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Protein

Follicle-stimulating hormone receptor

Gene

Fshr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Induces cAMP production through the activation of PI3K-AKT and SRC-ERK1/2 signaling pathways.By similarity

GO - Molecular functioni

GO - Biological processi

  • activation of adenylate cyclase activity Source: GO_Central
  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: GO_Central
  • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: MGI
  • adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: MGI
  • basement membrane organization Source: MGI
  • cellular water homeostasis Source: MGI
  • follicle-stimulating hormone signaling pathway Source: MGI
  • locomotory behavior Source: MGI
  • negative regulation of bone resorption Source: MGI
  • neuron projection development Source: MGI
  • ovarian follicle development Source: MGI
  • ovulation cycle process Source: MGI
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: MGI
  • positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
  • positive regulation of intracellular estrogen receptor signaling pathway Source: MGI
  • positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
  • primary ovarian follicle growth Source: MGI
  • regulation of acetylcholine metabolic process Source: MGI
  • regulation of chromosome organization Source: MGI
  • regulation of hormone metabolic process Source: MGI
  • regulation of intracellular estrogen receptor signaling pathway Source: MGI
  • regulation of MAPK cascade Source: MGI
  • regulation of osteoclast differentiation Source: MGI
  • regulation of platelet-derived growth factor receptor signaling pathway Source: MGI
  • regulation of protein kinase A signaling Source: UniProtKB
  • regulation of protein phosphorylation Source: MGI
  • regulation of systemic arterial blood pressure Source: MGI
  • Sertoli cell development Source: MGI
  • Sertoli cell proliferation Source: MGI
  • spermatid development Source: MGI
  • spermatogenesis Source: MGI
  • spermatogenesis, exchange of chromosomal proteins Source: MGI
  • sperm chromatin condensation Source: MGI
  • transcytosis Source: Ensembl
  • uterus development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375281. Hormone ligand-binding receptors.
R-MMU-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Follicle-stimulating hormone receptor
Short name:
FSH-R
Alternative name(s):
Follitropin receptor
Gene namesi
Name:Fshr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:95583. Fshr.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 365ExtracellularSequence analysisAdd BLAST348
Transmembranei366 – 386Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini387 – 397CytoplasmicSequence analysisAdd BLAST11
Transmembranei398 – 420Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini421 – 442ExtracellularSequence analysisAdd BLAST22
Transmembranei443 – 464Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini465 – 484CytoplasmicSequence analysisAdd BLAST20
Transmembranei485 – 507Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini508 – 527ExtracellularSequence analysisAdd BLAST20
Transmembranei528 – 549Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini550 – 572CytoplasmicSequence analysisAdd BLAST23
Transmembranei573 – 596Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini597 – 607ExtracellularSequence analysisAdd BLAST11
Transmembranei608 – 629Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini630 – 692CytoplasmicSequence analysisAdd BLAST63

GO - Cellular componenti

  • cell surface Source: MGI
  • endosome Source: Ensembl
  • integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000001277318 – 692Follicle-stimulating hormone receptorAdd BLAST675

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi18 ↔ 25PROSITE-ProRule annotation
Disulfide bondi23 ↔ 32PROSITE-ProRule annotation
Glycosylationi191N-linked (GlcNAc...)By similarity1
Glycosylationi199N-linked (GlcNAc...)Sequence analysis1
Glycosylationi293N-linked (GlcNAc...)By similarity1
Disulfide bondi441 ↔ 516PROSITE-ProRule annotation

Post-translational modificationi

N-glycosylated; indirectly required for FSH-binding, possibly via a conformational change that allows high affinity binding of hormone.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP35378.
PRIDEiP35378.

PTM databases

PhosphoSitePlusiP35378.

Expressioni

Gene expression databases

BgeeiENSMUSG00000032937.
CleanExiMM_FSHR.
ExpressionAtlasiP35378. baseline and differential.
GenevisibleiP35378. MM.

Interactioni

Subunit structurei

Interacts with ARRB2.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040477.

Structurei

3D structure databases

ProteinModelPortaliP35378.
SMRiP35378.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 46LRRNTAdd BLAST29
Repeati49 – 72LRR 1Add BLAST24
Repeati73 – 97LRR 2Add BLAST25
Repeati98 – 118LRR 3Add BLAST21
Repeati119 – 143LRR 4Add BLAST25
Repeati144 – 169LRR 5Add BLAST26
Repeati170 – 192LRR 6Add BLAST23
Repeati193 – 216LRR 7Add BLAST24
Repeati217 – 240LRR 8Add BLAST24
Repeati241 – 259LRR 9Add BLAST19

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.PROSITE-ProRule annotation
Contains 9 LRR (leucine-rich) repeats.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2087. Eukaryota.
ENOG410XR1T. LUCA.
GeneTreeiENSGT00760000119088.
HOGENOMiHOG000045902.
HOVERGENiHBG003521.
InParanoidiP35378.
KOiK04247.
OMAiFILLSKC.
OrthoDBiEOG091G02BV.
PhylomeDBiP35378.
TreeFamiTF316814.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR002272. FSH_rcpt.
IPR024635. GnHR_TM.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002131. Gphrmn_rcpt_fam.
IPR032675. L_dom-like.
IPR026906. LRR_5.
IPR000372. LRRNT.
[Graphical view]
PANTHERiPTHR24372. PTHR24372. 1 hit.
PTHR24372:SF5. PTHR24372:SF5. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
PF12369. GnHR_trans. 1 hit.
PF13306. LRR_5. 2 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
PRINTSiPR01143. FSHRECEPTOR.
PR00373. GLYCHORMONER.
PR00237. GPCRRHODOPSN.
SMARTiSM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35378-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLLVSLLA FLGSGSGCHH WLCHCSNRVF LCQDSKVTEI PPDLPRNAIE
60 70 80 90 100
LRFVLTKLRV IPKGSFSGFG DLEKIEISQN DVLEVIEADV FSNLPNLHEI
110 120 130 140 150
RIEKANNLLY INPEAFQNLP SLRYLLISNT GIKHLPAFHK IQSLQKVLLD
160 170 180 190 200
IQDNINIHII ARNSFMGLSF ESVILWLNKN GIQEIHNCAF NGTQLDELNL
210 220 230 240 250
SDNNNLEELP DDVFQGASGP VVLDISRTKV YSLPNHGLEN LKKLRARSTY
260 270 280 290 300
RLKKLPSLDK FVMLIEASLT YPSHCCAFAN WRRQTSELHP ICNKSISRQD
310 320 330 340 350
IDDMTQPGDQ RVSLVDDEPS YGKGSDMLYS EFDYDLCNEF VDVTCSPKPD
360 370 380 390 400
AFNPCEDIMG YNILRVLIWF ISILAITGNT TVLVVLTTSQ YKLTVPRFLM
410 420 430 440 450
CNLAFADLCI GIYLLLIASV DIHTKSQYHN YAIDWQTGAG CDAAGFFTVF
460 470 480 490 500
ASELSVYTLA AITLERWHTI THAMQLECKV QLCHAASIMV LGWAFAFAAA
510 520 530 540 550
LFPIFGISSY MKVSICLPMD IDSPLSQLYV MALLVLNALA FVVICGCYTH
560 570 580 590 600
IYLTVRNPNI VSSSRDTKIA KRMATLIFTD FLCMAPILFF AISASLKVPL
610 620 630 640 650
ITVSKAKILL VLFYPINSCA NPFLYAIFTK NFRRDFFVLM SKFGCYEVQA
660 670 680 690
QIYKTETSSI THNFHSRKNP CSSAPRVTNS YVLVPLNHSV QN
Length:692
Mass (Da):77,769
Last modified:September 26, 2001 - v2
Checksum:i4B57229180563A44
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti436Q → K in BAB30351 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095642 mRNA. Translation: AAC67559.1.
AK016635 mRNA. Translation: BAB30351.1.
S49632 Genomic DNA. Translation: AAB24401.1.
M87570 Genomic DNA. Translation: AAA37641.1.
CCDSiCCDS29026.1.
PIRiI57670.
RefSeqiNP_038551.3. NM_013523.3.
UniGeneiMm.57155.

Genome annotation databases

EnsembliENSMUST00000035701; ENSMUSP00000040477; ENSMUSG00000032937.
GeneIDi14309.
KEGGimmu:14309.
UCSCiuc008dvx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095642 mRNA. Translation: AAC67559.1.
AK016635 mRNA. Translation: BAB30351.1.
S49632 Genomic DNA. Translation: AAB24401.1.
M87570 Genomic DNA. Translation: AAA37641.1.
CCDSiCCDS29026.1.
PIRiI57670.
RefSeqiNP_038551.3. NM_013523.3.
UniGeneiMm.57155.

3D structure databases

ProteinModelPortaliP35378.
SMRiP35378.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040477.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP35378.

Proteomic databases

PaxDbiP35378.
PRIDEiP35378.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035701; ENSMUSP00000040477; ENSMUSG00000032937.
GeneIDi14309.
KEGGimmu:14309.
UCSCiuc008dvx.1. mouse.

Organism-specific databases

CTDi2492.
MGIiMGI:95583. Fshr.

Phylogenomic databases

eggNOGiKOG2087. Eukaryota.
ENOG410XR1T. LUCA.
GeneTreeiENSGT00760000119088.
HOGENOMiHOG000045902.
HOVERGENiHBG003521.
InParanoidiP35378.
KOiK04247.
OMAiFILLSKC.
OrthoDBiEOG091G02BV.
PhylomeDBiP35378.
TreeFamiTF316814.

Enzyme and pathway databases

ReactomeiR-MMU-375281. Hormone ligand-binding receptors.
R-MMU-418555. G alpha (s) signalling events.

Miscellaneous databases

PROiP35378.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032937.
CleanExiMM_FSHR.
ExpressionAtlasiP35378. baseline and differential.
GenevisibleiP35378. MM.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR002272. FSH_rcpt.
IPR024635. GnHR_TM.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002131. Gphrmn_rcpt_fam.
IPR032675. L_dom-like.
IPR026906. LRR_5.
IPR000372. LRRNT.
[Graphical view]
PANTHERiPTHR24372. PTHR24372. 1 hit.
PTHR24372:SF5. PTHR24372:SF5. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
PF12369. GnHR_trans. 1 hit.
PF13306. LRR_5. 2 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
PRINTSiPR01143. FSHRECEPTOR.
PR00373. GLYCHORMONER.
PR00237. GPCRRHODOPSN.
SMARTiSM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFSHR_MOUSE
AccessioniPrimary (citable) accession number: P35378
Secondary accession number(s): Q9D4C2, Q9QWV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: September 26, 2001
Last modified: November 2, 2016
This is version 156 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.