Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P35378

- FSHR_MOUSE

UniProt

P35378 - FSHR_MOUSE

Protein

Follicle-stimulating hormone receptor

Gene

Fshr

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 136 (01 Oct 2014)
      Sequence version 2 (26 Sep 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

    GO - Molecular functioni

    1. follicle-stimulating hormone receptor activity Source: MGI
    2. peptide hormone binding Source: Ensembl

    GO - Biological processi

    1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: Ensembl
    2. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: MGI
    3. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: MGI
    4. basement membrane organization Source: MGI
    5. cellular water homeostasis Source: MGI
    6. follicle-stimulating hormone signaling pathway Source: MGI
    7. locomotory behavior Source: MGI
    8. negative regulation of bone resorption Source: MGI
    9. neuron projection development Source: MGI
    10. ovarian follicle development Source: MGI
    11. ovulation cycle process Source: MGI
    12. phospholipase C-activating G-protein coupled receptor signaling pathway Source: MGI
    13. positive regulation of intracellular estrogen receptor signaling pathway Source: MGI
    14. primary ovarian follicle growth Source: MGI
    15. regulation of acetylcholine metabolic process Source: MGI
    16. regulation of chromosome organization Source: MGI
    17. regulation of hormone metabolic process Source: MGI
    18. regulation of intracellular estrogen receptor signaling pathway Source: MGI
    19. regulation of MAPK cascade Source: MGI
    20. regulation of osteoclast differentiation Source: MGI
    21. regulation of platelet-derived growth factor receptor signaling pathway Source: MGI
    22. regulation of protein phosphorylation Source: MGI
    23. regulation of systemic arterial blood pressure Source: MGI
    24. Sertoli cell development Source: MGI
    25. Sertoli cell proliferation Source: MGI
    26. spermatid development Source: MGI
    27. spermatogenesis Source: MGI
    28. spermatogenesis, exchange of chromosomal proteins Source: MGI
    29. sperm chromatin condensation Source: MGI
    30. transcytosis Source: Ensembl
    31. uterus development Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Follicle-stimulating hormone receptor
    Short name:
    FSH-R
    Alternative name(s):
    Follitropin receptor
    Gene namesi
    Name:Fshr
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:95583. Fshr.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: MGI
    2. endosome Source: Ensembl
    3. integral component of membrane Source: UniProtKB-KW
    4. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 692675Follicle-stimulating hormone receptorPRO_0000012773Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi18 ↔ 25PROSITE-ProRule annotation
    Disulfide bondi23 ↔ 32PROSITE-ProRule annotation
    Glycosylationi191 – 1911N-linked (GlcNAc...)By similarity
    Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi293 – 2931N-linked (GlcNAc...)By similarity
    Disulfide bondi441 ↔ 516PROSITE-ProRule annotation

    Post-translational modificationi

    N-glycosylated; indirectly required for FSH-binding, possibly via a conformational change that allows high affinity binding of hormone.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP35378.
    PRIDEiP35378.

    PTM databases

    PhosphoSiteiP35378.

    Expressioni

    Gene expression databases

    ArrayExpressiP35378.
    BgeeiP35378.
    CleanExiMM_FSHR.
    GenevestigatoriP35378.

    Interactioni

    Subunit structurei

    Interacts with ARRB2.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP35378.
    SMRiP35378. Positions 18-358, 367-636.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini18 – 365348ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini387 – 39711CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini421 – 44222ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini465 – 48420CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini508 – 52720ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini550 – 57223CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini597 – 60711ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini630 – 69263CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei366 – 38621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei398 – 42023Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei443 – 46422Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei485 – 50723Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei528 – 54922Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei573 – 59624Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei608 – 62922Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini18 – 4629LRRNTAdd
    BLAST
    Repeati49 – 7224LRR 1Add
    BLAST
    Repeati73 – 9725LRR 2Add
    BLAST
    Repeati98 – 11821LRR 3Add
    BLAST
    Repeati119 – 14325LRR 4Add
    BLAST
    Repeati144 – 16926LRR 5Add
    BLAST
    Repeati170 – 19223LRR 6Add
    BLAST
    Repeati193 – 21624LRR 7Add
    BLAST
    Repeati217 – 24024LRR 8Add
    BLAST
    Repeati241 – 25919LRR 9Add
    BLAST

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.PROSITE-ProRule annotation
    Contains 9 LRR (leucine-rich) repeats.Curated
    Contains 1 LRRNT domain.Curated

    Keywords - Domaini

    Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG285844.
    GeneTreeiENSGT00730000110262.
    HOGENOMiHOG000045902.
    HOVERGENiHBG003521.
    InParanoidiP35378.
    KOiK04247.
    OMAiSDTRIAK.
    OrthoDBiEOG73BVCG.
    PhylomeDBiP35378.
    TreeFamiTF316814.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR002272. FSH_rcpt.
    IPR024635. GnHR_TM.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR002131. Gphrmn_rcpt_fam.
    IPR001611. Leu-rich_rpt.
    IPR000372. LRR-contain_N.
    [Graphical view]
    PANTHERiPTHR24372. PTHR24372. 1 hit.
    PTHR24372:SF5. PTHR24372:SF5. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    PF12369. GnHR_trans. 1 hit.
    PF13855. LRR_8. 2 hits.
    PF01462. LRRNT. 1 hit.
    [Graphical view]
    PRINTSiPR01143. FSHRECEPTOR.
    PR00373. GLYCHORMONER.
    PR00237. GPCRRHODOPSN.
    SMARTiSM00013. LRRNT. 1 hit.
    [Graphical view]
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P35378-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALLLVSLLA FLGSGSGCHH WLCHCSNRVF LCQDSKVTEI PPDLPRNAIE    50
    LRFVLTKLRV IPKGSFSGFG DLEKIEISQN DVLEVIEADV FSNLPNLHEI 100
    RIEKANNLLY INPEAFQNLP SLRYLLISNT GIKHLPAFHK IQSLQKVLLD 150
    IQDNINIHII ARNSFMGLSF ESVILWLNKN GIQEIHNCAF NGTQLDELNL 200
    SDNNNLEELP DDVFQGASGP VVLDISRTKV YSLPNHGLEN LKKLRARSTY 250
    RLKKLPSLDK FVMLIEASLT YPSHCCAFAN WRRQTSELHP ICNKSISRQD 300
    IDDMTQPGDQ RVSLVDDEPS YGKGSDMLYS EFDYDLCNEF VDVTCSPKPD 350
    AFNPCEDIMG YNILRVLIWF ISILAITGNT TVLVVLTTSQ YKLTVPRFLM 400
    CNLAFADLCI GIYLLLIASV DIHTKSQYHN YAIDWQTGAG CDAAGFFTVF 450
    ASELSVYTLA AITLERWHTI THAMQLECKV QLCHAASIMV LGWAFAFAAA 500
    LFPIFGISSY MKVSICLPMD IDSPLSQLYV MALLVLNALA FVVICGCYTH 550
    IYLTVRNPNI VSSSRDTKIA KRMATLIFTD FLCMAPILFF AISASLKVPL 600
    ITVSKAKILL VLFYPINSCA NPFLYAIFTK NFRRDFFVLM SKFGCYEVQA 650
    QIYKTETSSI THNFHSRKNP CSSAPRVTNS YVLVPLNHSV QN 692
    Length:692
    Mass (Da):77,769
    Last modified:September 26, 2001 - v2
    Checksum:i4B57229180563A44
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti436 – 4361Q → K in BAB30351. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF095642 mRNA. Translation: AAC67559.1.
    AK016635 mRNA. Translation: BAB30351.1.
    S49632 Genomic DNA. Translation: AAB24401.1.
    M87570 Genomic DNA. Translation: AAA37641.1.
    CCDSiCCDS29026.1.
    PIRiI57670.
    RefSeqiNP_038551.3. NM_013523.3.
    UniGeneiMm.57155.

    Genome annotation databases

    EnsembliENSMUST00000035701; ENSMUSP00000040477; ENSMUSG00000032937.
    GeneIDi14309.
    KEGGimmu:14309.
    UCSCiuc008dvx.1. mouse.

    Cross-referencesi

    Web resourcesi

    GRIS

    Glycoprotein-hormone Receptors Information System

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF095642 mRNA. Translation: AAC67559.1 .
    AK016635 mRNA. Translation: BAB30351.1 .
    S49632 Genomic DNA. Translation: AAB24401.1 .
    M87570 Genomic DNA. Translation: AAA37641.1 .
    CCDSi CCDS29026.1.
    PIRi I57670.
    RefSeqi NP_038551.3. NM_013523.3.
    UniGenei Mm.57155.

    3D structure databases

    ProteinModelPortali P35378.
    SMRi P35378. Positions 18-358, 367-636.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    GuidetoPHARMACOLOGYi 253.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P35378.

    Proteomic databases

    PaxDbi P35378.
    PRIDEi P35378.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000035701 ; ENSMUSP00000040477 ; ENSMUSG00000032937 .
    GeneIDi 14309.
    KEGGi mmu:14309.
    UCSCi uc008dvx.1. mouse.

    Organism-specific databases

    CTDi 2492.
    MGIi MGI:95583. Fshr.

    Phylogenomic databases

    eggNOGi NOG285844.
    GeneTreei ENSGT00730000110262.
    HOGENOMi HOG000045902.
    HOVERGENi HBG003521.
    InParanoidi P35378.
    KOi K04247.
    OMAi SDTRIAK.
    OrthoDBi EOG73BVCG.
    PhylomeDBi P35378.
    TreeFami TF316814.

    Miscellaneous databases

    NextBioi 285731.
    PROi P35378.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P35378.
    Bgeei P35378.
    CleanExi MM_FSHR.
    Genevestigatori P35378.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR002272. FSH_rcpt.
    IPR024635. GnHR_TM.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR002131. Gphrmn_rcpt_fam.
    IPR001611. Leu-rich_rpt.
    IPR000372. LRR-contain_N.
    [Graphical view ]
    PANTHERi PTHR24372. PTHR24372. 1 hit.
    PTHR24372:SF5. PTHR24372:SF5. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    PF12369. GnHR_trans. 1 hit.
    PF13855. LRR_8. 2 hits.
    PF01462. LRRNT. 1 hit.
    [Graphical view ]
    PRINTSi PR01143. FSHRECEPTOR.
    PR00373. GLYCHORMONER.
    PR00237. GPCRRHODOPSN.
    SMARTi SM00013. LRRNT. 1 hit.
    [Graphical view ]
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of the mouse follicle-stimulating hormone receptor complementary deoxyribonucleic acid: functional expression of alternatively spliced variants and receptor inactivation by a C566T transition in exon 7 of the coding sequence."
      Tena-Sempere M., Manna P.R., Huhtaniemi I.T.
      Biol. Reprod. 60:1515-1527(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 129/Sv.
      Tissue: Testis.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Testis.
    3. "The murine luteinizing hormone and follicle-stimulating hormone receptor genes: transcription initiation sites, putative promoter sequences and promoter activity."
      Huhtaniemi I.T., Eskola V., Pakarinen P., Matikainen T., Sprengel R.
      Mol. Cell. Endocrinol. 88:55-66(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 1-51.

    Entry informationi

    Entry nameiFSHR_MOUSE
    AccessioniPrimary (citable) accession number: P35378
    Secondary accession number(s): Q9D4C2, Q9QWV8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: September 26, 2001
    Last modified: October 1, 2014
    This is version 136 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3