Nociceptin receptor - Rattus norvegicus (Rat)

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P35370 (OPRX_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 98. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Nociceptin receptor

Alternative name(s):
Kappa-type 3 opioid receptor
Short name=KOR-3
Orphanin FQ receptor
ROR-C
XOR1

Gene names

Name:	Oprl1
Synonyms:	Oor, Oprl

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	367 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for the neuropeptide nociceptin/orphanin FQ. Has a potential role in modulating a number of brain functions, including instinctive behaviors and emotions. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Highly expressed in several brain areas.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	elevation of cytosolic calcium ion concentration Inferred from electronic annotation. Source: Compara opioid receptor signaling pathway Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	nociceptin receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 367

367

Nociceptin receptor

PRO_0000069983

Regions

Topological domain

1 – 47

Extracellular Potential

Transmembrane

48 – 74

Helical; Name=1; Potential

Topological domain

75 – 84

Cytoplasmic Potential

Transmembrane

85 – 106

Helical; Name=2; Potential

Topological domain

107 – 121

Extracellular Potential

Transmembrane

122 – 143

Helical; Name=3; Potential

Topological domain

144 – 162

Cytoplasmic Potential

Transmembrane

163 – 185

Helical; Name=4; Potential

Topological domain

186 – 208

Extracellular Potential

Transmembrane

209 – 233

Helical; Name=5; Potential

Topological domain

234 – 261

Cytoplasmic Potential

Transmembrane

262 – 285

Helical; Name=6; Potential

Topological domain

286 – 297

Extracellular Potential

Transmembrane

298 – 319

Helical; Name=7; Potential

Topological domain

320 – 367

Cytoplasmic Potential

Amino acid modifications

Lipidation

331

S-palmitoyl cysteine Potential

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

N-linked (GlcNAc...) Potential

Disulfide bond

120 ↔ 197

By similarity

Experimental info

Sequence conflict

105

G → R in AAA16201. Ref.2

Sequence conflict

226

L → V in AAA16201. Ref.2

Sequence conflict

246

S → P in AAA16201. Ref.2

Sequence conflict

348

S → T Ref.3

Sequences

Sequence

Length

Mass (Da)

Tools

P35370 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: EB2637582747B4AD
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FASTA

367

40,523

        10         20         30         40         50         60 
MESLFPAPYW EVLYGSHFQG NLSLLNETVP HHLLLNASHS AFLPLGLKVT IVGLYLAVCI 

        70         80         90        100        110        120 
GGLLGNCLVM YVILRHTKMK TATNIYIFNL ALADTLVLLT LPFQGTDILL GFWPFGNALC 

       130        140        150        160        170        180 
KTVIAIDYYN MFTSTFTLTA MSVDRYVAIC HPIRALDVRT SSKAQAVNVA IWALASVVGV 

       190        200        210        220        230        240 
PVAIMGSAQV EDEEIECLVE IPAPQDYWGP VFAICIFLFS FIIPVLIISV CYSLMIRRLR 

       250        260        270        280        290        300 
GVRLLSGSRE KDRNLRRITR LVLVVVAVFV GCWTPVQVFV LVQGLGVQPG SETAVAILRF 

       310        320        330        340        350        360 
CTALGYVNSC LNPILYAFLD ENFKACFRKF CCASSLHREM QVSDRVRSIA KDVGLGCKTS 


ETVPRPA

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References

[1]	"cDNA cloning and regional distribution of a novel member of the opioid receptor family." Fukuda K., Kato S., Mori K., Nishi M., Takeshima H., Iwabe N., Miyata T., Houtani T., Sugimoto T. FEBS Lett. 343:42-46(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Wistar. Tissue: Brain.
[2]	Meng F., Xie G., Alfred M., Thompson R., Hoversten M., Watson S., Akil H. Submitted (JAN-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Hippocampus.
[3]	"Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a mu, delta or kappa opioid receptor type." Bunzow J.R., Saez C., Mortrud M., Bouvier C., Williams J.T., Low M., Grandy D.K. FEBS Lett. 347:284-288(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Brain.
[4]	"Molecular cloning, tissue distribution and chromosomal localization of a novel member of the opioid receptor gene family." Chen Y., Fan Y., Liu J., Mestek A., Tian M., Kozak C.A., Yu L. FEBS Lett. 347:279-283(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]	"Molecular cloning of a novel G protein-coupled receptor related to the opiate receptor family." Lachowicz J.E., Shen Y., Monsma F.J. Jr., Sibley D.R. J. Neurochem. 64:34-40(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[6]	"cDNA cloning of an orphan opiate receptor gene family member and its splice variant." Wang J.B., Johnson P.S., Imai Y., Persico A.M., Ozenberger B.A., Eppler C.M., Uhl G.R. FEBS Lett. 348:75-79(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[7]	"Isolation of a novel cDNA encoding a putative membrane receptor with high homology to the cloned mu, delta, and kappa opioid receptors." Wick M.J., Minnerath S.R., Lin X., Elde R.P., Law P.Y., Loh H.H. Brain Res. Mol. Brain Res. 27:37-44(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Brain.
[8]	"Molecular cloning of the orphanin FQ receptor gene and differential tissue expression of splice variants in rat." Curro D., Song I., Anderson M., Yoo J.H., Del Valle J., Owyang C. Gene 266:139-145(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[9]	"Modulation of Ca2+ channels by opioid receptor-like 1 receptors natively expressed in rat stellate ganglion neurons innervating cardiac muscle." Ruiz-Velasco V., Puhl H.L., Fuller B.C., Sumner A.D. J. Pharmacol. Exp. Ther. 314:987-994(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Wistar.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D16438 mRNA. Translation: BAA03908.1. U05239 mRNA. Translation: AAA16201.1. U01913 mRNA. Translation: AAA21025.1. L28144 mRNA. Translation: AAC37661.1. U07871 mRNA. Translation: AAA69927.1. L33916 mRNA. Translation: AAA50827.1. L29419 mRNA. Translation: AAC42041.1. AF216218 Genomic DNA. Translation: AAF80990.1. AY152731 mRNA. Translation: AAN77720.1.
IPI	IPI00197685.
PIR	I56520.
RefSeq	NP_113757.1. NM_031569.3.
UniGene	Rn.9762.
3D structure databases
ProteinModelPortal	P35370.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P35370.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000045845; ENSRNOP00000047053; ENSRNOG00000016768.
GeneID	29256.
KEGG	rno:29256.
UCSC	RGD:68438. rat.
Organism-specific databases
CTD	4987.
RGD	68438. Oprl1.
Phylogenomic databases
eggNOG	NOG299442.
GeneTree	ENSGT00630000089574.
HOGENOM	HOG000230486.
HOVERGEN	HBG106919.
InParanoid	P35370.
KO	K04216.
OMA	VFAICIF.
Gene expression databases
ArrayExpress	P35370.
Genevestigator	P35370.
GermOnline	ENSRNOG00000016768. Rattus norvegicus.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR001418. Opioid_rcpt. IPR001420. X_opioid_rcpt. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00384. OPIOIDR. PR00547. XOPIOIDR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P35370.
ChEMBL	CHEMBL4503.
NextBio	608564.

Entry information

Entry name

OPRX_RAT

Accession

Primary (citable) accession number: P35370
Secondary accession number(s): Q791R4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	April 3, 2013
This is version 98 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein family/group databases

PTM databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents