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Protein

Prostaglandin E2 receptor EP1 subtype

Gene

Ptger1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-391908. Prostanoid ligand receptors.
R-MMU-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin E2 receptor EP1 subtype
Short name:
PGE receptor EP1 subtype
Short name:
PGE2 receptor EP1 subtype
Alternative name(s):
Prostanoid EP1 receptor
Gene namesi
Name:Ptger1
Synonyms:Ptgerep1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:97793. Ptger1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 39ExtracellularSequence analysisAdd BLAST39
Transmembranei40 – 62Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini63 – 80CytoplasmicSequence analysisAdd BLAST18
Transmembranei81 – 99Helical; Name=2Sequence analysisAdd BLAST19
Topological domaini100 – 113ExtracellularSequence analysisAdd BLAST14
Transmembranei114 – 135Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini136 – 157CytoplasmicSequence analysisAdd BLAST22
Transmembranei158 – 179Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini180 – 202ExtracellularSequence analysisAdd BLAST23
Transmembranei203 – 228Helical; Name=5Sequence analysisAdd BLAST26
Topological domaini229 – 301CytoplasmicSequence analysisAdd BLAST73
Transmembranei302 – 323Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini324 – 337ExtracellularSequence analysisAdd BLAST14
Transmembranei338 – 357Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini358 – 405CytoplasmicSequence analysisAdd BLAST48

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2181.
GuidetoPHARMACOLOGYi340.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700511 – 405Prostaglandin E2 receptor EP1 subtypeAdd BLAST405

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi7N-linked (GlcNAc...)Sequence analysis1
Glycosylationi24N-linked (GlcNAc...)Sequence analysis1
Glycosylationi34N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi112 ↔ 190PROSITE-ProRule annotation

Post-translational modificationi

Phosphorylated.Curated

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP35375.
PRIDEiP35375.

PTM databases

iPTMnetiP35375.
PhosphoSitePlusiP35375.

Expressioni

Tissue specificityi

Abundant in kidney and in a lesser amount in lung.

Gene expression databases

BgeeiENSMUSG00000019464.
CleanExiMM_PTGER1.
ExpressionAtlasiP35375. baseline and differential.
GenevisibleiP35375. MM.

Interactioni

Protein-protein interaction databases

BioGridi202454. 1 interactor.
STRINGi10090.ENSMUSP00000019608.

Chemistry databases

BindingDBiP35375.

Structurei

3D structure databases

ProteinModelPortaliP35375.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119188.
HOGENOMiHOG000015238.
HOVERGENiHBG003621.
InParanoidiP35375.
KOiK04258.
OMAiAALVCNM.
OrthoDBiEOG091G0NMF.
PhylomeDBiP35375.
TreeFamiTF324982.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR001244. Prostglndn_DP_rcpt.
IPR000708. Prostglndn_EP1_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 2 hits.
PTHR11866:SF3. PTHR11866:SF3. 2 hits.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00428. PROSTAGLNDNR.
PR01788. PROSTANOIDR.
PR00580. PRSTNOIDEP1R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35375-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPCGLNLSL ADEAATCATP RLPNTSVVLP TGDNGTSPAL PIFSMTLGAV
60 70 80 90 100
SNVLALALLA QVAGRMRRRR SAATFLLFVA SLLAIDLAGH VIPGALVLRL
110 120 130 140 150
YTAGRAPAGG ACHFLGGCMV FFGLCPLLLG CGMAVERCVG VTQPLIHAAR
160 170 180 190 200
VSVARARLAL AVLAAMALAV ALLPLVHVGR YELQYPGTWC FISLGPRGGW
210 220 230 240 250
RQALLAGLFA GLGLAALLAA LVCNTLSGLA LLRARWRRRR SRRFRKTAGP
260 270 280 290 300
DDRRRWGSRG PRLASASSAS SITSATATLR SSRGGGSARR VHAHDVEMVG
310 320 330 340 350
QLVGIMVVSC ICWSPLLVLV VLAIGGWNSN SLQRPLFLAV RLASWNQILD
360 370 380 390 400
PWVYILLRQA MLRQLLRLLP LRVSAKGGPT ELGLTKSAWE ASSLRSSRHS

GFSHL
Length:405
Mass (Da):42,966
Last modified:June 1, 1994 - v1
Checksum:i2E64D421005CF8D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16338 mRNA. Translation: BAA03842.1.
Z49987 Genomic DNA. Translation: CAA90278.1.
Y07611 Genomic DNA. Translation: CAA68884.1.
CCDSiCCDS22458.1.
PIRiS66525.
RefSeqiNP_038669.1. NM_013641.2.
UniGeneiMm.213000.
Mm.448167.
Mm.474430.

Genome annotation databases

EnsembliENSMUST00000019608; ENSMUSP00000019608; ENSMUSG00000019464.
GeneIDi19216.
KEGGimmu:19216.
UCSCiuc009mkt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16338 mRNA. Translation: BAA03842.1.
Z49987 Genomic DNA. Translation: CAA90278.1.
Y07611 Genomic DNA. Translation: CAA68884.1.
CCDSiCCDS22458.1.
PIRiS66525.
RefSeqiNP_038669.1. NM_013641.2.
UniGeneiMm.213000.
Mm.448167.
Mm.474430.

3D structure databases

ProteinModelPortaliP35375.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202454. 1 interactor.
STRINGi10090.ENSMUSP00000019608.

Chemistry databases

BindingDBiP35375.
ChEMBLiCHEMBL2181.
GuidetoPHARMACOLOGYi340.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP35375.
PhosphoSitePlusiP35375.

Proteomic databases

PaxDbiP35375.
PRIDEiP35375.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019608; ENSMUSP00000019608; ENSMUSG00000019464.
GeneIDi19216.
KEGGimmu:19216.
UCSCiuc009mkt.1. mouse.

Organism-specific databases

CTDi5731.
MGIiMGI:97793. Ptger1.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119188.
HOGENOMiHOG000015238.
HOVERGENiHBG003621.
InParanoidiP35375.
KOiK04258.
OMAiAALVCNM.
OrthoDBiEOG091G0NMF.
PhylomeDBiP35375.
TreeFamiTF324982.

Enzyme and pathway databases

ReactomeiR-MMU-391908. Prostanoid ligand receptors.
R-MMU-416476. G alpha (q) signalling events.

Miscellaneous databases

ChiTaRSiPtger1. mouse.
PROiP35375.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019464.
CleanExiMM_PTGER1.
ExpressionAtlasiP35375. baseline and differential.
GenevisibleiP35375. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR001244. Prostglndn_DP_rcpt.
IPR000708. Prostglndn_EP1_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 2 hits.
PTHR11866:SF3. PTHR11866:SF3. 2 hits.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00428. PROSTAGLNDNR.
PR01788. PROSTANOIDR.
PR00580. PRSTNOIDEP1R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPE2R1_MOUSE
AccessioniPrimary (citable) accession number: P35375
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 2, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.