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P35374

- AGTR2_MOUSE

UniProt

P35374 - AGTR2_MOUSE

Protein

Type-2 angiotensin II receptor

Gene

Agtr2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.1 Publication

    GO - Molecular functioni

    1. angiotensin type II receptor activity Source: MGI
    2. peptide hormone binding Source: Ensembl

    GO - Biological processi

    1. aldosterone secretion Source: Ensembl
    2. angiotensin-activated signaling pathway Source: GOC
    3. brain renin-angiotensin system Source: MGI
    4. cell growth involved in cardiac muscle cell development Source: Ensembl
    5. cellular response to dexamethasone stimulus Source: Ensembl
    6. cellular sodium ion homeostasis Source: Ensembl
    7. cerebellar cortex development Source: Ensembl
    8. dopamine biosynthetic process Source: Ensembl
    9. exploration behavior Source: BHF-UCL
    10. G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger Source: BHF-UCL
    11. inflammatory response Source: MGI
    12. intracellular signal transduction Source: BHF-UCL
    13. negative regulation of fibroblast proliferation Source: Ensembl
    14. negative regulation of heart rate Source: BHF-UCL
    15. negative regulation of icosanoid secretion Source: Ensembl
    16. negative regulation of neurotrophin TRK receptor signaling pathway Source: Ensembl
    17. negative regulation of norepinephrine secretion Source: Ensembl
    18. positive regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
    19. positive regulation of cell proliferation Source: Ensembl
    20. positive regulation of cytokine secretion Source: Ensembl
    21. positive regulation of extrinsic apoptotic signaling pathway Source: Ensembl
    22. positive regulation of metanephric glomerulus development Source: UniProtKB
    23. positive regulation of nitric-oxide synthase activity Source: BHF-UCL
    24. positive regulation of phosphoprotein phosphatase activity Source: Ensembl
    25. positive regulation of renal sodium excretion Source: Ensembl
    26. positive regulation of transcription, DNA-templated Source: UniProtKB
    27. positive regulation of vasodilation Source: Ensembl
    28. regulation of metanephros size Source: UniProtKB
    29. regulation of systemic arterial blood pressure by circulatory renin-angiotensin Source: BHF-UCL
    30. regulation of transcription factor import into nucleus Source: Ensembl
    31. renin-angiotensin regulation of aldosterone production Source: Ensembl
    32. response to organonitrogen compound Source: Ensembl
    33. vasodilation by angiotensin involved in regulation of systemic arterial blood pressure Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Type-2 angiotensin II receptor
    Alternative name(s):
    Angiotensin II type-2 receptor
    Short name:
    AT2
    Gene namesi
    Name:Agtr2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:87966. Agtr2.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. perinuclear region of cytoplasm Source: Ensembl
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 363363Type-2 angiotensin II receptorPRO_0000069169Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi13 – 131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi24 – 241N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi29 – 291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi34 – 341N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi35 ↔ 2901 PublicationPROSITE-ProRule annotation
    Disulfide bondi117 ↔ 1951 PublicationPROSITE-ProRule annotation
    Modified residuei354 – 3541Phosphoserine; by PKCSequence Analysis

    Post-translational modificationi

    C-terminal Ser or Thr residues may be phosphorylated.

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PRIDEiP35374.

    PTM databases

    PhosphoSiteiP35374.

    Expressioni

    Tissue specificityi

    Expressed at highest levels in adrenal gland and uterus.1 Publication

    Gene expression databases

    BgeeiP35374.
    CleanExiMM_AGTR2.
    GenevestigatoriP35374.

    Interactioni

    Subunit structurei

    Interacts with MTUS1.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliP35374.
    SMRiP35374. Positions 46-330.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4545ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini72 – 809CytoplasmicSequence Analysis
    Topological domaini103 – 11917ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini141 – 16020CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini180 – 20829ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini235 – 25622CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini279 – 29719ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini319 – 36345CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei46 – 7126Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei81 – 10222Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei120 – 14021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei161 – 17919Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei209 – 23426Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei257 – 27822Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei298 – 31821Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG311643.
    GeneTreeiENSGT00720000108671.
    HOVERGENiHBG104998.
    InParanoidiP35374.
    KOiK04167.
    OMAiNCSHKPS.
    OrthoDBiEOG7TQV1F.
    PhylomeDBiP35374.
    TreeFamiTF330024.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000147. ATII_AT2_rcpt.
    IPR000248. ATII_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00241. ANGIOTENSINR.
    PR00636. ANGIOTENSN2R.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P35374-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKDNFSFAAT SRNITSSRPF DNLNATGTNE SAFNCSHKPS DKHLEAIPVL    50
    YYMIFVIGFA VNIVVVSLFC CQKGPKKVSS IYIFNLALAD LLLLATLPLW 100
    ATYYSYRYDW LFGPVMCKVF GSFLTLNMFA SIFFITCMSV DRYQSVIYPF 150
    LSQRRNPWQA SYVVPLVWCM ACLSSLPTFY FRDVRTIEYL GVNACIMAFP 200
    PEKYAQWSAG IALMKNILGF IIPLIFIATC YFGIRKHLLK TNSYGKNRIT 250
    RDQVLKMAAA VVLAFIICWL PFHVLTFLDA LTWMGIINSC EVIAVIDLAL 300
    PFAILLGFTN SCVNPFLYCF VGNRFQQKLR SVFRVPITWL QGKRETMSCR 350
    KGSSLREMDT FVS 363
    Length:363
    Mass (Da):41,374
    Last modified:June 1, 1994 - v1
    Checksum:i6C7D6E3B026D1E80
    GO

    Sequence cautioni

    The sequence AAB49539.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S67465 mRNA. Translation: AAB29336.1.
    U04828 mRNA. Translation: AAC52128.1.
    U00766 mRNA. Translation: AAC04933.1.
    L32840 mRNA. Translation: AAB49539.1. Different initiation.
    U11073 Genomic DNA. Translation: AAA82184.1.
    AK086334 mRNA. Translation: BAC39650.1.
    BC003811 mRNA. Translation: AAH03811.1.
    CCDSiCCDS40889.1.
    PIRiI48261.
    RefSeqiNP_031455.1. NM_007429.5.
    UniGeneiMm.2679.

    Genome annotation databases

    EnsembliENSMUST00000089188; ENSMUSP00000086592; ENSMUSG00000068122.
    GeneIDi11609.
    KEGGimmu:11609.
    UCSCiuc009suq.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S67465 mRNA. Translation: AAB29336.1 .
    U04828 mRNA. Translation: AAC52128.1 .
    U00766 mRNA. Translation: AAC04933.1 .
    L32840 mRNA. Translation: AAB49539.1 . Different initiation.
    U11073 Genomic DNA. Translation: AAA82184.1 .
    AK086334 mRNA. Translation: BAC39650.1 .
    BC003811 mRNA. Translation: AAH03811.1 .
    CCDSi CCDS40889.1.
    PIRi I48261.
    RefSeqi NP_031455.1. NM_007429.5.
    UniGenei Mm.2679.

    3D structure databases

    ProteinModelPortali P35374.
    SMRi P35374. Positions 46-330.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    GuidetoPHARMACOLOGYi 35.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P35374.

    Proteomic databases

    PRIDEi P35374.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000089188 ; ENSMUSP00000086592 ; ENSMUSG00000068122 .
    GeneIDi 11609.
    KEGGi mmu:11609.
    UCSCi uc009suq.2. mouse.

    Organism-specific databases

    CTDi 186.
    MGIi MGI:87966. Agtr2.

    Phylogenomic databases

    eggNOGi NOG311643.
    GeneTreei ENSGT00720000108671.
    HOVERGENi HBG104998.
    InParanoidi P35374.
    KOi K04167.
    OMAi NCSHKPS.
    OrthoDBi EOG7TQV1F.
    PhylomeDBi P35374.
    TreeFami TF330024.

    Miscellaneous databases

    NextBioi 279152.
    PROi P35374.
    SOURCEi Search...

    Gene expression databases

    Bgeei P35374.
    CleanExi MM_AGTR2.
    Genevestigatori P35374.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000147. ATII_AT2_rcpt.
    IPR000248. ATII_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00241. ANGIOTENSINR.
    PR00636. ANGIOTENSN2R.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of cDNA and analysis of the gene for mouse angiotensin II type 2 receptor."
      Nakajima M., Mukoyama M., Pratt R.E., Horiuchi M., Dzau V.J.
      Biochem. Biophys. Res. Commun. 197:393-399(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Fetus.
    2. "Cloning of the cDNA and the genomic DNA of the mouse angiotensin II type 2 receptor."
      Ichiki T., Herold C.L., Kambayashi Y., Bardhan S., Inagami T.
      Biochim. Biophys. Acta 1189:247-250(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
    3. "Molecular and functional characterization of angiotensin II AT2 receptor in neuroblastoma N1E-115 cells."
      Nahmias C., Cazaubon S.M., Sutren M., Masson M., Lazard D., Villageois P., Elbaz N., Strosberg A.D.
      Adv. Exp. Med. Biol. 396:167-173(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "The growth-dependent expression of angiotensin II type 2 receptor is regulated by transcription factors interferon regulatory factor-1 and -2."
      Horiuchi M., Koike G., Yamada T., Mukoyama M., Nakajima M., Dzau V.J.
      J. Biol. Chem. 270:20225-20230(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: BALB/c.
      Tissue: Liver.
    5. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Head.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Mammary gland.
    7. "Identification and function of disulfide bridges in the extracellular domains of the angiotensin II type 2 receptor."
      Heerding J.N., Hines J., Fluharty S.J., Yee D.K.
      Biochemistry 40:8369-8377(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISULFIDE BONDS.
    8. "Regulation of transport of the angiotensin AT2 receptor by a novel membrane-associated Golgi protein."
      Wruck C.J., Funke-Kaiser H., Pufe T., Kusserow H., Menk M., Schefe J.H., Kruse M.L., Stoll M., Unger T.
      Arterioscler. Thromb. Vasc. Biol. 25:57-64(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH MTUS1, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiAGTR2_MOUSE
    AccessioniPrimary (citable) accession number: P35374
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 124 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3