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P35364 (5HT5A_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
5-hydroxytryptamine receptor 5A

Short name=5-HT-5A
Short name=5-HT5A
Alternative name(s):
REC17
Serotonin receptor 5A
Gene names
Name:Htr5a
Synonyms:5ht5a
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length357 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Central nervous system.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3573575-hydroxytryptamine receptor 5A
PRO_0000068971

Regions

Topological domain1 – 4040Extracellular By similarity
Transmembrane41 – 6323Helical; Name=1; By similarity
Topological domain64 – 7815Cytoplasmic By similarity
Transmembrane79 – 9921Helical; Name=2; By similarity
Topological domain100 – 11516Extracellular By similarity
Transmembrane116 – 13722Helical; Name=3; By similarity
Topological domain138 – 15821Cytoplasmic By similarity
Transmembrane159 – 18123Helical; Name=4; By similarity
Topological domain182 – 19817Extracellular By similarity
Transmembrane199 – 21921Helical; Name=5; By similarity
Topological domain220 – 28263Cytoplasmic By similarity
Transmembrane283 – 30321Helical; Name=6; By similarity
Topological domain304 – 32017Extracellular By similarity
Transmembrane321 – 34121Helical; Name=7; By similarity
Topological domain342 – 35716Cytoplasmic By similarity

Amino acid modifications

Glycosylation61N-linked (GlcNAc...) Potential
Glycosylation211N-linked (GlcNAc...) Potential
Disulfide bond120 ↔ 192 By similarity

Sequences

Sequence LengthMass (Da)Tools
P35364 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 8C498A50C88408B5

FASTA35740,673
        10         20         30         40         50         60 
MDLPINLTSF SLSTPSTLEP NRSLDTEALR TSQSFLSAFR VLVLTLLGFL AAATFTWNLL 

        70         80         90        100        110        120 
VLATILRVRT FHRVPHNLVA SMAISDVLVA VLVMPLSLVH ELSGRRWQLG RRLCQLWIAC 

       130        140        150        160        170        180 
DVLCCTASIW NVTAIALDRY WSITRHLEYT LRARKRVSNV MILLTWALSA VISLAPLLFG 

       190        200        210        220        230        240 
WGETYSELSE ECQVSREPSY TVFSTVGAFY LPLCVVLFVY WKIYKAAKFR MGSRKTNSVS 

       250        260        270        280        290        300 
PIPEAVEVKD ASQHPQMVFT VRHATVTFQT EGDTWREQKE QRAALMVGIL IGVFVLCWFP 

       310        320        330        340        350 
FFVTELISPL CSWDIPALWK SIFLWLGYSN SFFNPLIYTA FNRSYSSAFK VFFSKQQ 

« Hide

References

[1]"Two members of a distinct subfamily of 5-hydroxytryptamine receptors differentially expressed in rat brain."
Erlander M.G., Lovenberg T.W., Baron B.M., de Lecea L., Danielson P.E., Racke M., Slone A.L., Siegel B.W., Foye P.E., Cannon K., Burns J.E., Sutcliffe G.J.
Proc. Natl. Acad. Sci. U.S.A. 90:3452-3456(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L10072 mRNA. Translation: AAA40615.1.
PIRB47472.
RefSeqNP_037280.1. NM_013148.1.
UniGeneRn.10569.

3D structure databases

ProteinModelPortalP35364.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000009317.

Chemistry

BindingDBP35364.
ChEMBLCHEMBL4655.
GuidetoPHARMACOLOGY10.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP35364.

Proteomic databases

PRIDEP35364.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000009317; ENSRNOP00000009317; ENSRNOG00000007066.
GeneID25689.
KEGGrno:25689.

Organism-specific databases

CTD3361.
RGD2851. Htr5a.

Phylogenomic databases

eggNOGNOG260742.
GeneTreeENSGT00750000117301.
HOGENOMHOG000239242.
HOVERGENHBG106962.
InParanoidP35364.
KOK04161.
OMANSAFKNF.
OrthoDBEOG7SXW3H.
PhylomeDBP35364.
TreeFamTF316350.

Gene expression databases

GenevestigatorP35364.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR001397. 5HT5A_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24247:SF14. PTHR24247:SF14. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00518. 5HT5ARECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio607685.
PROP35364.

Entry information

Entry name5HT5A_RAT
AccessionPrimary (citable) accession number: P35364
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: April 16, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries