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Protein

Prostaglandin E2 receptor EP1 subtype

Gene

Ptger1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues.

GO - Molecular functioni

GO - Biological processi

  • response to lipopolysaccharide Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_301895. Prostanoid ligand receptors.
REACT_347934. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin E2 receptor EP1 subtype
Short name:
PGE receptor EP1 subtype
Short name:
PGE2 receptor EP1 subtype
Alternative name(s):
Prostanoid EP1 receptor
Gene namesi
Name:Ptger1
Synonyms:Ptgerep1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:97793. Ptger1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3939ExtracellularSequence AnalysisAdd
BLAST
Transmembranei40 – 6223Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini63 – 8018CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei81 – 9919Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini100 – 11314ExtracellularSequence AnalysisAdd
BLAST
Transmembranei114 – 13522Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini136 – 15722CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei158 – 17922Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini180 – 20223ExtracellularSequence AnalysisAdd
BLAST
Transmembranei203 – 22826Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini229 – 30173CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei302 – 32322Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini324 – 33714ExtracellularSequence AnalysisAdd
BLAST
Transmembranei338 – 35720Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini358 – 40548CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 405405Prostaglandin E2 receptor EP1 subtypePRO_0000070051Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi7 – 71N-linked (GlcNAc...)Sequence Analysis
Glycosylationi24 – 241N-linked (GlcNAc...)Sequence Analysis
Glycosylationi34 – 341N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi112 ↔ 190PROSITE-ProRule annotation

Post-translational modificationi

Phosphorylated.Curated

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiP35375.

Expressioni

Tissue specificityi

Abundant in kidney and in a lesser amount in lung.

Gene expression databases

BgeeiP35375.
CleanExiMM_PTGER1.
ExpressionAtlasiP35375. baseline and differential.
GenevisibleiP35375. MM.

Interactioni

Protein-protein interaction databases

BioGridi202454. 1 interaction.
STRINGi10090.ENSMUSP00000019608.

Structurei

3D structure databases

ProteinModelPortaliP35375.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG253446.
GeneTreeiENSGT00760000119188.
HOGENOMiHOG000015238.
HOVERGENiHBG003621.
InParanoidiP35375.
KOiK04258.
OMAiCICWSPM.
OrthoDBiEOG7PP575.
PhylomeDBiP35375.
TreeFamiTF324982.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR001244. Prostglndn_DP_rcpt.
IPR000708. Prostglndn_EP1_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PTHR11866:SF3. PTHR11866:SF3. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00428. PROSTAGLNDNR.
PR01788. PROSTANOIDR.
PR00580. PRSTNOIDEP1R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35375-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPCGLNLSL ADEAATCATP RLPNTSVVLP TGDNGTSPAL PIFSMTLGAV
60 70 80 90 100
SNVLALALLA QVAGRMRRRR SAATFLLFVA SLLAIDLAGH VIPGALVLRL
110 120 130 140 150
YTAGRAPAGG ACHFLGGCMV FFGLCPLLLG CGMAVERCVG VTQPLIHAAR
160 170 180 190 200
VSVARARLAL AVLAAMALAV ALLPLVHVGR YELQYPGTWC FISLGPRGGW
210 220 230 240 250
RQALLAGLFA GLGLAALLAA LVCNTLSGLA LLRARWRRRR SRRFRKTAGP
260 270 280 290 300
DDRRRWGSRG PRLASASSAS SITSATATLR SSRGGGSARR VHAHDVEMVG
310 320 330 340 350
QLVGIMVVSC ICWSPLLVLV VLAIGGWNSN SLQRPLFLAV RLASWNQILD
360 370 380 390 400
PWVYILLRQA MLRQLLRLLP LRVSAKGGPT ELGLTKSAWE ASSLRSSRHS

GFSHL
Length:405
Mass (Da):42,966
Last modified:June 1, 1994 - v1
Checksum:i2E64D421005CF8D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16338 mRNA. Translation: BAA03842.1.
Z49987 Genomic DNA. Translation: CAA90278.1.
Y07611 Genomic DNA. Translation: CAA68884.1.
CCDSiCCDS22458.1.
PIRiS66525.
RefSeqiNP_038669.1. NM_013641.2.
UniGeneiMm.213000.
Mm.474430.

Genome annotation databases

EnsembliENSMUST00000019608; ENSMUSP00000019608; ENSMUSG00000019464.
GeneIDi19216.
KEGGimmu:19216.
UCSCiuc009mkt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16338 mRNA. Translation: BAA03842.1.
Z49987 Genomic DNA. Translation: CAA90278.1.
Y07611 Genomic DNA. Translation: CAA68884.1.
CCDSiCCDS22458.1.
PIRiS66525.
RefSeqiNP_038669.1. NM_013641.2.
UniGeneiMm.213000.
Mm.474430.

3D structure databases

ProteinModelPortaliP35375.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202454. 1 interaction.
STRINGi10090.ENSMUSP00000019608.

Chemistry

BindingDBiP35375.
ChEMBLiCHEMBL2181.
GuidetoPHARMACOLOGYi340.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PRIDEiP35375.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019608; ENSMUSP00000019608; ENSMUSG00000019464.
GeneIDi19216.
KEGGimmu:19216.
UCSCiuc009mkt.1. mouse.

Organism-specific databases

CTDi5731.
MGIiMGI:97793. Ptger1.

Phylogenomic databases

eggNOGiNOG253446.
GeneTreeiENSGT00760000119188.
HOGENOMiHOG000015238.
HOVERGENiHBG003621.
InParanoidiP35375.
KOiK04258.
OMAiCICWSPM.
OrthoDBiEOG7PP575.
PhylomeDBiP35375.
TreeFamiTF324982.

Enzyme and pathway databases

ReactomeiREACT_301895. Prostanoid ligand receptors.
REACT_347934. G alpha (q) signalling events.

Miscellaneous databases

ChiTaRSiPtger1. mouse.
NextBioi295976.
PROiP35375.
SOURCEiSearch...

Gene expression databases

BgeeiP35375.
CleanExiMM_PTGER1.
ExpressionAtlasiP35375. baseline and differential.
GenevisibleiP35375. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR001244. Prostglndn_DP_rcpt.
IPR000708. Prostglndn_EP1_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PTHR11866:SF3. PTHR11866:SF3. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00428. PROSTAGLNDNR.
PR01788. PROSTANOIDR.
PR00580. PRSTNOIDEP1R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and expression of cDNA for a mouse EP1 subtype of prostaglandin E receptor."
    Watabe A., Sugimoto Y., Honda A., Irie A., Namba T., Negishi M., Ito S., Narumiya S., Ichikawa A.
    J. Biol. Chem. 268:20175-20178(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ddY.
    Tissue: Kidney.
  2. "Molecular characterization of the mouse prostanoid EP1 receptor gene."
    Batshake B., Nilsson C., Sundelin J.
    Eur. J. Biochem. 231:809-814(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129.
  3. "The mouse genes for the EP1 prostanoid receptor and the PKN protein kinase overlap."
    Batshake B., Sundelin S.
    Biochem. Biophys. Res. Commun. 227:70-76(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129.

Entry informationi

Entry nameiPE2R1_MOUSE
AccessioniPrimary (citable) accession number: P35375
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: June 24, 2015
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.