Alpha-1B adrenergic receptor - Homo sapiens (Human)

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Reviewed, UniProtKB/Swiss-Prot P35368 (ADA1B_HUMAN)

Last modified November 24, 2009. Version 85. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Alpha-1B adrenergic receptor
Alternative name(s):
    Alpha 1B-adrenoreceptor
    Alpha 1B-adrenoceptor

Gene names

Name:

ADRA1B

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	520 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Function	This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

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Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	G-protein signaling, coupled to cAMP nucleotide second messenger Traceable author statement. Source: ProtInc cell proliferation Traceable author statement. Source: ProtInc cell-cell signaling Ref.1 Traceable author statement. Source: ProtInc protein kinase cascade Traceable author statement. Source: ProtInc
Cellular component	integral to plasma membrane Ref.1 Traceable author statement. Source: ProtInc
Molecular function	alpha1-adrenergic receptor activity Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 520

520

Alpha-1B adrenergic receptor

PRO_0000069069

Regions

Topological domain

1 – 45

Extracellular By similarity

Transmembrane

46 – 70

1 By similarity

Topological domain

71 – 83

Cytoplasmic By similarity

Transmembrane

84 – 105

2 By similarity

Topological domain

106 – 115

Extracellular By similarity

Transmembrane

116 – 141

3 By similarity

Topological domain

142 – 161

Cytoplasmic By similarity

Transmembrane

162 – 184

4 By similarity

Topological domain

185 – 201

Extracellular By similarity

Transmembrane

202 – 224

5 By similarity

Topological domain

225 – 295

Cytoplasmic By similarity

Transmembrane

296 – 319

6 By similarity

Topological domain

320 – 326

Extracellular By similarity

Transmembrane

327 – 351

7 By similarity

Topological domain

352 – 520

169

Cytoplasmic By similarity

Compositional bias

370 – 380

Poly-Arg

Amino acid modifications

Modified residue

264

Phosphothreonine By similarity

Modified residue

267

Phosphoserine By similarity

Lipidation

365

S-palmitoyl cysteine Potential

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

N-linked (GlcNAc...) Potential

Disulfide bond

118 ↔ 195

By similarity

Natural variations

Natural variant

V → G: dbSNP rs8192448.

VAR_019510

Experimental info

Sequence conflict

371

Missing Ref.1

Sequence conflict

371

Missing in AAB59485. Ref.3

Sequence conflict

498 – 501

AAAD → PRH Ref.1

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Sequences

Sequence

Length

Mass (Da)

Tools

P35368-1 [UniParc].

Last modified October 17, 2006. Version 3.
Checksum: F081A23D2F943F7F
Show »

FASTA

520

56,836

        10         20         30         40         50         60 
MNPDLDTGHN TSAPAHWGEL KNANFTGPNQ TSSNSTLPQL DITRAISVGL VLGAFILFAI 

        70         80         90        100        110        120 
VGNILVILSV ACNRHLRTPT NYFIVNLAMA DLLLSFTVLP FSAALEVLGY WVLGRIFCDI 

       130        140        150        160        170        180 
WAAVDVLCCT ASILSLCAIS IDRYIGVRYS LQYPTLVTRR KAILALLSVW VLSTVISIGP 

       190        200        210        220        230        240 
LLGWKEPAPN DDKECGVTEE PFYALFSSLG SFYIPLAVIL VMYCRVYIVA KRTTKNLEAG 

       250        260        270        280        290        300 
VMKEMSNSKE LTLRIHSKNF HEDTLSSTKA KGHNPRSSIA VKLFKFSREK KAAKTLGIVV 

       310        320        330        340        350        360 
GMFILCWLPF FIALPLGSLF STLKPPDAVF KVVFWLGYFN SCLNPIIYPC SSKEFKRAFV 

       370        380        390        400        410        420 
RILGCQCRGR GRRRRRRRRR LGGCAYTYRP WTRGGSLERS QSRKDSLDDS GSCLSGSQRT 

       430        440        450        460        470        480 
LPSASPSPGY LGRGAPPPVE LCAFPEWKAP GALLSLPAPE PPGRRGRHDS GPLFTFKLLT 

       490        500        510        520 
EPESPGTDGG ASNGGCEAAA DVANGQPGFK SNMPLAPGQF

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References

[1]	"Genomic organization and expression of the human alpha 1B-adrenergic receptor." Ramarao C.S., Denker J.M., Perez D.M., Gaivin R.J., Riek R.P., Graham R.M. J. Biol. Chem. 267:21936-21945(1992) [PubMed: 1328250] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype." Forray C., Bard J.A., Wetzel J.M., Chiu G., Shapiro E., Tang R., Lepor H., Hartig P.R., Weinshank R.L., Branchek T.A., Gluchowski C. Mol. Pharmacol. 45:703-708(1994) [PubMed: 8183249] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[3]	"Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues." Schwinn D.A., Johnston G.I., Page S.O., Mosley M.J., Wilson K.H., Worman N.P., Campbell S., Fidock M.D., Furness L.M., Parry-Smith D.J., Peter B., Bailey D.S. J. Pharmacol. Exp. Ther. 272:134-142(1995) [PubMed: 7815325] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

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Cross-references

Sequence databases
	M99589 Genomic DNA. No translation available. M99590 Genomic DNA. No translation available. U03865 mRNA. Translation: AAB60352.1. L31773 mRNA. Translation: AAB59485.1.
IPI	IPI00218912.
PIR	A45121.
RefSeq	NP_000670.1.
UniGene	Hs.368632
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P35368. 3 interactions.
STRING	P35368.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P35368.
Proteomic databases
PRIDE	P35368.
Genome annotation databases
Ensembl	ENST00000306675; ENSP00000306662; ENSG00000170214; Homo sapiens. [Genome view]
GeneID	147.
KEGG	hsa:147.
UCSC	uc003lxt.1. human.
Organism-specific databases
CTD	147.
GeneCards	GC05P159276.
HGNC	HGNC:278. ADRA1B.
MIM	104220. gene.
PharmGKB	PA33.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P35368.
HOVERGEN	P35368.
OMA	CAYTYRP
OrthoDB	EOG92NMJH
Enzyme and pathway databases
Pathway_Interaction_DB	lysophospholipid_pathway. LPA receptor mediated events.
Reactome	REACT_14797. Signaling by GPCR.
Gene expression databases
ArrayExpress	P35368.
Bgee	P35368.
CleanEx	HS_ADRA1B.
Genevestigator	P35368.
GermOnline	ENSG00000170214. Homo sapiens.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR001115. Adrene_rcpt_A1B. IPR002233. Adrnrgc_rcpt. IPR017452. GPCR_Rhodpsn_supfam. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR01103. ADRENERGICR. PR00556. ADRENRGCA1BR. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
DrugBank	DB00346. Alfuzosin. DB00217. Bethanidine. DB00298. Dapiprazole. DB04840. Debrisoquin. DB01576. Dextroamphetamine. DB00590. Doxazosin. DB00226. Guanadrel Sulfate. DB01170. Guanethidine. DB01018. Guanfacine. DB00598. Labetalol. DB01255. Lisdexamfetamine. DB01577. Methamphetamine. DB01403. Methotrimeprazine. DB00723. Methoxamine. DB00211. Midodrine. DB00745. Modafinil. DB01149. Nefazodone. DB00368. Norepinephrine. DB00334. Olanzapine. DB01579. Phendimetrazine. DB00388. Phenylephrine. DB00457. Prazosin. DB00420. Promazine. DB01608. Propericiazine. DB00777. Propiomazine. DB01224. Quetiapine. DB00734. Risperidone. DB06144. Sertindole. DB00706. Tamsulosin. DB01162. Terazosin. DB00656. Trazodone.
NextBio	581.
SOURCE	Search...

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Entry information

Entry name

ADA1B_HUMAN

Accession

Primary (citable) accession number: P35368

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	October 17, 2006
Last modified:	November 24, 2009
This is version 85 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents