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Protein

Heat shock protein beta-7

Gene

Hspb7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • filamin binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein beta-7
Short name:
HspB7
Alternative name(s):
Cardiovascular heat shock protein
Short name:
cvHsp
Heat shock protein 25 kDa 2
Protein p19/6.8
Gene namesi
Name:Hspb7
Synonyms:Cvhsp, Hsp25-2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1352494. Hspb7.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity
  • NucleusCajal body By similarity

  • Note: Resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.By similarity

GO - Cellular componenti

  • actin cytoskeleton Source: MGI
  • aggresome Source: MGI
  • Cajal body Source: UniProtKB-SubCell
  • cytoplasm Source: MGI
  • mitochondrion Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 169169Heat shock protein beta-7PRO_0000125942Add
BLAST

Proteomic databases

PaxDbiP35385.
PRIDEiP35385.

PTM databases

iPTMnetiP35385.

Expressioni

Tissue specificityi

Found in both cardiac and slow skeletal (soleus) muscle.

Gene expression databases

GenevisibleiP35385. MM.

Interactioni

Subunit structurei

Interacts with C-terminal domain of actin-binding protein 280.

GO - Molecular functioni

  • filamin binding Source: MGI

Protein-protein interaction databases

IntActiP35385. 1 interaction.
MINTiMINT-4098135.
STRINGi10090.ENSMUSP00000099544.

Structurei

3D structure databases

ProteinModelPortaliP35385.
SMRiP35385. Positions 79-150.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 7070Required for localization to SC35 splicing specklesBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi17 – 3014Poly-SerAdd
BLAST

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3591. Eukaryota.
ENOG410YERS. LUCA.
GeneTreeiENSGT00390000010674.
HOGENOMiHOG000072715.
HOVERGENiHBG052040.
InParanoidiP35385.
KOiK09546.
OMAiWMSHRTS.
OrthoDBiEOG7PZS03.
TreeFamiTF350564.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR001436. Alpha-crystallin/HSP.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PANTHERiPTHR11527. PTHR11527. 1 hit.
PfamiPF00011. HSP20. 1 hit.
[Graphical view]
PRINTSiPR00299. ACRYSTALLIN.
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35385-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHRTSSAFR AERSFRSSSS SSSSSSSSAS RALPAQDPPM EKALSMFSDD
60 70 80 90 100
FGSFMLPHSE PLAFPARPGG QGNIKTLGDA YEFTVDMRDF SPEDIIVTTF
110 120 130 140 150
NNHIEVRAEK LAADGTVMNT FAHKCQLPED VDPTSVTSAL REDGSLTIRA
160
RRHPHTEHVQ QTFRTEIKI
Length:169
Mass (Da):18,635
Last modified:October 3, 2012 - v3
Checksum:i15E45C854BF09E7C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 231S → P in CAB63266 (PubMed:10593960).Curated
Sequence conflicti23 – 231S → P in AAF20023 (PubMed:10593960).Curated
Sequence conflicti60 – 612EP → GD AA sequence (Ref. 6) Curated
Sequence conflicti153 – 1531H → N in CAB63266 (PubMed:10593960).Curated
Sequence conflicti153 – 1531H → N in AAF20023 (PubMed:10593960).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243192 mRNA. Translation: CAB63266.1.
AF155909 mRNA. Translation: AAF20023.1.
AK030025 mRNA. Translation: BAC26743.1.
AL670285 Genomic DNA. Translation: CAM20400.1.
CH466615 Genomic DNA. Translation: EDL13373.1.
BC089584 mRNA. Translation: AAH89584.1.
CCDSiCCDS18873.1.
RefSeqiNP_038896.2. NM_013868.4.
UniGeneiMm.46181.

Genome annotation databases

EnsembliENSMUST00000102486; ENSMUSP00000099544; ENSMUSG00000006221.
GeneIDi29818.
KEGGimmu:29818.
UCSCiuc008voj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243192 mRNA. Translation: CAB63266.1.
AF155909 mRNA. Translation: AAF20023.1.
AK030025 mRNA. Translation: BAC26743.1.
AL670285 Genomic DNA. Translation: CAM20400.1.
CH466615 Genomic DNA. Translation: EDL13373.1.
BC089584 mRNA. Translation: AAH89584.1.
CCDSiCCDS18873.1.
RefSeqiNP_038896.2. NM_013868.4.
UniGeneiMm.46181.

3D structure databases

ProteinModelPortaliP35385.
SMRiP35385. Positions 79-150.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP35385. 1 interaction.
MINTiMINT-4098135.
STRINGi10090.ENSMUSP00000099544.

PTM databases

iPTMnetiP35385.

Proteomic databases

PaxDbiP35385.
PRIDEiP35385.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102486; ENSMUSP00000099544; ENSMUSG00000006221.
GeneIDi29818.
KEGGimmu:29818.
UCSCiuc008voj.1. mouse.

Organism-specific databases

CTDi27129.
MGIiMGI:1352494. Hspb7.

Phylogenomic databases

eggNOGiKOG3591. Eukaryota.
ENOG410YERS. LUCA.
GeneTreeiENSGT00390000010674.
HOGENOMiHOG000072715.
HOVERGENiHBG052040.
InParanoidiP35385.
KOiK09546.
OMAiWMSHRTS.
OrthoDBiEOG7PZS03.
TreeFamiTF350564.

Miscellaneous databases

PROiP35385.
SOURCEiSearch...

Gene expression databases

GenevisibleiP35385. MM.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR001436. Alpha-crystallin/HSP.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PANTHERiPTHR11527. PTHR11527. 1 hit.
PfamiPF00011. HSP20. 1 hit.
[Graphical view]
PRINTSiPR00299. ACRYSTALLIN.
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of cvHsp. A novel human small stress protein selectively expressed in cardiovascular and insulin-sensitive tissues."
    Krief S., Faivre J.-F., Robert P., Le Douarin B., Brument-Larignon N., Lefrere I., Bouzyk M.M., Anderson K.M., Greller L.D., Tobin F.L., Souchet M., Bril A.
    J. Biol. Chem. 274:36592-36600(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  6. Kluxen F.-W., Vandekerckhove J., Schoeffl F., Jockusch H.
    Mouse News Lett. 84:76-77(1989)
    Cited for: PROTEIN SEQUENCE OF 43-61 AND 76-87.
    Tissue: Muscle.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Heart.

Entry informationi

Entry nameiHSPB7_MOUSE
AccessioniPrimary (citable) accession number: P35385
Secondary accession number(s): Q5FW72, Q8CDI0, Q9QUS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 3, 2012
Last modified: June 8, 2016
This is version 108 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.