P35372 (OPRM_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mu-type opioid receptor
Short name=M-OR-1
Short name=MOR-1

Alternative name(s):
Mu opiate receptor
Mu opioid receptor
Short name=MOP
Short name=hMOP

Gene names

Name:	OPRM1
Synonyms:	MOR1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	400 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Receptor for beta-endorphin.
Subunit structure	Forms a complex with G(alpha)z/i2 subunits and the RGSZ proteins, RGSZ17 and RGSZ20. The formation of this complex results in mu-opioid receptor desensitization. Interacts with RGSZ17 and RGSZ20 By similarity. The C-terminal tail interacts with the C-terminal section of DNAJB4. Ref.17
Subcellular location	Cell membrane; Multi-pass membrane protein.
Polymorphism	Variant Asp-40 does not show altered binding affinities for most opioid peptides and alkaloids tested, but it binds beta-endorphin, an endogenous opioid that activates the mu opioid receptor, approximately 3 times more tightly than the most common allelic form.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.
Sequence caution	The sequence CAI20458.1 differs from that shown. Reason: Erroneous initiation. The sequence EAW47705.1 differs from that shown. Reason: Erroneous initiation. Isoform 9: The sequence AAQ77392.1 differs from that shown. Reason: a polymorphism leading to premature termination of translation (position: 411:Q->Stop)

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Uncategorized	mu-opioid receptor activity Traceable author statement. Source: ProtInc
Biological process	negative regulation of cell proliferation Traceable author statement. Source: ProtInc sensory perception Traceable author statement. Source: ProtInc
Cellular component	Golgi apparatus Traceable author statement. Source: ProtInc endoplasmic reticulum Traceable author statement. Source: ProtInc integral to plasma membrane Traceable author statement. Source: ProtInc
Molecular function	opioid receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 11 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P35372-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P35372-2) Also known as: MOR1A; MOR-1A; The sequence of this isoform differs from the canonical sequence as follows:      389-400: LENLEAETAPLP → VRSL
Isoform 3 (identifier: P35372-3) Also known as: MOR-1R; The sequence of this isoform differs from the canonical sequence as follows:      389-400: LENLEAETAPLP → CLPIPSLSCWALEQGCLVVYPGPLQGPLVRYDLPAILHSSCLRGNTAPSPSGGAFLLS
Sequence annotation (Features)
	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
	Sequence conflict	402	1	Q → H in AAK74189. Ref.4
Isoform 4 (identifier: P35372-4) Also known as: MOR-1B3; The sequence of this isoform differs from the canonical sequence as follows:      389-400: LENLEAETAPLP → GPPAKFVADQLAGSS
Isoform 5 (identifier: P35372-5) Also known as: MOR-1C; The sequence of this isoform differs from the canonical sequence as follows:      389-400: LENLEAETAPLP → PPLAVSMAQIFTRYPPPTHREKTCNDYMKR
Isoform 6 (identifier: P35372-6) Also known as: MOR-1V; MOR-1Y; The sequence of this isoform differs from the canonical sequence as follows:      389-400: LENLEAETAPLP → IRDPISNLPRVSVF
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Isoform 7 (identifier: P35372-7) Also known as: MOR-1B1; The sequence of this isoform differs from the canonical sequence as follows:      389-400: LENLEAETAPLP → KIDLFQKSSLLNCEHTKG
Isoform 8 (identifier: P35372-8) Also known as: MOR-1B2; The sequence of this isoform differs from the canonical sequence as follows:      389-400: LENLEAETAPLP → RERRQKSDW
Isoform 9 (identifier: P35372-9) Also known as: MOR-1B5; The sequence of this isoform differs from the canonical sequence as follows:      389-400: LENLEAETAPLP → VELNLDCHCENAKPWPLSYNAGQSPFPFPGRV
Isoform 10 (identifier: P35372-10) Also known as: MOR-1H; The sequence of this isoform differs from the canonical sequence as follows:      1-1: M → MCLHRRVPSE...SGARPAVSTM
Isoform 11 (identifier: P35372-11) Also known as: MOR-1B4; The sequence of this isoform differs from the canonical sequence as follows:      389-400: LENLEAETAPLP → S

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 400	400	Mu-type opioid receptor		PRO_0000069972
Regions
	Topological domain	1 – 66	66	Extracellular Potential
	Transmembrane	67 – 96	30	Helical; Name=1; Potential
	Topological domain	97 – 105	9	Cytoplasmic Potential
	Transmembrane	106 – 123	18	Helical; Name=2; Potential
	Topological domain	124 – 145	22	Extracellular Potential
	Transmembrane	146 – 165	20	Helical; Name=3; Potential
	Topological domain	166 – 195	30	Cytoplasmic Potential
	Transmembrane	196 – 211	16	Helical; Name=4; Potential
	Topological domain	212 – 236	25	Extracellular Potential
	Transmembrane	237 – 259	23	Helical; Name=5; Potential
	Topological domain	260 – 282	23	Cytoplasmic Potential
	Transmembrane	283 – 305	23	Helical; Name=6; Potential
	Topological domain	306 – 313	8	Extracellular Potential
	Transmembrane	314 – 330	17	Helical; Name=7; Potential
	Topological domain	331 – 400	70	Cytoplasmic Potential
Amino acid modifications
	Lipidation	353	1	S-palmitoyl cysteine Potential
	Glycosylation	9	1	N-linked (GlcNAc...) Potential
	Glycosylation	12	1	N-linked (GlcNAc...) Potential
	Glycosylation	33	1	N-linked (GlcNAc...) Potential
	Glycosylation	40	1	N-linked (GlcNAc...) Potential
	Glycosylation	48	1	N-linked (GlcNAc...) Potential
	Disulfide bond	142 ↔ 219		By similarity
Natural variations
	Alternative sequence	1	1	M → MCLHRRVPSEETYSLDRFAQ NPPLFPPPSLPASESRMAHA PLLQRCGAARTGFCKKQQEL WQRRKEAAEALGTRKVSVLL ATSHSGARPAVSTM in isoform 10.		VSP_037693
	Alternative sequence	389 – 400	12	LENLE…TAPLP → S in isoform 11.		VSP_037694
	Alternative sequence	389 – 400	12	LENLE…TAPLP → VRSL in isoform 2.		VSP_001896
	Alternative sequence	389 – 400	12	LENLE…TAPLP → CLPIPSLSCWALEQGCLVVY PGPLQGPLVRYDLPAILHSS CLRGNTAPSPSGGAFLLS in isoform 3.		VSP_037695
	Alternative sequence	389 – 400	12	LENLE…TAPLP → GPPAKFVADQLAGSS in isoform 4.		VSP_037696
	Alternative sequence	389 – 400	12	LENLE…TAPLP → PPLAVSMAQIFTRYPPPTHR EKTCNDYMKR in isoform 5.		VSP_037697
	Alternative sequence	389 – 400	12	LENLE…TAPLP → IRDPISNLPRVSVF in isoform 6.		VSP_037698
	Alternative sequence	389 – 400	12	LENLE…TAPLP → KIDLFQKSSLLNCEHTKG in isoform 7.		VSP_037699
	Alternative sequence	389 – 400	12	LENLE…TAPLP → RERRQKSDW in isoform 8.		VSP_037700
	Alternative sequence	389 – 400	12	LENLE…TAPLP → VELNLDCHCENAKPWPLSYN AGQSPFPFPGRV in isoform 9.		VSP_037701
	Natural variant	6	1	A → V. Ref.10 Ref.14 Ref.18 Ref.19 Corresponds to variant rs1799972 [ dbSNP | Ensembl ].		VAR_009525
	Natural variant	40	1	N → D in 10% of the population. Ref.2 Ref.10 Ref.18 Ref.19 Corresponds to variant rs1799971 [ dbSNP | Ensembl ].		VAR_009524
	Natural variant	63	1	G → V. Corresponds to variant rs9282817 [ dbSNP | Ensembl ].		VAR_049426
	Natural variant	66	1	S → F. Corresponds to variant rs9282819 [ dbSNP | Ensembl ].		VAR_049427
	Natural variant	147	1	S → C Rare polymorphism. Ref.10 Ref.18 Corresponds to variant rs17174794 [ dbSNP | Ensembl ].		VAR_009526
	Natural variant	152	1	N → D. Ref.10 Corresponds to variant rs17174801 [ dbSNP | Ensembl ].		VAR_019252
	Natural variant	260	1	R → H Rare polymorphism. Ref.19 Corresponds to variant rs1799974 [ dbSNP | Ensembl ].		VAR_009527
	Natural variant	265	1	R → C. Ref.10 Corresponds to variant rs17174822 [ dbSNP | Ensembl ].		VAR_019253
	Natural variant	274	1	D → N. Ref.10 Corresponds to variant rs17174829 [ dbSNP | Ensembl ].		VAR_019254
Experimental info
	Sequence conflict	26	1	P → L in BAG36624. Ref.8
	Sequence conflict	51	1	D → N in AAA20580. Ref.1
	Sequence conflict	109	1	I → V in AAQ77391. Ref.5
	Sequence conflict	207	1	M → I in AAB60354. Ref.2
	Sequence conflict	234	1	L → V in AAA20580. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 15, 1998. Version 2. Checksum: 1DABEBEC9AFF6F66	FASTA	400	44,779
	10 20 30 40 50 60 MDSSAAPTNA SNCTDALAYS SCSPAPSPGS WVNLSHLDGN LSDPCGPNRT DLGGRDSLCP 70 80 90 100 110 120 PTGSPSMITA ITIMALYSIV CVVGLFGNFL VMYVIVRYTK MKTATNIYIF NLALADALAT 130 140 150 160 170 180 STLPFQSVNY LMGTWPFGTI LCKIVISIDY YNMFTSIFTL CTMSVDRYIA VCHPVKALDF 190 200 210 220 230 240 RTPRNAKIIN VCNWILSSAI GLPVMFMATT KYRQGSIDCT LTFSHPTWYW ENLLKICVFI 250 260 270 280 290 300 FAFIMPVLII TVCYGLMILR LKSVRMLSGS KEKDRNLRRI TRMVLVVVAV FIVCWTPIHI 310 320 330 340 350 360 YVIIKALVTI PETTFQTVSW HFCIALGYTN SCLNPVLYAF LDENFKRCFR EFCIPTSSNI 370 380 390 400 EQQNSTRIRQ NTRDHPSTAN TVDRTNHQLE NLEAETAPLP
	Isoform 2 (MOR1A) (MOR-1A) [UniParc]. Checksum: 14184C69F06AFCBE	FASTA	392	43,957
	10 20 30 40 50 60 MDSSAAPTNA SNCTDALAYS SCSPAPSPGS WVNLSHLDGN LSDPCGPNRT DLGGRDSLCP 70 80 90 100 110 120 PTGSPSMITA ITIMALYSIV CVVGLFGNFL VMYVIVRYTK MKTATNIYIF NLALADALAT 130 140 150 160 170 180 STLPFQSVNY LMGTWPFGTI LCKIVISIDY YNMFTSIFTL CTMSVDRYIA VCHPVKALDF 190 200 210 220 230 240 RTPRNAKIIN VCNWILSSAI GLPVMFMATT KYRQGSIDCT LTFSHPTWYW ENLLKICVFI 250 260 270 280 290 300 FAFIMPVLII TVCYGLMILR LKSVRMLSGS KEKDRNLRRI TRMVLVVVAV FIVCWTPIHI 310 320 330 340 350 360 YVIIKALVTI PETTFQTVSW HFCIALGYTN SCLNPVLYAF LDENFKRCFR EFCIPTSSNI 370 380 390 EQQNSTRIRQ NTRDHPSTAN TVDRTNHQVR SL
	Isoform 3 (MOR-1R) [UniParc]. Checksum: 42DC76968E6352A8	FASTA	446	49,520
	10 20 30 40 50 60 MDSSAAPTNA SNCTDALAYS SCSPAPSPGS WVNLSHLDGN LSDPCGPNRT DLGGRDSLCP 70 80 90 100 110 120 PTGSPSMITA ITIMALYSIV CVVGLFGNFL VMYVIVRYTK MKTATNIYIF NLALADALAT 130 140 150 160 170 180 STLPFQSVNY LMGTWPFGTI LCKIVISIDY YNMFTSIFTL CTMSVDRYIA VCHPVKALDF 190 200 210 220 230 240 RTPRNAKIIN VCNWILSSAI GLPVMFMATT KYRQGSIDCT LTFSHPTWYW ENLLKICVFI 250 260 270 280 290 300 FAFIMPVLII TVCYGLMILR LKSVRMLSGS KEKDRNLRRI TRMVLVVVAV FIVCWTPIHI 310 320 330 340 350 360 YVIIKALVTI PETTFQTVSW HFCIALGYTN SCLNPVLYAF LDENFKRCFR EFCIPTSSNI 370 380 390 400 410 420 EQQNSTRIRQ NTRDHPSTAN TVDRTNHQCL PIPSLSCWAL EQGCLVVYPG PLQGPLVRYD 430 440 LPAILHSSCL RGNTAPSPSG GAFLLS
	Isoform 4 (MOR-1B3) [UniParc]. Checksum: B3FFA10F7B1C5311	FASTA	403	44,928
	10 20 30 40 50 60 MDSSAAPTNA SNCTDALAYS SCSPAPSPGS WVNLSHLDGN LSDPCGPNRT DLGGRDSLCP 70 80 90 100 110 120 PTGSPSMITA ITIMALYSIV CVVGLFGNFL VMYVIVRYTK MKTATNIYIF NLALADALAT 130 140 150 160 170 180 STLPFQSVNY LMGTWPFGTI LCKIVISIDY YNMFTSIFTL CTMSVDRYIA VCHPVKALDF 190 200 210 220 230 240 RTPRNAKIIN VCNWILSSAI GLPVMFMATT KYRQGSIDCT LTFSHPTWYW ENLLKICVFI 250 260 270 280 290 300 FAFIMPVLII TVCYGLMILR LKSVRMLSGS KEKDRNLRRI TRMVLVVVAV FIVCWTPIHI 310 320 330 340 350 360 YVIIKALVTI PETTFQTVSW HFCIALGYTN SCLNPVLYAF LDENFKRCFR EFCIPTSSNI 370 380 390 400 EQQNSTRIRQ NTRDHPSTAN TVDRTNHQGP PAKFVADQLA GSS
	Isoform 5 (MOR-1C) [UniParc]. Checksum: 51B9E7B131122196	FASTA	418	47,032
	10 20 30 40 50 60 MDSSAAPTNA SNCTDALAYS SCSPAPSPGS WVNLSHLDGN LSDPCGPNRT DLGGRDSLCP 70 80 90 100 110 120 PTGSPSMITA ITIMALYSIV CVVGLFGNFL VMYVIVRYTK MKTATNIYIF NLALADALAT 130 140 150 160 170 180 STLPFQSVNY LMGTWPFGTI LCKIVISIDY YNMFTSIFTL CTMSVDRYIA VCHPVKALDF 190 200 210 220 230 240 RTPRNAKIIN VCNWILSSAI GLPVMFMATT KYRQGSIDCT LTFSHPTWYW ENLLKICVFI 250 260 270 280 290 300 FAFIMPVLII TVCYGLMILR LKSVRMLSGS KEKDRNLRRI TRMVLVVVAV FIVCWTPIHI 310 320 330 340 350 360 YVIIKALVTI PETTFQTVSW HFCIALGYTN SCLNPVLYAF LDENFKRCFR EFCIPTSSNI 370 380 390 400 410 EQQNSTRIRQ NTRDHPSTAN TVDRTNHQPP LAVSMAQIFT RYPPPTHREK TCNDYMKR
	Isoform 6 (MOR-1V) (MOR-1Y) [UniParc]. Checksum: 5BC8380AB8196D70	FASTA	402	45,096
	10 20 30 40 50 60 MDSSAAPTNA SNCTDALAYS SCSPAPSPGS WVNLSHLDGN LSDPCGPNRT DLGGRDSLCP 70 80 90 100 110 120 PTGSPSMITA ITIMALYSIV CVVGLFGNFL VMYVIVRYTK MKTATNIYIF NLALADALAT 130 140 150 160 170 180 STLPFQSVNY LMGTWPFGTI LCKIVISIDY YNMFTSIFTL CTMSVDRYIA VCHPVKALDF 190 200 210 220 230 240 RTPRNAKIIN VCNWILSSAI GLPVMFMATT KYRQGSIDCT LTFSHPTWYW ENLLKICVFI 250 260 270 280 290 300 FAFIMPVLII TVCYGLMILR LKSVRMLSGS KEKDRNLRRI TRMVLVVVAV FIVCWTPIHI 310 320 330 340 350 360 YVIIKALVTI PETTFQTVSW HFCIALGYTN SCLNPVLYAF LDENFKRCFR EFCIPTSSNI 370 380 390 400 EQQNSTRIRQ NTRDHPSTAN TVDRTNHQIR DPISNLPRVS VF
	Isoform 7 (MOR-1B1) [UniParc]. Checksum: 1A0330578A82B183	FASTA	406	45,544
	10 20 30 40 50 60 MDSSAAPTNA SNCTDALAYS SCSPAPSPGS WVNLSHLDGN LSDPCGPNRT DLGGRDSLCP 70 80 90 100 110 120 PTGSPSMITA ITIMALYSIV CVVGLFGNFL VMYVIVRYTK MKTATNIYIF NLALADALAT 130 140 150 160 170 180 STLPFQSVNY LMGTWPFGTI LCKIVISIDY YNMFTSIFTL CTMSVDRYIA VCHPVKALDF 190 200 210 220 230 240 RTPRNAKIIN VCNWILSSAI GLPVMFMATT KYRQGSIDCT LTFSHPTWYW ENLLKICVFI 250 260 270 280 290 300 FAFIMPVLII TVCYGLMILR LKSVRMLSGS KEKDRNLRRI TRMVLVVVAV FIVCWTPIHI 310 320 330 340 350 360 YVIIKALVTI PETTFQTVSW HFCIALGYTN SCLNPVLYAF LDENFKRCFR EFCIPTSSNI 370 380 390 400 EQQNSTRIRQ NTRDHPSTAN TVDRTNHQKI DLFQKSSLLN CEHTKG
	Isoform 8 (MOR-1B2) [UniParc]. Checksum: 3BC7E1C19B9739E3	FASTA	397	44,743
	10 20 30 40 50 60 MDSSAAPTNA SNCTDALAYS SCSPAPSPGS WVNLSHLDGN LSDPCGPNRT DLGGRDSLCP 70 80 90 100 110 120 PTGSPSMITA ITIMALYSIV CVVGLFGNFL VMYVIVRYTK MKTATNIYIF NLALADALAT 130 140 150 160 170 180 STLPFQSVNY LMGTWPFGTI LCKIVISIDY YNMFTSIFTL CTMSVDRYIA VCHPVKALDF 190 200 210 220 230 240 RTPRNAKIIN VCNWILSSAI GLPVMFMATT KYRQGSIDCT LTFSHPTWYW ENLLKICVFI 250 260 270 280 290 300 FAFIMPVLII TVCYGLMILR LKSVRMLSGS KEKDRNLRRI TRMVLVVVAV FIVCWTPIHI 310 320 330 340 350 360 YVIIKALVTI PETTFQTVSW HFCIALGYTN SCLNPVLYAF LDENFKRCFR EFCIPTSSNI 370 380 390 EQQNSTRIRQ NTRDHPSTAN TVDRTNHQRE RRQKSDW
	Isoform 9 (MOR-1B5) [UniParc]. Checksum: 63301322222198DE	FASTA	420	47,070
	10 20 30 40 50 60 MDSSAAPTNA SNCTDALAYS SCSPAPSPGS WVNLSHLDGN LSDPCGPNRT DLGGRDSLCP 70 80 90 100 110 120 PTGSPSMITA ITIMALYSIV CVVGLFGNFL VMYVIVRYTK MKTATNIYIF NLALADALAT 130 140 150 160 170 180 STLPFQSVNY LMGTWPFGTI LCKIVISIDY YNMFTSIFTL CTMSVDRYIA VCHPVKALDF 190 200 210 220 230 240 RTPRNAKIIN VCNWILSSAI GLPVMFMATT KYRQGSIDCT LTFSHPTWYW ENLLKICVFI 250 260 270 280 290 300 FAFIMPVLII TVCYGLMILR LKSVRMLSGS KEKDRNLRRI TRMVLVVVAV FIVCWTPIHI 310 320 330 340 350 360 YVIIKALVTI PETTFQTVSW HFCIALGYTN SCLNPVLYAF LDENFKRCFR EFCIPTSSNI 370 380 390 400 410 420 EQQNSTRIRQ NTRDHPSTAN TVDRTNHQVE LNLDCHCENA KPWPLSYNAG QSPFPFPGRV
	Isoform 10 (MOR-1H) [UniParc]. Checksum: 14A90F782A013067	FASTA	493	55,045
	10 20 30 40 50 60 MCLHRRVPSE ETYSLDRFAQ NPPLFPPPSL PASESRMAHA PLLQRCGAAR TGFCKKQQEL 70 80 90 100 110 120 WQRRKEAAEA LGTRKVSVLL ATSHSGARPA VSTMDSSAAP TNASNCTDAL AYSSCSPAPS 130 140 150 160 170 180 PGSWVNLSHL DGNLSDPCGP NRTDLGGRDS LCPPTGSPSM ITAITIMALY SIVCVVGLFG 190 200 210 220 230 240 NFLVMYVIVR YTKMKTATNI YIFNLALADA LATSTLPFQS VNYLMGTWPF GTILCKIVIS 250 260 270 280 290 300 IDYYNMFTSI FTLCTMSVDR YIAVCHPVKA LDFRTPRNAK IINVCNWILS SAIGLPVMFM 310 320 330 340 350 360 ATTKYRQGSI DCTLTFSHPT WYWENLLKIC VFIFAFIMPV LIITVCYGLM ILRLKSVRML 370 380 390 400 410 420 SGSKEKDRNL RRITRMVLVV VAVFIVCWTP IHIYVIIKAL VTIPETTFQT VSWHFCIALG 430 440 450 460 470 480 YTNSCLNPVL YAFLDENFKR CFREFCIPTS SNIEQQNSTR IRQNTRDHPS TANTVDRTNH 490 QLENLEAETA PLP
	Isoform 11 (MOR-1B4) [UniParc]. Checksum: 7E806AFCBE572CD5	FASTA	389	43,588
	10 20 30 40 50 60 MDSSAAPTNA SNCTDALAYS SCSPAPSPGS WVNLSHLDGN LSDPCGPNRT DLGGRDSLCP 70 80 90 100 110 120 PTGSPSMITA ITIMALYSIV CVVGLFGNFL VMYVIVRYTK MKTATNIYIF NLALADALAT 130 140 150 160 170 180 STLPFQSVNY LMGTWPFGTI LCKIVISIDY YNMFTSIFTL CTMSVDRYIA VCHPVKALDF 190 200 210 220 230 240 RTPRNAKIIN VCNWILSSAI GLPVMFMATT KYRQGSIDCT LTFSHPTWYW ENLLKICVFI 250 260 270 280 290 300 FAFIMPVLII TVCYGLMILR LKSVRMLSGS KEKDRNLRRI TRMVLVVVAV FIVCWTPIHI 310 320 330 340 350 360 YVIIKALVTI PETTFQTVSW HFCIALGYTN SCLNPVLYAF LDENFKRCFR EFCIPTSSNI 370 380 EQQNSTRIRQ NTRDHPSTAN TVDRTNHQS

References

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[1]	"Human mu opiate receptor. cDNA and genomic clones, pharmacologic characterization and chromosomal assignment." Wang J.-B., Johnson P.S., Persico A.M., Hawkins A.L., Griffin C.A., Uhl G.R. FEBS Lett. 338:217-222(1994) [PubMed: 7905839] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain.
[2]	"Expression of two variants of the human mu opioid receptor mRNA in SK-N-SH cells and human brain." Bare L.A., Mansson E., Yang D. FEBS Lett. 354:213-216(1994) [PubMed: 7957926] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT ASP-40. Tissue: Brain.
[3]	"The human mu opioid receptor: modulation of functional desensitization by calcium/calmodulin-dependent protein kinase and protein kinase C." Mestek A. Jr., Hurley J.H., Bye L.S., Campbell A.D., Chen Y., Tian M., Liu J., Schulman H., Yu L. J. Neurosci. 15:2396-2406(1995) [PubMed: 7891175] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain.
[4]	"Identification and characterization of two new human mu opioid receptor splice variants, hMOR-1O and hMOR-1X." Pan Y.X., Xu J., Mahurter L., Xu M., Gilbert A.K., Pasternak G.W. Biochem. Biophys. Res. Commun. 301:1057-1061(2003) [PubMed: 12589820] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 5).
[5]	"Identification and characterization of six new alternatively spliced variants of the human mu opioid receptor gene, Oprm." Pan L., Xu J., Yu R., Xu M.-M., Pan Y.-X., Pasternak G.W. Neuroscience 133:209-220(2005) [PubMed: 15893644] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 4; 6; 7; 8; 9 AND 11).
[6]	"Isolation and characterization of new exon 11-associated N-terminal splice variants of the human mu opioid receptor gene." Xu J., Xu M., Hurd Y.L., Pasternak G.W., Pan Y.X. J. Neurochem. 108:962-972(2009) [PubMed: 19077058] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 10).
[7]	"Novel variants of the human mu opioid receptor are generated by alternative splicing and transcription from different positions in the OPRM1 gene." Baar C., Kvam T.-M., Rakvag T.T., Kaasa S., Skorpen F. Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6). Tissue: Brain.
[8]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[9]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Kopatz S.A., Aronstam R.S., Sharma S.V. Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[10]	NIEHS SNPs program Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-6; ASP-40; CYS-147; ASP-152; CYS-265 AND ASN-274.
[11]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[12]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[13]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[14]	"An homozygous Ala 6 Val (GCC->GTC) mutation was detected on human mu opioid receptor gene of an African American individual with sickle cell anemia." Metha S., Glendenning M., Kutlar A., Kutlar F. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-20, VARIANT VAL-6. Tissue: Blood.
[15]	"The mu opiate receptor as a candidate gene for pain: polymorphisms, variations in expression, nociception, and opiate responses." Uhl G.R., Sora I., Wang Z. Proc. Natl. Acad. Sci. U.S.A. 96:7752-7755(1999) [PubMed: 10393893] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-47.
[16]	"Mu opioid receptor gene expression in immune cells." Chuang T.K., Killam K.F. Jr., Chuang L.F., Kung H.F., Sheng W.S., Chao C.C., Yu L., Chuang R.Y. Biochem. Biophys. Res. Commun. 216:922-930(1995) [PubMed: 7488213] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 229-374.
[17]	"A member of the heat shock protein 40 family, hlj1, binds to the carboxyl tail of the human mu opioid receptor." Ancevska-Taneva N., Onoprishvili I., Andria M.L., Hiller J.M., Simon E.J. Brain Res. 1081:28-33(2006) [PubMed: 16542645] [Abstract] Cited for: INTERACTION WITH DNAJB4.
[18]	"Mu opioid receptor gene variants: lack of association with alcohol dependence." Bergen A.W., Kokoszka J., Peterson R., Long J.C., Virkkunen M., Linnoila M., Goldman D. Mol. Psychiatry 2:490-494(1997) [PubMed: 9399694] [Abstract] Cited for: VARIANTS VAL-6; ASP-40 AND CYS-147.
[19]	"Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction." Bond C., LaForge K.S., Tian M., Melia D., Zhang S., Borg L., Gong J., Schluger J., Strong J.A., Leal S.M., Tischfield J.A., Kreek M.J., Yu L. Proc. Natl. Acad. Sci. U.S.A. 95:9608-9613(1998) [PubMed: 9689128] [Abstract] Cited for: VARIANTS VAL-6; ASP-40 AND HIS-260.
+	Additional computationally mapped references.

Web resources

Wikipedia

Mu opioid receptor entry

NIEHS-SNPs

Cross-references

Sequence databases
EMBL GenBank DDBJ	L25119 mRNA. Translation: AAA20580.1. U12569 mRNA. Translation: AAB60354.1. L29301 mRNA. Translation: AAA73958.1. AY036622 mRNA. Translation: AAK74189.1. AY036623 mRNA. Translation: AAK74190.1. AY225404 mRNA. Translation: AAP44727.1. AY309001 mRNA. Translation: AAQ77385.1. AY309005 mRNA. Translation: AAQ77389.1. AY309006 mRNA. Translation: AAQ77390.1. AY309007 mRNA. Translation: AAQ77391.1. AY309008 mRNA. Translation: AAQ77392.1. AY309009 mRNA. Translation: AAQ77393.1. EU340241 mRNA. Translation: ACA49726.1. AY364230 mRNA. Translation: AAR12887.1. AK313901 mRNA. Translation: BAG36624.1. AY521028 mRNA. Translation: AAS00462.1. AY587764 Genomic DNA. Translation: AAS83107.1. AL132774, AL136444 Genomic DNA. Translation: CAI20458.1. Different initiation. CH471051 Genomic DNA. Translation: EAW47705.1. Different initiation. BC074927 mRNA. Translation: AAH74927.1. AY292290 Genomic DNA. Translation: AAP44409.1. AY292291 Genomic DNA. Translation: AAP44410.1. AF153500 Genomic DNA. Translation: AAD44318.1.
IPI	IPI00217416. IPI00514084. IPI00922493. IPI00922515. IPI00922551. IPI00922644. IPI00922913. IPI00942295. IPI00943201. IPI00967650. IPI00975883.
PIR	I56553. S65693.
RefSeq	NP_000905.3. NM_000914.3. NP_001008503.2. NM_001008503.1. NP_001008504.2. NM_001008504.2. NP_001008505.2. NM_001008505.1. NP_001138751.1. NM_001145279.2. NP_001138754.1. NM_001145282.1. NP_001138755.1. NM_001145283.1. NP_001138756.1. NM_001145284.2. NP_001138757.1. NM_001145285.1. NP_001138758.1. NM_001145286.1. NP_001138759.1. NM_001145287.1.
UniGene	Hs.2353.
3D structure databases
ProteinModelPortal	P35372.
SMR	P35372. Positions 71-355.
DisProt	DP00272.
ModBase	Search...
Protein-protein interaction databases
IntAct	P35372. 1 interaction.
STRING	P35372.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P35372.
Polymorphism databases
DMDM	2851402.
Proteomic databases
PRIDE	P35372.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000330432; ENSP00000328264; ENSG00000112038. ENST00000434900; ENSP00000394624; ENSG00000112038.
GeneID	4988.
KEGG	hsa:4988.
UCSC	uc003qpr.1. human.
Organism-specific databases
CTD	4988.
GeneCards	GC06P154391.
H-InvDB	HIX0032850.
HGNC	HGNC:8156. OPRM1.
HPA	HPA014509.
MIM	600018. gene.
neXtProt	NX_P35372.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG106919.
InParanoid	P35372.
OMA	DRTNHQC.
OrthoDB	EOG4KD6MF.
Enzyme and pathway databases
Pathway_Interaction_DB	il4_2pathway. IL4-mediated signaling events.
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	P35372.
Bgee	P35372.
CleanEx	HS_OPRM1.
Genevestigator	P35372.
GermOnline	ENSG00000112038. Homo sapiens.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR000105. Mu_opioid_rcpt. IPR001418. Opioid_rcpt. [Graphical view]
KO	K04215.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00537. MUOPIOIDR. PR00384. OPIOIDR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
DrugBank	DB00802. Alfentanil. DB00913. Anileridine. DB00921. Buprenorphine. DB00611. Butorphanol. DB00318. Codeine. DB01209. Dezocine. DB01081. Diphenoxylate. DB00813. Fentanyl. DB00956. Hydrocodone. DB00327. Hydromorphone. DB00504. Levallorphan. DB01227. Levomethadyl Acetate. DB00854. Levorphanol. DB00836. Loperamide. DB00333. Methadone. DB01433. Methadyl Acetate. DB00295. Morphine. DB00844. Nalbuphine. DB01183. Naloxone. DB00704. Naltrexone. DB00497. Oxycodone. DB01192. Oxymorphone. DB00652. Pentazocine. DB00647. Propoxyphene. DB00899. Remifentanil. DB00708. Sufentanil. DB00193. Tramadol.
NextBio	19206.
SOURCE	Search...

Entry information

Entry name

OPRM_HUMAN

Accession

Primary (citable) accession number: P35372
Secondary accession number(s): B2R9S7 , B8Q1L7, Q12930, Q4VWM1, Q4VWM2, Q4VWM3, Q4VWM4, Q4VWM6, Q4VWX6, Q5TDA1, Q6UQ80, Q7Z2D8, Q8IWW3, Q8IWW4, Q9UCZ4, Q9UN57

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	July 15, 1998
Last modified:	January 25, 2012
This is version 119 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.