SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P35374

- AGTR2_MOUSE

UniProt

P35374 - AGTR2_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Type-2 angiotensin II receptor

Gene
Agtr2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.1 Publication

GO - Molecular functioni

  1. angiotensin type II receptor activity Source: MGI
  2. peptide hormone binding Source: Ensembl

GO - Biological processi

  1. aldosterone secretion Source: Ensembl
  2. angiotensin-activated signaling pathway Source: GOC
  3. brain renin-angiotensin system Source: MGI
  4. cell growth involved in cardiac muscle cell development Source: Ensembl
  5. cellular response to dexamethasone stimulus Source: Ensembl
  6. cellular sodium ion homeostasis Source: Ensembl
  7. cerebellar cortex development Source: Ensembl
  8. dopamine biosynthetic process Source: Ensembl
  9. exploration behavior Source: BHF-UCL
  10. G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger Source: BHF-UCL
  11. inflammatory response Source: MGI
  12. intracellular signal transduction Source: BHF-UCL
  13. negative regulation of fibroblast proliferation Source: Ensembl
  14. negative regulation of heart rate Source: BHF-UCL
  15. negative regulation of icosanoid secretion Source: Ensembl
  16. negative regulation of neurotrophin TRK receptor signaling pathway Source: Ensembl
  17. negative regulation of norepinephrine secretion Source: Ensembl
  18. positive regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
  19. positive regulation of cell proliferation Source: Ensembl
  20. positive regulation of cytokine secretion Source: Ensembl
  21. positive regulation of extrinsic apoptotic signaling pathway Source: Ensembl
  22. positive regulation of metanephric glomerulus development Source: UniProtKB
  23. positive regulation of nitric-oxide synthase activity Source: BHF-UCL
  24. positive regulation of phosphoprotein phosphatase activity Source: Ensembl
  25. positive regulation of renal sodium excretion Source: Ensembl
  26. positive regulation of transcription, DNA-templated Source: UniProtKB
  27. positive regulation of vasodilation Source: Ensembl
  28. regulation of metanephros size Source: UniProtKB
  29. regulation of systemic arterial blood pressure by circulatory renin-angiotensin Source: BHF-UCL
  30. regulation of transcription factor import into nucleus Source: Ensembl
  31. renin-angiotensin regulation of aldosterone production Source: Ensembl
  32. response to organonitrogen compound Source: Ensembl
  33. vasodilation by angiotensin involved in regulation of systemic arterial blood pressure Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Type-2 angiotensin II receptor
Alternative name(s):
Angiotensin II type-2 receptor
Short name:
AT2
Gene namesi
Name:Agtr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:87966. Agtr2.

Subcellular locationi

Cell membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4545Extracellular Reviewed predictionAdd
BLAST
Transmembranei46 – 7126Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini72 – 809Cytoplasmic Reviewed prediction
Transmembranei81 – 10222Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini103 – 11917Extracellular Reviewed predictionAdd
BLAST
Transmembranei120 – 14021Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini141 – 16020Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei161 – 17919Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini180 – 20829Extracellular Reviewed predictionAdd
BLAST
Transmembranei209 – 23426Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini235 – 25622Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei257 – 27822Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini279 – 29719Extracellular Reviewed predictionAdd
BLAST
Transmembranei298 – 31821Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini319 – 36345Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. perinuclear region of cytoplasm Source: Ensembl
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 363363Type-2 angiotensin II receptorPRO_0000069169Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...) Reviewed prediction
Glycosylationi13 – 131N-linked (GlcNAc...) Reviewed prediction
Glycosylationi24 – 241N-linked (GlcNAc...) Reviewed prediction
Glycosylationi29 – 291N-linked (GlcNAc...) Reviewed prediction
Glycosylationi34 – 341N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi35 ↔ 2901 Publication
Disulfide bondi117 ↔ 1951 Publication
Modified residuei354 – 3541Phosphoserine; by PKC Reviewed prediction

Post-translational modificationi

C-terminal Ser or Thr residues may be phosphorylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiP35374.

PTM databases

PhosphoSiteiP35374.

Expressioni

Tissue specificityi

Expressed at highest levels in adrenal gland and uterus.1 Publication

Gene expression databases

BgeeiP35374.
CleanExiMM_AGTR2.
GenevestigatoriP35374.

Interactioni

Subunit structurei

Interacts with MTUS1.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP35374.
SMRiP35374. Positions 46-330.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG311643.
GeneTreeiENSGT00720000108671.
HOVERGENiHBG104998.
InParanoidiP35374.
KOiK04167.
OMAiNCSHKPS.
OrthoDBiEOG7TQV1F.
PhylomeDBiP35374.
TreeFamiTF330024.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000147. ATII_AT2_rcpt.
IPR000248. ATII_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00241. ANGIOTENSINR.
PR00636. ANGIOTENSN2R.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35374-1 [UniParc]FASTAAdd to Basket

« Hide

MKDNFSFAAT SRNITSSRPF DNLNATGTNE SAFNCSHKPS DKHLEAIPVL    50
YYMIFVIGFA VNIVVVSLFC CQKGPKKVSS IYIFNLALAD LLLLATLPLW 100
ATYYSYRYDW LFGPVMCKVF GSFLTLNMFA SIFFITCMSV DRYQSVIYPF 150
LSQRRNPWQA SYVVPLVWCM ACLSSLPTFY FRDVRTIEYL GVNACIMAFP 200
PEKYAQWSAG IALMKNILGF IIPLIFIATC YFGIRKHLLK TNSYGKNRIT 250
RDQVLKMAAA VVLAFIICWL PFHVLTFLDA LTWMGIINSC EVIAVIDLAL 300
PFAILLGFTN SCVNPFLYCF VGNRFQQKLR SVFRVPITWL QGKRETMSCR 350
KGSSLREMDT FVS 363
Length:363
Mass (Da):41,374
Last modified:June 1, 1994 - v1
Checksum:i6C7D6E3B026D1E80
GO

Sequence cautioni

The sequence AAB49539.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S67465 mRNA. Translation: AAB29336.1.
U04828 mRNA. Translation: AAC52128.1.
U00766 mRNA. Translation: AAC04933.1.
L32840 mRNA. Translation: AAB49539.1. Different initiation.
U11073 Genomic DNA. Translation: AAA82184.1.
AK086334 mRNA. Translation: BAC39650.1.
BC003811 mRNA. Translation: AAH03811.1.
CCDSiCCDS40889.1.
PIRiI48261.
RefSeqiNP_031455.1. NM_007429.5.
UniGeneiMm.2679.

Genome annotation databases

EnsembliENSMUST00000089188; ENSMUSP00000086592; ENSMUSG00000068122.
GeneIDi11609.
KEGGimmu:11609.
UCSCiuc009suq.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S67465 mRNA. Translation: AAB29336.1 .
U04828 mRNA. Translation: AAC52128.1 .
U00766 mRNA. Translation: AAC04933.1 .
L32840 mRNA. Translation: AAB49539.1 . Different initiation.
U11073 Genomic DNA. Translation: AAA82184.1 .
AK086334 mRNA. Translation: BAC39650.1 .
BC003811 mRNA. Translation: AAH03811.1 .
CCDSi CCDS40889.1.
PIRi I48261.
RefSeqi NP_031455.1. NM_007429.5.
UniGenei Mm.2679.

3D structure databases

ProteinModelPortali P35374.
SMRi P35374. Positions 46-330.
ModBasei Search...
MobiDBi Search...

Chemistry

GuidetoPHARMACOLOGYi 35.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P35374.

Proteomic databases

PRIDEi P35374.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000089188 ; ENSMUSP00000086592 ; ENSMUSG00000068122 .
GeneIDi 11609.
KEGGi mmu:11609.
UCSCi uc009suq.2. mouse.

Organism-specific databases

CTDi 186.
MGIi MGI:87966. Agtr2.

Phylogenomic databases

eggNOGi NOG311643.
GeneTreei ENSGT00720000108671.
HOVERGENi HBG104998.
InParanoidi P35374.
KOi K04167.
OMAi NCSHKPS.
OrthoDBi EOG7TQV1F.
PhylomeDBi P35374.
TreeFami TF330024.

Miscellaneous databases

NextBioi 279152.
PROi P35374.
SOURCEi Search...

Gene expression databases

Bgeei P35374.
CleanExi MM_AGTR2.
Genevestigatori P35374.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000147. ATII_AT2_rcpt.
IPR000248. ATII_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00241. ANGIOTENSINR.
PR00636. ANGIOTENSN2R.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of cDNA and analysis of the gene for mouse angiotensin II type 2 receptor."
    Nakajima M., Mukoyama M., Pratt R.E., Horiuchi M., Dzau V.J.
    Biochem. Biophys. Res. Commun. 197:393-399(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Fetus.
  2. "Cloning of the cDNA and the genomic DNA of the mouse angiotensin II type 2 receptor."
    Ichiki T., Herold C.L., Kambayashi Y., Bardhan S., Inagami T.
    Biochim. Biophys. Acta 1189:247-250(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  3. "Molecular and functional characterization of angiotensin II AT2 receptor in neuroblastoma N1E-115 cells."
    Nahmias C., Cazaubon S.M., Sutren M., Masson M., Lazard D., Villageois P., Elbaz N., Strosberg A.D.
    Adv. Exp. Med. Biol. 396:167-173(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The growth-dependent expression of angiotensin II type 2 receptor is regulated by transcription factors interferon regulatory factor-1 and -2."
    Horiuchi M., Koike G., Yamada T., Mukoyama M., Nakajima M., Dzau V.J.
    J. Biol. Chem. 270:20225-20230(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/c.
    Tissue: Liver.
  5. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.
  7. "Identification and function of disulfide bridges in the extracellular domains of the angiotensin II type 2 receptor."
    Heerding J.N., Hines J., Fluharty S.J., Yee D.K.
    Biochemistry 40:8369-8377(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISULFIDE BONDS.
  8. "Regulation of transport of the angiotensin AT2 receptor by a novel membrane-associated Golgi protein."
    Wruck C.J., Funke-Kaiser H., Pufe T., Kusserow H., Menk M., Schefe J.H., Kruse M.L., Stoll M., Unger T.
    Arterioscler. Thromb. Vasc. Biol. 25:57-64(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH MTUS1, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiAGTR2_MOUSE
AccessioniPrimary (citable) accession number: P35374
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: July 9, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi