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Protein

Histamine H1 receptor

Gene

HRH1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc
  • histamine receptor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:G66-33559-MONOMER.
ReactomeiR-HSA-390650. Histamine receptors.
R-HSA-416476. G alpha (q) signalling events.
SIGNORiP35367.

Names & Taxonomyi

Protein namesi
Recommended name:
Histamine H1 receptor
Short name:
H1R
Short name:
HH1R
Gene namesi
Name:HRH1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:5182. HRH1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29Extracellular1 PublicationAdd BLAST29
Transmembranei30 – 52Helical; Name=1Add BLAST23
Topological domaini53 – 62Cytoplasmic1 Publication10
Transmembranei63 – 83Helical; Name=2Add BLAST21
Topological domaini84 – 101Extracellular1 PublicationAdd BLAST18
Transmembranei102 – 123Helical; Name=3Add BLAST22
Topological domaini124 – 143Cytoplasmic1 PublicationAdd BLAST20
Transmembranei144 – 164Helical; Name=4Add BLAST21
Topological domaini165 – 189Extracellular1 PublicationAdd BLAST25
Transmembranei190 – 210Helical; Name=5Add BLAST21
Topological domaini211 – 416Cytoplasmic1 PublicationAdd BLAST206
Transmembranei417 – 438Helical; Name=6Add BLAST22
Topological domaini439 – 450Extracellular1 PublicationAdd BLAST12
Transmembranei451 – 470Helical; Name=7Add BLAST20
Topological domaini471 – 487Cytoplasmic1 PublicationAdd BLAST17

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3269.
OpenTargetsiENSG00000196639.
PharmGKBiPA29456.

Chemistry databases

ChEMBLiCHEMBL231.
DrugBankiDB01615. Aceprometazine.
DB06766. Alcaftadine.
DB01246. Alimemazine.
DB00321. Amitriptyline.
DB00543. Amoxapine.
DB08799. Antazoline.
DB01238. Aripiprazole.
DB06216. Asenapine.
DB00637. Astemizole.
DB00719. Azatadine.
DB00972. Azelastine.
DB00245. Benzatropine.
DB04890. Bepotastine.
DB06698. Betahistine.
DB01237. Bromodiphenhydramine.
DB00835. Brompheniramine.
DB00354. Buclizine.
DB09016. Butriptyline.
DB00748. Carbinoxamine.
DB06016. Cariprazine.
DB00341. Cetirizine.
DB08936. Chlorcyclizine.
DB08800. Chloropyramine.
DB01114. Chlorphenamine.
DB00477. Chlorpromazine.
DB01239. Chlorprothixene.
DB00568. Cinnarizine.
DB00215. Citalopram.
DB00283. Clemastine.
DB04837. Clofedanol.
DB00363. Clozapine.
DB01176. Cyclizine.
DB00434. Cyproheptadine.
DB01151. Desipramine.
DB00967. Desloratadine.
DB00405. Dexbrompheniramine.
DB00985. Dimenhydrinate.
DB08801. Dimetindene.
DB01075. Diphenhydramine.
DB01146. Diphenylpyraline.
DB01142. Doxepin.
DB00366. Doxylamine.
DB01084. Emedastine.
DB00751. Epinastine.
DB01175. Escitalopram.
DB00950. Fexofenadine.
DB04841. Flunarizine.
DB00667. Histamine Phosphate.
DB00557. Hydroxyzine.
DB04946. Iloperidone.
DB00458. Imipramine.
DB08802. Isothipendyl.
DB00920. Ketotifen.
DB01106. Levocabastine.
DB06282. Levocetirizine.
DB00455. Loratadine.
DB00408. Loxapine.
DB00934. Maprotiline.
DB00737. Meclizine.
DB06691. Mepyramine.
DB01071. Mequitazine.
DB00902. Methdilazine.
DB01403. Methotrimeprazine.
DB06148. Mianserin.
DB00370. Mirtazapine.
DB00540. Nortriptyline.
DB00334. Olanzapine.
DB00768. Olopatadine.
DB01173. Orphenadrine.
DB01267. Paliperidone.
DB01619. Phenindamine.
DB01620. Pheniramine.
DB00420. Promazine.
DB01069. Promethazine.
DB00777. Propiomazine.
DB01224. Quetiapine.
DB00734. Risperidone.
DB00797. Tolazoline.
DB00656. Trazodone.
DB00726. Trimipramine.
DB00792. Tripelennamine.
DB00427. Triprolidine.
DB00246. Ziprasidone.
DB01624. Zuclopenthixol.
GuidetoPHARMACOLOGYi262.

Polymorphism and mutation databases

BioMutaiHRH1.
DMDMi547645.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000696761 – 487Histamine H1 receptorAdd BLAST487

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Glycosylationi18N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi100 ↔ 180PROSITE-ProRule annotation1 Publication
Modified residuei140Phosphothreonine1 Publication1
Modified residuei142Phosphothreonine1 Publication1
Modified residuei230PhosphoserineCombined sources1
Modified residuei279PhosphothreonineCombined sources1
Modified residuei344PhosphoserineBy similarity1
Modified residuei347PhosphoserineBy similarity1
Modified residuei380PhosphoserineBy similarity1
Modified residuei396Phosphoserine1 Publication1
Modified residuei398Phosphoserine1 Publication1
Disulfide bondi441 ↔ 444PROSITE-ProRule annotation1 Publication

Post-translational modificationi

Phosphorylation at sites in the second and third cytoplasmic loops independently contribute to agonist-induced receptor downregulation.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP35367.
PaxDbiP35367.
PeptideAtlasiP35367.
PRIDEiP35367.

PTM databases

iPTMnetiP35367.
PhosphoSitePlusiP35367.

Expressioni

Gene expression databases

BgeeiENSG00000196639.
CleanExiHS_HRH1.
ExpressionAtlasiP35367. baseline and differential.
GenevisibleiP35367. HS.

Organism-specific databases

HPAiHPA029740.

Interactioni

Protein-protein interaction databases

BioGridi109505. 1 interactor.
DIPiDIP-41996N.
IntActiP35367. 1 interactor.
MINTiMINT-190077.
STRINGi9606.ENSP00000380247.

Chemistry databases

BindingDBiP35367.

Structurei

Secondary structure

1487
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi29 – 31Combined sources3
Helixi33 – 54Combined sources22
Helixi61 – 63Combined sources3
Helixi64 – 78Combined sources15
Helixi80 – 89Combined sources10
Beta strandi90 – 92Combined sources3
Helixi96 – 130Combined sources35
Turni135 – 138Combined sources4
Helixi141 – 155Combined sources15
Helixi156 – 158Combined sources3
Helixi159 – 163Combined sources5
Beta strandi177 – 180Combined sources4
Helixi188 – 198Combined sources11
Helixi200 – 216Combined sources17
Helixi408 – 441Combined sources34
Turni447 – 449Combined sources3
Helixi450 – 471Combined sources22
Helixi473 – 483Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3RZEX-ray3.10A20-221[»]
A405-487[»]
ProteinModelPortaliP35367.
SMRiP35367.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni107 – 112Important for agonist binding6
Regioni424 – 428Important for agonist binding5

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4220. Eukaryota.
ENOG410YCQR. LUCA.
GeneTreeiENSGT00780000121874.
HOGENOMiHOG000273869.
HOVERGENiHBG101103.
InParanoidiP35367.
KOiK04149.
OMAiYIKFTWK.
OrthoDBiEOG091G06VI.
PhylomeDBiP35367.
TreeFamiTF333432.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000921. Histamine_H1_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00530. HISTAMINEH1R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35367-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLPNSSCLL EDKMCEGNKT TMASPQLMPL VVVLSTICLV TVGLNLLVLY
60 70 80 90 100
AVRSERKLHT VGNLYIVSLS VADLIVGAVV MPMNILYLLM SKWSLGRPLC
110 120 130 140 150
LFWLSMDYVA STASIFSVFI LCIDRYRSVQ QPLRYLKYRT KTRASATILG
160 170 180 190 200
AWFLSFLWVI PILGWNHFMQ QTSVRREDKC ETDFYDVTWF KVMTAIINFY
210 220 230 240 250
LPTLLMLWFY AKIYKAVRQH CQHRELINRS LPSFSEIKLR PENPKGDAKK
260 270 280 290 300
PGKESPWEVL KRKPKDAGGG SVLKSPSQTP KEMKSPVVFS QEDDREVDKL
310 320 330 340 350
YCFPLDIVHM QAAAEGSSRD YVAVNRSHGQ LKTDEQGLNT HGASEISEDQ
360 370 380 390 400
MLGDSQSFSR TDSDTTTETA PGKGKLRSGS NTGLDYIKFT WKRLRSHSRQ
410 420 430 440 450
YVSGLHMNRE RKAAKQLGFI MAAFILCWIP YFIFFMVIAF CKNCCNEHLH
460 470 480
MFTIWLGYIN STLNPLIYPL CNENFKKTFK RILHIRS
Length:487
Mass (Da):55,784
Last modified:June 1, 1994 - v1
Checksum:iE5DB418A4C17A985
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti308V → E in AAH60802 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04941019K → N.Corresponds to variant rs2067466dbSNPEnsembl.1
Natural variantiVAR_033476270G → E.Corresponds to variant rs7651620dbSNPEnsembl.1
Natural variantiVAR_035761385D → E in a colorectal cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z34897 mRNA. Translation: CAA84380.1.
X76786 Genomic DNA. Translation: CAA54182.1.
D14436 Genomic DNA. Translation: BAA03319.1.
D28481 mRNA. Translation: BAA05840.1.
AF026261 mRNA. Translation: AAB95156.1.
AB041380 Genomic DNA. Translation: BAA94465.1.
AY136743 mRNA. Translation: AAN01269.1.
AK289412 mRNA. Translation: BAF82101.1.
CH471055 Genomic DNA. Translation: EAW64092.1.
BC060802 mRNA. Translation: AAH60802.1.
CCDSiCCDS2604.1.
PIRiJC2495.
RefSeqiNP_000852.1. NM_000861.3.
NP_001091681.1. NM_001098211.1.
NP_001091682.1. NM_001098212.1.
NP_001091683.1. NM_001098213.1.
XP_011531954.1. XM_011533652.1.
XP_011531955.1. XM_011533653.2.
XP_016861772.1. XM_017006283.1.
XP_016861773.1. XM_017006284.1.
UniGeneiHs.1570.

Genome annotation databases

EnsembliENST00000397056; ENSP00000380247; ENSG00000196639.
ENST00000431010; ENSP00000397028; ENSG00000196639.
ENST00000438284; ENSP00000406705; ENSG00000196639.
GeneIDi3269.
KEGGihsa:3269.
UCSCiuc003bwb.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z34897 mRNA. Translation: CAA84380.1.
X76786 Genomic DNA. Translation: CAA54182.1.
D14436 Genomic DNA. Translation: BAA03319.1.
D28481 mRNA. Translation: BAA05840.1.
AF026261 mRNA. Translation: AAB95156.1.
AB041380 Genomic DNA. Translation: BAA94465.1.
AY136743 mRNA. Translation: AAN01269.1.
AK289412 mRNA. Translation: BAF82101.1.
CH471055 Genomic DNA. Translation: EAW64092.1.
BC060802 mRNA. Translation: AAH60802.1.
CCDSiCCDS2604.1.
PIRiJC2495.
RefSeqiNP_000852.1. NM_000861.3.
NP_001091681.1. NM_001098211.1.
NP_001091682.1. NM_001098212.1.
NP_001091683.1. NM_001098213.1.
XP_011531954.1. XM_011533652.1.
XP_011531955.1. XM_011533653.2.
XP_016861772.1. XM_017006283.1.
XP_016861773.1. XM_017006284.1.
UniGeneiHs.1570.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3RZEX-ray3.10A20-221[»]
A405-487[»]
ProteinModelPortaliP35367.
SMRiP35367.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109505. 1 interactor.
DIPiDIP-41996N.
IntActiP35367. 1 interactor.
MINTiMINT-190077.
STRINGi9606.ENSP00000380247.

Chemistry databases

BindingDBiP35367.
ChEMBLiCHEMBL231.
DrugBankiDB01615. Aceprometazine.
DB06766. Alcaftadine.
DB01246. Alimemazine.
DB00321. Amitriptyline.
DB00543. Amoxapine.
DB08799. Antazoline.
DB01238. Aripiprazole.
DB06216. Asenapine.
DB00637. Astemizole.
DB00719. Azatadine.
DB00972. Azelastine.
DB00245. Benzatropine.
DB04890. Bepotastine.
DB06698. Betahistine.
DB01237. Bromodiphenhydramine.
DB00835. Brompheniramine.
DB00354. Buclizine.
DB09016. Butriptyline.
DB00748. Carbinoxamine.
DB06016. Cariprazine.
DB00341. Cetirizine.
DB08936. Chlorcyclizine.
DB08800. Chloropyramine.
DB01114. Chlorphenamine.
DB00477. Chlorpromazine.
DB01239. Chlorprothixene.
DB00568. Cinnarizine.
DB00215. Citalopram.
DB00283. Clemastine.
DB04837. Clofedanol.
DB00363. Clozapine.
DB01176. Cyclizine.
DB00434. Cyproheptadine.
DB01151. Desipramine.
DB00967. Desloratadine.
DB00405. Dexbrompheniramine.
DB00985. Dimenhydrinate.
DB08801. Dimetindene.
DB01075. Diphenhydramine.
DB01146. Diphenylpyraline.
DB01142. Doxepin.
DB00366. Doxylamine.
DB01084. Emedastine.
DB00751. Epinastine.
DB01175. Escitalopram.
DB00950. Fexofenadine.
DB04841. Flunarizine.
DB00667. Histamine Phosphate.
DB00557. Hydroxyzine.
DB04946. Iloperidone.
DB00458. Imipramine.
DB08802. Isothipendyl.
DB00920. Ketotifen.
DB01106. Levocabastine.
DB06282. Levocetirizine.
DB00455. Loratadine.
DB00408. Loxapine.
DB00934. Maprotiline.
DB00737. Meclizine.
DB06691. Mepyramine.
DB01071. Mequitazine.
DB00902. Methdilazine.
DB01403. Methotrimeprazine.
DB06148. Mianserin.
DB00370. Mirtazapine.
DB00540. Nortriptyline.
DB00334. Olanzapine.
DB00768. Olopatadine.
DB01173. Orphenadrine.
DB01267. Paliperidone.
DB01619. Phenindamine.
DB01620. Pheniramine.
DB00420. Promazine.
DB01069. Promethazine.
DB00777. Propiomazine.
DB01224. Quetiapine.
DB00734. Risperidone.
DB00797. Tolazoline.
DB00656. Trazodone.
DB00726. Trimipramine.
DB00792. Tripelennamine.
DB00427. Triprolidine.
DB00246. Ziprasidone.
DB01624. Zuclopenthixol.
GuidetoPHARMACOLOGYi262.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP35367.
PhosphoSitePlusiP35367.

Polymorphism and mutation databases

BioMutaiHRH1.
DMDMi547645.

Proteomic databases

MaxQBiP35367.
PaxDbiP35367.
PeptideAtlasiP35367.
PRIDEiP35367.

Protocols and materials databases

DNASUi3269.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000397056; ENSP00000380247; ENSG00000196639.
ENST00000431010; ENSP00000397028; ENSG00000196639.
ENST00000438284; ENSP00000406705; ENSG00000196639.
GeneIDi3269.
KEGGihsa:3269.
UCSCiuc003bwb.5. human.

Organism-specific databases

CTDi3269.
DisGeNETi3269.
GeneCardsiHRH1.
HGNCiHGNC:5182. HRH1.
HPAiHPA029740.
MIMi600167. gene.
neXtProtiNX_P35367.
OpenTargetsiENSG00000196639.
PharmGKBiPA29456.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4220. Eukaryota.
ENOG410YCQR. LUCA.
GeneTreeiENSGT00780000121874.
HOGENOMiHOG000273869.
HOVERGENiHBG101103.
InParanoidiP35367.
KOiK04149.
OMAiYIKFTWK.
OrthoDBiEOG091G06VI.
PhylomeDBiP35367.
TreeFamiTF333432.

Enzyme and pathway databases

BioCyciZFISH:G66-33559-MONOMER.
ReactomeiR-HSA-390650. Histamine receptors.
R-HSA-416476. G alpha (q) signalling events.
SIGNORiP35367.

Miscellaneous databases

ChiTaRSiHRH1. human.
GeneWikiiHistamine_H1_receptor.
GenomeRNAii3269.
PROiP35367.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196639.
CleanExiHS_HRH1.
ExpressionAtlasiP35367. baseline and differential.
GenevisibleiP35367. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000921. Histamine_H1_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00530. HISTAMINEH1R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHRH1_HUMAN
AccessioniPrimary (citable) accession number: P35367
Secondary accession number(s): A8K047, Q6P9E5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 2, 2016
This is version 156 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.