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P35365 (5HT5B_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
5-hydroxytryptamine receptor 5B
Short name=5-HT-5B
Short name=5-HT5B
Alternative name(s):
MR22
Serotonin receptor 5B
Gene names
Name:Htr5b
Synonyms:5ht5b
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length370 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins. Probably involved in anxiety and depression.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Brain; in the CA1 region of hippocampus, the medial habenula, and raphe nuclei.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3703705-hydroxytryptamine receptor 5B
PRO_0000068973

Regions

Topological domain1 – 5252Extracellular By similarity
Transmembrane53 – 7523Helical; Name=1; By similarity
Topological domain76 – 9015Cytoplasmic By similarity
Transmembrane91 – 11121Helical; Name=2; By similarity
Topological domain112 – 12817Extracellular By similarity
Transmembrane129 – 15022Helical; Name=3; By similarity
Topological domain151 – 17121Cytoplasmic By similarity
Transmembrane172 – 19423Helical; Name=4; By similarity
Topological domain195 – 21117Extracellular By similarity
Transmembrane212 – 23221Helical; Name=5; By similarity
Topological domain233 – 29563Cytoplasmic By similarity
Transmembrane296 – 31621Helical; Name=6; By similarity
Topological domain317 – 33317Extracellular By similarity
Transmembrane334 – 35421Helical; Name=7; By similarity
Topological domain355 – 37016Cytoplasmic By similarity

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Disulfide bond127 ↔ 205 By similarity

Sequences

Sequence LengthMass (Da)Tools
P35365 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 8EC5F789BFD647E5

FASTA37041,122
        10         20         30         40         50         60 
MEVSNLSGAT PGIAFPPGPE SCSDSPSSGR SMGSTPGGLI LSGREPPFSA FTVLVVTLLV 

        70         80         90        100        110        120 
LLIAATFLWN LLVLVTILRV RAFHRVPHNL VASTAVSDVL VAALVMPLSL VSELSAGRRW 

       130        140        150        160        170        180 
QLGRSLCHVW ISFDVLCCTA SIWNVAAIAL DRYWTITRHL QYTLRTRRRA SALMIAITWA 

       190        200        210        220        230        240 
LSALIALAPL LFGWGEAYDA RLQRCQVSQE PSYAVFSTCG AFYVPLAVVL FVYWKIYKAA 

       250        260        270        280        290        300 
KFRFGRRRRA VVPLPATTQA KEAPQESETV FTARCRATVA FQTSGDSWRE QKEKRAAMMV 

       310        320        330        340        350        360 
GILIGVFVLC WIPFFLTELV SPLCACSLPP IWKSIFLWLG YSNSFFNPLI YTAFNKNYNN 

       370 
AFKSLFTKQR

« Hide

References

[1]"Two members of a distinct subfamily of 5-hydroxytryptamine receptors differentially expressed in rat brain."
Erlander M.G., Lovenberg T.W., Baron B.M., de Lecea L., Danielson P.E., Racke M., Slone A.L., Siegel B.W., Foye P.E., Cannon K., Burns J.E., Sutcliffe G.J.
Proc. Natl. Acad. Sci. U.S.A. 90:3452-3456(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Brain.
[2]"Cloning and characterization of the rat 5-HT5B receptor. Evidence that the 5-HT5B receptor couples to a G protein in mammalian cell membranes."
Wisden W., Parker E.M., Mahle C.D., Grisel D.A., Nowak H.P., Yocca F.D., Felder C.C., Seeburg P.H., Voigt M.M.
FEBS Lett. 333:25-31(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L10073 mRNA. Translation: AAA40616.1.
IPIIPI00197662.
PIRS38744.
RefSeqNP_077371.1. NM_024395.1.
UniGeneRn.202942.

3D structure databases

ProteinModelPortalP35365.
ModBaseSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000003441.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP35365.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000003441; ENSRNOP00000003441; ENSRNOG00000002549.
GeneID79247.
KEGGrno:79247.
UCSCRGD:62388. rat.

Organism-specific databases

CTD15564.
RGD62388. Htr5b.

Phylogenomic databases

eggNOGNOG260742.
GeneTreeENSGT00650000092921.
HOGENOMHOG000239242.
HOVERGENHBG106962.
InParanoidP35365.
KOK04161.
OMARCQVSQE.
OrthoDBEOG4K6G4Q.

Gene expression databases

GenevestigatorP35365.
GermOnlineENSRNOG00000002549. Rattus norvegicus.

Family and domain databases

InterProIPR000431. 5HT5B_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00519. 5HT5BRECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

BindingDBP35365.
ChEMBLCHEMBL2619.
NextBio614710.

Entry information

Entry name5HT5B_RAT
AccessionPrimary (citable) accession number: P35365
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: April 3, 2013
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

SIMILARITY comments

Index of protein domains and families

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