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P35393

- BLAC_STRLA

UniProt

P35393 - BLAC_STRLA

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Protein

Beta-lactamase

Gene
N/A
Organism
Streptomyces lavendulae
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei82 – 821Acyl-ester intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC

GO - Biological processi

  1. beta-lactam antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase (EC:3.5.2.6)
Alternative name(s):
Penicillinase
OrganismiStreptomyces lavendulae
Taxonomic identifieri1914 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434Tat-type signalPROSITE-ProRule annotationAdd
BLAST
Chaini35 – 305271Beta-lactamasePRO_0000017019Add
BLAST

Post-translational modificationi

Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

Structurei

3D structure databases

ProteinModelPortaliP35393.
SMRiP35393. Positions 41-305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni250 – 2523Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the class-A beta-lactamase family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
IPR006311. TAT_signal.
[Graphical view]
PfamiPF00144. Beta-lactamase. 1 hit.
[Graphical view]
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
PS51318. TAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35393-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGTTGARPSR RAVLTAAAGA AVAGIPLGGS TAFAAPRGNP DVLRQLRALE
60 70 80 90 100
QEHSARLGVY ARDTATGRTV LHRAEERFPM CSVFKTLAVA AVLRDLDRDG
110 120 130 140 150
EFLATRLFYT EQEVKDSGFG PVTGLPENLA AGMTVERLCA AAICQSDNAA
160 170 180 190 200
ANLLLRELGG PEAVTRFCRS VGDRTTRLDR WEPELNSAEP GRLTDTTTPR
210 220 230 240 250
AIGATYGELV LGDALAPRDR ERLTGWLLAN TTSTERFRKG LPADWTLGDK
260 270 280 290 300
TGGGAYGTNN DAGVTWPPHR PPVVMVVLTT HDRPDAVADN PLVAKTAALL

ASALG
Length:305
Mass (Da):32,354
Last modified:June 1, 1994 - v1
Checksum:i7F29DA5436650647
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34180 Genomic DNA. Translation: AAA26708.1.
PIRiC45822.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34180 Genomic DNA. Translation: AAA26708.1 .
PIRi C45822.

3D structure databases

ProteinModelPortali P35393.
SMRi P35393. Positions 41-305.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
IPR006311. TAT_signal.
[Graphical view ]
Pfami PF00144. Beta-lactamase. 1 hit.
[Graphical view ]
PRINTSi PR00118. BLACTAMASEA.
SUPFAMi SSF56601. SSF56601. 1 hit.
PROSITEi PS00146. BETA_LACTAMASE_A. 1 hit.
PS51318. TAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular analysis of beta-lactamases from four species of Streptomyces: comparison of amino acid sequences with those of other beta-lactamases."
    Forsman M., Haeggstroem B., Lindgren L., Jaurin B.
    J. Gen. Microbiol. 136:589-598(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: DSM 2014.

Entry informationi

Entry nameiBLAC_STRLA
AccessioniPrimary (citable) accession number: P35393
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: October 1, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3