Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P35364

- 5HT5A_RAT

UniProt

P35364 - 5HT5A_RAT

Protein

5-hydroxytryptamine receptor 5A

Gene

Htr5a

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins.

    GO - Molecular functioni

    1. serotonin receptor activity Source: RGD

    GO - Biological processi

    1. brain development Source: RGD
    2. cAMP-mediated signaling Source: Ensembl
    3. G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: RGD
    4. hippocampus development Source: RGD
    5. response to estradiol Source: RGD

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5-hydroxytryptamine receptor 5A
    Short name:
    5-HT-5A
    Short name:
    5-HT5A
    Alternative name(s):
    REC17
    Serotonin receptor 5A
    Gene namesi
    Name:Htr5a
    Synonyms:5ht5a
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 4

    Organism-specific databases

    RGDi2851. Htr5a.

    Subcellular locationi

    GO - Cellular componenti

    1. dendrite Source: RGD
    2. Golgi apparatus Source: RGD
    3. integral component of plasma membrane Source: InterPro
    4. perikaryon Source: RGD
    5. rough endoplasmic reticulum Source: RGD

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3573575-hydroxytryptamine receptor 5APRO_0000068971Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi120 ↔ 192PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP35364.

    PTM databases

    PhosphoSiteiP35364.

    Expressioni

    Tissue specificityi

    Central nervous system.

    Gene expression databases

    GenevestigatoriP35364.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000009317.

    Structurei

    3D structure databases

    ProteinModelPortaliP35364.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4040ExtracellularBy similarityAdd
    BLAST
    Topological domaini64 – 7815CytoplasmicBy similarityAdd
    BLAST
    Topological domaini100 – 11516ExtracellularBy similarityAdd
    BLAST
    Topological domaini138 – 15821CytoplasmicBy similarityAdd
    BLAST
    Topological domaini182 – 19817ExtracellularBy similarityAdd
    BLAST
    Topological domaini220 – 28263CytoplasmicBy similarityAdd
    BLAST
    Topological domaini304 – 32017ExtracellularBy similarityAdd
    BLAST
    Topological domaini342 – 35716CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei41 – 6323Helical; Name=1By similarityAdd
    BLAST
    Transmembranei79 – 9921Helical; Name=2By similarityAdd
    BLAST
    Transmembranei116 – 13722Helical; Name=3By similarityAdd
    BLAST
    Transmembranei159 – 18123Helical; Name=4By similarityAdd
    BLAST
    Transmembranei199 – 21921Helical; Name=5By similarityAdd
    BLAST
    Transmembranei283 – 30321Helical; Name=6By similarityAdd
    BLAST
    Transmembranei321 – 34121Helical; Name=7By similarityAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG260742.
    GeneTreeiENSGT00750000117301.
    HOGENOMiHOG000239242.
    HOVERGENiHBG106962.
    InParanoidiP35364.
    KOiK04161.
    OMAiNSAFKNF.
    OrthoDBiEOG7SXW3H.
    PhylomeDBiP35364.
    TreeFamiTF316350.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR001397. 5HT5A_rcpt.
    IPR002231. 5HT_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24247:SF14. PTHR24247:SF14. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00518. 5HT5ARECEPTR.
    PR01101. 5HTRECEPTOR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P35364-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLPINLTSF SLSTPSTLEP NRSLDTEALR TSQSFLSAFR VLVLTLLGFL    50
    AAATFTWNLL VLATILRVRT FHRVPHNLVA SMAISDVLVA VLVMPLSLVH 100
    ELSGRRWQLG RRLCQLWIAC DVLCCTASIW NVTAIALDRY WSITRHLEYT 150
    LRARKRVSNV MILLTWALSA VISLAPLLFG WGETYSELSE ECQVSREPSY 200
    TVFSTVGAFY LPLCVVLFVY WKIYKAAKFR MGSRKTNSVS PIPEAVEVKD 250
    ASQHPQMVFT VRHATVTFQT EGDTWREQKE QRAALMVGIL IGVFVLCWFP 300
    FFVTELISPL CSWDIPALWK SIFLWLGYSN SFFNPLIYTA FNRSYSSAFK 350
    VFFSKQQ 357
    Length:357
    Mass (Da):40,673
    Last modified:June 1, 1994 - v1
    Checksum:i8C498A50C88408B5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L10072 mRNA. Translation: AAA40615.1.
    PIRiB47472.
    RefSeqiNP_037280.1. NM_013148.1.
    UniGeneiRn.10569.

    Genome annotation databases

    EnsembliENSRNOT00000009317; ENSRNOP00000009317; ENSRNOG00000007066.
    GeneIDi25689.
    KEGGirno:25689.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L10072 mRNA. Translation: AAA40615.1 .
    PIRi B47472.
    RefSeqi NP_037280.1. NM_013148.1.
    UniGenei Rn.10569.

    3D structure databases

    ProteinModelPortali P35364.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000009317.

    Chemistry

    BindingDBi P35364.
    ChEMBLi CHEMBL4655.
    GuidetoPHARMACOLOGYi 10.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P35364.

    Proteomic databases

    PRIDEi P35364.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000009317 ; ENSRNOP00000009317 ; ENSRNOG00000007066 .
    GeneIDi 25689.
    KEGGi rno:25689.

    Organism-specific databases

    CTDi 3361.
    RGDi 2851. Htr5a.

    Phylogenomic databases

    eggNOGi NOG260742.
    GeneTreei ENSGT00750000117301.
    HOGENOMi HOG000239242.
    HOVERGENi HBG106962.
    InParanoidi P35364.
    KOi K04161.
    OMAi NSAFKNF.
    OrthoDBi EOG7SXW3H.
    PhylomeDBi P35364.
    TreeFami TF316350.

    Miscellaneous databases

    NextBioi 607685.
    PROi P35364.

    Gene expression databases

    Genevestigatori P35364.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR001397. 5HT5A_rcpt.
    IPR002231. 5HT_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24247:SF14. PTHR24247:SF14. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00518. 5HT5ARECEPTR.
    PR01101. 5HTRECEPTOR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Two members of a distinct subfamily of 5-hydroxytryptamine receptors differentially expressed in rat brain."
      Erlander M.G., Lovenberg T.W., Baron B.M., de Lecea L., Danielson P.E., Racke M., Slone A.L., Siegel B.W., Foye P.E., Cannon K., Burns J.E., Sutcliffe G.J.
      Proc. Natl. Acad. Sci. U.S.A. 90:3452-3456(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Brain.

    Entry informationi

    Entry namei5HT5A_RAT
    AccessioniPrimary (citable) accession number: P35364
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3