SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P35364

- 5HT5A_RAT

UniProt

P35364 - 5HT5A_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
5-hydroxytryptamine receptor 5A
Gene
Htr5a, 5ht5a
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins.

GO - Molecular functioni

  1. serotonin receptor activity Source: RGD
Complete GO annotation...

GO - Biological processi

  1. G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: RGD
  2. brain development Source: RGD
  3. cAMP-mediated signaling Source: Ensembl
  4. hippocampus development Source: RGD
  5. response to estradiol Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 5A
Short name:
5-HT-5A
Short name:
5-HT5A
Alternative name(s):
REC17
Serotonin receptor 5A
Gene namesi
Name:Htr5a
Synonyms:5ht5a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 4

Organism-specific databases

RGDi2851. Htr5a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4040Extracellular By similarity
Add
BLAST
Transmembranei41 – 6323Helical; Name=1; By similarity
Add
BLAST
Topological domaini64 – 7815Cytoplasmic By similarity
Add
BLAST
Transmembranei79 – 9921Helical; Name=2; By similarity
Add
BLAST
Topological domaini100 – 11516Extracellular By similarity
Add
BLAST
Transmembranei116 – 13722Helical; Name=3; By similarity
Add
BLAST
Topological domaini138 – 15821Cytoplasmic By similarity
Add
BLAST
Transmembranei159 – 18123Helical; Name=4; By similarity
Add
BLAST
Topological domaini182 – 19817Extracellular By similarity
Add
BLAST
Transmembranei199 – 21921Helical; Name=5; By similarity
Add
BLAST
Topological domaini220 – 28263Cytoplasmic By similarity
Add
BLAST
Transmembranei283 – 30321Helical; Name=6; By similarity
Add
BLAST
Topological domaini304 – 32017Extracellular By similarity
Add
BLAST
Transmembranei321 – 34121Helical; Name=7; By similarity
Add
BLAST
Topological domaini342 – 35716Cytoplasmic By similarity
Add
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: RGD
  2. dendrite Source: RGD
  3. integral component of plasma membrane Source: InterPro
  4. perikaryon Source: RGD
  5. rough endoplasmic reticulum Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3573575-hydroxytryptamine receptor 5A
PRO_0000068971Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...) Reviewed prediction
Glycosylationi21 – 211N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi120 ↔ 192 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP35364.

PTM databases

PhosphoSiteiP35364.

Expressioni

Tissue specificityi

Central nervous system.

Gene expression databases

GenevestigatoriP35364.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009317.

Structurei

3D structure databases

ProteinModelPortaliP35364.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG260742.
GeneTreeiENSGT00750000117301.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP35364.
KOiK04161.
OMAiNSAFKNF.
OrthoDBiEOG7SXW3H.
PhylomeDBiP35364.
TreeFamiTF316350.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR001397. 5HT5A_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24247:SF14. PTHR24247:SF14. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00518. 5HT5ARECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35364-1 [UniParc]FASTAAdd to Basket

« Hide

MDLPINLTSF SLSTPSTLEP NRSLDTEALR TSQSFLSAFR VLVLTLLGFL    50
AAATFTWNLL VLATILRVRT FHRVPHNLVA SMAISDVLVA VLVMPLSLVH 100
ELSGRRWQLG RRLCQLWIAC DVLCCTASIW NVTAIALDRY WSITRHLEYT 150
LRARKRVSNV MILLTWALSA VISLAPLLFG WGETYSELSE ECQVSREPSY 200
TVFSTVGAFY LPLCVVLFVY WKIYKAAKFR MGSRKTNSVS PIPEAVEVKD 250
ASQHPQMVFT VRHATVTFQT EGDTWREQKE QRAALMVGIL IGVFVLCWFP 300
FFVTELISPL CSWDIPALWK SIFLWLGYSN SFFNPLIYTA FNRSYSSAFK 350
VFFSKQQ 357
Length:357
Mass (Da):40,673
Last modified:June 1, 1994 - v1
Checksum:i8C498A50C88408B5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L10072 mRNA. Translation: AAA40615.1.
PIRiB47472.
RefSeqiNP_037280.1. NM_013148.1.
UniGeneiRn.10569.

Genome annotation databases

EnsembliENSRNOT00000009317; ENSRNOP00000009317; ENSRNOG00000007066.
GeneIDi25689.
KEGGirno:25689.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L10072 mRNA. Translation: AAA40615.1 .
PIRi B47472.
RefSeqi NP_037280.1. NM_013148.1.
UniGenei Rn.10569.

3D structure databases

ProteinModelPortali P35364.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000009317.

Chemistry

BindingDBi P35364.
ChEMBLi CHEMBL4655.
GuidetoPHARMACOLOGYi 10.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P35364.

Proteomic databases

PRIDEi P35364.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000009317 ; ENSRNOP00000009317 ; ENSRNOG00000007066 .
GeneIDi 25689.
KEGGi rno:25689.

Organism-specific databases

CTDi 3361.
RGDi 2851. Htr5a.

Phylogenomic databases

eggNOGi NOG260742.
GeneTreei ENSGT00750000117301.
HOGENOMi HOG000239242.
HOVERGENi HBG106962.
InParanoidi P35364.
KOi K04161.
OMAi NSAFKNF.
OrthoDBi EOG7SXW3H.
PhylomeDBi P35364.
TreeFami TF316350.

Miscellaneous databases

NextBioi 607685.
PROi P35364.

Gene expression databases

Genevestigatori P35364.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR001397. 5HT5A_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24247:SF14. PTHR24247:SF14. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00518. 5HT5ARECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Two members of a distinct subfamily of 5-hydroxytryptamine receptors differentially expressed in rat brain."
    Erlander M.G., Lovenberg T.W., Baron B.M., de Lecea L., Danielson P.E., Racke M., Slone A.L., Siegel B.W., Foye P.E., Cannon K., Burns J.E., Sutcliffe G.J.
    Proc. Natl. Acad. Sci. U.S.A. 90:3452-3456(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry namei5HT5A_RAT
AccessioniPrimary (citable) accession number: P35364
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: April 16, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi