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Protein

ATP synthase subunit alpha, mitochondrial

Gene

blw

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F1. Rotation of the central stalk against the surrounding alpha3beta3 subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei412Required for activityBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi211 – 218ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

  • ATP synthesis coupled proton transport Source: FlyBase
  • electron transport chain Source: FlyBase
  • growth Source: FlyBase
  • lipid storage Source: FlyBase
  • proton transmembrane transport Source: FlyBase
  • regulation of choline O-acetyltransferase activity Source: FlyBase

Keywordsi

Biological processATP synthesis, Hydrogen ion transport, Ion transport, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-163210 Formation of ATP by chemiosmotic coupling
R-DME-8949613 Cristae formation

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit alpha, mitochondrial
Alternative name(s):
Protein bellwether
Gene namesi
Name:blw
Synonyms:ATPSYN-ALPHA
ORF Names:CG3612
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0011211 blw

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CF(1), Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 47MitochondrionSequence analysisAdd BLAST47
ChainiPRO_000000242948 – 552ATP synthase subunit alpha, mitochondrialAdd BLAST505

Proteomic databases

PaxDbiP35381
PRIDEiP35381

Expressioni

Gene expression databases

BgeeiFBgn0011211
GenevisibleiP35381 DM

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c.

Protein-protein interaction databases

BioGridi63229, 52 interactors
DIPiDIP-19192N
IntActiP35381, 6 interactors
MINTiP35381
STRINGi7227.FBpp0071794

Structurei

3D structure databases

ProteinModelPortaliP35381
SMRiP35381
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase alpha/beta chains family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1353 Eukaryota
COG0056 LUCA
GeneTreeiENSGT00550000074846
InParanoidiP35381
KOiK02132
OMAiGNAQIKS
OrthoDBiEOG091G0D1M
PhylomeDBiP35381

Family and domain databases

CDDicd01132 F1_ATPase_alpha, 1 hit
Gene3Di1.20.150.20, 1 hit
2.40.30.20, 1 hit
HAMAPiMF_01346 ATP_synth_alpha_bact, 1 hit
InterProiView protein in InterPro
IPR023366 ATP_synth_asu-like_sf
IPR000793 ATP_synth_asu_C
IPR038376 ATP_synth_asu_C_sf
IPR033732 ATP_synth_F1_a
IPR005294 ATP_synth_F1_asu
IPR020003 ATPase_a/bsu_AS
IPR004100 ATPase_F1/V1/A1_a/bsu_N
IPR036121 ATPase_F1/V1/A1_a/bsu_N_sf
IPR000194 ATPase_F1/V1/A1_a/bsu_nucl-bd
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00006 ATP-synt_ab, 1 hit
PF00306 ATP-synt_ab_C, 1 hit
PF02874 ATP-synt_ab_N, 1 hit
PIRSFiPIRSF039088 F_ATPase_subunit_alpha, 1 hit
SUPFAMiSSF50615 SSF50615, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00962 atpA, 1 hit
PROSITEiView protein in PROSITE
PS00152 ATPASE_ALPHA_BETA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35381-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIFSARLAS SVARNLPKAA NQVACKAAYP AASLAARKLH VASTQRSAEI
60 70 80 90 100
SNILEERILG VAPKADLEET GRVLSIGDGI ARVYGLNNIQ ADEMVEFSSG
110 120 130 140 150
LKGMALNLEP DNVGVVVFGN DKLIKQGDIV KRTGAIVDVP VGDELLGRVV
160 170 180 190 200
DALGNAIDGK GAINTKDRFR VGIKAPGIIP RVSVREPMQT GIKAVDSLVP
210 220 230 240 250
IGRGQRELII GDRQTGKTAL AIDTIINQKR FNEAQDESKK LYCIYVAIGQ
260 270 280 290 300
KRSTVAQIVK RLTDSGAMGY SVIVSATASD AAPLQYLAPY SGCAMGEYFR
310 320 330 340 350
DKGKHALIIY DDLSKQAVAY RQMSLLLRRP PGREAYPGDV FYLHSRLLER
360 370 380 390 400
AAKMSPAMGG GSLTALPVIE TQAGDVSAYI PTNVISITDG QIFLETELFY
410 420 430 440 450
KGIRPAINVG LSVSRVGSAA QTKAMKQVAG SMKLELAQYR EVAAFAQFGS
460 470 480 490 500
DLDAATQQLL NRGVRLTELL KQGQYVPMAI EDQVAVIYCG VRGHLDKMDP
510 520 530 540 550
AKITKFEKEF LQHIKTSEQA LLDTIAKDGA ISEASDAKLK DIVAKFMSTF

QG
Length:552
Mass (Da):59,422
Last modified:December 15, 1998 - v2
Checksum:i68DB3E77A4726FEA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07894 mRNA Translation: CAA69202.1
AE013599 Genomic DNA Translation: AAF46903.1
BT003592 mRNA Translation: AAO39595.1
RefSeqiNP_726243.1, NM_166554.3
UniGeneiDm.7300

Genome annotation databases

EnsemblMetazoaiFBtr0071883; FBpp0071794; FBgn0011211
GeneIDi37617
KEGGidme:Dmel_CG3612

Similar proteinsi

Entry informationi

Entry nameiATPA_DROME
AccessioniPrimary (citable) accession number: P35381
Secondary accession number(s): Q53YF5, Q94512, Q9W1Z7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: December 15, 1998
Last modified: May 23, 2018
This is version 170 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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