANF_lig-bd_rcpt.
    IPR000337. GPCR_3.
    IPR011500. GPCR_3_9-Cys_dom.
    IPR017978. GPCR_3_C.
    IPR017979. GPCR_3_CS.
    IPR000162. GPCR_3_mtglu_rcpt.
    IPR001883. GPCR_3_mtglu_rcpt_7.
    IPR028082. Peripla_BP_I.
    [Graphical view ]
    Pfami PF00003. 7tm_3. 1 hit.
    PF01094. ANF_receptor. 1 hit.
    PF07562. NCD3G. 1 hit.
    [Graphical view ]
    PRINTSi PR00248. GPCRMGR.
    PR01057. MTABOTROPC7R.
    PR00593. MTABOTROPICR.
    SUPFAMi SSF53822. SSF53822. 1 hit.
    PROSITEi PS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
    PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
    PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
    PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction."
      Okamoto N., Hori S., Akazawa C., Hayashi Y., Shigemoto R., Mizuno N., Nakanishi S.
      J. Biol. Chem. 269:1231-1236(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Strain: Sprague-Dawley.
      Tissue: Brain.
    2. "Cloning and expression of a new member of the L-2-amino-4-phosphonobutyric acid-sensitive class of metabotropic glutamate receptors."
      Saugstad J.A., Kinzie J.M., Mulvihill E.R., Segerson T.P., Westbrook G.L.
      Mol. Pharmacol. 45:367-372(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Strain: Sprague-Dawley.
      Tissue: Olfactory bulb.
    3. "Interaction of the C-terminal tail region of the metabotropic glutamate receptor 7 with the protein kinase C substrate PICK1."
      El Far O., Airas J., Wischmeyer E., Nehring R.B., Karschin A., Betz H.
      Eur. J. Neurosci. 12:4215-4221(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PICK1.
    4. "Structures of the extracellular regions of the group II/III metabotropic glutamate receptors."
      Muto T., Tsuchiya D., Morikawa K., Jingami H.
      Proc. Natl. Acad. Sci. U.S.A. 104:3759-3764(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF 33-521, DISULFIDE BONDS.

    Entry informationi

    Entry nameiGRM7_RAT
    AccessioniPrimary (citable) accession number: P35400
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3