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P35393 (BLAC_STRLA) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-lactamase

EC=3.5.2.6
Alternative name(s):
Penicillinase
OrganismStreptomyces lavendulae
Taxonomic identifier1914 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Protein attributes

Sequence length305 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

A beta-lactam + H2O = a substituted beta-amino acid.

Post-translational modification

Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

Sequence similarities

Belongs to the class-A beta-lactamase family.

Ontologies

Keywords
   Biological processAntibiotic resistance
   DomainSignal
   Molecular functionHydrolase
Gene Ontology (GO)
   Biological_processbeta-lactam antibiotic catabolic process

Inferred from electronic annotation. Source: InterPro

response to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionbeta-lactamase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3434Tat-type signal Potential
Chain35 – 305271Beta-lactamase
PRO_0000017019

Regions

Region250 – 2523Substrate binding By similarity

Sites

Active site821Acyl-ester intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
P35393 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 7F29DA5436650647

FASTA30532,354
        10         20         30         40         50         60 
MGTTGARPSR RAVLTAAAGA AVAGIPLGGS TAFAAPRGNP DVLRQLRALE QEHSARLGVY 

        70         80         90        100        110        120 
ARDTATGRTV LHRAEERFPM CSVFKTLAVA AVLRDLDRDG EFLATRLFYT EQEVKDSGFG 

       130        140        150        160        170        180 
PVTGLPENLA AGMTVERLCA AAICQSDNAA ANLLLRELGG PEAVTRFCRS VGDRTTRLDR 

       190        200        210        220        230        240 
WEPELNSAEP GRLTDTTTPR AIGATYGELV LGDALAPRDR ERLTGWLLAN TTSTERFRKG 

       250        260        270        280        290        300 
LPADWTLGDK TGGGAYGTNN DAGVTWPPHR PPVVMVVLTT HDRPDAVADN PLVAKTAALL 


ASALG 

« Hide

References

[1]"Molecular analysis of beta-lactamases from four species of Streptomyces: comparison of amino acid sequences with those of other beta-lactamases."
Forsman M., Haeggstroem B., Lindgren L., Jaurin B.
J. Gen. Microbiol. 136:589-598(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: DSM 2014.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M34180 Genomic DNA. Translation: AAA26708.1.
PIRC45822.

3D structure databases

ProteinModelPortalP35393.
SMRP35393. Positions 41-305.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.710.10. 1 hit.
InterProIPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
IPR006311. TAT_signal.
[Graphical view]
PfamPF00144. Beta-lactamase. 1 hit.
[Graphical view]
PRINTSPR00118. BLACTAMASEA.
SUPFAMSSF56601. SSF56601. 1 hit.
PROSITEPS00146. BETA_LACTAMASE_A. 1 hit.
PS51318. TAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBLAC_STRLA
AccessionPrimary (citable) accession number: P35393
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: October 16, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families