Prostaglandin E2 receptor EP1 subtype

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P35375 (PE2R1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 106. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Prostaglandin E2 receptor EP1 subtype
Short name=PGE receptor EP1 subtype
Short name=PGE2 receptor EP1 subtype

Alternative name(s):
Prostanoid EP1 receptor

Gene names

Name:	Ptger1
Synonyms:	Ptgerep1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	405 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Abundant in kidney and in a lesser amount in lung.
Post-translational modification	Phosphorylated Potential.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	response to lipopolysaccharide Inferred from mutant phenotype PubMed 15834430. Source: MGI
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	prostaglandin E receptor activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 405

405

Prostaglandin E2 receptor EP1 subtype

PRO_0000070051

Regions

Topological domain

1 – 39

Extracellular Potential

Transmembrane

40 – 62

Helical; Name=1; Potential

Topological domain

63 – 80

Cytoplasmic Potential

Transmembrane

81 – 99

Helical; Name=2; Potential

Topological domain

100 – 113

Extracellular Potential

Transmembrane

114 – 135

Helical; Name=3; Potential

Topological domain

136 – 157

Cytoplasmic Potential

Transmembrane

158 – 179

Helical; Name=4; Potential

Topological domain

180 – 202

Extracellular Potential

Transmembrane

203 – 228

Helical; Name=5; Potential

Topological domain

229 – 301

Cytoplasmic Potential

Transmembrane

302 – 323

Helical; Name=6; Potential

Topological domain

324 – 337

Extracellular Potential

Transmembrane

338 – 357

Helical; Name=7; Potential

Topological domain

358 – 405

Cytoplasmic Potential

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

N-linked (GlcNAc...) Potential

Disulfide bond

112 ↔ 190

By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

P35375 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 2E64D421005CF8D6
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FASTA

405

42,966

        10         20         30         40         50         60 
MSPCGLNLSL ADEAATCATP RLPNTSVVLP TGDNGTSPAL PIFSMTLGAV SNVLALALLA 

        70         80         90        100        110        120 
QVAGRMRRRR SAATFLLFVA SLLAIDLAGH VIPGALVLRL YTAGRAPAGG ACHFLGGCMV 

       130        140        150        160        170        180 
FFGLCPLLLG CGMAVERCVG VTQPLIHAAR VSVARARLAL AVLAAMALAV ALLPLVHVGR 

       190        200        210        220        230        240 
YELQYPGTWC FISLGPRGGW RQALLAGLFA GLGLAALLAA LVCNTLSGLA LLRARWRRRR 

       250        260        270        280        290        300 
SRRFRKTAGP DDRRRWGSRG PRLASASSAS SITSATATLR SSRGGGSARR VHAHDVEMVG 

       310        320        330        340        350        360 
QLVGIMVVSC ICWSPLLVLV VLAIGGWNSN SLQRPLFLAV RLASWNQILD PWVYILLRQA 

       370        380        390        400 
MLRQLLRLLP LRVSAKGGPT ELGLTKSAWE ASSLRSSRHS GFSHL

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References

[1]	"Cloning and expression of cDNA for a mouse EP1 subtype of prostaglandin E receptor." Watabe A., Sugimoto Y., Honda A., Irie A., Namba T., Negishi M., Ito S., Narumiya S., Ichikawa A. J. Biol. Chem. 268:20175-20178(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: ddY. Tissue: Kidney.
[2]	"Molecular characterization of the mouse prostanoid EP1 receptor gene." Batshake B., Nilsson C., Sundelin J. Eur. J. Biochem. 231:809-814(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129.
[3]	"The mouse genes for the EP1 prostanoid receptor and the PKN protein kinase overlap." Batshake B., Sundelin S. Biochem. Biophys. Res. Commun. 227:70-76(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D16338 mRNA. Translation: BAA03842.1. Z49987 Genomic DNA. Translation: CAA90278.1. Y07611 Genomic DNA. Translation: CAA68884.1.
IPI	IPI00117523.
PIR	S66525.
RefSeq	NP_038669.1. NM_013641.2.
UniGene	Mm.213000. Mm.474430.
3D structure databases
ProteinModelPortal	P35375.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PRIDE	P35375.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000019608; ENSMUSP00000019608; ENSMUSG00000019464.
GeneID	19216.
KEGG	mmu:19216.
Organism-specific databases
CTD	5731.
MGI	MGI:97793. Ptger1.
Phylogenomic databases
eggNOG	NOG253446.
GeneTree	ENSGT00690000102015.
HOGENOM	HOG000015238.
HOVERGEN	HBG003621.
InParanoid	P35375.
KO	K04258.
OMA	CFIGLGP.
OrthoDB	EOG469QVW.
Gene expression databases
ArrayExpress	P35375.
Bgee	P35375.
CleanEx	MM_PTGER1.
Genevestigator	P35375.
GermOnline	ENSMUSG00000019464. Mus musculus.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR008365. Prostanoid_rcpt. IPR001244. Prostglndn_DP_rcpt. IPR000708. Prostglndn_EP1_rcpt. [Graphical view]
PANTHER	PTHR11866. PTHR11866. 1 hit. PTHR11866:SF3. PTHR11866:SF3. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00428. PROSTAGLNDNR. PR01788. PROSTANOIDR. PR00580. PRSTNOIDEP1R.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P35375.
ChEMBL	CHEMBL2181.
ChiTaRS	PTGER1. mouse.
NextBio	295976.
SOURCE	Search...

Entry information

Entry name

PE2R1_MOUSE

Accession

Primary (citable) accession number: P35375

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	April 3, 2013
This is version 106 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents