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P35375

- PE2R1_MOUSE

UniProt

P35375 - PE2R1_MOUSE

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Protein
Prostaglandin E2 receptor EP1 subtype
Gene
Ptger1, Ptgerep1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues.

GO - Molecular functioni

  1. prostaglandin E receptor activity Source: Ensembl

GO - Biological processi

  1. response to lipopolysaccharide Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin E2 receptor EP1 subtype
Short name:
PGE receptor EP1 subtype
Short name:
PGE2 receptor EP1 subtype
Alternative name(s):
Prostanoid EP1 receptor
Gene namesi
Name:Ptger1
Synonyms:Ptgerep1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:97793. Ptger1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3939Extracellular Reviewed prediction
Add
BLAST
Transmembranei40 – 6223Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini63 – 8018Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei81 – 9919Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini100 – 11314Extracellular Reviewed prediction
Add
BLAST
Transmembranei114 – 13522Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini136 – 15722Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei158 – 17922Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini180 – 20223Extracellular Reviewed prediction
Add
BLAST
Transmembranei203 – 22826Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini229 – 30173Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei302 – 32322Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini324 – 33714Extracellular Reviewed prediction
Add
BLAST
Transmembranei338 – 35720Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini358 – 40548Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 405405Prostaglandin E2 receptor EP1 subtype
PRO_0000070051Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi7 – 71N-linked (GlcNAc...) Reviewed prediction
Glycosylationi24 – 241N-linked (GlcNAc...) Reviewed prediction
Glycosylationi34 – 341N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi112 ↔ 190 By similarity

Post-translational modificationi

Phosphorylated Reviewed prediction.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiP35375.

Expressioni

Tissue specificityi

Abundant in kidney and in a lesser amount in lung.

Gene expression databases

BgeeiP35375.
CleanExiMM_PTGER1.
GenevestigatoriP35375.

Interactioni

Protein-protein interaction databases

BioGridi202454. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP35375.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG253446.
GeneTreeiENSGT00690000102015.
HOGENOMiHOG000015238.
HOVERGENiHBG003621.
InParanoidiP35375.
KOiK04258.
OMAiPAGGACH.
OrthoDBiEOG7PP575.
PhylomeDBiP35375.
TreeFamiTF324982.

Family and domain databases

Gene3Di1.20.1070.10. 2 hits.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR001244. Prostglndn_DP_rcpt.
IPR000708. Prostglndn_EP1_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PTHR11866:SF3. PTHR11866:SF3. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00428. PROSTAGLNDNR.
PR01788. PROSTANOIDR.
PR00580. PRSTNOIDEP1R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35375-1 [UniParc]FASTAAdd to Basket

« Hide

MSPCGLNLSL ADEAATCATP RLPNTSVVLP TGDNGTSPAL PIFSMTLGAV    50
SNVLALALLA QVAGRMRRRR SAATFLLFVA SLLAIDLAGH VIPGALVLRL 100
YTAGRAPAGG ACHFLGGCMV FFGLCPLLLG CGMAVERCVG VTQPLIHAAR 150
VSVARARLAL AVLAAMALAV ALLPLVHVGR YELQYPGTWC FISLGPRGGW 200
RQALLAGLFA GLGLAALLAA LVCNTLSGLA LLRARWRRRR SRRFRKTAGP 250
DDRRRWGSRG PRLASASSAS SITSATATLR SSRGGGSARR VHAHDVEMVG 300
QLVGIMVVSC ICWSPLLVLV VLAIGGWNSN SLQRPLFLAV RLASWNQILD 350
PWVYILLRQA MLRQLLRLLP LRVSAKGGPT ELGLTKSAWE ASSLRSSRHS 400
GFSHL 405
Length:405
Mass (Da):42,966
Last modified:June 1, 1994 - v1
Checksum:i2E64D421005CF8D6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D16338 mRNA. Translation: BAA03842.1.
Z49987 Genomic DNA. Translation: CAA90278.1.
Y07611 Genomic DNA. Translation: CAA68884.1.
CCDSiCCDS22458.1.
PIRiS66525.
RefSeqiNP_038669.1. NM_013641.2.
UniGeneiMm.213000.
Mm.474430.

Genome annotation databases

EnsembliENSMUST00000019608; ENSMUSP00000019608; ENSMUSG00000019464.
GeneIDi19216.
KEGGimmu:19216.
UCSCiuc009mkt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D16338 mRNA. Translation: BAA03842.1 .
Z49987 Genomic DNA. Translation: CAA90278.1 .
Y07611 Genomic DNA. Translation: CAA68884.1 .
CCDSi CCDS22458.1.
PIRi S66525.
RefSeqi NP_038669.1. NM_013641.2.
UniGenei Mm.213000.
Mm.474430.

3D structure databases

ProteinModelPortali P35375.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 202454. 1 interaction.

Chemistry

BindingDBi P35375.
ChEMBLi CHEMBL2181.
GuidetoPHARMACOLOGYi 340.

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PRIDEi P35375.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000019608 ; ENSMUSP00000019608 ; ENSMUSG00000019464 .
GeneIDi 19216.
KEGGi mmu:19216.
UCSCi uc009mkt.1. mouse.

Organism-specific databases

CTDi 5731.
MGIi MGI:97793. Ptger1.

Phylogenomic databases

eggNOGi NOG253446.
GeneTreei ENSGT00690000102015.
HOGENOMi HOG000015238.
HOVERGENi HBG003621.
InParanoidi P35375.
KOi K04258.
OMAi PAGGACH.
OrthoDBi EOG7PP575.
PhylomeDBi P35375.
TreeFami TF324982.

Enzyme and pathway databases

Reactomei REACT_207651. G alpha (q) signalling events.

Miscellaneous databases

ChiTaRSi PTGER1. mouse.
NextBioi 295976.
PROi P35375.
SOURCEi Search...

Gene expression databases

Bgeei P35375.
CleanExi MM_PTGER1.
Genevestigatori P35375.

Family and domain databases

Gene3Di 1.20.1070.10. 2 hits.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR001244. Prostglndn_DP_rcpt.
IPR000708. Prostglndn_EP1_rcpt.
[Graphical view ]
PANTHERi PTHR11866. PTHR11866. 1 hit.
PTHR11866:SF3. PTHR11866:SF3. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00428. PROSTAGLNDNR.
PR01788. PROSTANOIDR.
PR00580. PRSTNOIDEP1R.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and expression of cDNA for a mouse EP1 subtype of prostaglandin E receptor."
    Watabe A., Sugimoto Y., Honda A., Irie A., Namba T., Negishi M., Ito S., Narumiya S., Ichikawa A.
    J. Biol. Chem. 268:20175-20178(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ddY.
    Tissue: Kidney.
  2. "Molecular characterization of the mouse prostanoid EP1 receptor gene."
    Batshake B., Nilsson C., Sundelin J.
    Eur. J. Biochem. 231:809-814(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129.
  3. "The mouse genes for the EP1 prostanoid receptor and the PKN protein kinase overlap."
    Batshake B., Sundelin S.
    Biochem. Biophys. Res. Commun. 227:70-76(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129.

Entry informationi

Entry nameiPE2R1_MOUSE
AccessioniPrimary (citable) accession number: P35375
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: September 3, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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