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P35375

- PE2R1_MOUSE

UniProt

P35375 - PE2R1_MOUSE

Protein

Prostaglandin E2 receptor EP1 subtype

Gene

Ptger1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues.

    GO - Molecular functioni

    1. prostaglandin E receptor activity Source: Ensembl

    GO - Biological processi

    1. response to lipopolysaccharide Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_207651. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Prostaglandin E2 receptor EP1 subtype
    Short name:
    PGE receptor EP1 subtype
    Short name:
    PGE2 receptor EP1 subtype
    Alternative name(s):
    Prostanoid EP1 receptor
    Gene namesi
    Name:Ptger1
    Synonyms:Ptgerep1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:97793. Ptger1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 405405Prostaglandin E2 receptor EP1 subtypePRO_0000070051Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi7 – 71N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi24 – 241N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi34 – 341N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi112 ↔ 190PROSITE-ProRule annotation

    Post-translational modificationi

    Phosphorylated.Curated

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PRIDEiP35375.

    Expressioni

    Tissue specificityi

    Abundant in kidney and in a lesser amount in lung.

    Gene expression databases

    BgeeiP35375.
    CleanExiMM_PTGER1.
    GenevestigatoriP35375.

    Interactioni

    Protein-protein interaction databases

    BioGridi202454. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP35375.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3939ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini63 – 8018CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini100 – 11314ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini136 – 15722CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini180 – 20223ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini229 – 30173CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini324 – 33714ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini358 – 40548CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei40 – 6223Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei81 – 9919Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei114 – 13522Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei158 – 17922Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei203 – 22826Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei302 – 32322Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei338 – 35720Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG253446.
    GeneTreeiENSGT00690000102015.
    HOGENOMiHOG000015238.
    HOVERGENiHBG003621.
    InParanoidiP35375.
    KOiK04258.
    OMAiPAGGACH.
    OrthoDBiEOG7PP575.
    PhylomeDBiP35375.
    TreeFamiTF324982.

    Family and domain databases

    Gene3Di1.20.1070.10. 2 hits.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR008365. Prostanoid_rcpt.
    IPR001244. Prostglndn_DP_rcpt.
    IPR000708. Prostglndn_EP1_rcpt.
    [Graphical view]
    PANTHERiPTHR11866. PTHR11866. 1 hit.
    PTHR11866:SF3. PTHR11866:SF3. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00428. PROSTAGLNDNR.
    PR01788. PROSTANOIDR.
    PR00580. PRSTNOIDEP1R.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P35375-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSPCGLNLSL ADEAATCATP RLPNTSVVLP TGDNGTSPAL PIFSMTLGAV    50
    SNVLALALLA QVAGRMRRRR SAATFLLFVA SLLAIDLAGH VIPGALVLRL 100
    YTAGRAPAGG ACHFLGGCMV FFGLCPLLLG CGMAVERCVG VTQPLIHAAR 150
    VSVARARLAL AVLAAMALAV ALLPLVHVGR YELQYPGTWC FISLGPRGGW 200
    RQALLAGLFA GLGLAALLAA LVCNTLSGLA LLRARWRRRR SRRFRKTAGP 250
    DDRRRWGSRG PRLASASSAS SITSATATLR SSRGGGSARR VHAHDVEMVG 300
    QLVGIMVVSC ICWSPLLVLV VLAIGGWNSN SLQRPLFLAV RLASWNQILD 350
    PWVYILLRQA MLRQLLRLLP LRVSAKGGPT ELGLTKSAWE ASSLRSSRHS 400
    GFSHL 405
    Length:405
    Mass (Da):42,966
    Last modified:June 1, 1994 - v1
    Checksum:i2E64D421005CF8D6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D16338 mRNA. Translation: BAA03842.1.
    Z49987 Genomic DNA. Translation: CAA90278.1.
    Y07611 Genomic DNA. Translation: CAA68884.1.
    CCDSiCCDS22458.1.
    PIRiS66525.
    RefSeqiNP_038669.1. NM_013641.2.
    UniGeneiMm.213000.
    Mm.474430.

    Genome annotation databases

    EnsembliENSMUST00000019608; ENSMUSP00000019608; ENSMUSG00000019464.
    GeneIDi19216.
    KEGGimmu:19216.
    UCSCiuc009mkt.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D16338 mRNA. Translation: BAA03842.1 .
    Z49987 Genomic DNA. Translation: CAA90278.1 .
    Y07611 Genomic DNA. Translation: CAA68884.1 .
    CCDSi CCDS22458.1.
    PIRi S66525.
    RefSeqi NP_038669.1. NM_013641.2.
    UniGenei Mm.213000.
    Mm.474430.

    3D structure databases

    ProteinModelPortali P35375.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 202454. 1 interaction.

    Chemistry

    BindingDBi P35375.
    ChEMBLi CHEMBL2181.
    GuidetoPHARMACOLOGYi 340.

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PRIDEi P35375.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000019608 ; ENSMUSP00000019608 ; ENSMUSG00000019464 .
    GeneIDi 19216.
    KEGGi mmu:19216.
    UCSCi uc009mkt.1. mouse.

    Organism-specific databases

    CTDi 5731.
    MGIi MGI:97793. Ptger1.

    Phylogenomic databases

    eggNOGi NOG253446.
    GeneTreei ENSGT00690000102015.
    HOGENOMi HOG000015238.
    HOVERGENi HBG003621.
    InParanoidi P35375.
    KOi K04258.
    OMAi PAGGACH.
    OrthoDBi EOG7PP575.
    PhylomeDBi P35375.
    TreeFami TF324982.

    Enzyme and pathway databases

    Reactomei REACT_207651. G alpha (q) signalling events.

    Miscellaneous databases

    ChiTaRSi PTGER1. mouse.
    NextBioi 295976.
    PROi P35375.
    SOURCEi Search...

    Gene expression databases

    Bgeei P35375.
    CleanExi MM_PTGER1.
    Genevestigatori P35375.

    Family and domain databases

    Gene3Di 1.20.1070.10. 2 hits.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR008365. Prostanoid_rcpt.
    IPR001244. Prostglndn_DP_rcpt.
    IPR000708. Prostglndn_EP1_rcpt.
    [Graphical view ]
    PANTHERi PTHR11866. PTHR11866. 1 hit.
    PTHR11866:SF3. PTHR11866:SF3. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00428. PROSTAGLNDNR.
    PR01788. PROSTANOIDR.
    PR00580. PRSTNOIDEP1R.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of cDNA for a mouse EP1 subtype of prostaglandin E receptor."
      Watabe A., Sugimoto Y., Honda A., Irie A., Namba T., Negishi M., Ito S., Narumiya S., Ichikawa A.
      J. Biol. Chem. 268:20175-20178(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: ddY.
      Tissue: Kidney.
    2. "Molecular characterization of the mouse prostanoid EP1 receptor gene."
      Batshake B., Nilsson C., Sundelin J.
      Eur. J. Biochem. 231:809-814(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129.
    3. "The mouse genes for the EP1 prostanoid receptor and the PKN protein kinase overlap."
      Batshake B., Sundelin S.
      Biochem. Biophys. Res. Commun. 227:70-76(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129.

    Entry informationi

    Entry nameiPE2R1_MOUSE
    AccessioniPrimary (citable) accession number: P35375
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3