Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P35391 (BLAC_STRBA) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-lactamase

EC=3.5.2.6
Alternative name(s):
Penicillinase
OrganismStreptomyces badius
Taxonomic identifier1941 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Protein attributes

Sequence length313 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

A beta-lactam + H2O = a substituted beta-amino acid.

Sequence similarities

Belongs to the class-A beta-lactamase family.

Ontologies

Keywords
   Biological processAntibiotic resistance
   DomainSignal
   Molecular functionHydrolase
Gene Ontology (GO)
   Biological_processbeta-lactam antibiotic catabolic process

Inferred from electronic annotation. Source: InterPro

response to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionbeta-lactamase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 By similarity
Chain27 – 313287Beta-lactamase
PRO_0000017014

Regions

Region256 – 2583Substrate binding By similarity

Sites

Active site931Acyl-ester intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
P35391 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 9C71C07DDC0EBF57

FASTA31333,720
        10         20         30         40         50         60 
MHHPRVRTAV AGLVAVLSLV PLAACGQSDS TAPPSSAKPA TSASASLPRP KPYTGDFKKL 

        70         80         90        100        110        120 
EREFDARLGV YAIDTGTGRE VTHNDRARFA YHSTFKALQA AVVLSTYSLD GLDKRVTYTR 

       130        140        150        160        170        180 
EDLVAHSPVT EKHVDTGMTL KELCDASVRY SDNTAANLLF DPRAAGPKGL DASLEKLGDD 

       190        200        210        220        230        240 
ITRMDREEPE LSRWVPGEKR DTSTPRALAE DLRAFVLGKA LRAPERAQLT TWLRTNTTGD 

       250        260        270        280        290        300 
AVIRAGVPEN WVVGDKTGTG SYYGARNDIA VVWPPDSAPI VIAILSHRGT KDAEPDDELI 

       310 
AEAASVVVDS LSS 

« Hide

References

[1]"Molecular analysis of beta-lactamases from four species of Streptomyces: comparison of amino acid sequences with those of other beta-lactamases."
Forsman M., Haeggstroem B., Lindgren L., Jaurin B.
J. Gen. Microbiol. 136:589-598(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: DSM 40139.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M34178 Genomic DNA. Translation: AAA26707.1.
PIRA45822.

3D structure databases

ProteinModelPortalP35391.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.710.10. 1 hit.
InterProIPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PfamPF00144. Beta-lactamase. 1 hit.
[Graphical view]
PRINTSPR00118. BLACTAMASEA.
SUPFAMSSF56601. SSF56601. 1 hit.
PROSITEPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBLAC_STRBA
AccessionPrimary (citable) accession number: P35391
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: October 16, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families