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P35391

- BLAC_STRBA

UniProt

P35391 - BLAC_STRBA

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Protein
Beta-lactamase
Gene
N/A
Organism
Streptomyces badius
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei93 – 931Acyl-ester intermediate By similarity

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC

GO - Biological processi

  1. beta-lactam antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase (EC:3.5.2.6)
Alternative name(s):
Penicillinase
OrganismiStreptomyces badius
Taxonomic identifieri1941 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 By similarity
Add
BLAST
Chaini27 – 313287Beta-lactamase
PRO_0000017014Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP35391.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni256 – 2583Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PfamiPF00144. Beta-lactamase. 1 hit.
[Graphical view]
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35391-1 [UniParc]FASTAAdd to Basket

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MHHPRVRTAV AGLVAVLSLV PLAACGQSDS TAPPSSAKPA TSASASLPRP    50
KPYTGDFKKL EREFDARLGV YAIDTGTGRE VTHNDRARFA YHSTFKALQA 100
AVVLSTYSLD GLDKRVTYTR EDLVAHSPVT EKHVDTGMTL KELCDASVRY 150
SDNTAANLLF DPRAAGPKGL DASLEKLGDD ITRMDREEPE LSRWVPGEKR 200
DTSTPRALAE DLRAFVLGKA LRAPERAQLT TWLRTNTTGD AVIRAGVPEN 250
WVVGDKTGTG SYYGARNDIA VVWPPDSAPI VIAILSHRGT KDAEPDDELI 300
AEAASVVVDS LSS 313
Length:313
Mass (Da):33,720
Last modified:June 1, 1994 - v1
Checksum:i9C71C07DDC0EBF57
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M34178 Genomic DNA. Translation: AAA26707.1.
PIRiA45822.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M34178 Genomic DNA. Translation: AAA26707.1 .
PIRi A45822.

3D structure databases

ProteinModelPortali P35391.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view ]
Pfami PF00144. Beta-lactamase. 1 hit.
[Graphical view ]
PRINTSi PR00118. BLACTAMASEA.
SUPFAMi SSF56601. SSF56601. 1 hit.
PROSITEi PS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular analysis of beta-lactamases from four species of Streptomyces: comparison of amino acid sequences with those of other beta-lactamases."
    Forsman M., Haeggstroem B., Lindgren L., Jaurin B.
    J. Gen. Microbiol. 136:589-598(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: DSM 40139.

Entry informationi

Entry nameiBLAC_STRBA
AccessioniPrimary (citable) accession number: P35391
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: October 16, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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