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Protein

Type-2 angiotensin II receptor

Gene

Agtr2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.1 Publication

GO - Molecular functioni

  • angiotensin type II receptor activity Source: MGI
  • peptide hormone binding Source: Ensembl

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_319210. Peptide ligand-binding receptors.
REACT_331048. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Type-2 angiotensin II receptor
Alternative name(s):
Angiotensin II type-2 receptor
Short name:
AT2
Gene namesi
Name:Agtr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:87966. Agtr2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4545ExtracellularSequence AnalysisAdd
BLAST
Transmembranei46 – 7126Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini72 – 809CytoplasmicSequence Analysis
Transmembranei81 – 10222Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini103 – 11917ExtracellularSequence AnalysisAdd
BLAST
Transmembranei120 – 14021Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini141 – 16020CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei161 – 17919Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini180 – 20829ExtracellularSequence AnalysisAdd
BLAST
Transmembranei209 – 23426Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini235 – 25622CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei257 – 27822Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini279 – 29719ExtracellularSequence AnalysisAdd
BLAST
Transmembranei298 – 31821Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini319 – 36345CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 363363Type-2 angiotensin II receptorPRO_0000069169Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
Glycosylationi13 – 131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi24 – 241N-linked (GlcNAc...)Sequence Analysis
Glycosylationi29 – 291N-linked (GlcNAc...)Sequence Analysis
Glycosylationi34 – 341N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi35 ↔ 290PROSITE-ProRule annotation1 Publication
Disulfide bondi117 ↔ 195PROSITE-ProRule annotation1 Publication
Modified residuei354 – 3541Phosphoserine; by PKCSequence Analysis

Post-translational modificationi

C-terminal Ser or Thr residues may be phosphorylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiP35374.

PTM databases

PhosphoSiteiP35374.

Expressioni

Tissue specificityi

Expressed at highest levels in adrenal gland and uterus.1 Publication

Gene expression databases

BgeeiP35374.
CleanExiMM_AGTR2.
GenevisibleiP35374. MM.

Interactioni

Subunit structurei

Interacts with MTUS1.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000086592.

Structurei

3D structure databases

ProteinModelPortaliP35374.
SMRiP35374. Positions 46-330.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG311643.
GeneTreeiENSGT00760000119055.
HOVERGENiHBG104998.
InParanoidiP35374.
KOiK04167.
OMAiNCSHKPS.
OrthoDBiEOG7TQV1F.
PhylomeDBiP35374.
TreeFamiTF330024.

Family and domain databases

InterProiIPR000147. ATII_AT2_rcpt.
IPR000248. ATII_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00241. ANGIOTENSINR.
PR00636. ANGIOTENSN2R.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35374-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDNFSFAAT SRNITSSRPF DNLNATGTNE SAFNCSHKPS DKHLEAIPVL
60 70 80 90 100
YYMIFVIGFA VNIVVVSLFC CQKGPKKVSS IYIFNLALAD LLLLATLPLW
110 120 130 140 150
ATYYSYRYDW LFGPVMCKVF GSFLTLNMFA SIFFITCMSV DRYQSVIYPF
160 170 180 190 200
LSQRRNPWQA SYVVPLVWCM ACLSSLPTFY FRDVRTIEYL GVNACIMAFP
210 220 230 240 250
PEKYAQWSAG IALMKNILGF IIPLIFIATC YFGIRKHLLK TNSYGKNRIT
260 270 280 290 300
RDQVLKMAAA VVLAFIICWL PFHVLTFLDA LTWMGIINSC EVIAVIDLAL
310 320 330 340 350
PFAILLGFTN SCVNPFLYCF VGNRFQQKLR SVFRVPITWL QGKRETMSCR
360
KGSSLREMDT FVS
Length:363
Mass (Da):41,374
Last modified:June 1, 1994 - v1
Checksum:i6C7D6E3B026D1E80
GO

Sequence cautioni

The sequence AAB49539.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S67465 mRNA. Translation: AAB29336.1.
U04828 mRNA. Translation: AAC52128.1.
U00766 mRNA. Translation: AAC04933.1.
L32840 mRNA. Translation: AAB49539.1. Different initiation.
U11073 Genomic DNA. Translation: AAA82184.1.
AK086334 mRNA. Translation: BAC39650.1.
BC003811 mRNA. Translation: AAH03811.1.
CCDSiCCDS40889.1.
PIRiI48261.
RefSeqiNP_031455.1. NM_007429.5.
UniGeneiMm.2679.

Genome annotation databases

EnsembliENSMUST00000089188; ENSMUSP00000086592; ENSMUSG00000068122.
GeneIDi11609.
KEGGimmu:11609.
UCSCiuc009suq.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S67465 mRNA. Translation: AAB29336.1.
U04828 mRNA. Translation: AAC52128.1.
U00766 mRNA. Translation: AAC04933.1.
L32840 mRNA. Translation: AAB49539.1. Different initiation.
U11073 Genomic DNA. Translation: AAA82184.1.
AK086334 mRNA. Translation: BAC39650.1.
BC003811 mRNA. Translation: AAH03811.1.
CCDSiCCDS40889.1.
PIRiI48261.
RefSeqiNP_031455.1. NM_007429.5.
UniGeneiMm.2679.

3D structure databases

ProteinModelPortaliP35374.
SMRiP35374. Positions 46-330.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000086592.

Chemistry

GuidetoPHARMACOLOGYi35.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP35374.

Proteomic databases

PRIDEiP35374.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000089188; ENSMUSP00000086592; ENSMUSG00000068122.
GeneIDi11609.
KEGGimmu:11609.
UCSCiuc009suq.3. mouse.

Organism-specific databases

CTDi186.
MGIiMGI:87966. Agtr2.

Phylogenomic databases

eggNOGiNOG311643.
GeneTreeiENSGT00760000119055.
HOVERGENiHBG104998.
InParanoidiP35374.
KOiK04167.
OMAiNCSHKPS.
OrthoDBiEOG7TQV1F.
PhylomeDBiP35374.
TreeFamiTF330024.

Enzyme and pathway databases

ReactomeiREACT_319210. Peptide ligand-binding receptors.
REACT_331048. G alpha (i) signalling events.

Miscellaneous databases

NextBioi279152.
PROiP35374.
SOURCEiSearch...

Gene expression databases

BgeeiP35374.
CleanExiMM_AGTR2.
GenevisibleiP35374. MM.

Family and domain databases

InterProiIPR000147. ATII_AT2_rcpt.
IPR000248. ATII_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00241. ANGIOTENSINR.
PR00636. ANGIOTENSN2R.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of cDNA and analysis of the gene for mouse angiotensin II type 2 receptor."
    Nakajima M., Mukoyama M., Pratt R.E., Horiuchi M., Dzau V.J.
    Biochem. Biophys. Res. Commun. 197:393-399(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Fetus.
  2. "Cloning of the cDNA and the genomic DNA of the mouse angiotensin II type 2 receptor."
    Ichiki T., Herold C.L., Kambayashi Y., Bardhan S., Inagami T.
    Biochim. Biophys. Acta 1189:247-250(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  3. "Molecular and functional characterization of angiotensin II AT2 receptor in neuroblastoma N1E-115 cells."
    Nahmias C., Cazaubon S.M., Sutren M., Masson M., Lazard D., Villageois P., Elbaz N., Strosberg A.D.
    Adv. Exp. Med. Biol. 396:167-173(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The growth-dependent expression of angiotensin II type 2 receptor is regulated by transcription factors interferon regulatory factor-1 and -2."
    Horiuchi M., Koike G., Yamada T., Mukoyama M., Nakajima M., Dzau V.J.
    J. Biol. Chem. 270:20225-20230(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/c.
    Tissue: Liver.
  5. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.
  7. "Identification and function of disulfide bridges in the extracellular domains of the angiotensin II type 2 receptor."
    Heerding J.N., Hines J., Fluharty S.J., Yee D.K.
    Biochemistry 40:8369-8377(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISULFIDE BONDS.
  8. "Regulation of transport of the angiotensin AT2 receptor by a novel membrane-associated Golgi protein."
    Wruck C.J., Funke-Kaiser H., Pufe T., Kusserow H., Menk M., Schefe J.H., Kruse M.L., Stoll M., Unger T.
    Arterioscler. Thromb. Vasc. Biol. 25:57-64(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH MTUS1, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiAGTR2_MOUSE
AccessioniPrimary (citable) accession number: P35374
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: July 22, 2015
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.