Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P35375 (PE2R1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Prostaglandin E2 receptor EP1 subtype

Short name=PGE receptor EP1 subtype
Short name=PGE2 receptor EP1 subtype
Alternative name(s):
Prostanoid EP1 receptor
Gene names
Name:Ptger1
Synonyms:Ptgerep1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length405 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Abundant in kidney and in a lesser amount in lung.

Post-translational modification

Phosphorylated Potential.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 405405Prostaglandin E2 receptor EP1 subtype
PRO_0000070051

Regions

Topological domain1 – 3939Extracellular Potential
Transmembrane40 – 6223Helical; Name=1; Potential
Topological domain63 – 8018Cytoplasmic Potential
Transmembrane81 – 9919Helical; Name=2; Potential
Topological domain100 – 11314Extracellular Potential
Transmembrane114 – 13522Helical; Name=3; Potential
Topological domain136 – 15722Cytoplasmic Potential
Transmembrane158 – 17922Helical; Name=4; Potential
Topological domain180 – 20223Extracellular Potential
Transmembrane203 – 22826Helical; Name=5; Potential
Topological domain229 – 30173Cytoplasmic Potential
Transmembrane302 – 32322Helical; Name=6; Potential
Topological domain324 – 33714Extracellular Potential
Transmembrane338 – 35720Helical; Name=7; Potential
Topological domain358 – 40548Cytoplasmic Potential

Amino acid modifications

Glycosylation71N-linked (GlcNAc...) Potential
Glycosylation241N-linked (GlcNAc...) Potential
Glycosylation341N-linked (GlcNAc...) Potential
Disulfide bond112 ↔ 190 By similarity

Sequences

Sequence LengthMass (Da)Tools
P35375 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 2E64D421005CF8D6

FASTA40542,966
        10         20         30         40         50         60 
MSPCGLNLSL ADEAATCATP RLPNTSVVLP TGDNGTSPAL PIFSMTLGAV SNVLALALLA 

        70         80         90        100        110        120 
QVAGRMRRRR SAATFLLFVA SLLAIDLAGH VIPGALVLRL YTAGRAPAGG ACHFLGGCMV 

       130        140        150        160        170        180 
FFGLCPLLLG CGMAVERCVG VTQPLIHAAR VSVARARLAL AVLAAMALAV ALLPLVHVGR 

       190        200        210        220        230        240 
YELQYPGTWC FISLGPRGGW RQALLAGLFA GLGLAALLAA LVCNTLSGLA LLRARWRRRR 

       250        260        270        280        290        300 
SRRFRKTAGP DDRRRWGSRG PRLASASSAS SITSATATLR SSRGGGSARR VHAHDVEMVG 

       310        320        330        340        350        360 
QLVGIMVVSC ICWSPLLVLV VLAIGGWNSN SLQRPLFLAV RLASWNQILD PWVYILLRQA 

       370        380        390        400 
MLRQLLRLLP LRVSAKGGPT ELGLTKSAWE ASSLRSSRHS GFSHL 

« Hide

References

[1]"Cloning and expression of cDNA for a mouse EP1 subtype of prostaglandin E receptor."
Watabe A., Sugimoto Y., Honda A., Irie A., Namba T., Negishi M., Ito S., Narumiya S., Ichikawa A.
J. Biol. Chem. 268:20175-20178(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: ddY.
Tissue: Kidney.
[2]"Molecular characterization of the mouse prostanoid EP1 receptor gene."
Batshake B., Nilsson C., Sundelin J.
Eur. J. Biochem. 231:809-814(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129.
[3]"The mouse genes for the EP1 prostanoid receptor and the PKN protein kinase overlap."
Batshake B., Sundelin S.
Biochem. Biophys. Res. Commun. 227:70-76(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D16338 mRNA. Translation: BAA03842.1.
Z49987 Genomic DNA. Translation: CAA90278.1.
Y07611 Genomic DNA. Translation: CAA68884.1.
PIRS66525.
RefSeqNP_038669.1. NM_013641.2.
UniGeneMm.213000.
Mm.474430.

3D structure databases

ProteinModelPortalP35375.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid202454. 1 interaction.

Chemistry

BindingDBP35375.
ChEMBLCHEMBL2181.
GuidetoPHARMACOLOGY340.

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PRIDEP35375.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000019608; ENSMUSP00000019608; ENSMUSG00000019464.
GeneID19216.
KEGGmmu:19216.
UCSCuc009mkt.1. mouse.

Organism-specific databases

CTD5731.
MGIMGI:97793. Ptger1.

Phylogenomic databases

eggNOGNOG253446.
GeneTreeENSGT00690000102015.
HOGENOMHOG000015238.
HOVERGENHBG003621.
InParanoidP35375.
KOK04258.
OMAPAGGACH.
OrthoDBEOG7PP575.
PhylomeDBP35375.
TreeFamTF324982.

Gene expression databases

BgeeP35375.
CleanExMM_PTGER1.
GenevestigatorP35375.

Family and domain databases

Gene3D1.20.1070.10. 2 hits.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR001244. Prostglndn_DP_rcpt.
IPR000708. Prostglndn_EP1_rcpt.
[Graphical view]
PANTHERPTHR11866. PTHR11866. 1 hit.
PTHR11866:SF3. PTHR11866:SF3. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00428. PROSTAGLNDNR.
PR01788. PROSTANOIDR.
PR00580. PRSTNOIDEP1R.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPTGER1. mouse.
NextBio295976.
PROP35375.
SOURCESearch...

Entry information

Entry namePE2R1_MOUSE
AccessionPrimary (citable) accession number: P35375
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: April 16, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries