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Protein

Follicle-stimulating hormone receptor

Gene

Fshr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

GO - Molecular functioni

GO - Biological processi

  • activation of adenylate cyclase activity Source: GO_Central
  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: GO_Central
  • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: MGI
  • adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: MGI
  • basement membrane organization Source: MGI
  • cellular water homeostasis Source: MGI
  • female gonad development Source: GO_Central
  • follicle-stimulating hormone signaling pathway Source: MGI
  • hormone-mediated signaling pathway Source: GO_Central
  • locomotory behavior Source: MGI
  • negative regulation of bone resorption Source: MGI
  • neuron projection development Source: MGI
  • ovarian follicle development Source: MGI
  • ovulation cycle process Source: MGI
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: MGI
  • positive regulation of intracellular estrogen receptor signaling pathway Source: MGI
  • primary ovarian follicle growth Source: MGI
  • regulation of acetylcholine metabolic process Source: MGI
  • regulation of chromosome organization Source: MGI
  • regulation of hormone metabolic process Source: MGI
  • regulation of intracellular estrogen receptor signaling pathway Source: MGI
  • regulation of MAPK cascade Source: MGI
  • regulation of osteoclast differentiation Source: MGI
  • regulation of platelet-derived growth factor receptor signaling pathway Source: MGI
  • regulation of protein phosphorylation Source: MGI
  • regulation of systemic arterial blood pressure Source: MGI
  • Sertoli cell development Source: MGI
  • Sertoli cell proliferation Source: MGI
  • spermatid development Source: MGI
  • spermatogenesis Source: MGI
  • spermatogenesis, exchange of chromosomal proteins Source: MGI
  • sperm chromatin condensation Source: MGI
  • transcytosis Source: Ensembl
  • uterus development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_295506. Hormone ligand-binding receptors.
REACT_313192. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Follicle-stimulating hormone receptor
Short name:
FSH-R
Alternative name(s):
Follitropin receptor
Gene namesi
Name:Fshr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:95583. Fshr.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 365348ExtracellularSequence AnalysisAdd
BLAST
Transmembranei366 – 38621Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini387 – 39711CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei398 – 42023Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini421 – 44222ExtracellularSequence AnalysisAdd
BLAST
Transmembranei443 – 46422Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini465 – 48420CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei485 – 50723Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini508 – 52720ExtracellularSequence AnalysisAdd
BLAST
Transmembranei528 – 54922Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini550 – 57223CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei573 – 59624Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini597 – 60711ExtracellularSequence AnalysisAdd
BLAST
Transmembranei608 – 62922Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini630 – 69263CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • cell surface Source: MGI
  • endosome Source: Ensembl
  • integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 692675Follicle-stimulating hormone receptorPRO_0000012773Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi18 ↔ 25PROSITE-ProRule annotation
Disulfide bondi23 ↔ 32PROSITE-ProRule annotation
Glycosylationi191 – 1911N-linked (GlcNAc...)By similarity
Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi293 – 2931N-linked (GlcNAc...)By similarity
Disulfide bondi441 ↔ 516PROSITE-ProRule annotation

Post-translational modificationi

N-glycosylated; indirectly required for FSH-binding, possibly via a conformational change that allows high affinity binding of hormone.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP35378.
PRIDEiP35378.

PTM databases

PhosphoSiteiP35378.

Expressioni

Gene expression databases

BgeeiP35378.
CleanExiMM_FSHR.
ExpressionAtlasiP35378. baseline and differential.
GenevisibleiP35378. MM.

Interactioni

Subunit structurei

Interacts with ARRB2.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040477.

Structurei

3D structure databases

ProteinModelPortaliP35378.
SMRiP35378. Positions 18-358, 367-636.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 4629LRRNTAdd
BLAST
Repeati49 – 7224LRR 1Add
BLAST
Repeati73 – 9725LRR 2Add
BLAST
Repeati98 – 11821LRR 3Add
BLAST
Repeati119 – 14325LRR 4Add
BLAST
Repeati144 – 16926LRR 5Add
BLAST
Repeati170 – 19223LRR 6Add
BLAST
Repeati193 – 21624LRR 7Add
BLAST
Repeati217 – 24024LRR 8Add
BLAST
Repeati241 – 25919LRR 9Add
BLAST

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.PROSITE-ProRule annotation
Contains 9 LRR (leucine-rich) repeats.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG285844.
GeneTreeiENSGT00760000119088.
HOGENOMiHOG000045902.
HOVERGENiHBG003521.
InParanoidiP35378.
KOiK04247.
OMAiDVHKIHS.
OrthoDBiEOG73BVCG.
PhylomeDBiP35378.
TreeFamiTF316814.

Family and domain databases

InterProiIPR002272. FSH_rcpt.
IPR024635. GnHR_TM.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002131. Gphrmn_rcpt_fam.
IPR001611. Leu-rich_rpt.
IPR000372. LRR-contain_N.
[Graphical view]
PANTHERiPTHR24372. PTHR24372. 1 hit.
PTHR24372:SF5. PTHR24372:SF5. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
PF12369. GnHR_trans. 1 hit.
PF13855. LRR_8. 2 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
PRINTSiPR01143. FSHRECEPTOR.
PR00373. GLYCHORMONER.
PR00237. GPCRRHODOPSN.
SMARTiSM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35378-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLLVSLLA FLGSGSGCHH WLCHCSNRVF LCQDSKVTEI PPDLPRNAIE
60 70 80 90 100
LRFVLTKLRV IPKGSFSGFG DLEKIEISQN DVLEVIEADV FSNLPNLHEI
110 120 130 140 150
RIEKANNLLY INPEAFQNLP SLRYLLISNT GIKHLPAFHK IQSLQKVLLD
160 170 180 190 200
IQDNINIHII ARNSFMGLSF ESVILWLNKN GIQEIHNCAF NGTQLDELNL
210 220 230 240 250
SDNNNLEELP DDVFQGASGP VVLDISRTKV YSLPNHGLEN LKKLRARSTY
260 270 280 290 300
RLKKLPSLDK FVMLIEASLT YPSHCCAFAN WRRQTSELHP ICNKSISRQD
310 320 330 340 350
IDDMTQPGDQ RVSLVDDEPS YGKGSDMLYS EFDYDLCNEF VDVTCSPKPD
360 370 380 390 400
AFNPCEDIMG YNILRVLIWF ISILAITGNT TVLVVLTTSQ YKLTVPRFLM
410 420 430 440 450
CNLAFADLCI GIYLLLIASV DIHTKSQYHN YAIDWQTGAG CDAAGFFTVF
460 470 480 490 500
ASELSVYTLA AITLERWHTI THAMQLECKV QLCHAASIMV LGWAFAFAAA
510 520 530 540 550
LFPIFGISSY MKVSICLPMD IDSPLSQLYV MALLVLNALA FVVICGCYTH
560 570 580 590 600
IYLTVRNPNI VSSSRDTKIA KRMATLIFTD FLCMAPILFF AISASLKVPL
610 620 630 640 650
ITVSKAKILL VLFYPINSCA NPFLYAIFTK NFRRDFFVLM SKFGCYEVQA
660 670 680 690
QIYKTETSSI THNFHSRKNP CSSAPRVTNS YVLVPLNHSV QN
Length:692
Mass (Da):77,769
Last modified:September 26, 2001 - v2
Checksum:i4B57229180563A44
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti436 – 4361Q → K in BAB30351 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095642 mRNA. Translation: AAC67559.1.
AK016635 mRNA. Translation: BAB30351.1.
S49632 Genomic DNA. Translation: AAB24401.1.
M87570 Genomic DNA. Translation: AAA37641.1.
CCDSiCCDS29026.1.
PIRiI57670.
RefSeqiNP_038551.3. NM_013523.3.
UniGeneiMm.57155.

Genome annotation databases

EnsembliENSMUST00000035701; ENSMUSP00000040477; ENSMUSG00000032937.
GeneIDi14309.
KEGGimmu:14309.
UCSCiuc008dvx.1. mouse.

Cross-referencesi

Web resourcesi

GRIS

Glycoprotein-hormone Receptors Information System

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095642 mRNA. Translation: AAC67559.1.
AK016635 mRNA. Translation: BAB30351.1.
S49632 Genomic DNA. Translation: AAB24401.1.
M87570 Genomic DNA. Translation: AAA37641.1.
CCDSiCCDS29026.1.
PIRiI57670.
RefSeqiNP_038551.3. NM_013523.3.
UniGeneiMm.57155.

3D structure databases

ProteinModelPortaliP35378.
SMRiP35378. Positions 18-358, 367-636.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040477.

Chemistry

GuidetoPHARMACOLOGYi253.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP35378.

Proteomic databases

PaxDbiP35378.
PRIDEiP35378.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035701; ENSMUSP00000040477; ENSMUSG00000032937.
GeneIDi14309.
KEGGimmu:14309.
UCSCiuc008dvx.1. mouse.

Organism-specific databases

CTDi2492.
MGIiMGI:95583. Fshr.

Phylogenomic databases

eggNOGiNOG285844.
GeneTreeiENSGT00760000119088.
HOGENOMiHOG000045902.
HOVERGENiHBG003521.
InParanoidiP35378.
KOiK04247.
OMAiDVHKIHS.
OrthoDBiEOG73BVCG.
PhylomeDBiP35378.
TreeFamiTF316814.

Enzyme and pathway databases

ReactomeiREACT_295506. Hormone ligand-binding receptors.
REACT_313192. G alpha (s) signalling events.

Miscellaneous databases

NextBioi285731.
PROiP35378.
SOURCEiSearch...

Gene expression databases

BgeeiP35378.
CleanExiMM_FSHR.
ExpressionAtlasiP35378. baseline and differential.
GenevisibleiP35378. MM.

Family and domain databases

InterProiIPR002272. FSH_rcpt.
IPR024635. GnHR_TM.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002131. Gphrmn_rcpt_fam.
IPR001611. Leu-rich_rpt.
IPR000372. LRR-contain_N.
[Graphical view]
PANTHERiPTHR24372. PTHR24372. 1 hit.
PTHR24372:SF5. PTHR24372:SF5. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
PF12369. GnHR_trans. 1 hit.
PF13855. LRR_8. 2 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
PRINTSiPR01143. FSHRECEPTOR.
PR00373. GLYCHORMONER.
PR00237. GPCRRHODOPSN.
SMARTiSM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of the mouse follicle-stimulating hormone receptor complementary deoxyribonucleic acid: functional expression of alternatively spliced variants and receptor inactivation by a C566T transition in exon 7 of the coding sequence."
    Tena-Sempere M., Manna P.R., Huhtaniemi I.T.
    Biol. Reprod. 60:1515-1527(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 129/Sv.
    Tissue: Testis.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  3. "The murine luteinizing hormone and follicle-stimulating hormone receptor genes: transcription initiation sites, putative promoter sequences and promoter activity."
    Huhtaniemi I.T., Eskola V., Pakarinen P., Matikainen T., Sprengel R.
    Mol. Cell. Endocrinol. 88:55-66(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 1-51.

Entry informationi

Entry nameiFSHR_MOUSE
AccessioniPrimary (citable) accession number: P35378
Secondary accession number(s): Q9D4C2, Q9QWV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: September 26, 2001
Last modified: June 24, 2015
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.