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Protein

5-hydroxytryptamine receptor 5B

Gene

Htr5b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins. Probably involved in anxiety and depression.

GO - Molecular functioni

  • drug binding Source: RGD
  • G-protein coupled serotonin receptor activity Source: RGD
  • neurotransmitter receptor activity Source: GO_Central
  • serotonin binding Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 5B
Short name:
5-HT-5B
Short name:
5-HT5B
Alternative name(s):
MR22
Serotonin receptor 5B
Gene namesi
Name:Htr5b
Synonyms:5ht5b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi62388. Htr5b.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 52ExtracellularBy similarityAdd BLAST52
Transmembranei53 – 75Helical; Name=1By similarityAdd BLAST23
Topological domaini76 – 90CytoplasmicBy similarityAdd BLAST15
Transmembranei91 – 111Helical; Name=2By similarityAdd BLAST21
Topological domaini112 – 128ExtracellularBy similarityAdd BLAST17
Transmembranei129 – 150Helical; Name=3By similarityAdd BLAST22
Topological domaini151 – 171CytoplasmicBy similarityAdd BLAST21
Transmembranei172 – 194Helical; Name=4By similarityAdd BLAST23
Topological domaini195 – 211ExtracellularBy similarityAdd BLAST17
Transmembranei212 – 232Helical; Name=5By similarityAdd BLAST21
Topological domaini233 – 295CytoplasmicBy similarityAdd BLAST63
Transmembranei296 – 316Helical; Name=6By similarityAdd BLAST21
Topological domaini317 – 333ExtracellularBy similarityAdd BLAST17
Transmembranei334 – 354Helical; Name=7By similarityAdd BLAST21
Topological domaini355 – 370CytoplasmicBy similarityAdd BLAST16

GO - Cellular componenti

  • dendrite Source: GO_Central
  • integral component of plasma membrane Source: GO_Central
  • membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2619.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000689731 – 3705-hydroxytryptamine receptor 5BAdd BLAST370

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi127 ↔ 205PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP35365.

PTM databases

PhosphoSitePlusiP35365.

Expressioni

Tissue specificityi

Brain; in the CA1 region of hippocampus, the medial habenula, and raphe nuclei.

Gene expression databases

BgeeiENSRNOG00000002549.
GenevisibleiP35365. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003441.

Chemistry databases

BindingDBiP35365.

Structurei

3D structure databases

ProteinModelPortaliP35365.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118795.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP35365.
KOiK04161.
OMAiRCQVSQE.
OrthoDBiEOG091G06VI.
PhylomeDBiP35365.
TreeFamiTF316350.

Family and domain databases

InterProiIPR000431. 5HT5B_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24247:SF14. PTHR24247:SF14. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00519. 5HT5BRECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35365-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVSNLSGAT PGIAFPPGPE SCSDSPSSGR SMGSTPGGLI LSGREPPFSA
60 70 80 90 100
FTVLVVTLLV LLIAATFLWN LLVLVTILRV RAFHRVPHNL VASTAVSDVL
110 120 130 140 150
VAALVMPLSL VSELSAGRRW QLGRSLCHVW ISFDVLCCTA SIWNVAAIAL
160 170 180 190 200
DRYWTITRHL QYTLRTRRRA SALMIAITWA LSALIALAPL LFGWGEAYDA
210 220 230 240 250
RLQRCQVSQE PSYAVFSTCG AFYVPLAVVL FVYWKIYKAA KFRFGRRRRA
260 270 280 290 300
VVPLPATTQA KEAPQESETV FTARCRATVA FQTSGDSWRE QKEKRAAMMV
310 320 330 340 350
GILIGVFVLC WIPFFLTELV SPLCACSLPP IWKSIFLWLG YSNSFFNPLI
360 370
YTAFNKNYNN AFKSLFTKQR
Length:370
Mass (Da):41,122
Last modified:June 1, 1994 - v1
Checksum:i8EC5F789BFD647E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10073 mRNA. Translation: AAA40616.1.
PIRiS38744.
RefSeqiNP_077371.1. NM_024395.1.
UniGeneiRn.202942.

Genome annotation databases

EnsembliENSRNOT00000003441; ENSRNOP00000003441; ENSRNOG00000002549.
GeneIDi79247.
KEGGirno:79247.
UCSCiRGD:62388. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10073 mRNA. Translation: AAA40616.1.
PIRiS38744.
RefSeqiNP_077371.1. NM_024395.1.
UniGeneiRn.202942.

3D structure databases

ProteinModelPortaliP35365.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003441.

Chemistry databases

BindingDBiP35365.
ChEMBLiCHEMBL2619.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP35365.

Proteomic databases

PaxDbiP35365.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000003441; ENSRNOP00000003441; ENSRNOG00000002549.
GeneIDi79247.
KEGGirno:79247.
UCSCiRGD:62388. rat.

Organism-specific databases

CTDi15564.
RGDi62388. Htr5b.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118795.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP35365.
KOiK04161.
OMAiRCQVSQE.
OrthoDBiEOG091G06VI.
PhylomeDBiP35365.
TreeFamiTF316350.

Miscellaneous databases

PROiP35365.

Gene expression databases

BgeeiENSRNOG00000002549.
GenevisibleiP35365. RN.

Family and domain databases

InterProiIPR000431. 5HT5B_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24247:SF14. PTHR24247:SF14. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00519. 5HT5BRECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry namei5HT5B_RAT
AccessioniPrimary (citable) accession number: P35365
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 2, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.