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P35368

- ADA1B_HUMAN

UniProt

P35368 - ADA1B_HUMAN

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Protein
Alpha-1B adrenergic receptor
Gene
ADRA1B
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.2 Publications

GO - Molecular functioni

  1. alpha1-adrenergic receptor activity Source: ProtInc
  2. protein heterodimerization activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: ProtInc
  2. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: ProtInc
  3. adrenergic receptor signaling pathway Source: GOC
  4. adult heart development Source: Ensembl
  5. behavioral response to cocaine Source: Ensembl
  6. blood vessel remodeling Source: Ensembl
  7. cell growth Source: Ensembl
  8. cell proliferation Source: ProtInc
  9. cell-cell signaling Source: ProtInc
  10. glucose homeostasis Source: Ensembl
  11. intracellular signal transduction Source: ProtInc
  12. locomotory behavior Source: Ensembl
  13. multicellular organismal development Source: ProtInc
  14. negative regulation of glycogen catabolic process Source: Ensembl
  15. organ growth Source: Ensembl
  16. positive regulation of MAPK cascade Source: UniProtKB
  17. positive regulation of glycogen catabolic process Source: Ensembl
  18. positive regulation of heart rate by epinephrine-norepinephrine Source: Ensembl
  19. positive regulation of the force of heart contraction by epinephrine-norepinephrine Source: Ensembl
  20. regulation of cardiac muscle contraction Source: InterPro
  21. regulation of vasoconstriction Source: InterPro
  22. response to amphetamine Source: Ensembl
  23. response to morphine Source: Ensembl
  24. vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure Source: Ensembl
  25. visual learning Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_16927. Adrenoceptors.
REACT_18283. G alpha (q) signalling events.
REACT_18407. G alpha (12/13) signalling events.
SignaLinkiP35368.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1B adrenergic receptor
Alternative name(s):
Alpha-1B adrenoreceptor
Short name:
Alpha-1B adrenoceptor
Gene namesi
Name:ADRA1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:278. ADRA1B.

Subcellular locationi

Nucleus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein
Note: Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes.2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4545Extracellular By similarity
Add
BLAST
Transmembranei46 – 7025Helical; Name=1; By similarity
Add
BLAST
Topological domaini71 – 8313Cytoplasmic By similarity
Add
BLAST
Transmembranei84 – 10522Helical; Name=2; By similarity
Add
BLAST
Topological domaini106 – 11510Extracellular By similarity
Transmembranei116 – 14126Helical; Name=3; By similarity
Add
BLAST
Topological domaini142 – 16120Cytoplasmic By similarity
Add
BLAST
Transmembranei162 – 18423Helical; Name=4; By similarity
Add
BLAST
Topological domaini185 – 20117Extracellular By similarity
Add
BLAST
Transmembranei202 – 22423Helical; Name=5; By similarity
Add
BLAST
Topological domaini225 – 29571Cytoplasmic By similarity
Add
BLAST
Transmembranei296 – 31924Helical; Name=6; By similarity
Add
BLAST
Topological domaini320 – 3267Extracellular By similarity
Transmembranei327 – 35125Helical; Name=7; By similarity
Add
BLAST
Topological domaini352 – 520169Cytoplasmic By similarity
Add
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. nuclear membrane Source: UniProtKB
  3. nucleus Source: UniProtKB
  4. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi368 – 38013RGRGR…RRRRR → AGAGAAAAAAAAA: Abolishes targeting to the nuclear membrane of cardiac myocytes. 1 Publication
Add
BLAST

Organism-specific databases

PharmGKBiPA33.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 520520Alpha-1B adrenergic receptor
PRO_0000069069Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi10 – 101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi24 – 241N-linked (GlcNAc...) Reviewed prediction
Glycosylationi29 – 291N-linked (GlcNAc...) Reviewed prediction
Glycosylationi34 – 341N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi118 ↔ 195 By similarity
Lipidationi365 – 3651S-palmitoyl cysteine Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

MaxQBiP35368.
PaxDbiP35368.
PRIDEiP35368.

PTM databases

PhosphoSiteiP35368.

Expressioni

Gene expression databases

BgeeiP35368.
CleanExiHS_ADRA1B.
GenevestigatoriP35368.

Interactioni

Subunit structurei

Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes.1 Publication

Protein-protein interaction databases

BioGridi106657. 2 interactions.
DIPiDIP-33399N.
IntActiP35368. 4 interactions.
MINTiMINT-120889.
STRINGi9606.ENSP00000306662.

Structurei

3D structure databases

ProteinModelPortaliP35368.
SMRiP35368. Positions 48-364.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni368 – 38013Nuclear localization signal
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi370 – 38011Poly-Arg
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG253615.
HOGENOMiHOG000239244.
HOVERGENiHBG106962.
InParanoidiP35368.
KOiK04136.
OMAiTYRPWTR.
OrthoDBiEOG7H4DTB.
PhylomeDBiP35368.
TreeFamiTF331895.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR002233. ADR_fam.
IPR001115. ADRA1B_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24248:SF17. PTHR24248:SF17. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00556. ADRENRGCA1BR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35368-1 [UniParc]FASTAAdd to Basket

« Hide

MNPDLDTGHN TSAPAHWGEL KNANFTGPNQ TSSNSTLPQL DITRAISVGL    50
VLGAFILFAI VGNILVILSV ACNRHLRTPT NYFIVNLAMA DLLLSFTVLP 100
FSAALEVLGY WVLGRIFCDI WAAVDVLCCT ASILSLCAIS IDRYIGVRYS 150
LQYPTLVTRR KAILALLSVW VLSTVISIGP LLGWKEPAPN DDKECGVTEE 200
PFYALFSSLG SFYIPLAVIL VMYCRVYIVA KRTTKNLEAG VMKEMSNSKE 250
LTLRIHSKNF HEDTLSSTKA KGHNPRSSIA VKLFKFSREK KAAKTLGIVV 300
GMFILCWLPF FIALPLGSLF STLKPPDAVF KVVFWLGYFN SCLNPIIYPC 350
SSKEFKRAFV RILGCQCRGR GRRRRRRRRR LGGCAYTYRP WTRGGSLERS 400
QSRKDSLDDS GSCLSGSQRT LPSASPSPGY LGRGAPPPVE LCAFPEWKAP 450
GALLSLPAPE PPGRRGRHDS GPLFTFKLLT EPESPGTDGG ASNGGCEAAA 500
DVANGQPGFK SNMPLAPGQF 520
Length:520
Mass (Da):56,836
Last modified:October 17, 2006 - v3
Checksum:iF081A23D2F943F7F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti51 – 511V → G.
Corresponds to variant rs8192448 [ dbSNP | Ensembl ].
VAR_019510

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti371 – 3711Missing1 Publication
Sequence conflicti371 – 3711Missing in AAB59485. 1 Publication
Sequence conflicti498 – 5014AAAD → PRH1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M99589 Genomic DNA. No translation available.
M99590 Genomic DNA. No translation available.
U03865 mRNA. Translation: AAB60352.1.
L31773 mRNA. Translation: AAB59485.1.
EU332831 Genomic DNA. Translation: ABY87520.1.
BC136568 mRNA. Translation: AAI36569.1.
BC136569 mRNA. Translation: AAI36570.1.
CCDSiCCDS4347.1.
PIRiA45121.
RefSeqiNP_000670.1. NM_000679.3.
UniGeneiHs.368632.

Genome annotation databases

EnsembliENST00000306675; ENSP00000306662; ENSG00000170214.
GeneIDi147.
KEGGihsa:147.
UCSCiuc003lxt.1. human.

Polymorphism databases

DMDMi116241241.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M99589 Genomic DNA. No translation available.
M99590 Genomic DNA. No translation available.
U03865 mRNA. Translation: AAB60352.1 .
L31773 mRNA. Translation: AAB59485.1 .
EU332831 Genomic DNA. Translation: ABY87520.1 .
BC136568 mRNA. Translation: AAI36569.1 .
BC136569 mRNA. Translation: AAI36570.1 .
CCDSi CCDS4347.1.
PIRi A45121.
RefSeqi NP_000670.1. NM_000679.3.
UniGenei Hs.368632.

3D structure databases

ProteinModelPortali P35368.
SMRi P35368. Positions 48-364.
ModBasei Search...

Protein-protein interaction databases

BioGridi 106657. 2 interactions.
DIPi DIP-33399N.
IntActi P35368. 4 interactions.
MINTi MINT-120889.
STRINGi 9606.ENSP00000306662.

Chemistry

BindingDBi P35368.
ChEMBLi CHEMBL232.
DrugBanki DB00346. Alfuzosin.
DB00217. Bethanidine.
DB00298. Dapiprazole.
DB04840. Debrisoquin.
DB01576. Dextroamphetamine.
DB00590. Doxazosin.
DB00226. Guanadrel Sulfate.
DB01170. Guanethidine.
DB01018. Guanfacine.
DB00598. Labetalol.
DB01255. Lisdexamfetamine.
DB01577. Methamphetamine.
DB01403. Methotrimeprazine.
DB00723. Methoxamine.
DB00211. Midodrine.
DB00745. Modafinil.
DB01149. Nefazodone.
DB00368. Norepinephrine.
DB00334. Olanzapine.
DB01579. Phendimetrazine.
DB00388. Phenylephrine.
DB00457. Prazosin.
DB00420. Promazine.
DB01608. Propericiazine.
DB00777. Propiomazine.
DB01224. Quetiapine.
DB00734. Risperidone.
DB06144. Sertindole.
DB00706. Tamsulosin.
DB01162. Terazosin.
DB00656. Trazodone.
GuidetoPHARMACOLOGYi 23.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P35368.

Polymorphism databases

DMDMi 116241241.

Proteomic databases

MaxQBi P35368.
PaxDbi P35368.
PRIDEi P35368.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000306675 ; ENSP00000306662 ; ENSG00000170214 .
GeneIDi 147.
KEGGi hsa:147.
UCSCi uc003lxt.1. human.

Organism-specific databases

CTDi 147.
GeneCardsi GC05P159276.
HGNCi HGNC:278. ADRA1B.
MIMi 104220. gene.
neXtProti NX_P35368.
PharmGKBi PA33.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG253615.
HOGENOMi HOG000239244.
HOVERGENi HBG106962.
InParanoidi P35368.
KOi K04136.
OMAi TYRPWTR.
OrthoDBi EOG7H4DTB.
PhylomeDBi P35368.
TreeFami TF331895.

Enzyme and pathway databases

Reactomei REACT_16927. Adrenoceptors.
REACT_18283. G alpha (q) signalling events.
REACT_18407. G alpha (12/13) signalling events.
SignaLinki P35368.

Miscellaneous databases

GeneWikii Alpha-1B_adrenergic_receptor.
GenomeRNAii 147.
NextBioi 581.
PROi P35368.
SOURCEi Search...

Gene expression databases

Bgeei P35368.
CleanExi HS_ADRA1B.
Genevestigatori P35368.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR002233. ADR_fam.
IPR001115. ADRA1B_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24248:SF17. PTHR24248:SF17. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR01103. ADRENERGICR.
PR00556. ADRENRGCA1BR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic organization and expression of the human alpha 1B-adrenergic receptor."
    Ramarao C.S., Denker J.M., Perez D.M., Gaivin R.J., Riek R.P., Graham R.M.
    J. Biol. Chem. 267:21936-21945(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype."
    Forray C., Bard J.A., Wetzel J.M., Chiu G., Shapiro E., Tang R., Lepor H., Hartig P.R., Weinshank R.L., Branchek T.A., Gluchowski C.
    Mol. Pharmacol. 45:703-708(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  3. "Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues."
    Schwinn D.A., Johnston G.I., Page S.O., Mosley M.J., Wilson K.H., Worman N.P., Campbell S., Fidock M.D., Furness L.M., Parry-Smith D.J., Peter B., Bailey D.S.
    J. Pharmacol. Exp. Ther. 272:134-142(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. NIEHS SNPs program
    Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Nuclear alpha1-adrenergic receptors signal activated ERK localization to caveolae in adult cardiac myocytes."
    Wright C.D., Chen Q., Baye N.L., Huang Y., Healy C.L., Kasinathan S., O'Connell T.D.
    Circ. Res. 103:992-1000(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, FUNCTION.
  7. "Nuclear localization drives alpha1-adrenergic receptor oligomerization and signaling in cardiac myocytes."
    Wright C.D., Wu S.C., Dahl E.F., Sazama A.J., O'Connell T.D.
    Cell. Signal. 24:794-802(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, SUBUNIT, FUNCTION, MUTAGENESIS OF 368-ARG--ARG-380.

Entry informationi

Entry nameiADA1B_HUMAN
AccessioniPrimary (citable) accession number: P35368
Secondary accession number(s): B0LPE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: October 17, 2006
Last modified: September 3, 2014
This is version 129 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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