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Protein

Peroxisome proliferator-activated receptor delta

Gene

Ppard

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi70 – 144Nuclear receptorPROSITE-ProRule annotationAdd BLAST75
Zinc fingeri73 – 93NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri110 – 132NR C4-typePROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: MGI
  • DNA binding transcription factor activity Source: MGI
  • drug binding Source: UniProtKB
  • enzyme activator activity Source: UniProtKB
  • linoleic acid binding Source: UniProtKB
  • lipid binding Source: UniProtKB
  • nuclear receptor activity Source: UniProtKB
  • prostacyclin receptor activity Source: UniProtKB
  • protein heterodimerization activity Source: MGI
  • retinoid X receptor binding Source: UniProtKB
  • sequence-specific DNA binding Source: InterPro
  • steroid hormone receptor activity Source: InterPro
  • transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: BHF-UCL
  • transcription coactivator activity Source: Ensembl
  • transcription factor binding Source: MGI
  • zinc ion binding Source: InterPro

GO - Biological processi

  • adipose tissue development Source: MGI
  • apoptotic process Source: MGI
  • apoptotic signaling pathway Source: MGI
  • axon ensheathment Source: MGI
  • cell differentiation Source: MGI
  • cell proliferation Source: MGI
  • cell-substrate adhesion Source: MGI
  • cellular process Source: MGI
  • cellular response to hypoxia Source: MGI
  • cellular response to lipopolysaccharide Source: Ensembl
  • decidualization Source: Ensembl
  • embryo implantation Source: MGI
  • epidermis development Source: MGI
  • fatty acid beta-oxidation Source: UniProtKB
  • fatty acid transport Source: UniProtKB
  • heart development Source: Ensembl
  • keratinocyte migration Source: MGI
  • keratinocyte proliferation Source: MGI
  • lipid metabolic process Source: MGI
  • mRNA transcription Source: Ensembl
  • negative regulation of apoptotic process Source: Ensembl
  • negative regulation of cell growth Source: Ensembl
  • negative regulation of collagen biosynthetic process Source: Ensembl
  • negative regulation of epithelial cell proliferation Source: MGI
  • negative regulation of inflammatory response Source: Ensembl
  • negative regulation of myoblast differentiation Source: CACAO
  • negative regulation of pri-miRNA transcription by RNA polymerase II Source: BHF-UCL
  • negative regulation of smooth muscle cell migration Source: Ensembl
  • negative regulation of smooth muscle cell proliferation Source: Ensembl
  • negative regulation of transcription by RNA polymerase II Source: MGI
  • phospholipid biosynthetic process Source: Ensembl
  • placenta development Source: MGI
  • positive regulation of blood vessel diameter Source: Ensembl
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of epidermis development Source: Ensembl
  • positive regulation of gene expression Source: CACAO
  • positive regulation of insulin secretion Source: Ensembl
  • positive regulation of myoblast proliferation Source: CACAO
  • positive regulation of phosphatidylinositol 3-kinase signaling Source: MGI
  • positive regulation of skeletal muscle tissue regeneration Source: CACAO
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • proteoglycan metabolic process Source: Ensembl
  • regulation of cell proliferation Source: MGI
  • regulation of fat cell differentiation Source: MGI
  • regulation of insulin secretion Source: UniProtKB
  • regulation of skeletal muscle satellite cell proliferation Source: CACAO
  • response to activity Source: Ensembl
  • response to glucose Source: Ensembl
  • response to vitamin A Source: Ensembl
  • vitamin A metabolic process Source: Ensembl
  • wound healing Source: MGI

Keywordsi

Molecular functionActivator, DNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-200425 Import of palmitoyl-CoA into the mitochondrial matrix
R-MMU-204174 Regulation of pyruvate dehydrogenase (PDH) complex
R-MMU-383280 Nuclear Receptor transcription pathway
R-MMU-5362517 Signaling by Retinoic Acid

Chemistry databases

SwissLipidsiSLP:000000397

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisome proliferator-activated receptor delta
Short name:
PPAR-delta
Alternative name(s):
Nuclear hormone receptor 1
Short name:
NUC1
Nuclear receptor subfamily 1 group C member 2
Peroxisome proliferator-activated receptor beta
Short name:
PPAR-beta
Gene namesi
Name:Ppard
Synonyms:Nr1c2, Pparb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:101884 Ppard

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2458

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000534871 – 440Peroxisome proliferator-activated receptor deltaAdd BLAST440

Proteomic databases

EPDiP35396
PaxDbiP35396
PRIDEiP35396

PTM databases

PhosphoSitePlusiP35396

Expressioni

Tissue specificityi

Heart, adrenal and intestine.

Gene expression databases

BgeeiENSMUSG00000002250
CleanExiMM_PPARD
ExpressionAtlasiP35396 baseline and differential
GenevisibleiP35396 MM

Interactioni

Subunit structurei

Heterodimer with the retinoid X receptor.

GO - Molecular functioni

  • protein heterodimerization activity Source: MGI
  • retinoid X receptor binding Source: UniProtKB
  • transcription factor binding Source: MGI

Protein-protein interaction databases

BioGridi202319, 12 interactors
DIPiDIP-29851N
IntActiP35396, 4 interactors
STRINGi10090.ENSMUSP00000002320

Chemistry databases

BindingDBiP35396

Structurei

3D structure databases

ProteinModelPortaliP35396
SMRiP35396
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini210 – 438NR LBDPROSITE-ProRule annotationAdd BLAST229

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri73 – 93NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri110 – 132NR C4-typePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00870000136388
HOGENOMiHOG000261626
HOVERGENiHBG106004
InParanoidiP35396
KOiK04504
OMAiSLGMSHN
OrthoDBiEOG091G05U8
PhylomeDBiP35396
TreeFamiTF316304

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR003074 1Cnucl_rcpt
IPR003075 1Cnucl_rcpt_B
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR01288 PROXISOMEPAR
PR01290 PROXISOMPABR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequencei

Sequence statusi: Complete.

P35396-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQPQEETPE AREEEKEEVA MGDGAPELNG GPEHTLPSSS CADLSQNSSP
60 70 80 90 100
SSLLDQLQMG CDGASGGSLN MECRVCGDKA SGFHYGVHAC EGCKGFFRRT
110 120 130 140 150
IRMKLEYEKC DRICKIQKKN RNKCQYCRFQ KCLALGMSHN AIRFGRMPEA
160 170 180 190 200
EKRKLVAGLT ASEGCQHNPQ LADLKAFSKH IYNAYLKNFN MTKKKARSIL
210 220 230 240 250
TGKSSHNAPF VIHDIETLWQ AEKGLVWKQL VNGLPPYNEI SVHVFYRCQS
260 270 280 290 300
TTVETVRELT EFAKNIPNFS SLFLNDQVTL LKYGVHEAIF AMLASIVNKD
310 320 330 340 350
GLLVANGSGF VTHEFLRSLR KPFSDIIEPK FEFAVKFNAL ELDDSDLALF
360 370 380 390 400
IAAIILCGDR PGLMNVPQVE AIQDTILRAL EFHLQVNHPD SQYLFPKLLQ
410 420 430 440
KMADLRQLVT EHAQMMQWLK KTESETLLHP LLQEIYKDMY
Length:440
Mass (Da):49,715
Last modified:June 1, 1994 - v1
Checksum:i58E0F595DD193FDA
GO

Sequence cautioni

The sequence AAA03332 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti149 – 150EA → DG in AAA19972 (PubMed:8041794).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L28116 mRNA Translation: AAA63394.1
U10375 mRNA Translation: AAA19972.1
BC070398 mRNA Translation: AAH70398.1
U01665 mRNA Translation: AAA03332.1 Different initiation.
CCDSiCCDS28575.1
PIRiI55442
RefSeqiNP_035275.1, NM_011145.3
UniGeneiMm.328914

Genome annotation databases

EnsembliENSMUST00000002320; ENSMUSP00000002320; ENSMUSG00000002250
GeneIDi19015
KEGGimmu:19015
UCSCiuc008bqk.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPPARD_MOUSE
AccessioniPrimary (citable) accession number: P35396
Secondary accession number(s): P37239
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: May 23, 2018
This is version 177 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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