Nociceptin receptor - Mus musculus (Mouse)

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P35377 (OPRX_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 121. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Nociceptin receptor

Alternative name(s):
K3 opiate receptor
Kappa-type 3 opioid receptor
Short name=KOR-3
ORGC
Orphanin FQ receptor

Gene names

Name:	Oprl1
Synonyms:	Oor, Oprl

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	367 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for the neuropeptide nociceptin/orphanin FQ. Has a potential role in modulating a number of brain functions, including instinctive behaviors and emotions. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	In the brain, isoform KOR3 and isoform KOR3C are most abundant in hypothalamus and periaqueductal gray. Isoform KOR3A is highly expressed in cortex, striatum and brainstem. Isoform KOR3D is highly expressed in cerebellum, hypothalamus and brainstem. Ref.6
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	elevation of cytosolic calcium ion concentration Inferred from electronic annotation. Source: Compara opioid receptor signaling pathway Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	nociceptin receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform KOR3 (identifier: P35377-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform KOR3A (identifier: P35377-2) The sequence of this isoform differs from the canonical sequence as follows: 75-99: RHTKMKTATNIYIFNLALADTLVLL → SWEGIEGNWRQQAHQDEDCYQHLHI 100-367: Missing.

Isoform KOR3B (identifier: P35377-3) The sequence of this isoform differs from the canonical sequence as follows: 76-111: HTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLG → QCPENPLRGVLRETEERRQHLSLLIPSTNSHSGTPR 112-367: Missing.

Isoform KOR3C (identifier: P35377-4) The sequence of this isoform differs from the canonical sequence as follows: 76-95: HTKMKTATNIYIFNLALADT → QHCALGRSLMNFTGSALKTL 96-367: Missing.

Isoform KOR3D (identifier: P35377-5) The sequence of this isoform differs from the canonical sequence as follows: 71-75: Missing.

Isoform KOR3E (identifier: P35377-6) The sequence of this isoform differs from the canonical sequence as follows: 194-213: EIECLVEIPAPQDYWGPVFA → GQWAVLLPDQSVPHGSCRPL 214-367: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 367

367

Nociceptin receptor

PRO_0000069981

Regions

Topological domain

1 – 47

Extracellular Potential

Transmembrane

48 – 74

Helical; Name=1; Potential

Topological domain

75 – 84

Cytoplasmic Potential

Transmembrane

85 – 106

Helical; Name=2; Potential

Topological domain

107 – 121

Extracellular Potential

Transmembrane

122 – 143

Helical; Name=3; Potential

Topological domain

144 – 162

Cytoplasmic Potential

Transmembrane

163 – 185

Helical; Name=4; Potential

Topological domain

186 – 208

Extracellular Potential

Transmembrane

209 – 233

Helical; Name=5; Potential

Topological domain

234 – 261

Cytoplasmic Potential

Transmembrane

262 – 285

Helical; Name=6; Potential

Topological domain

286 – 297

Extracellular Potential

Transmembrane

298 – 319

Helical; Name=7; Potential

Topological domain

320 – 367

Cytoplasmic Potential

Amino acid modifications

Lipidation

331

S-palmitoyl cysteine Potential

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

N-linked (GlcNAc...) Potential

Disulfide bond

120 ↔ 197

By similarity

Natural variations

Alternative sequence

71 – 75

Missing in isoform KOR3D.

VSP_001898

Alternative sequence

75 – 99

RHTKM…TLVLL → SWEGIEGNWRQQAHQDEDCY QHLHI in isoform KOR3A.

VSP_001899

Alternative sequence

76 – 111

HTKMK…DILLG → QCPENPLRGVLRETEERRQH LSLLIPSTNSHSGTPR in isoform KOR3B.

VSP_001903

Alternative sequence

76 – 95

HTKMK…ALADT → QHCALGRSLMNFTGSALKTL in isoform KOR3C.

VSP_001901

Alternative sequence

96 – 367

272

Missing in isoform KOR3C.

VSP_001902

Alternative sequence

100 – 367

268

Missing in isoform KOR3A.

VSP_001900

Alternative sequence

112 – 367

256

Missing in isoform KOR3B.

VSP_001904

Alternative sequence

194 – 213

EIECL…GPVFA → GQWAVLLPDQSVPHGSCRPL in isoform KOR3E.

VSP_001905

Alternative sequence

214 – 367

154

Missing in isoform KOR3E.

VSP_001906

Experimental info

Sequence conflict

348 – 349

SI → TV in AAA81333. Ref.2

Sequences

Sequence		Length	Mass (Da)
Isoform KOR3 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: E498CA9FE5276026 Show »	FASTA	367	40,491
10 20 30 40 50 60 MESLFPAPFW EVLYGSHFQG NLSLLNETVP HHLLLNASHS AFLPLGLKVT IVGLYLAVCI 70 80 90 100 110 120 GGLLGNCLVM YVILRHTKMK TATNIYIFNL ALADTLVLLT LPFQGTDILL GFWPFGNALC 130 140 150 160 170 180 KTVIAIDYYN MFTSTFTLTA MSVDRYVAIC HPIRALDVRT SSKAQAVNVA IWALASVVGV 190 200 210 220 230 240 PVAIMGSAQV EDEEIECLVE IPAPQDYWGP VFAICIFLFS FIIPVLIISV CYSLMIRRLR 250 260 270 280 290 300 GVRLLSGSRE KDRNLRRITR LVLVVVAVFV GCWTPVQVFV LVQGLGVQPG SETAVAILRF 310 320 330 340 350 360 CTALGYVNSC LNPILYAFLD ENFKACFRKF CCASALHREM QVSDRVRSIA KDVGLGCKTS ETVPRPA « Hide
Isoform KOR3A [UniParc]. Checksum: 9165BB34BB5CFC80 Show »	FASTA	99	11,129
10 20 30 40 50 60 MESLFPAPFW EVLYGSHFQG NLSLLNETVP HHLLLNASHS AFLPLGLKVT IVGLYLAVCI 70 80 90 GGLLGNCLVM YVILSWEGIE GNWRQQAHQD EDCYQHLHI « Hide
Isoform KOR3B [UniParc]. Checksum: 3901CF41856A774F Show »	FASTA	111	12,314
10 20 30 40 50 60 MESLFPAPFW EVLYGSHFQG NLSLLNETVP HHLLLNASHS AFLPLGLKVT IVGLYLAVCI 70 80 90 100 110 GGLLGNCLVM YVILRQCPEN PLRGVLRETE ERRQHLSLLI PSTNSHSGTP R « Hide
Isoform KOR3C [UniParc]. Checksum: 0E495CD1381489CC Show »	FASTA	95	10,353
10 20 30 40 50 60 MESLFPAPFW EVLYGSHFQG NLSLLNETVP HHLLLNASHS AFLPLGLKVT IVGLYLAVCI 70 80 90 GGLLGNCLVM YVILRQHCAL GRSLMNFTGS ALKTL « Hide
Isoform KOR3D [UniParc]. Checksum: 8B9A7C66E35E3A3D Show »	FASTA	362	39,846
10 20 30 40 50 60 MESLFPAPFW EVLYGSHFQG NLSLLNETVP HHLLLNASHS AFLPLGLKVT IVGLYLAVCI 70 80 90 100 110 120 GGLLGNCLVM HTKMKTATNI YIFNLALADT LVLLTLPFQG TDILLGFWPF GNALCKTVIA 130 140 150 160 170 180 IDYYNMFTST FTLTAMSVDR YVAICHPIRA LDVRTSSKAQ AVNVAIWALA SVVGVPVAIM 190 200 210 220 230 240 GSAQVEDEEI ECLVEIPAPQ DYWGPVFAIC IFLFSFIIPV LIISVCYSLM IRRLRGVRLL 250 260 270 280 290 300 SGSREKDRNL RRITRLVLVV VAVFVGCWTP VQVFVLVQGL GVQPGSETAV AILRFCTALG 310 320 330 340 350 360 YVNSCLNPIL YAFLDENFKA CFRKFCCASA LHREMQVSDR VRSIAKDVGL GCKTSETVPR PA « Hide
Isoform KOR3E [UniParc]. Checksum: 0444B4CFD7DB4751 Show »	FASTA	213	23,205
10 20 30 40 50 60 MESLFPAPFW EVLYGSHFQG NLSLLNETVP HHLLLNASHS AFLPLGLKVT IVGLYLAVCI 70 80 90 100 110 120 GGLLGNCLVM YVILRHTKMK TATNIYIFNL ALADTLVLLT LPFQGTDILL GFWPFGNALC 130 140 150 160 170 180 KTVIAIDYYN MFTSTFTLTA MSVDRYVAIC HPIRALDVRT SSKAQAVNVA IWALASVVGV 190 200 210 PVAIMGSAQV EDEGQWAVLL PDQSVPHGSC RPL « Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Yasuda K., Jones E., Reisine T., Bell G.I. Submitted (JAN-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE (ISOFORM KOR3). Strain: C57BL/6N. Tissue: Brain.
[2]	"Structure and chromosomal mapping of genes for the mouse kappa-opioid receptor and an opioid receptor homologue (MOR-C)." Nishi M., Takeshima H., Mori M., Nakagawara K., Takeuchi T. Biochem. Biophys. Res. Commun. 205:1353-1357(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM KOR3).
[3]	"Functional selectivity of orphanin FQ for its receptor coexpressed with potassium channel subunits in Xenopus laevis oocytes." Matthes H.W.D., Seward E.P., Kieffer B., North R.A. Mol. Pharmacol. 50:447-450(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM KOR3). Tissue: Brain.
[4]	Pan Y.-X., Xu J., Pasternak G.W. Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE (ISOFORM KOR3).
[5]	"Cloning and functional characterization through antisense mapping of a kappa 3-related opioid receptor." Pan Y.-X., Cheng J., Xu J., Rossi G., Jacobson E., Ryan-Moro J., Brooks A.I., Dean G.E., Standifer K.M., Pasternak G.W. Mol. Pharmacol. 47:1180-1188(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM KOR3).
[6]	"Identification and differential regional expression of KOR-3/ORL-1 gene splice variants in mouse brain." Pan Y.-X., Xu J., Wan B.-L., Zuckerman A., Pasternak G.W. FEBS Lett. 435:65-68(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS KOR3A; KOR3B; KOR3C; KOR3D AND KOR3E), TISSUE SPECIFICITY. Strain: C57BL/6. Tissue: Brain.
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM KOR3). Strain: C57BL/6. Tissue: Brain.
[8]	"Functional role and sequence analysis of a lymphocyte orphan opioid receptor." Halford W.P., Gebhardt B.M., Carr D.J.J. J. Neuroimmunol. 59:91-101(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-357 (ISOFORM KOR3). Strain: BALB/c. Tissue: Spleen.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U04952 mRNA. Translation: AAA03730.1. D31667 Genomic DNA. Translation: BAA06509.1. X91813 mRNA. Translation: CAA62922.1. U32932, U32928, U32930 Genomic DNA. Translation: AAC52669.1. U09421 mRNA. Translation: AAA81333.1. AF043276 mRNA. Translation: AAC64507.1. AF043277 mRNA. Translation: AAC64508.1. AF043278 mRNA. Translation: AAC64509.1. AF062381 mRNA. Translation: AAF21258.1. AF075605 mRNA. Translation: AAF21781.1. AF126469 mRNA. Translation: AAL54889.1. BC050885 mRNA. Translation: AAH50885.1. U14165 mRNA. Translation: AAA87899.1.
IPI	IPI00117529. IPI00225779. IPI00225780. IPI00225781. IPI00225783. IPI00378023.
PIR	I49022. JC2421.
RefSeq	NP_001239494.1. NM_001252565.1. NP_035142.1. NM_011012.5.
UniGene	Mm.285075.
3D structure databases
ProteinModelPortal	P35377.
SMR	P35377. Positions 44-328.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P35377.
Proteomic databases
PRIDE	P35377.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000071585; ENSMUSP00000071513; ENSMUSG00000027584. ENSMUST00000108766; ENSMUSP00000104397; ENSMUSG00000027584. ENSMUST00000108767; ENSMUSP00000104398; ENSMUSG00000027584. ENSMUST00000108768; ENSMUSP00000104399; ENSMUSG00000027584.
GeneID	18389.
KEGG	mmu:18389.
UCSC	uc008onj.2. mouse. uc008ono.1. mouse.
Organism-specific databases
CTD	4987.
MGI	MGI:97440. Oprl1.
Phylogenomic databases
eggNOG	NOG299442.
GeneTree	ENSGT00630000089574.
HOVERGEN	HBG106919.
InParanoid	P35377.
KO	K04216.
OMA	VFAICIF.
OrthoDB	EOG4Z62NR.
Gene expression databases
ArrayExpress	P35377.
Bgee	P35377.
CleanEx	MM_OPRL1.
Genevestigator	P35377.
GermOnline	ENSMUSG00000027584. Mus musculus.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR001418. Opioid_rcpt. IPR001420. X_opioid_rcpt. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00384. OPIOIDR. PR00547. XOPIOIDR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P35377.
ChEMBL	CHEMBL3621.
ChiTaRS	OPRL1. mouse.
NextBio	293984.
SOURCE	Search...

Entry information

Entry name

OPRX_MOUSE

Accession

Primary (citable) accession number: P35377
Secondary accession number(s): Q60645

Q9Z2N0

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	May 29, 2013
This is version 121 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents