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P35365

- 5HT5B_RAT

UniProt

P35365 - 5HT5B_RAT

Protein

5-hydroxytryptamine receptor 5B

Gene

Htr5b

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins. Probably involved in anxiety and depression.

    GO - Molecular functioni

    1. drug binding Source: RGD
    2. serotonin binding Source: RGD
    3. serotonin receptor activity Source: RGD

    GO - Biological processi

    1. serotonin receptor signaling pathway Source: RGD

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5-hydroxytryptamine receptor 5B
    Short name:
    5-HT-5B
    Short name:
    5-HT5B
    Alternative name(s):
    MR22
    Serotonin receptor 5B
    Gene namesi
    Name:Htr5b
    Synonyms:5ht5b
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 13

    Organism-specific databases

    RGDi62388. Htr5b.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: InterPro
    2. membrane Source: RGD

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3703705-hydroxytryptamine receptor 5BPRO_0000068973Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi127 ↔ 205PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    PTM databases

    PhosphoSiteiP35365.

    Expressioni

    Tissue specificityi

    Brain; in the CA1 region of hippocampus, the medial habenula, and raphe nuclei.

    Gene expression databases

    GenevestigatoriP35365.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000003441.

    Structurei

    3D structure databases

    ProteinModelPortaliP35365.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5252ExtracellularBy similarityAdd
    BLAST
    Topological domaini76 – 9015CytoplasmicBy similarityAdd
    BLAST
    Topological domaini112 – 12817ExtracellularBy similarityAdd
    BLAST
    Topological domaini151 – 17121CytoplasmicBy similarityAdd
    BLAST
    Topological domaini195 – 21117ExtracellularBy similarityAdd
    BLAST
    Topological domaini233 – 29563CytoplasmicBy similarityAdd
    BLAST
    Topological domaini317 – 33317ExtracellularBy similarityAdd
    BLAST
    Topological domaini355 – 37016CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei53 – 7523Helical; Name=1By similarityAdd
    BLAST
    Transmembranei91 – 11121Helical; Name=2By similarityAdd
    BLAST
    Transmembranei129 – 15022Helical; Name=3By similarityAdd
    BLAST
    Transmembranei172 – 19423Helical; Name=4By similarityAdd
    BLAST
    Transmembranei212 – 23221Helical; Name=5By similarityAdd
    BLAST
    Transmembranei296 – 31621Helical; Name=6By similarityAdd
    BLAST
    Transmembranei334 – 35421Helical; Name=7By similarityAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG260742.
    GeneTreeiENSGT00750000117301.
    HOGENOMiHOG000239242.
    HOVERGENiHBG106962.
    InParanoidiP35365.
    KOiK04161.
    OMAiAFHRVPH.
    OrthoDBiEOG7SXW3H.
    PhylomeDBiP35365.
    TreeFamiTF316350.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000431. 5HT5B_rcpt.
    IPR002231. 5HT_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24247:SF15. PTHR24247:SF15. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00519. 5HT5BRECEPTR.
    PR01101. 5HTRECEPTOR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P35365-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEVSNLSGAT PGIAFPPGPE SCSDSPSSGR SMGSTPGGLI LSGREPPFSA    50
    FTVLVVTLLV LLIAATFLWN LLVLVTILRV RAFHRVPHNL VASTAVSDVL 100
    VAALVMPLSL VSELSAGRRW QLGRSLCHVW ISFDVLCCTA SIWNVAAIAL 150
    DRYWTITRHL QYTLRTRRRA SALMIAITWA LSALIALAPL LFGWGEAYDA 200
    RLQRCQVSQE PSYAVFSTCG AFYVPLAVVL FVYWKIYKAA KFRFGRRRRA 250
    VVPLPATTQA KEAPQESETV FTARCRATVA FQTSGDSWRE QKEKRAAMMV 300
    GILIGVFVLC WIPFFLTELV SPLCACSLPP IWKSIFLWLG YSNSFFNPLI 350
    YTAFNKNYNN AFKSLFTKQR 370
    Length:370
    Mass (Da):41,122
    Last modified:June 1, 1994 - v1
    Checksum:i8EC5F789BFD647E5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L10073 mRNA. Translation: AAA40616.1.
    PIRiS38744.
    RefSeqiNP_077371.1. NM_024395.1.
    UniGeneiRn.202942.

    Genome annotation databases

    EnsembliENSRNOT00000003441; ENSRNOP00000003441; ENSRNOG00000002549.
    GeneIDi79247.
    KEGGirno:79247.
    UCSCiRGD:62388. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L10073 mRNA. Translation: AAA40616.1 .
    PIRi S38744.
    RefSeqi NP_077371.1. NM_024395.1.
    UniGenei Rn.202942.

    3D structure databases

    ProteinModelPortali P35365.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000003441.

    Chemistry

    BindingDBi P35365.
    ChEMBLi CHEMBL2094123.
    GuidetoPHARMACOLOGYi 648.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P35365.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000003441 ; ENSRNOP00000003441 ; ENSRNOG00000002549 .
    GeneIDi 79247.
    KEGGi rno:79247.
    UCSCi RGD:62388. rat.

    Organism-specific databases

    CTDi 15564.
    RGDi 62388. Htr5b.

    Phylogenomic databases

    eggNOGi NOG260742.
    GeneTreei ENSGT00750000117301.
    HOGENOMi HOG000239242.
    HOVERGENi HBG106962.
    InParanoidi P35365.
    KOi K04161.
    OMAi AFHRVPH.
    OrthoDBi EOG7SXW3H.
    PhylomeDBi P35365.
    TreeFami TF316350.

    Miscellaneous databases

    NextBioi 614710.
    PROi P35365.

    Gene expression databases

    Genevestigatori P35365.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000431. 5HT5B_rcpt.
    IPR002231. 5HT_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24247:SF15. PTHR24247:SF15. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00519. 5HT5BRECEPTR.
    PR01101. 5HTRECEPTOR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Two members of a distinct subfamily of 5-hydroxytryptamine receptors differentially expressed in rat brain."
      Erlander M.G., Lovenberg T.W., Baron B.M., de Lecea L., Danielson P.E., Racke M., Slone A.L., Siegel B.W., Foye P.E., Cannon K., Burns J.E., Sutcliffe G.J.
      Proc. Natl. Acad. Sci. U.S.A. 90:3452-3456(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Brain.
    2. "Cloning and characterization of the rat 5-HT5B receptor. Evidence that the 5-HT5B receptor couples to a G protein in mammalian cell membranes."
      Wisden W., Parker E.M., Mahle C.D., Grisel D.A., Nowak H.P., Yocca F.D., Felder C.C., Seeburg P.H., Voigt M.M.
      FEBS Lett. 333:25-31(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry namei5HT5B_RAT
    AccessioniPrimary (citable) accession number: P35365
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3