SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P35378

- FSHR_MOUSE

UniProt

P35378 - FSHR_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Follicle-stimulating hormone receptor
Gene
Fshr
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

GO - Molecular functioni

  1. follicle-stimulating hormone receptor activity Source: MGI
  2. peptide hormone binding Source: Ensembl

GO - Biological processi

  1. Sertoli cell development Source: MGI
  2. Sertoli cell proliferation Source: MGI
  3. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: Ensembl
  4. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: MGI
  5. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: MGI
  6. basement membrane organization Source: MGI
  7. cellular water homeostasis Source: MGI
  8. follicle-stimulating hormone signaling pathway Source: MGI
  9. locomotory behavior Source: MGI
  10. negative regulation of bone resorption Source: MGI
  11. neuron projection development Source: MGI
  12. ovarian follicle development Source: MGI
  13. ovulation cycle process Source: MGI
  14. phospholipase C-activating G-protein coupled receptor signaling pathway Source: MGI
  15. positive regulation of intracellular estrogen receptor signaling pathway Source: MGI
  16. primary ovarian follicle growth Source: MGI
  17. regulation of MAPK cascade Source: MGI
  18. regulation of acetylcholine metabolic process Source: MGI
  19. regulation of chromosome organization Source: MGI
  20. regulation of hormone metabolic process Source: MGI
  21. regulation of intracellular estrogen receptor signaling pathway Source: MGI
  22. regulation of osteoclast differentiation Source: MGI
  23. regulation of platelet-derived growth factor receptor signaling pathway Source: MGI
  24. regulation of protein phosphorylation Source: MGI
  25. regulation of systemic arterial blood pressure Source: MGI
  26. sperm chromatin condensation Source: MGI
  27. spermatid development Source: MGI
  28. spermatogenesis Source: MGI
  29. spermatogenesis, exchange of chromosomal proteins Source: MGI
  30. transcytosis Source: Ensembl
  31. uterus development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Follicle-stimulating hormone receptor
Short name:
FSH-R
Alternative name(s):
Follitropin receptor
Gene namesi
Name:Fshr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:95583. Fshr.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 365348Extracellular Reviewed prediction
Add
BLAST
Transmembranei366 – 38621Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini387 – 39711Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei398 – 42023Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini421 – 44222Extracellular Reviewed prediction
Add
BLAST
Transmembranei443 – 46422Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini465 – 48420Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei485 – 50723Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini508 – 52720Extracellular Reviewed prediction
Add
BLAST
Transmembranei528 – 54922Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini550 – 57223Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei573 – 59624Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini597 – 60711Extracellular Reviewed prediction
Add
BLAST
Transmembranei608 – 62922Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini630 – 69263Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell surface Source: MGI
  2. endosome Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed prediction
Add
BLAST
Chaini18 – 692675Follicle-stimulating hormone receptor
PRO_0000012773Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi18 ↔ 25 By similarity
Disulfide bondi23 ↔ 32 By similarity
Glycosylationi191 – 1911N-linked (GlcNAc...) By similarity
Glycosylationi199 – 1991N-linked (GlcNAc...) Reviewed prediction
Glycosylationi293 – 2931N-linked (GlcNAc...) By similarity
Disulfide bondi441 ↔ 516 By similarity

Post-translational modificationi

N-glycosylated; indirectly required for FSH-binding, possibly via a conformational change that allows high affinity binding of hormone By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP35378.
PRIDEiP35378.

PTM databases

PhosphoSiteiP35378.

Expressioni

Gene expression databases

ArrayExpressiP35378.
BgeeiP35378.
CleanExiMM_FSHR.
GenevestigatoriP35378.

Interactioni

Subunit structurei

Interacts with ARRB2 By similarity.

Structurei

3D structure databases

ProteinModelPortaliP35378.
SMRiP35378. Positions 18-358, 367-636.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 4629LRRNT
Add
BLAST
Repeati49 – 7224LRR 1
Add
BLAST
Repeati73 – 9725LRR 2
Add
BLAST
Repeati98 – 11821LRR 3
Add
BLAST
Repeati119 – 14325LRR 4
Add
BLAST
Repeati144 – 16926LRR 5
Add
BLAST
Repeati170 – 19223LRR 6
Add
BLAST
Repeati193 – 21624LRR 7
Add
BLAST
Repeati217 – 24024LRR 8
Add
BLAST
Repeati241 – 25919LRR 9
Add
BLAST

Sequence similaritiesi

Contains 1 LRRNT domain.

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG285844.
GeneTreeiENSGT00730000110262.
HOGENOMiHOG000045902.
HOVERGENiHBG003521.
InParanoidiP35378.
KOiK04247.
OMAiSDTRIAK.
OrthoDBiEOG73BVCG.
PhylomeDBiP35378.
TreeFamiTF316814.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR002272. FSH_rcpt.
IPR024635. GnHR_TM.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002131. Gphrmn_rcpt_fam.
IPR001611. Leu-rich_rpt.
IPR000372. LRR-contain_N.
[Graphical view]
PANTHERiPTHR24372. PTHR24372. 1 hit.
PTHR24372:SF5. PTHR24372:SF5. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
PF12369. GnHR_trans. 1 hit.
PF13855. LRR_8. 2 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
PRINTSiPR01143. FSHRECEPTOR.
PR00373. GLYCHORMONER.
PR00237. GPCRRHODOPSN.
SMARTiSM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35378-1 [UniParc]FASTAAdd to Basket

« Hide

MALLLVSLLA FLGSGSGCHH WLCHCSNRVF LCQDSKVTEI PPDLPRNAIE    50
LRFVLTKLRV IPKGSFSGFG DLEKIEISQN DVLEVIEADV FSNLPNLHEI 100
RIEKANNLLY INPEAFQNLP SLRYLLISNT GIKHLPAFHK IQSLQKVLLD 150
IQDNINIHII ARNSFMGLSF ESVILWLNKN GIQEIHNCAF NGTQLDELNL 200
SDNNNLEELP DDVFQGASGP VVLDISRTKV YSLPNHGLEN LKKLRARSTY 250
RLKKLPSLDK FVMLIEASLT YPSHCCAFAN WRRQTSELHP ICNKSISRQD 300
IDDMTQPGDQ RVSLVDDEPS YGKGSDMLYS EFDYDLCNEF VDVTCSPKPD 350
AFNPCEDIMG YNILRVLIWF ISILAITGNT TVLVVLTTSQ YKLTVPRFLM 400
CNLAFADLCI GIYLLLIASV DIHTKSQYHN YAIDWQTGAG CDAAGFFTVF 450
ASELSVYTLA AITLERWHTI THAMQLECKV QLCHAASIMV LGWAFAFAAA 500
LFPIFGISSY MKVSICLPMD IDSPLSQLYV MALLVLNALA FVVICGCYTH 550
IYLTVRNPNI VSSSRDTKIA KRMATLIFTD FLCMAPILFF AISASLKVPL 600
ITVSKAKILL VLFYPINSCA NPFLYAIFTK NFRRDFFVLM SKFGCYEVQA 650
QIYKTETSSI THNFHSRKNP CSSAPRVTNS YVLVPLNHSV QN 692
Length:692
Mass (Da):77,769
Last modified:September 26, 2001 - v2
Checksum:i4B57229180563A44
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti436 – 4361Q → K in BAB30351. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF095642 mRNA. Translation: AAC67559.1.
AK016635 mRNA. Translation: BAB30351.1.
S49632 Genomic DNA. Translation: AAB24401.1.
M87570 Genomic DNA. Translation: AAA37641.1.
CCDSiCCDS29026.1.
PIRiI57670.
RefSeqiNP_038551.3. NM_013523.3.
UniGeneiMm.57155.

Genome annotation databases

EnsembliENSMUST00000035701; ENSMUSP00000040477; ENSMUSG00000032937.
GeneIDi14309.
KEGGimmu:14309.
UCSCiuc008dvx.1. mouse.

Cross-referencesi

Web resourcesi

GRIS

Glycoprotein-hormone Receptors Information System

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF095642 mRNA. Translation: AAC67559.1 .
AK016635 mRNA. Translation: BAB30351.1 .
S49632 Genomic DNA. Translation: AAB24401.1 .
M87570 Genomic DNA. Translation: AAA37641.1 .
CCDSi CCDS29026.1.
PIRi I57670.
RefSeqi NP_038551.3. NM_013523.3.
UniGenei Mm.57155.

3D structure databases

ProteinModelPortali P35378.
SMRi P35378. Positions 18-358, 367-636.
ModBasei Search...
MobiDBi Search...

Chemistry

GuidetoPHARMACOLOGYi 253.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P35378.

Proteomic databases

PaxDbi P35378.
PRIDEi P35378.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000035701 ; ENSMUSP00000040477 ; ENSMUSG00000032937 .
GeneIDi 14309.
KEGGi mmu:14309.
UCSCi uc008dvx.1. mouse.

Organism-specific databases

CTDi 2492.
MGIi MGI:95583. Fshr.

Phylogenomic databases

eggNOGi NOG285844.
GeneTreei ENSGT00730000110262.
HOGENOMi HOG000045902.
HOVERGENi HBG003521.
InParanoidi P35378.
KOi K04247.
OMAi SDTRIAK.
OrthoDBi EOG73BVCG.
PhylomeDBi P35378.
TreeFami TF316814.

Miscellaneous databases

NextBioi 285731.
PROi P35378.
SOURCEi Search...

Gene expression databases

ArrayExpressi P35378.
Bgeei P35378.
CleanExi MM_FSHR.
Genevestigatori P35378.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR002272. FSH_rcpt.
IPR024635. GnHR_TM.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002131. Gphrmn_rcpt_fam.
IPR001611. Leu-rich_rpt.
IPR000372. LRR-contain_N.
[Graphical view ]
PANTHERi PTHR24372. PTHR24372. 1 hit.
PTHR24372:SF5. PTHR24372:SF5. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
PF12369. GnHR_trans. 1 hit.
PF13855. LRR_8. 2 hits.
PF01462. LRRNT. 1 hit.
[Graphical view ]
PRINTSi PR01143. FSHRECEPTOR.
PR00373. GLYCHORMONER.
PR00237. GPCRRHODOPSN.
SMARTi SM00013. LRRNT. 1 hit.
[Graphical view ]
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of the mouse follicle-stimulating hormone receptor complementary deoxyribonucleic acid: functional expression of alternatively spliced variants and receptor inactivation by a C566T transition in exon 7 of the coding sequence."
    Tena-Sempere M., Manna P.R., Huhtaniemi I.T.
    Biol. Reprod. 60:1515-1527(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 129/Sv.
    Tissue: Testis.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  3. "The murine luteinizing hormone and follicle-stimulating hormone receptor genes: transcription initiation sites, putative promoter sequences and promoter activity."
    Huhtaniemi I.T., Eskola V., Pakarinen P., Matikainen T., Sprengel R.
    Mol. Cell. Endocrinol. 88:55-66(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 1-51.

Entry informationi

Entry nameiFSHR_MOUSE
AccessioniPrimary (citable) accession number: P35378
Secondary accession number(s): Q9D4C2, Q9QWV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: September 26, 2001
Last modified: July 9, 2014
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi