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P35391

- BLAC_STRBA

UniProt

P35391 - BLAC_STRBA

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Protein

Beta-lactamase

Gene
N/A
Organism
Streptomyces badius
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei93 – 931Acyl-ester intermediateBy similarity
Sitei96 – 961Increases nucleophilicity of active site SerBy similarity
Binding sitei151 – 1511SubstrateBy similarity
Active sitei188 – 1881Proton acceptorBy similarity

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC

GO - Biological processi

  1. beta-lactam antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase (EC:3.5.2.6)
Alternative name(s):
Penicillinase
OrganismiStreptomyces badius
Taxonomic identifieri1941 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626By similarityAdd
BLAST
Chaini27 – 313287Beta-lactamasePRO_0000017014Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP35391.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni256 – 2583Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the class-A beta-lactamase family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PfamiPF00144. Beta-lactamase. 1 hit.
[Graphical view]
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35391-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHHPRVRTAV AGLVAVLSLV PLAACGQSDS TAPPSSAKPA TSASASLPRP
60 70 80 90 100
KPYTGDFKKL EREFDARLGV YAIDTGTGRE VTHNDRARFA YHSTFKALQA
110 120 130 140 150
AVVLSTYSLD GLDKRVTYTR EDLVAHSPVT EKHVDTGMTL KELCDASVRY
160 170 180 190 200
SDNTAANLLF DPRAAGPKGL DASLEKLGDD ITRMDREEPE LSRWVPGEKR
210 220 230 240 250
DTSTPRALAE DLRAFVLGKA LRAPERAQLT TWLRTNTTGD AVIRAGVPEN
260 270 280 290 300
WVVGDKTGTG SYYGARNDIA VVWPPDSAPI VIAILSHRGT KDAEPDDELI
310
AEAASVVVDS LSS
Length:313
Mass (Da):33,720
Last modified:June 1, 1994 - v1
Checksum:i9C71C07DDC0EBF57
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34178 Genomic DNA. Translation: AAA26707.1.
PIRiA45822.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34178 Genomic DNA. Translation: AAA26707.1 .
PIRi A45822.

3D structure databases

ProteinModelPortali P35391.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view ]
Pfami PF00144. Beta-lactamase. 1 hit.
[Graphical view ]
PRINTSi PR00118. BLACTAMASEA.
SUPFAMi SSF56601. SSF56601. 1 hit.
PROSITEi PS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular analysis of beta-lactamases from four species of Streptomyces: comparison of amino acid sequences with those of other beta-lactamases."
    Forsman M., Haeggstroem B., Lindgren L., Jaurin B.
    J. Gen. Microbiol. 136:589-598(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: DSM 40139.

Entry informationi

Entry nameiBLAC_STRBA
AccessioniPrimary (citable) accession number: P35391
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: October 29, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3