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P35367

- HRH1_HUMAN

UniProt

P35367 - HRH1_HUMAN

Protein

Histamine H1 receptor

Gene

HRH1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 134 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: ProtInc
    2. histamine receptor activity Source: UniProtKB

    GO - Biological processi

    1. cellular response to histamine Source: UniProtKB
    2. eosinophil chemotaxis Source: InterPro
    3. G-protein coupled receptor signaling pathway Source: UniProtKB
    4. inflammatory response Source: ProtInc
    5. inositol phosphate-mediated signaling Source: BHF-UCL
    6. memory Source: Ensembl
    7. phospholipase C-activating G-protein coupled receptor signaling pathway Source: ProtInc
    8. positive regulation of inositol trisphosphate biosynthetic process Source: BHF-UCL
    9. positive regulation of vasoconstriction Source: InterPro
    10. regulation of synaptic plasticity Source: Ensembl
    11. regulation of vascular permeability Source: InterPro
    12. visual learning Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_16903. Histamine receptors.
    REACT_18283. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histamine H1 receptor
    Short name:
    H1R
    Short name:
    HH1R
    Gene namesi
    Name:HRH1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:5182. HRH1.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of plasma membrane Source: UniProtKB
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29456.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 487487Histamine H1 receptorPRO_0000069676Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi18 – 181N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi100 ↔ 1801 PublicationPROSITE-ProRule annotation
    Modified residuei140 – 1401Phosphothreonine1 Publication
    Modified residuei142 – 1421Phosphothreonine1 Publication
    Modified residuei279 – 2791Phosphothreonine1 Publication
    Modified residuei396 – 3961Phosphoserine1 Publication
    Modified residuei398 – 3981Phosphoserine1 Publication
    Disulfide bondi441 ↔ 4441 PublicationPROSITE-ProRule annotation

    Post-translational modificationi

    Phosphorylation at sites in the second and third cytoplasmic loops independently contribute to agonist-induced receptor downregulation.2 Publications

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiP35367.
    PaxDbiP35367.
    PRIDEiP35367.

    PTM databases

    PhosphoSiteiP35367.

    Expressioni

    Gene expression databases

    BgeeiP35367.
    CleanExiHS_HRH1.
    GenevestigatoriP35367.

    Organism-specific databases

    HPAiHPA029740.

    Interactioni

    Protein-protein interaction databases

    BioGridi109505. 1 interaction.
    IntActiP35367. 1 interaction.
    MINTiMINT-190077.
    STRINGi9606.ENSP00000347299.

    Structurei

    Secondary structure

    1
    487
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi29 – 313
    Helixi33 – 5422
    Helixi61 – 633
    Helixi64 – 7815
    Helixi80 – 8910
    Beta strandi90 – 923
    Helixi96 – 13035
    Turni135 – 1384
    Helixi141 – 15515
    Helixi156 – 1583
    Helixi159 – 1635
    Beta strandi177 – 1804
    Helixi188 – 19811
    Helixi200 – 21617
    Helixi408 – 44134
    Turni447 – 4493
    Helixi450 – 47122
    Helixi473 – 48311

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3RZEX-ray3.10A20-221[»]
    A405-487[»]
    ProteinModelPortaliP35367.
    SMRiP35367. Positions 19-256, 405-485.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2929Extracellular1 PublicationAdd
    BLAST
    Topological domaini53 – 6210Cytoplasmic1 Publication
    Topological domaini84 – 10118Extracellular1 PublicationAdd
    BLAST
    Topological domaini124 – 14320Cytoplasmic1 PublicationAdd
    BLAST
    Topological domaini165 – 18925Extracellular1 PublicationAdd
    BLAST
    Topological domaini211 – 416206Cytoplasmic1 PublicationAdd
    BLAST
    Topological domaini439 – 45012Extracellular1 PublicationAdd
    BLAST
    Topological domaini471 – 48717Cytoplasmic1 PublicationAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei30 – 5223Helical; Name=1Add
    BLAST
    Transmembranei63 – 8321Helical; Name=2Add
    BLAST
    Transmembranei102 – 12322Helical; Name=3Add
    BLAST
    Transmembranei144 – 16421Helical; Name=4Add
    BLAST
    Transmembranei190 – 21021Helical; Name=5Add
    BLAST
    Transmembranei417 – 43822Helical; Name=6Add
    BLAST
    Transmembranei451 – 47020Helical; Name=7Add
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni107 – 1126Important for agonist binding
    Regioni424 – 4285Important for agonist binding

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG318797.
    HOGENOMiHOG000273869.
    HOVERGENiHBG101103.
    InParanoidiP35367.
    KOiK04149.
    OMAiEDKMCEG.
    OrthoDBiEOG70CR7W.
    PhylomeDBiP35367.
    TreeFamiTF333432.

    Family and domain databases

    Gene3Di1.20.1070.10. 2 hits.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000921. Histamine_H1_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00530. HISTAMINEH1R.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P35367-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLPNSSCLL EDKMCEGNKT TMASPQLMPL VVVLSTICLV TVGLNLLVLY    50
    AVRSERKLHT VGNLYIVSLS VADLIVGAVV MPMNILYLLM SKWSLGRPLC 100
    LFWLSMDYVA STASIFSVFI LCIDRYRSVQ QPLRYLKYRT KTRASATILG 150
    AWFLSFLWVI PILGWNHFMQ QTSVRREDKC ETDFYDVTWF KVMTAIINFY 200
    LPTLLMLWFY AKIYKAVRQH CQHRELINRS LPSFSEIKLR PENPKGDAKK 250
    PGKESPWEVL KRKPKDAGGG SVLKSPSQTP KEMKSPVVFS QEDDREVDKL 300
    YCFPLDIVHM QAAAEGSSRD YVAVNRSHGQ LKTDEQGLNT HGASEISEDQ 350
    MLGDSQSFSR TDSDTTTETA PGKGKLRSGS NTGLDYIKFT WKRLRSHSRQ 400
    YVSGLHMNRE RKAAKQLGFI MAAFILCWIP YFIFFMVIAF CKNCCNEHLH 450
    MFTIWLGYIN STLNPLIYPL CNENFKKTFK RILHIRS 487
    Length:487
    Mass (Da):55,784
    Last modified:June 1, 1994 - v1
    Checksum:iE5DB418A4C17A985
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti308 – 3081V → E in AAH60802. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti19 – 191K → N.
    Corresponds to variant rs2067466 [ dbSNP | Ensembl ].
    VAR_049410
    Natural varianti270 – 2701G → E.
    Corresponds to variant rs7651620 [ dbSNP | Ensembl ].
    VAR_033476
    Natural varianti385 – 3851D → E in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_035761

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z34897 mRNA. Translation: CAA84380.1.
    X76786 Genomic DNA. Translation: CAA54182.1.
    D14436 Genomic DNA. Translation: BAA03319.1.
    D28481 mRNA. Translation: BAA05840.1.
    AF026261 mRNA. Translation: AAB95156.1.
    AB041380 Genomic DNA. Translation: BAA94465.1.
    AY136743 mRNA. Translation: AAN01269.1.
    AK289412 mRNA. Translation: BAF82101.1.
    CH471055 Genomic DNA. Translation: EAW64092.1.
    BC060802 mRNA. Translation: AAH60802.1.
    CCDSiCCDS2604.1.
    PIRiJC2495.
    RefSeqiNP_000852.1. NM_000861.3.
    NP_001091681.1. NM_001098211.1.
    NP_001091682.1. NM_001098212.1.
    NP_001091683.1. NM_001098213.1.
    UniGeneiHs.1570.

    Genome annotation databases

    EnsembliENST00000397056; ENSP00000380247; ENSG00000196639.
    ENST00000431010; ENSP00000397028; ENSG00000196639.
    ENST00000438284; ENSP00000406705; ENSG00000196639.
    GeneIDi3269.
    KEGGihsa:3269.
    UCSCiuc003bwb.4. human.

    Polymorphism databases

    DMDMi547645.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z34897 mRNA. Translation: CAA84380.1 .
    X76786 Genomic DNA. Translation: CAA54182.1 .
    D14436 Genomic DNA. Translation: BAA03319.1 .
    D28481 mRNA. Translation: BAA05840.1 .
    AF026261 mRNA. Translation: AAB95156.1 .
    AB041380 Genomic DNA. Translation: BAA94465.1 .
    AY136743 mRNA. Translation: AAN01269.1 .
    AK289412 mRNA. Translation: BAF82101.1 .
    CH471055 Genomic DNA. Translation: EAW64092.1 .
    BC060802 mRNA. Translation: AAH60802.1 .
    CCDSi CCDS2604.1.
    PIRi JC2495.
    RefSeqi NP_000852.1. NM_000861.3.
    NP_001091681.1. NM_001098211.1.
    NP_001091682.1. NM_001098212.1.
    NP_001091683.1. NM_001098213.1.
    UniGenei Hs.1570.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3RZE X-ray 3.10 A 20-221 [» ]
    A 405-487 [» ]
    ProteinModelPortali P35367.
    SMRi P35367. Positions 19-256, 405-485.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109505. 1 interaction.
    IntActi P35367. 1 interaction.
    MINTi MINT-190077.
    STRINGi 9606.ENSP00000347299.

    Chemistry

    BindingDBi P35367.
    ChEMBLi CHEMBL231.
    DrugBanki DB01615. Aceprometazine.
    DB00637. Astemizole.
    DB00719. Azatadine.
    DB00972. Azelastine.
    DB00767. Benzquinamide.
    DB04890. Bepotastine.
    DB01237. Bromodiphenhydramine.
    DB00835. Brompheniramine.
    DB00354. Buclizine.
    DB00748. Carbinoxamine.
    DB00341. Cetirizine.
    DB04837. Chlophedianol.
    DB01114. Chlorpheniramine.
    DB01239. Chlorprothixene.
    DB00568. Cinnarizine.
    DB00283. Clemastine.
    DB00363. Clozapine.
    DB01176. Cyclizine.
    DB00434. Cyproheptadine.
    DB01151. Desipramine.
    DB00967. Desloratadine.
    DB00405. Dexbrompheniramine.
    DB00985. Dimenhydrinate.
    DB01075. Diphenhydramine.
    DB01146. Diphenylpyraline.
    DB01142. Doxepin.
    DB00366. Doxylamine.
    DB01084. Emedastine.
    DB00751. Epinastine.
    DB00950. Fexofenadine.
    DB04841. Flunarizine.
    DB00667. Histamine Phosphate.
    DB00557. Hydroxyzine.
    DB00920. Ketotifen.
    DB01106. Levocabastine.
    DB00455. Loratadine.
    DB00934. Maprotiline.
    DB00737. Meclizine.
    DB01071. Mequitazine.
    DB00902. Methdilazine.
    DB01403. Methotrimeprazine.
    DB06148. Mianserin.
    DB00370. Mirtazapine.
    DB00716. Nedocromil.
    DB00334. Olanzapine.
    DB00768. Olopatadine.
    DB01173. Orphenadrine.
    DB00885. Pemirolast.
    DB01619. Phenindamine.
    DB01620. Pheniramine.
    DB00433. Prochlorperazine.
    DB00420. Promazine.
    DB01069. Promethazine.
    DB00777. Propiomazine.
    DB01224. Quetiapine.
    DB00734. Risperidone.
    DB00342. Terfenadine.
    DB00372. Thiethylperazine.
    DB00656. Trazodone.
    DB01246. Trimeprazine.
    DB00792. Tripelennamine.
    DB00427. Triprolidine.
    DB00246. Ziprasidone.
    GuidetoPHARMACOLOGYi 262.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P35367.

    Polymorphism databases

    DMDMi 547645.

    Proteomic databases

    MaxQBi P35367.
    PaxDbi P35367.
    PRIDEi P35367.

    Protocols and materials databases

    DNASUi 3269.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000397056 ; ENSP00000380247 ; ENSG00000196639 .
    ENST00000431010 ; ENSP00000397028 ; ENSG00000196639 .
    ENST00000438284 ; ENSP00000406705 ; ENSG00000196639 .
    GeneIDi 3269.
    KEGGi hsa:3269.
    UCSCi uc003bwb.4. human.

    Organism-specific databases

    CTDi 3269.
    GeneCardsi GC03P011113.
    HGNCi HGNC:5182. HRH1.
    HPAi HPA029740.
    MIMi 600167. gene.
    neXtProti NX_P35367.
    PharmGKBi PA29456.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG318797.
    HOGENOMi HOG000273869.
    HOVERGENi HBG101103.
    InParanoidi P35367.
    KOi K04149.
    OMAi EDKMCEG.
    OrthoDBi EOG70CR7W.
    PhylomeDBi P35367.
    TreeFami TF333432.

    Enzyme and pathway databases

    Reactomei REACT_16903. Histamine receptors.
    REACT_18283. G alpha (q) signalling events.

    Miscellaneous databases

    ChiTaRSi HRH1. human.
    GeneWikii Histamine_H1_receptor.
    GenomeRNAii 3269.
    NextBioi 12981.
    PROi P35367.
    SOURCEi Search...

    Gene expression databases

    Bgeei P35367.
    CleanExi HS_HRH1.
    Genevestigatori P35367.

    Family and domain databases

    Gene3Di 1.20.1070.10. 2 hits.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000921. Histamine_H1_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00530. HISTAMINEH1R.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic cloning, heterologous expression and pharmacological characterization of a human histamine H1 receptor."
      de Backer M.D., Gommeren W., Moereels H., Nobels G., van Gompel P., Leysen J.E., Luyten W.H.M.L.
      Biochem. Biophys. Res. Commun. 197:1601-1608(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Stable expression of human H1-histamine-receptor cDNA in Chinese hamster ovary cells. Pharmacological characterisation of the protein, tissue distribution of messenger RNA and chromosomal localisation of the gene."
      Moguilevsky N., Varsalona F., Noyer M., Gillard M., Guillaume J.P., Garcia L., Szpirer C., Szpirer J., Bollen A.
      Eur. J. Biochem. 224:489-495(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. Rae J.L., Shepard A.R.
      Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lens epithelium.
    5. "Human-specific amino acid changes found in 103 protein-coding genes."
      Kitano T., Liu Y.-H., Ueda S., Saitou N.
      Mol. Biol. Evol. 21:936-944(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    6. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Puhl H.L. III, Ikeda S.R., Aronstam R.S.
      Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    10. "Two threonine residues and two serine residues in the second and third intracellular loops are both involved in histamine H1 receptor downregulation."
      Horio S., Kato T., Ogawa M., Fujimoto K., Fukui H.
      FEBS Lett. 573:226-230(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT THR-140; THR-142; SER-396 AND SER-398.
    11. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-279, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF 20-487 IN COMPLEX WITH ANTAGONIST, DISULFIDE BOND, SUBCELLULAR LOCATION, TOPOLOGY.
    14. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLU-385.

    Entry informationi

    Entry nameiHRH1_HUMAN
    AccessioniPrimary (citable) accession number: P35367
    Secondary accession number(s): A8K047, Q6P9E5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 134 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

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