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P35392

- BLAC_STRFR

UniProt

P35392 - BLAC_STRFR

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Protein

Beta-lactamase

Gene
blaF
Organism
Streptomyces fradiae (Streptomyces roseoflavus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei82 – 821Acyl-ester intermediate By similarity

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC

GO - Biological processi

  1. beta-lactam antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase (EC:3.5.2.6)
Alternative name(s):
Penicillinase
Gene namesi
Name:blaF
OrganismiStreptomyces fradiae (Streptomyces roseoflavus)
Taxonomic identifieri1906 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434Tat-type signal Reviewed predictionAdd
BLAST
Chaini35 – 306272Beta-lactamasePRO_0000017018Add
BLAST

Post-translational modificationi

Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

Structurei

3D structure databases

ProteinModelPortaliP35392.
SMRiP35392. Positions 43-304.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni250 – 2523Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR006311. TAT_signal.
[Graphical view]
PfamiPF00144. Beta-lactamase. 1 hit.
[Graphical view]
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS51318. TAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35392-1 [UniParc]FASTAAdd to Basket

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MDRTTARPNR RAVLATGVGA ALAATAAAAG PAHAAPGRGA RVEGRLRALE    50
RTHDARLGAF AYDTGTGRTV AYRADERFPI ASMFKTIAVA AVLRDLDRDG 100
EVLARRVHYT ADYVKRSGYS PVTGLPENVA NGMTVAELCE ATLTRSDNTA 150
ANLLLRDLGG PTAVTRFCRS VGDHVTRLDR WEPELNSAEP GRVTDTTSPR 200
AIGRTYGRLI LGDLLAAHDR ERLTRWMLDN RTSDERFRKG LPADWLLADK 250
TGGGDYGTNN DAGVAWPPGR PPVVLAVQTT RFTPDAEADN VLVAEAARLL 300
AEAMTD 306
Length:306
Mass (Da):32,931
Last modified:June 1, 1994 - v1
Checksum:i8FAEF14220812A17
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M34179 Genomic DNA. Translation: AAA26709.1.
M94255 Genomic DNA. Translation: AAC41397.1.
PIRiB45822.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M34179 Genomic DNA. Translation: AAA26709.1 .
M94255 Genomic DNA. Translation: AAC41397.1 .
PIRi B45822.

3D structure databases

ProteinModelPortali P35392.
SMRi P35392. Positions 43-304.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR006311. TAT_signal.
[Graphical view ]
Pfami PF00144. Beta-lactamase. 1 hit.
[Graphical view ]
PRINTSi PR00118. BLACTAMASEA.
SUPFAMi SSF56601. SSF56601. 1 hit.
PROSITEi PS51318. TAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular analysis of beta-lactamases from four species of Streptomyces: comparison of amino acid sequences with those of other beta-lactamases."
    Forsman M., Haeggstroem B., Lindgren L., Jaurin B.
    J. Gen. Microbiol. 136:589-598(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 10745 / CBS 498.68 / DSM 40063 / JCM 4133 / NBRC 12773 / NCIMB 8233 / NRRL B-1195 / VKM Ac-150.
  2. "Mutagenic analysis of the promoter of the Streptomyces fradiae beta-lactamase-encoding gene."
    Forsman M., Granstroem M.
    Gene 121:87-94(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-40.

Entry informationi

Entry nameiBLAC_STRFR
AccessioniPrimary (citable) accession number: P35392
Secondary accession number(s): P72435
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: February 19, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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