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P35396

- PPARD_MOUSE

UniProt

P35396 - PPARD_MOUSE

Protein

Peroxisome proliferator-activated receptor delta

Gene

Ppard

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 142 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi70 – 14475Nuclear receptorPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri73 – 9321NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri110 – 13223NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. drug binding Source: UniProtKB
    3. enzyme activator activity Source: UniProtKB
    4. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: UniProtKB
    5. linoleic acid binding Source: UniProtKB
    6. lipid binding Source: UniProtKB
    7. prostacyclin receptor activity Source: UniProtKB
    8. protein heterodimerization activity Source: UniProtKB
    9. retinoid X receptor binding Source: UniProtKB
    10. sequence-specific DNA binding Source: InterPro
    11. steroid hormone receptor activity Source: InterPro
    12. transcription coactivator activity Source: Ensembl
    13. zinc ion binding Source: InterPro

    GO - Biological processi

    1. adipose tissue development Source: MGI
    2. anagen Source: MGI
    3. apoptotic signaling pathway Source: Ensembl
    4. axon ensheathment Source: MGI
    5. cell differentiation Source: MGI
    6. cell proliferation Source: MGI
    7. cell-substrate adhesion Source: MGI
    8. cellular process Source: MGI
    9. cellular response to hypoxia Source: MGI
    10. decidualization Source: Ensembl
    11. embryo implantation Source: UniProtKB
    12. epidermis development Source: MGI
    13. fatty acid beta-oxidation Source: UniProtKB
    14. fatty acid transport Source: UniProtKB
    15. G-protein coupled receptor signaling pathway Source: GOC
    16. heart development Source: Ensembl
    17. keratinocyte migration Source: MGI
    18. keratinocyte proliferation Source: MGI
    19. lipid metabolic process Source: MGI
    20. mRNA transcription Source: Ensembl
    21. negative regulation of apoptotic process Source: Ensembl
    22. negative regulation of cell growth Source: Ensembl
    23. negative regulation of collagen biosynthetic process Source: Ensembl
    24. negative regulation of epithelial cell proliferation Source: MGI
    25. negative regulation of inflammatory response Source: Ensembl
    26. negative regulation of smooth muscle cell migration Source: Ensembl
    27. negative regulation of smooth muscle cell proliferation Source: Ensembl
    28. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    29. phospholipid biosynthetic process Source: Ensembl
    30. placenta development Source: MGI
    31. positive regulation of catalytic activity Source: GOC
    32. positive regulation of cell proliferation Source: MGI
    33. positive regulation of epidermis development Source: Ensembl
    34. positive regulation of insulin secretion Source: Ensembl
    35. positive regulation of phosphatidylinositol 3-kinase signaling Source: MGI
    36. positive regulation of transcription, DNA-templated Source: UniProtKB
    37. positive regulation of vasodilation Source: Ensembl
    38. proteoglycan metabolic process Source: Ensembl
    39. regulation of cell proliferation Source: MGI
    40. regulation of fat cell differentiation Source: MGI
    41. regulation of insulin secretion Source: UniProtKB
    42. response to activity Source: Ensembl
    43. response to glucose Source: Ensembl
    44. response to vitamin A Source: Ensembl
    45. vitamin A metabolic process Source: Ensembl
    46. wound healing Source: MGI

    Keywords - Molecular functioni

    Activator, Receptor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peroxisome proliferator-activated receptor delta
    Short name:
    PPAR-delta
    Alternative name(s):
    Nuclear hormone receptor 1
    Short name:
    NUC1
    Nuclear receptor subfamily 1 group C member 2
    Peroxisome proliferator-activated receptor beta
    Short name:
    PPAR-beta
    Gene namesi
    Name:Ppard
    Synonyms:Nr1c2, Pparb
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:101884. Ppard.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 440440Peroxisome proliferator-activated receptor deltaPRO_0000053487Add
    BLAST

    Proteomic databases

    PRIDEiP35396.

    PTM databases

    PhosphoSiteiP35396.

    Expressioni

    Tissue specificityi

    Heart, adrenal and intestine.

    Gene expression databases

    BgeeiP35396.
    CleanExiMM_PPARD.
    GenevestigatoriP35396.

    Interactioni

    Subunit structurei

    Heterodimer with the retinoid X receptor.

    Protein-protein interaction databases

    BioGridi202319. 11 interactions.
    DIPiDIP-29851N.
    IntActiP35396. 3 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP35396.
    SMRiP35396. Positions 64-440.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni253 – 440188Ligand-bindingSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri73 – 9321NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri110 – 13223NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG266867.
    HOGENOMiHOG000261626.
    HOVERGENiHBG106004.
    InParanoidiP35396.
    KOiK04504.
    OMAiMNVPQVE.
    OrthoDBiEOG7X9G7F.
    PhylomeDBiP35396.
    TreeFamiTF316304.

    Family and domain databases

    Gene3Di1.10.565.10. 2 hits.
    3.30.50.10. 1 hit.
    InterProiIPR003074. 1Cnucl_rcpt.
    IPR003075. 1Cnucl_rcpt_B.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PfamiPF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view]
    PRINTSiPR01288. PROXISOMEPAR.
    PR01290. PROXISOMPABR.
    PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTiSM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view]
    SUPFAMiSSF48508. SSF48508. 1 hit.
    PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P35396-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEQPQEETPE AREEEKEEVA MGDGAPELNG GPEHTLPSSS CADLSQNSSP    50
    SSLLDQLQMG CDGASGGSLN MECRVCGDKA SGFHYGVHAC EGCKGFFRRT 100
    IRMKLEYEKC DRICKIQKKN RNKCQYCRFQ KCLALGMSHN AIRFGRMPEA 150
    EKRKLVAGLT ASEGCQHNPQ LADLKAFSKH IYNAYLKNFN MTKKKARSIL 200
    TGKSSHNAPF VIHDIETLWQ AEKGLVWKQL VNGLPPYNEI SVHVFYRCQS 250
    TTVETVRELT EFAKNIPNFS SLFLNDQVTL LKYGVHEAIF AMLASIVNKD 300
    GLLVANGSGF VTHEFLRSLR KPFSDIIEPK FEFAVKFNAL ELDDSDLALF 350
    IAAIILCGDR PGLMNVPQVE AIQDTILRAL EFHLQVNHPD SQYLFPKLLQ 400
    KMADLRQLVT EHAQMMQWLK KTESETLLHP LLQEIYKDMY 440
    Length:440
    Mass (Da):49,715
    Last modified:June 1, 1994 - v1
    Checksum:i58E0F595DD193FDA
    GO

    Sequence cautioni

    The sequence AAA03332.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti149 – 1502EA → DG in AAA19972. (PubMed:8041794)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L28116 mRNA. Translation: AAA63394.1.
    U10375 mRNA. Translation: AAA19972.1.
    BC070398 mRNA. Translation: AAH70398.1.
    U01665 mRNA. Translation: AAA03332.1. Different initiation.
    CCDSiCCDS28575.1.
    PIRiI55442.
    RefSeqiNP_035275.1. NM_011145.3.
    XP_006523922.1. XM_006523859.1.
    XP_006536796.1. XM_006536733.1.
    UniGeneiMm.328914.

    Genome annotation databases

    EnsembliENSMUST00000002320; ENSMUSP00000002320; ENSMUSG00000002250.
    GeneIDi19015.
    KEGGimmu:19015.
    UCSCiuc008bqk.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L28116 mRNA. Translation: AAA63394.1 .
    U10375 mRNA. Translation: AAA19972.1 .
    BC070398 mRNA. Translation: AAH70398.1 .
    U01665 mRNA. Translation: AAA03332.1 . Different initiation.
    CCDSi CCDS28575.1.
    PIRi I55442.
    RefSeqi NP_035275.1. NM_011145.3.
    XP_006523922.1. XM_006523859.1.
    XP_006536796.1. XM_006536733.1.
    UniGenei Mm.328914.

    3D structure databases

    ProteinModelPortali P35396.
    SMRi P35396. Positions 64-440.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 202319. 11 interactions.
    DIPi DIP-29851N.
    IntActi P35396. 3 interactions.

    Chemistry

    BindingDBi P35396.
    ChEMBLi CHEMBL2458.

    PTM databases

    PhosphoSitei P35396.

    Proteomic databases

    PRIDEi P35396.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000002320 ; ENSMUSP00000002320 ; ENSMUSG00000002250 .
    GeneIDi 19015.
    KEGGi mmu:19015.
    UCSCi uc008bqk.1. mouse.

    Organism-specific databases

    CTDi 5467.
    MGIi MGI:101884. Ppard.

    Phylogenomic databases

    eggNOGi NOG266867.
    HOGENOMi HOG000261626.
    HOVERGENi HBG106004.
    InParanoidi P35396.
    KOi K04504.
    OMAi MNVPQVE.
    OrthoDBi EOG7X9G7F.
    PhylomeDBi P35396.
    TreeFami TF316304.

    Miscellaneous databases

    NextBioi 295440.
    PROi P35396.
    SOURCEi Search...

    Gene expression databases

    Bgeei P35396.
    CleanExi MM_PPARD.
    Genevestigatori P35396.

    Family and domain databases

    Gene3Di 1.10.565.10. 2 hits.
    3.30.50.10. 1 hit.
    InterProi IPR003074. 1Cnucl_rcpt.
    IPR003075. 1Cnucl_rcpt_B.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    Pfami PF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view ]
    PRINTSi PR01288. PROXISOMEPAR.
    PR01290. PROXISOMPABR.
    PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTi SM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48508. SSF48508. 1 hit.
    PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a protein that mediates transcriptional effects of fatty acids in preadipocytes. Homology to peroxisome proliferator-activated receptors."
      Amri E.-Z., Bonino F., Ailhaud G., Abumrad N.A., Grimaldi P.A.
      J. Biol. Chem. 270:2367-2371(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.
      Tissue: Adipocyte.
    2. "Differential expression and activation of a family of murine peroxisome proliferator-activated receptors."
      Kliewer S.A., Forman B.M., Blumberg B., Ong E.S., Borgmeyer U., Mangelsdorf D.J., Umesono K., Evans R.M.
      Proc. Natl. Acad. Sci. U.S.A. 91:7355-7359(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    4. "Identification of two mPPAR related receptors and evidence for the existence of five subfamily members."
      Chen F., Law S.W., O'Malley B.W.
      Biochem. Biophys. Res. Commun. 196:671-677(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-145.
      Strain: BALB/c.
      Tissue: Brain.

    Entry informationi

    Entry nameiPPARD_MOUSE
    AccessioniPrimary (citable) accession number: P35396
    Secondary accession number(s): P37239
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 142 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3