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Protein

Type-2 angiotensin II receptor

Gene

Agtr2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.1 Publication

GO - Molecular functioni

  • angiotensin type II receptor activity Source: MGI
  • peptide hormone binding Source: Ensembl

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Type-2 angiotensin II receptor
Alternative name(s):
Angiotensin II type-2 receptor
Short name:
AT2
Gene namesi
Name:Agtr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:87966. Agtr2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 45ExtracellularSequence analysisAdd BLAST45
Transmembranei46 – 71Helical; Name=1Sequence analysisAdd BLAST26
Topological domaini72 – 80CytoplasmicSequence analysis9
Transmembranei81 – 102Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini103 – 119ExtracellularSequence analysisAdd BLAST17
Transmembranei120 – 140Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini141 – 160CytoplasmicSequence analysisAdd BLAST20
Transmembranei161 – 179Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini180 – 208ExtracellularSequence analysisAdd BLAST29
Transmembranei209 – 234Helical; Name=5Sequence analysisAdd BLAST26
Topological domaini235 – 256CytoplasmicSequence analysisAdd BLAST22
Transmembranei257 – 278Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini279 – 297ExtracellularSequence analysisAdd BLAST19
Transmembranei298 – 318Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini319 – 363CytoplasmicSequence analysisAdd BLAST45

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000691691 – 363Type-2 angiotensin II receptorAdd BLAST363

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1
Glycosylationi13N-linked (GlcNAc...)Sequence analysis1
Glycosylationi24N-linked (GlcNAc...)Sequence analysis1
Glycosylationi29N-linked (GlcNAc...)Sequence analysis1
Glycosylationi34N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi35 ↔ 290PROSITE-ProRule annotation1 Publication
Disulfide bondi117 ↔ 195PROSITE-ProRule annotation1 Publication
Modified residuei354Phosphoserine; by PKCSequence analysis1

Post-translational modificationi

C-terminal Ser or Thr residues may be phosphorylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP35374.
PRIDEiP35374.

PTM databases

iPTMnetiP35374.
PhosphoSitePlusiP35374.

Expressioni

Tissue specificityi

Expressed at highest levels in adrenal gland and uterus.1 Publication

Gene expression databases

BgeeiENSMUSG00000068122.
CleanExiMM_AGTR2.
GenevisibleiP35374. MM.

Interactioni

Subunit structurei

Interacts with MTUS1.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000086592.

Structurei

3D structure databases

ProteinModelPortaliP35374.
SMRiP35374.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119055.
HOVERGENiHBG104998.
InParanoidiP35374.
KOiK04167.
OMAiNCSHKPS.
OrthoDBiEOG091G0HEN.
PhylomeDBiP35374.
TreeFamiTF330024.

Family and domain databases

InterProiIPR000147. ATII_AT2_rcpt.
IPR000248. ATII_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00241. ANGIOTENSINR.
PR00636. ANGIOTENSN2R.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35374-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDNFSFAAT SRNITSSRPF DNLNATGTNE SAFNCSHKPS DKHLEAIPVL
60 70 80 90 100
YYMIFVIGFA VNIVVVSLFC CQKGPKKVSS IYIFNLALAD LLLLATLPLW
110 120 130 140 150
ATYYSYRYDW LFGPVMCKVF GSFLTLNMFA SIFFITCMSV DRYQSVIYPF
160 170 180 190 200
LSQRRNPWQA SYVVPLVWCM ACLSSLPTFY FRDVRTIEYL GVNACIMAFP
210 220 230 240 250
PEKYAQWSAG IALMKNILGF IIPLIFIATC YFGIRKHLLK TNSYGKNRIT
260 270 280 290 300
RDQVLKMAAA VVLAFIICWL PFHVLTFLDA LTWMGIINSC EVIAVIDLAL
310 320 330 340 350
PFAILLGFTN SCVNPFLYCF VGNRFQQKLR SVFRVPITWL QGKRETMSCR
360
KGSSLREMDT FVS
Length:363
Mass (Da):41,374
Last modified:June 1, 1994 - v1
Checksum:i6C7D6E3B026D1E80
GO

Sequence cautioni

The sequence AAB49539 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S67465 mRNA. Translation: AAB29336.1.
U04828 mRNA. Translation: AAC52128.1.
U00766 mRNA. Translation: AAC04933.1.
L32840 mRNA. Translation: AAB49539.1. Different initiation.
U11073 Genomic DNA. Translation: AAA82184.1.
AK086334 mRNA. Translation: BAC39650.1.
BC003811 mRNA. Translation: AAH03811.1.
CCDSiCCDS40889.1.
PIRiI48261.
RefSeqiNP_031455.1. NM_007429.5.
UniGeneiMm.2679.

Genome annotation databases

EnsembliENSMUST00000089188; ENSMUSP00000086592; ENSMUSG00000068122.
GeneIDi11609.
KEGGimmu:11609.
UCSCiuc009suq.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S67465 mRNA. Translation: AAB29336.1.
U04828 mRNA. Translation: AAC52128.1.
U00766 mRNA. Translation: AAC04933.1.
L32840 mRNA. Translation: AAB49539.1. Different initiation.
U11073 Genomic DNA. Translation: AAA82184.1.
AK086334 mRNA. Translation: BAC39650.1.
BC003811 mRNA. Translation: AAH03811.1.
CCDSiCCDS40889.1.
PIRiI48261.
RefSeqiNP_031455.1. NM_007429.5.
UniGeneiMm.2679.

3D structure databases

ProteinModelPortaliP35374.
SMRiP35374.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000086592.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP35374.
PhosphoSitePlusiP35374.

Proteomic databases

PaxDbiP35374.
PRIDEiP35374.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000089188; ENSMUSP00000086592; ENSMUSG00000068122.
GeneIDi11609.
KEGGimmu:11609.
UCSCiuc009suq.3. mouse.

Organism-specific databases

CTDi186.
MGIiMGI:87966. Agtr2.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119055.
HOVERGENiHBG104998.
InParanoidiP35374.
KOiK04167.
OMAiNCSHKPS.
OrthoDBiEOG091G0HEN.
PhylomeDBiP35374.
TreeFamiTF330024.

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiP35374.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000068122.
CleanExiMM_AGTR2.
GenevisibleiP35374. MM.

Family and domain databases

InterProiIPR000147. ATII_AT2_rcpt.
IPR000248. ATII_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00241. ANGIOTENSINR.
PR00636. ANGIOTENSN2R.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAGTR2_MOUSE
AccessioniPrimary (citable) accession number: P35374
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 2, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.