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P35365

- 5HT5B_RAT

UniProt

P35365 - 5HT5B_RAT

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Protein

5-hydroxytryptamine receptor 5B

Gene

Htr5b

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins. Probably involved in anxiety and depression.

GO - Molecular functioni

  1. drug binding Source: RGD
  2. serotonin binding Source: RGD
  3. serotonin receptor activity Source: RGD

GO - Biological processi

  1. serotonin receptor signaling pathway Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_233455. G alpha (i) signalling events.
REACT_246144. Serotonin receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 5B
Short name:
5-HT-5B
Short name:
5-HT5B
Alternative name(s):
MR22
Serotonin receptor 5B
Gene namesi
Name:Htr5b
Synonyms:5ht5b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 13

Organism-specific databases

RGDi62388. Htr5b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5252ExtracellularBy similarityAdd
BLAST
Transmembranei53 – 7523Helical; Name=1By similarityAdd
BLAST
Topological domaini76 – 9015CytoplasmicBy similarityAdd
BLAST
Transmembranei91 – 11121Helical; Name=2By similarityAdd
BLAST
Topological domaini112 – 12817ExtracellularBy similarityAdd
BLAST
Transmembranei129 – 15022Helical; Name=3By similarityAdd
BLAST
Topological domaini151 – 17121CytoplasmicBy similarityAdd
BLAST
Transmembranei172 – 19423Helical; Name=4By similarityAdd
BLAST
Topological domaini195 – 21117ExtracellularBy similarityAdd
BLAST
Transmembranei212 – 23221Helical; Name=5By similarityAdd
BLAST
Topological domaini233 – 29563CytoplasmicBy similarityAdd
BLAST
Transmembranei296 – 31621Helical; Name=6By similarityAdd
BLAST
Topological domaini317 – 33317ExtracellularBy similarityAdd
BLAST
Transmembranei334 – 35421Helical; Name=7By similarityAdd
BLAST
Topological domaini355 – 37016CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: InterPro
  2. membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3703705-hydroxytryptamine receptor 5BPRO_0000068973Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi127 ↔ 205PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

PTM databases

PhosphoSiteiP35365.

Expressioni

Tissue specificityi

Brain; in the CA1 region of hippocampus, the medial habenula, and raphe nuclei.

Gene expression databases

GenevestigatoriP35365.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003441.

Structurei

3D structure databases

ProteinModelPortaliP35365.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG260742.
GeneTreeiENSGT00760000118795.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP35365.
KOiK04161.
OMAiAFHRVPH.
OrthoDBiEOG7SXW3H.
PhylomeDBiP35365.
TreeFamiTF316350.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000431. 5HT5B_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24247:SF15. PTHR24247:SF15. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00519. 5HT5BRECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35365-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEVSNLSGAT PGIAFPPGPE SCSDSPSSGR SMGSTPGGLI LSGREPPFSA
60 70 80 90 100
FTVLVVTLLV LLIAATFLWN LLVLVTILRV RAFHRVPHNL VASTAVSDVL
110 120 130 140 150
VAALVMPLSL VSELSAGRRW QLGRSLCHVW ISFDVLCCTA SIWNVAAIAL
160 170 180 190 200
DRYWTITRHL QYTLRTRRRA SALMIAITWA LSALIALAPL LFGWGEAYDA
210 220 230 240 250
RLQRCQVSQE PSYAVFSTCG AFYVPLAVVL FVYWKIYKAA KFRFGRRRRA
260 270 280 290 300
VVPLPATTQA KEAPQESETV FTARCRATVA FQTSGDSWRE QKEKRAAMMV
310 320 330 340 350
GILIGVFVLC WIPFFLTELV SPLCACSLPP IWKSIFLWLG YSNSFFNPLI
360 370
YTAFNKNYNN AFKSLFTKQR
Length:370
Mass (Da):41,122
Last modified:June 1, 1994 - v1
Checksum:i8EC5F789BFD647E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10073 mRNA. Translation: AAA40616.1.
PIRiS38744.
RefSeqiNP_077371.1. NM_024395.1.
UniGeneiRn.202942.

Genome annotation databases

EnsembliENSRNOT00000003441; ENSRNOP00000003441; ENSRNOG00000002549.
GeneIDi79247.
KEGGirno:79247.
UCSCiRGD:62388. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10073 mRNA. Translation: AAA40616.1 .
PIRi S38744.
RefSeqi NP_077371.1. NM_024395.1.
UniGenei Rn.202942.

3D structure databases

ProteinModelPortali P35365.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000003441.

Chemistry

BindingDBi P35365.
ChEMBLi CHEMBL2094123.
GuidetoPHARMACOLOGYi 648.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P35365.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000003441 ; ENSRNOP00000003441 ; ENSRNOG00000002549 .
GeneIDi 79247.
KEGGi rno:79247.
UCSCi RGD:62388. rat.

Organism-specific databases

CTDi 15564.
RGDi 62388. Htr5b.

Phylogenomic databases

eggNOGi NOG260742.
GeneTreei ENSGT00760000118795.
HOGENOMi HOG000239242.
HOVERGENi HBG106962.
InParanoidi P35365.
KOi K04161.
OMAi AFHRVPH.
OrthoDBi EOG7SXW3H.
PhylomeDBi P35365.
TreeFami TF316350.

Enzyme and pathway databases

Reactomei REACT_233455. G alpha (i) signalling events.
REACT_246144. Serotonin receptors.

Miscellaneous databases

NextBioi 614710.
PROi P35365.

Gene expression databases

Genevestigatori P35365.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000431. 5HT5B_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24247:SF15. PTHR24247:SF15. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00519. 5HT5BRECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Two members of a distinct subfamily of 5-hydroxytryptamine receptors differentially expressed in rat brain."
    Erlander M.G., Lovenberg T.W., Baron B.M., de Lecea L., Danielson P.E., Racke M., Slone A.L., Siegel B.W., Foye P.E., Cannon K., Burns J.E., Sutcliffe G.J.
    Proc. Natl. Acad. Sci. U.S.A. 90:3452-3456(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.
  2. "Cloning and characterization of the rat 5-HT5B receptor. Evidence that the 5-HT5B receptor couples to a G protein in mammalian cell membranes."
    Wisden W., Parker E.M., Mahle C.D., Grisel D.A., Nowak H.P., Yocca F.D., Felder C.C., Seeburg P.H., Voigt M.M.
    FEBS Lett. 333:25-31(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry namei5HT5B_RAT
AccessioniPrimary (citable) accession number: P35365
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 26, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3