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Protein

Alpha-1B adrenergic receptor

Gene

ADRA1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.2 Publications

GO - Molecular functioni

  • alpha1-adrenergic receptor activity Source: ProtInc
  • protein heterodimerization activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170214-MONOMER.
ReactomeiR-HSA-390696. Adrenoceptors.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-416482. G alpha (12/13) signalling events.
SignaLinkiP35368.
SIGNORiP35368.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1B adrenergic receptor
Alternative name(s):
Alpha-1B adrenoreceptor
Short name:
Alpha-1B adrenoceptor
Gene namesi
Name:ADRA1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:278. ADRA1B.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 45ExtracellularBy similarityAdd BLAST45
Transmembranei46 – 70Helical; Name=1By similarityAdd BLAST25
Topological domaini71 – 83CytoplasmicBy similarityAdd BLAST13
Transmembranei84 – 105Helical; Name=2By similarityAdd BLAST22
Topological domaini106 – 115ExtracellularBy similarity10
Transmembranei116 – 141Helical; Name=3By similarityAdd BLAST26
Topological domaini142 – 161CytoplasmicBy similarityAdd BLAST20
Transmembranei162 – 184Helical; Name=4By similarityAdd BLAST23
Topological domaini185 – 201ExtracellularBy similarityAdd BLAST17
Transmembranei202 – 224Helical; Name=5By similarityAdd BLAST23
Topological domaini225 – 295CytoplasmicBy similarityAdd BLAST71
Transmembranei296 – 319Helical; Name=6By similarityAdd BLAST24
Topological domaini320 – 326ExtracellularBy similarity7
Transmembranei327 – 351Helical; Name=7By similarityAdd BLAST25
Topological domaini352 – 520CytoplasmicBy similarityAdd BLAST169

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • nuclear membrane Source: UniProtKB
  • nucleus Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi368 – 380RGRGR…RRRRR → AGAGAAAAAAAAA: Abolishes targeting to the nuclear membrane of cardiac myocytes. 1 PublicationAdd BLAST13

Organism-specific databases

DisGeNETi147.
OpenTargetsiENSG00000170214.
PharmGKBiPA33.

Chemistry databases

ChEMBLiCHEMBL232.
DrugBankiDB01614. Acepromazine.
DB00346. Alfuzosin.
DB00321. Amitriptyline.
DB00543. Amoxapine.
DB00182. Amphetamine.
DB01238. Aripiprazole.
DB09128. Brexpiprazole.
DB01200. Bromocriptine.
DB00248. Cabergoline.
DB01136. Carvedilol.
DB00477. Chlorpromazine.
DB00575. Clonidine.
DB00363. Clozapine.
DB00298. Dapiprazole.
DB01151. Desipramine.
DB01576. Dextroamphetamine.
DB00590. Doxazosin.
DB01142. Doxepin.
DB04855. Dronedarone.
DB06262. Droxidopa.
DB00668. Epinephrine.
DB01049. Ergoloid mesylate.
DB00696. Ergotamine.
DB00800. Fenoldopam.
DB00458. Imipramine.
DB00598. Labetalol.
DB01255. Lisdexamfetamine.
DB00408. Loxapine.
DB00934. Maprotiline.
DB01365. Mephentermine.
DB01403. Methotrimeprazine.
DB00723. Methoxamine.
DB06148. Mianserin.
DB00211. Midodrine.
DB00370. Mirtazapine.
DB00745. Modafinil.
DB01149. Nefazodone.
DB00622. Nicardipine.
DB00368. Norepinephrine.
DB00540. Nortriptyline.
DB00334. Olanzapine.
DB00935. Oxymetazoline.
DB01267. Paliperidone.
DB01186. Pergolide.
DB01579. Phendimetrazine.
DB00925. Phenoxybenzamine.
DB00388. Phenylephrine.
DB00457. Prazosin.
DB00420. Promazine.
DB01608. Propericiazine.
DB00777. Propiomazine.
DB01224. Quetiapine.
DB00734. Risperidone.
DB06144. Sertindole.
DB06207. Silodosin.
DB00706. Tamsulosin.
DB01162. Terazosin.
DB01622. Thioproperazine.
DB00679. Thioridazine.
DB00726. Trimipramine.
DB06694. Xylometazoline.
DB00246. Ziprasidone.
GuidetoPHARMACOLOGYi23.

Polymorphism and mutation databases

BioMutaiADRA1B.
DMDMi116241241.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000690691 – 520Alpha-1B adrenergic receptorAdd BLAST520

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi10N-linked (GlcNAc...)Sequence analysis1
Glycosylationi24N-linked (GlcNAc...)Sequence analysis1
Glycosylationi29N-linked (GlcNAc...)Sequence analysis1
Glycosylationi34N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi118 ↔ 195PROSITE-ProRule annotation
Modified residuei264PhosphothreonineBy similarity1
Lipidationi365S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiP35368.
PaxDbiP35368.
PeptideAtlasiP35368.
PRIDEiP35368.

PTM databases

iPTMnetiP35368.
PhosphoSitePlusiP35368.

Expressioni

Gene expression databases

BgeeiENSG00000170214.
CleanExiHS_ADRA1B.
GenevisibleiP35368. HS.

Interactioni

Subunit structurei

Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes.1 Publication

GO - Molecular functioni

  • protein heterodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi106657. 3 interactors.
DIPiDIP-33399N.
IntActiP35368. 4 interactors.
MINTiMINT-120889.
STRINGi9606.ENSP00000306662.

Chemistry databases

BindingDBiP35368.

Structurei

3D structure databases

ProteinModelPortaliP35368.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi368 – 380Nuclear localization signalAdd BLAST13

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi370 – 380Poly-ArgAdd BLAST11

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1B sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118795.
HOGENOMiHOG000239244.
HOVERGENiHBG106962.
InParanoidiP35368.
KOiK04136.
OMAiTYRPWTR.
OrthoDBiEOG091G06VI.
PhylomeDBiP35368.
TreeFamiTF331895.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR001115. ADRA1B_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24248:SF17. PTHR24248:SF17. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00556. ADRENRGCA1BR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35368-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPDLDTGHN TSAPAHWGEL KNANFTGPNQ TSSNSTLPQL DITRAISVGL
60 70 80 90 100
VLGAFILFAI VGNILVILSV ACNRHLRTPT NYFIVNLAMA DLLLSFTVLP
110 120 130 140 150
FSAALEVLGY WVLGRIFCDI WAAVDVLCCT ASILSLCAIS IDRYIGVRYS
160 170 180 190 200
LQYPTLVTRR KAILALLSVW VLSTVISIGP LLGWKEPAPN DDKECGVTEE
210 220 230 240 250
PFYALFSSLG SFYIPLAVIL VMYCRVYIVA KRTTKNLEAG VMKEMSNSKE
260 270 280 290 300
LTLRIHSKNF HEDTLSSTKA KGHNPRSSIA VKLFKFSREK KAAKTLGIVV
310 320 330 340 350
GMFILCWLPF FIALPLGSLF STLKPPDAVF KVVFWLGYFN SCLNPIIYPC
360 370 380 390 400
SSKEFKRAFV RILGCQCRGR GRRRRRRRRR LGGCAYTYRP WTRGGSLERS
410 420 430 440 450
QSRKDSLDDS GSCLSGSQRT LPSASPSPGY LGRGAPPPVE LCAFPEWKAP
460 470 480 490 500
GALLSLPAPE PPGRRGRHDS GPLFTFKLLT EPESPGTDGG ASNGGCEAAA
510 520
DVANGQPGFK SNMPLAPGQF
Length:520
Mass (Da):56,836
Last modified:October 17, 2006 - v3
Checksum:iF081A23D2F943F7F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti371Missing (PubMed:1328250).Curated1
Sequence conflicti371Missing in AAB59485 (PubMed:7815325).Curated1
Sequence conflicti498 – 501AAAD → PRH (PubMed:1328250).Curated4

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01951051V → G.Corresponds to variant rs8192448dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M99589 Genomic DNA. No translation available.
M99590 Genomic DNA. No translation available.
U03865 mRNA. Translation: AAB60352.1.
L31773 mRNA. Translation: AAB59485.1.
EU332831 Genomic DNA. Translation: ABY87520.1.
BC136568 mRNA. Translation: AAI36569.1.
BC136569 mRNA. Translation: AAI36570.1.
CCDSiCCDS4347.1.
PIRiA45121.
RefSeqiNP_000670.1. NM_000679.3.
UniGeneiHs.368632.
Hs.670012.

Genome annotation databases

EnsembliENST00000306675; ENSP00000306662; ENSG00000170214.
GeneIDi147.
KEGGihsa:147.
UCSCiuc003lxt.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M99589 Genomic DNA. No translation available.
M99590 Genomic DNA. No translation available.
U03865 mRNA. Translation: AAB60352.1.
L31773 mRNA. Translation: AAB59485.1.
EU332831 Genomic DNA. Translation: ABY87520.1.
BC136568 mRNA. Translation: AAI36569.1.
BC136569 mRNA. Translation: AAI36570.1.
CCDSiCCDS4347.1.
PIRiA45121.
RefSeqiNP_000670.1. NM_000679.3.
UniGeneiHs.368632.
Hs.670012.

3D structure databases

ProteinModelPortaliP35368.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106657. 3 interactors.
DIPiDIP-33399N.
IntActiP35368. 4 interactors.
MINTiMINT-120889.
STRINGi9606.ENSP00000306662.

Chemistry databases

BindingDBiP35368.
ChEMBLiCHEMBL232.
DrugBankiDB01614. Acepromazine.
DB00346. Alfuzosin.
DB00321. Amitriptyline.
DB00543. Amoxapine.
DB00182. Amphetamine.
DB01238. Aripiprazole.
DB09128. Brexpiprazole.
DB01200. Bromocriptine.
DB00248. Cabergoline.
DB01136. Carvedilol.
DB00477. Chlorpromazine.
DB00575. Clonidine.
DB00363. Clozapine.
DB00298. Dapiprazole.
DB01151. Desipramine.
DB01576. Dextroamphetamine.
DB00590. Doxazosin.
DB01142. Doxepin.
DB04855. Dronedarone.
DB06262. Droxidopa.
DB00668. Epinephrine.
DB01049. Ergoloid mesylate.
DB00696. Ergotamine.
DB00800. Fenoldopam.
DB00458. Imipramine.
DB00598. Labetalol.
DB01255. Lisdexamfetamine.
DB00408. Loxapine.
DB00934. Maprotiline.
DB01365. Mephentermine.
DB01403. Methotrimeprazine.
DB00723. Methoxamine.
DB06148. Mianserin.
DB00211. Midodrine.
DB00370. Mirtazapine.
DB00745. Modafinil.
DB01149. Nefazodone.
DB00622. Nicardipine.
DB00368. Norepinephrine.
DB00540. Nortriptyline.
DB00334. Olanzapine.
DB00935. Oxymetazoline.
DB01267. Paliperidone.
DB01186. Pergolide.
DB01579. Phendimetrazine.
DB00925. Phenoxybenzamine.
DB00388. Phenylephrine.
DB00457. Prazosin.
DB00420. Promazine.
DB01608. Propericiazine.
DB00777. Propiomazine.
DB01224. Quetiapine.
DB00734. Risperidone.
DB06144. Sertindole.
DB06207. Silodosin.
DB00706. Tamsulosin.
DB01162. Terazosin.
DB01622. Thioproperazine.
DB00679. Thioridazine.
DB00726. Trimipramine.
DB06694. Xylometazoline.
DB00246. Ziprasidone.
GuidetoPHARMACOLOGYi23.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP35368.
PhosphoSitePlusiP35368.

Polymorphism and mutation databases

BioMutaiADRA1B.
DMDMi116241241.

Proteomic databases

MaxQBiP35368.
PaxDbiP35368.
PeptideAtlasiP35368.
PRIDEiP35368.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306675; ENSP00000306662; ENSG00000170214.
GeneIDi147.
KEGGihsa:147.
UCSCiuc003lxt.2. human.

Organism-specific databases

CTDi147.
DisGeNETi147.
GeneCardsiADRA1B.
HGNCiHGNC:278. ADRA1B.
MIMi104220. gene.
neXtProtiNX_P35368.
OpenTargetsiENSG00000170214.
PharmGKBiPA33.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118795.
HOGENOMiHOG000239244.
HOVERGENiHBG106962.
InParanoidiP35368.
KOiK04136.
OMAiTYRPWTR.
OrthoDBiEOG091G06VI.
PhylomeDBiP35368.
TreeFamiTF331895.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170214-MONOMER.
ReactomeiR-HSA-390696. Adrenoceptors.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-416482. G alpha (12/13) signalling events.
SignaLinkiP35368.
SIGNORiP35368.

Miscellaneous databases

GeneWikiiAlpha-1B_adrenergic_receptor.
GenomeRNAii147.
PROiP35368.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170214.
CleanExiHS_ADRA1B.
GenevisibleiP35368. HS.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR001115. ADRA1B_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24248:SF17. PTHR24248:SF17. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00556. ADRENRGCA1BR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADA1B_HUMAN
AccessioniPrimary (citable) accession number: P35368
Secondary accession number(s): B0LPE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: October 17, 2006
Last modified: November 2, 2016
This is version 148 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.