Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P35368

- ADA1B_HUMAN

UniProt

P35368 - ADA1B_HUMAN

Protein

Alpha-1B adrenergic receptor

Gene

ADRA1B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 3 (17 Oct 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.2 Publications

    GO - Molecular functioni

    1. alpha1-adrenergic receptor activity Source: ProtInc
    2. protein heterodimerization activity Source: UniProtKB

    GO - Biological processi

    1. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: ProtInc
    2. adrenergic receptor signaling pathway Source: GOC
    3. adult heart development Source: Ensembl
    4. behavioral response to cocaine Source: Ensembl
    5. blood vessel remodeling Source: Ensembl
    6. cell-cell signaling Source: ProtInc
    7. cell growth Source: Ensembl
    8. cell proliferation Source: ProtInc
    9. glucose homeostasis Source: Ensembl
    10. G-protein coupled receptor signaling pathway Source: ProtInc
    11. intracellular signal transduction Source: ProtInc
    12. locomotory behavior Source: Ensembl
    13. multicellular organismal development Source: ProtInc
    14. negative regulation of glycogen catabolic process Source: Ensembl
    15. organ growth Source: Ensembl
    16. positive regulation of glycogen catabolic process Source: Ensembl
    17. positive regulation of heart rate by epinephrine-norepinephrine Source: Ensembl
    18. positive regulation of MAPK cascade Source: UniProtKB
    19. positive regulation of the force of heart contraction by epinephrine-norepinephrine Source: Ensembl
    20. regulation of cardiac muscle contraction Source: InterPro
    21. regulation of vasoconstriction Source: InterPro
    22. response to amphetamine Source: Ensembl
    23. response to morphine Source: Ensembl
    24. vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure Source: Ensembl
    25. visual learning Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_16927. Adrenoceptors.
    REACT_18283. G alpha (q) signalling events.
    REACT_18407. G alpha (12/13) signalling events.
    SignaLinkiP35368.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-1B adrenergic receptor
    Alternative name(s):
    Alpha-1B adrenoreceptor
    Short name:
    Alpha-1B adrenoceptor
    Gene namesi
    Name:ADRA1B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:278. ADRA1B.

    Subcellular locationi

    Nucleus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein
    Note: Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes.

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. nuclear membrane Source: UniProtKB
    3. nucleus Source: UniProtKB
    4. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi368 – 38013RGRGR…RRRRR → AGAGAAAAAAAAA: Abolishes targeting to the nuclear membrane of cardiac myocytes. 1 PublicationAdd
    BLAST

    Organism-specific databases

    PharmGKBiPA33.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 520520Alpha-1B adrenergic receptorPRO_0000069069Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi24 – 241N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi29 – 291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi34 – 341N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi118 ↔ 195PROSITE-ProRule annotation
    Lipidationi365 – 3651S-palmitoyl cysteineSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    MaxQBiP35368.
    PaxDbiP35368.
    PRIDEiP35368.

    PTM databases

    PhosphoSiteiP35368.

    Expressioni

    Gene expression databases

    BgeeiP35368.
    CleanExiHS_ADRA1B.
    GenevestigatoriP35368.

    Interactioni

    Subunit structurei

    Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes.1 Publication

    Protein-protein interaction databases

    BioGridi106657. 2 interactions.
    DIPiDIP-33399N.
    IntActiP35368. 4 interactions.
    MINTiMINT-120889.
    STRINGi9606.ENSP00000306662.

    Structurei

    3D structure databases

    ProteinModelPortaliP35368.
    SMRiP35368. Positions 48-364.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4545ExtracellularBy similarityAdd
    BLAST
    Topological domaini71 – 8313CytoplasmicBy similarityAdd
    BLAST
    Topological domaini106 – 11510ExtracellularBy similarity
    Topological domaini142 – 16120CytoplasmicBy similarityAdd
    BLAST
    Topological domaini185 – 20117ExtracellularBy similarityAdd
    BLAST
    Topological domaini225 – 29571CytoplasmicBy similarityAdd
    BLAST
    Topological domaini320 – 3267ExtracellularBy similarity
    Topological domaini352 – 520169CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei46 – 7025Helical; Name=1By similarityAdd
    BLAST
    Transmembranei84 – 10522Helical; Name=2By similarityAdd
    BLAST
    Transmembranei116 – 14126Helical; Name=3By similarityAdd
    BLAST
    Transmembranei162 – 18423Helical; Name=4By similarityAdd
    BLAST
    Transmembranei202 – 22423Helical; Name=5By similarityAdd
    BLAST
    Transmembranei296 – 31924Helical; Name=6By similarityAdd
    BLAST
    Transmembranei327 – 35125Helical; Name=7By similarityAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni368 – 38013Nuclear localization signalAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi370 – 38011Poly-ArgAdd
    BLAST

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1B sub-subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG253615.
    HOGENOMiHOG000239244.
    HOVERGENiHBG106962.
    InParanoidiP35368.
    KOiK04136.
    OMAiTYRPWTR.
    OrthoDBiEOG7H4DTB.
    PhylomeDBiP35368.
    TreeFamiTF331895.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR002233. ADR_fam.
    IPR001115. ADRA1B_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24248:SF17. PTHR24248:SF17. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR01103. ADRENERGICR.
    PR00556. ADRENRGCA1BR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P35368-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNPDLDTGHN TSAPAHWGEL KNANFTGPNQ TSSNSTLPQL DITRAISVGL    50
    VLGAFILFAI VGNILVILSV ACNRHLRTPT NYFIVNLAMA DLLLSFTVLP 100
    FSAALEVLGY WVLGRIFCDI WAAVDVLCCT ASILSLCAIS IDRYIGVRYS 150
    LQYPTLVTRR KAILALLSVW VLSTVISIGP LLGWKEPAPN DDKECGVTEE 200
    PFYALFSSLG SFYIPLAVIL VMYCRVYIVA KRTTKNLEAG VMKEMSNSKE 250
    LTLRIHSKNF HEDTLSSTKA KGHNPRSSIA VKLFKFSREK KAAKTLGIVV 300
    GMFILCWLPF FIALPLGSLF STLKPPDAVF KVVFWLGYFN SCLNPIIYPC 350
    SSKEFKRAFV RILGCQCRGR GRRRRRRRRR LGGCAYTYRP WTRGGSLERS 400
    QSRKDSLDDS GSCLSGSQRT LPSASPSPGY LGRGAPPPVE LCAFPEWKAP 450
    GALLSLPAPE PPGRRGRHDS GPLFTFKLLT EPESPGTDGG ASNGGCEAAA 500
    DVANGQPGFK SNMPLAPGQF 520
    Length:520
    Mass (Da):56,836
    Last modified:October 17, 2006 - v3
    Checksum:iF081A23D2F943F7F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti371 – 3711Missing(PubMed:1328250)Curated
    Sequence conflicti371 – 3711Missing in AAB59485. (PubMed:7815325)Curated
    Sequence conflicti498 – 5014AAAD → PRH(PubMed:1328250)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti51 – 511V → G.
    Corresponds to variant rs8192448 [ dbSNP | Ensembl ].
    VAR_019510

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M99589 Genomic DNA. No translation available.
    M99590 Genomic DNA. No translation available.
    U03865 mRNA. Translation: AAB60352.1.
    L31773 mRNA. Translation: AAB59485.1.
    EU332831 Genomic DNA. Translation: ABY87520.1.
    BC136568 mRNA. Translation: AAI36569.1.
    BC136569 mRNA. Translation: AAI36570.1.
    CCDSiCCDS4347.1.
    PIRiA45121.
    RefSeqiNP_000670.1. NM_000679.3.
    UniGeneiHs.368632.

    Genome annotation databases

    EnsembliENST00000306675; ENSP00000306662; ENSG00000170214.
    GeneIDi147.
    KEGGihsa:147.
    UCSCiuc003lxt.1. human.

    Polymorphism databases

    DMDMi116241241.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M99589 Genomic DNA. No translation available.
    M99590 Genomic DNA. No translation available.
    U03865 mRNA. Translation: AAB60352.1 .
    L31773 mRNA. Translation: AAB59485.1 .
    EU332831 Genomic DNA. Translation: ABY87520.1 .
    BC136568 mRNA. Translation: AAI36569.1 .
    BC136569 mRNA. Translation: AAI36570.1 .
    CCDSi CCDS4347.1.
    PIRi A45121.
    RefSeqi NP_000670.1. NM_000679.3.
    UniGenei Hs.368632.

    3D structure databases

    ProteinModelPortali P35368.
    SMRi P35368. Positions 48-364.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106657. 2 interactions.
    DIPi DIP-33399N.
    IntActi P35368. 4 interactions.
    MINTi MINT-120889.
    STRINGi 9606.ENSP00000306662.

    Chemistry

    BindingDBi P35368.
    ChEMBLi CHEMBL232.
    DrugBanki DB00346. Alfuzosin.
    DB00217. Bethanidine.
    DB00298. Dapiprazole.
    DB04840. Debrisoquin.
    DB01576. Dextroamphetamine.
    DB00590. Doxazosin.
    DB00226. Guanadrel Sulfate.
    DB01170. Guanethidine.
    DB01018. Guanfacine.
    DB00598. Labetalol.
    DB01255. Lisdexamfetamine.
    DB01577. Methamphetamine.
    DB01403. Methotrimeprazine.
    DB00723. Methoxamine.
    DB00211. Midodrine.
    DB00745. Modafinil.
    DB01149. Nefazodone.
    DB00368. Norepinephrine.
    DB00334. Olanzapine.
    DB01579. Phendimetrazine.
    DB00388. Phenylephrine.
    DB00457. Prazosin.
    DB00420. Promazine.
    DB01608. Propericiazine.
    DB00777. Propiomazine.
    DB01224. Quetiapine.
    DB00734. Risperidone.
    DB06144. Sertindole.
    DB00706. Tamsulosin.
    DB01162. Terazosin.
    DB00656. Trazodone.
    GuidetoPHARMACOLOGYi 23.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P35368.

    Polymorphism databases

    DMDMi 116241241.

    Proteomic databases

    MaxQBi P35368.
    PaxDbi P35368.
    PRIDEi P35368.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000306675 ; ENSP00000306662 ; ENSG00000170214 .
    GeneIDi 147.
    KEGGi hsa:147.
    UCSCi uc003lxt.1. human.

    Organism-specific databases

    CTDi 147.
    GeneCardsi GC05P159276.
    HGNCi HGNC:278. ADRA1B.
    MIMi 104220. gene.
    neXtProti NX_P35368.
    PharmGKBi PA33.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG253615.
    HOGENOMi HOG000239244.
    HOVERGENi HBG106962.
    InParanoidi P35368.
    KOi K04136.
    OMAi TYRPWTR.
    OrthoDBi EOG7H4DTB.
    PhylomeDBi P35368.
    TreeFami TF331895.

    Enzyme and pathway databases

    Reactomei REACT_16927. Adrenoceptors.
    REACT_18283. G alpha (q) signalling events.
    REACT_18407. G alpha (12/13) signalling events.
    SignaLinki P35368.

    Miscellaneous databases

    GeneWikii Alpha-1B_adrenergic_receptor.
    GenomeRNAii 147.
    NextBioi 581.
    PROi P35368.
    SOURCEi Search...

    Gene expression databases

    Bgeei P35368.
    CleanExi HS_ADRA1B.
    Genevestigatori P35368.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR002233. ADR_fam.
    IPR001115. ADRA1B_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24248:SF17. PTHR24248:SF17. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01103. ADRENERGICR.
    PR00556. ADRENRGCA1BR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic organization and expression of the human alpha 1B-adrenergic receptor."
      Ramarao C.S., Denker J.M., Perez D.M., Gaivin R.J., Riek R.P., Graham R.M.
      J. Biol. Chem. 267:21936-21945(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype."
      Forray C., Bard J.A., Wetzel J.M., Chiu G., Shapiro E., Tang R., Lepor H., Hartig P.R., Weinshank R.L., Branchek T.A., Gluchowski C.
      Mol. Pharmacol. 45:703-708(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    3. "Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues."
      Schwinn D.A., Johnston G.I., Page S.O., Mosley M.J., Wilson K.H., Worman N.P., Campbell S., Fidock M.D., Furness L.M., Parry-Smith D.J., Peter B., Bailey D.S.
      J. Pharmacol. Exp. Ther. 272:134-142(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. NIEHS SNPs program
      Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "Nuclear alpha1-adrenergic receptors signal activated ERK localization to caveolae in adult cardiac myocytes."
      Wright C.D., Chen Q., Baye N.L., Huang Y., Healy C.L., Kasinathan S., O'Connell T.D.
      Circ. Res. 103:992-1000(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, FUNCTION.
    7. "Nuclear localization drives alpha1-adrenergic receptor oligomerization and signaling in cardiac myocytes."
      Wright C.D., Wu S.C., Dahl E.F., Sazama A.J., O'Connell T.D.
      Cell. Signal. 24:794-802(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, SUBUNIT, FUNCTION, MUTAGENESIS OF 368-ARG--ARG-380.

    Entry informationi

    Entry nameiADA1B_HUMAN
    AccessioniPrimary (citable) accession number: P35368
    Secondary accession number(s): B0LPE1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 130 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3