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P35396

- PPARD_MOUSE

UniProt

P35396 - PPARD_MOUSE

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Protein
Peroxisome proliferator-activated receptor delta
Gene
Ppard, Nr1c2, Pparb
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi70 – 14475Nuclear receptor
Add
BLAST
Zinc fingeri73 – 9321NR C4-type
Add
BLAST
Zinc fingeri110 – 13223NR C4-type
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. drug binding Source: UniProtKB
  3. enzyme activator activity Source: UniProtKB
  4. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: UniProtKB
  5. linoleic acid binding Source: UniProtKB
  6. lipid binding Source: UniProtKB
  7. prostacyclin receptor activity Source: UniProtKB
  8. protein heterodimerization activity Source: UniProtKB
  9. retinoid X receptor binding Source: UniProtKB
  10. sequence-specific DNA binding Source: InterPro
  11. steroid hormone receptor activity Source: InterPro
  12. transcription coactivator activity Source: Ensembl
  13. zinc ion binding Source: InterPro

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: GOC
  2. adipose tissue development Source: MGI
  3. anagen Source: MGI
  4. apoptotic signaling pathway Source: Ensembl
  5. axon ensheathment Source: MGI
  6. cell differentiation Source: MGI
  7. cell proliferation Source: MGI
  8. cell-substrate adhesion Source: MGI
  9. cellular process Source: MGI
  10. cellular response to hypoxia Source: MGI
  11. decidualization Source: Ensembl
  12. embryo implantation Source: UniProtKB
  13. epidermis development Source: MGI
  14. fatty acid beta-oxidation Source: UniProtKB
  15. fatty acid transport Source: UniProtKB
  16. heart development Source: Ensembl
  17. keratinocyte migration Source: MGI
  18. keratinocyte proliferation Source: MGI
  19. lipid metabolic process Source: MGI
  20. mRNA transcription Source: Ensembl
  21. negative regulation of apoptotic process Source: Ensembl
  22. negative regulation of cell growth Source: Ensembl
  23. negative regulation of collagen biosynthetic process Source: Ensembl
  24. negative regulation of epithelial cell proliferation Source: MGI
  25. negative regulation of inflammatory response Source: Ensembl
  26. negative regulation of smooth muscle cell migration Source: Ensembl
  27. negative regulation of smooth muscle cell proliferation Source: Ensembl
  28. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  29. phospholipid biosynthetic process Source: Ensembl
  30. placenta development Source: MGI
  31. positive regulation of catalytic activity Source: GOC
  32. positive regulation of cell proliferation Source: MGI
  33. positive regulation of epidermis development Source: Ensembl
  34. positive regulation of insulin secretion Source: Ensembl
  35. positive regulation of phosphatidylinositol 3-kinase signaling Source: MGI
  36. positive regulation of transcription, DNA-templated Source: UniProtKB
  37. positive regulation of vasodilation Source: Ensembl
  38. proteoglycan metabolic process Source: Ensembl
  39. regulation of cell proliferation Source: MGI
  40. regulation of fat cell differentiation Source: MGI
  41. regulation of insulin secretion Source: UniProtKB
  42. response to activity Source: Ensembl
  43. response to glucose Source: Ensembl
  44. response to vitamin A Source: Ensembl
  45. vitamin A metabolic process Source: Ensembl
  46. wound healing Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator, Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisome proliferator-activated receptor delta
Short name:
PPAR-delta
Alternative name(s):
Nuclear hormone receptor 1
Short name:
NUC1
Nuclear receptor subfamily 1 group C member 2
Peroxisome proliferator-activated receptor beta
Short name:
PPAR-beta
Gene namesi
Name:Ppard
Synonyms:Nr1c2, Pparb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:101884. Ppard.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 440440Peroxisome proliferator-activated receptor delta
PRO_0000053487Add
BLAST

Proteomic databases

PRIDEiP35396.

PTM databases

PhosphoSiteiP35396.

Expressioni

Tissue specificityi

Heart, adrenal and intestine.

Gene expression databases

BgeeiP35396.
CleanExiMM_PPARD.
GenevestigatoriP35396.

Interactioni

Subunit structurei

Heterodimer with the retinoid X receptor.

Protein-protein interaction databases

BioGridi202319. 11 interactions.
DIPiDIP-29851N.
IntActiP35396. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliP35396.
SMRiP35396. Positions 64-440.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni253 – 440188Ligand-binding Reviewed prediction
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG266867.
HOGENOMiHOG000261626.
HOVERGENiHBG106004.
InParanoidiP35396.
KOiK04504.
OMAiMNVPQVE.
OrthoDBiEOG7X9G7F.
PhylomeDBiP35396.
TreeFamiTF316304.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR003074. 1Cnucl_rcpt.
IPR003075. 1Cnucl_rcpt_B.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01288. PROXISOMEPAR.
PR01290. PROXISOMPABR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35396-1 [UniParc]FASTAAdd to Basket

« Hide

MEQPQEETPE AREEEKEEVA MGDGAPELNG GPEHTLPSSS CADLSQNSSP    50
SSLLDQLQMG CDGASGGSLN MECRVCGDKA SGFHYGVHAC EGCKGFFRRT 100
IRMKLEYEKC DRICKIQKKN RNKCQYCRFQ KCLALGMSHN AIRFGRMPEA 150
EKRKLVAGLT ASEGCQHNPQ LADLKAFSKH IYNAYLKNFN MTKKKARSIL 200
TGKSSHNAPF VIHDIETLWQ AEKGLVWKQL VNGLPPYNEI SVHVFYRCQS 250
TTVETVRELT EFAKNIPNFS SLFLNDQVTL LKYGVHEAIF AMLASIVNKD 300
GLLVANGSGF VTHEFLRSLR KPFSDIIEPK FEFAVKFNAL ELDDSDLALF 350
IAAIILCGDR PGLMNVPQVE AIQDTILRAL EFHLQVNHPD SQYLFPKLLQ 400
KMADLRQLVT EHAQMMQWLK KTESETLLHP LLQEIYKDMY 440
Length:440
Mass (Da):49,715
Last modified:June 1, 1994 - v1
Checksum:i58E0F595DD193FDA
GO

Sequence cautioni

The sequence AAA03332.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti149 – 1502EA → DG in AAA19972. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L28116 mRNA. Translation: AAA63394.1.
U10375 mRNA. Translation: AAA19972.1.
BC070398 mRNA. Translation: AAH70398.1.
U01665 mRNA. Translation: AAA03332.1. Different initiation.
CCDSiCCDS28575.1.
PIRiI55442.
RefSeqiNP_035275.1. NM_011145.3.
XP_006523922.1. XM_006523859.1.
XP_006536796.1. XM_006536733.1.
UniGeneiMm.328914.

Genome annotation databases

EnsembliENSMUST00000002320; ENSMUSP00000002320; ENSMUSG00000002250.
GeneIDi19015.
KEGGimmu:19015.
UCSCiuc008bqk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L28116 mRNA. Translation: AAA63394.1 .
U10375 mRNA. Translation: AAA19972.1 .
BC070398 mRNA. Translation: AAH70398.1 .
U01665 mRNA. Translation: AAA03332.1 . Different initiation.
CCDSi CCDS28575.1.
PIRi I55442.
RefSeqi NP_035275.1. NM_011145.3.
XP_006523922.1. XM_006523859.1.
XP_006536796.1. XM_006536733.1.
UniGenei Mm.328914.

3D structure databases

ProteinModelPortali P35396.
SMRi P35396. Positions 64-440.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 202319. 11 interactions.
DIPi DIP-29851N.
IntActi P35396. 3 interactions.

Chemistry

BindingDBi P35396.
ChEMBLi CHEMBL2458.

PTM databases

PhosphoSitei P35396.

Proteomic databases

PRIDEi P35396.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000002320 ; ENSMUSP00000002320 ; ENSMUSG00000002250 .
GeneIDi 19015.
KEGGi mmu:19015.
UCSCi uc008bqk.1. mouse.

Organism-specific databases

CTDi 5467.
MGIi MGI:101884. Ppard.

Phylogenomic databases

eggNOGi NOG266867.
HOGENOMi HOG000261626.
HOVERGENi HBG106004.
InParanoidi P35396.
KOi K04504.
OMAi MNVPQVE.
OrthoDBi EOG7X9G7F.
PhylomeDBi P35396.
TreeFami TF316304.

Miscellaneous databases

NextBioi 295440.
PROi P35396.
SOURCEi Search...

Gene expression databases

Bgeei P35396.
CleanExi MM_PPARD.
Genevestigatori P35396.

Family and domain databases

Gene3Di 1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProi IPR003074. 1Cnucl_rcpt.
IPR003075. 1Cnucl_rcpt_B.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view ]
PRINTSi PR01288. PROXISOMEPAR.
PR01290. PROXISOMPABR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTi SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 1 hit.
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a protein that mediates transcriptional effects of fatty acids in preadipocytes. Homology to peroxisome proliferator-activated receptors."
    Amri E.-Z., Bonino F., Ailhaud G., Abumrad N.A., Grimaldi P.A.
    J. Biol. Chem. 270:2367-2371(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Adipocyte.
  2. "Differential expression and activation of a family of murine peroxisome proliferator-activated receptors."
    Kliewer S.A., Forman B.M., Blumberg B., Ong E.S., Borgmeyer U., Mangelsdorf D.J., Umesono K., Evans R.M.
    Proc. Natl. Acad. Sci. U.S.A. 91:7355-7359(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  4. "Identification of two mPPAR related receptors and evidence for the existence of five subfamily members."
    Chen F., Law S.W., O'Malley B.W.
    Biochem. Biophys. Res. Commun. 196:671-677(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-145.
    Strain: BALB/c.
    Tissue: Brain.

Entry informationi

Entry nameiPPARD_MOUSE
AccessioniPrimary (citable) accession number: P35396
Secondary accession number(s): P37239
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: July 9, 2014
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi