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Protein

5-hydroxytryptamine receptor 5A

Gene

Htr5a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins.

GO - Molecular functioni

  1. serotonin receptor activity Source: RGD

GO - Biological processi

  1. brain development Source: RGD
  2. cAMP-mediated signaling Source: Ensembl
  3. G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: RGD
  4. hippocampus development Source: RGD
  5. response to estradiol Source: RGD
  6. serotonin receptor signaling pathway Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_233455. G alpha (i) signalling events.
REACT_246144. Serotonin receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 5A
Short name:
5-HT-5A
Short name:
5-HT5A
Alternative name(s):
REC17
Serotonin receptor 5A
Gene namesi
Name:Htr5a
Synonyms:5ht5a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 4

Organism-specific databases

RGDi2851. Htr5a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4040ExtracellularBy similarityAdd
BLAST
Transmembranei41 – 6323Helical; Name=1By similarityAdd
BLAST
Topological domaini64 – 7815CytoplasmicBy similarityAdd
BLAST
Transmembranei79 – 9921Helical; Name=2By similarityAdd
BLAST
Topological domaini100 – 11516ExtracellularBy similarityAdd
BLAST
Transmembranei116 – 13722Helical; Name=3By similarityAdd
BLAST
Topological domaini138 – 15821CytoplasmicBy similarityAdd
BLAST
Transmembranei159 – 18123Helical; Name=4By similarityAdd
BLAST
Topological domaini182 – 19817ExtracellularBy similarityAdd
BLAST
Transmembranei199 – 21921Helical; Name=5By similarityAdd
BLAST
Topological domaini220 – 28263CytoplasmicBy similarityAdd
BLAST
Transmembranei283 – 30321Helical; Name=6By similarityAdd
BLAST
Topological domaini304 – 32017ExtracellularBy similarityAdd
BLAST
Transmembranei321 – 34121Helical; Name=7By similarityAdd
BLAST
Topological domaini342 – 35716CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  1. dendrite Source: RGD
  2. Golgi apparatus Source: RGD
  3. integral component of plasma membrane Source: InterPro
  4. perikaryon Source: RGD
  5. rough endoplasmic reticulum Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3573575-hydroxytryptamine receptor 5APRO_0000068971Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi120 ↔ 192PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP35364.

PTM databases

PhosphoSiteiP35364.

Expressioni

Tissue specificityi

Central nervous system.

Gene expression databases

GenevestigatoriP35364.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009317.

Structurei

3D structure databases

ProteinModelPortaliP35364.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG260742.
GeneTreeiENSGT00760000118795.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP35364.
KOiK04161.
OMAiNSAFKNF.
OrthoDBiEOG7SXW3H.
PhylomeDBiP35364.
TreeFamiTF316350.

Family and domain databases

InterProiIPR001397. 5HT5A_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24247:SF14. PTHR24247:SF14. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00518. 5HT5ARECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35364-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLPINLTSF SLSTPSTLEP NRSLDTEALR TSQSFLSAFR VLVLTLLGFL
60 70 80 90 100
AAATFTWNLL VLATILRVRT FHRVPHNLVA SMAISDVLVA VLVMPLSLVH
110 120 130 140 150
ELSGRRWQLG RRLCQLWIAC DVLCCTASIW NVTAIALDRY WSITRHLEYT
160 170 180 190 200
LRARKRVSNV MILLTWALSA VISLAPLLFG WGETYSELSE ECQVSREPSY
210 220 230 240 250
TVFSTVGAFY LPLCVVLFVY WKIYKAAKFR MGSRKTNSVS PIPEAVEVKD
260 270 280 290 300
ASQHPQMVFT VRHATVTFQT EGDTWREQKE QRAALMVGIL IGVFVLCWFP
310 320 330 340 350
FFVTELISPL CSWDIPALWK SIFLWLGYSN SFFNPLIYTA FNRSYSSAFK

VFFSKQQ
Length:357
Mass (Da):40,673
Last modified:June 1, 1994 - v1
Checksum:i8C498A50C88408B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10072 mRNA. Translation: AAA40615.1.
PIRiB47472.
RefSeqiNP_037280.1. NM_013148.1.
UniGeneiRn.10569.

Genome annotation databases

EnsembliENSRNOT00000009317; ENSRNOP00000009317; ENSRNOG00000007066.
GeneIDi25689.
KEGGirno:25689.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10072 mRNA. Translation: AAA40615.1.
PIRiB47472.
RefSeqiNP_037280.1. NM_013148.1.
UniGeneiRn.10569.

3D structure databases

ProteinModelPortaliP35364.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009317.

Chemistry

BindingDBiP35364.
ChEMBLiCHEMBL4655.
GuidetoPHARMACOLOGYi10.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP35364.

Proteomic databases

PRIDEiP35364.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000009317; ENSRNOP00000009317; ENSRNOG00000007066.
GeneIDi25689.
KEGGirno:25689.

Organism-specific databases

CTDi3361.
RGDi2851. Htr5a.

Phylogenomic databases

eggNOGiNOG260742.
GeneTreeiENSGT00760000118795.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP35364.
KOiK04161.
OMAiNSAFKNF.
OrthoDBiEOG7SXW3H.
PhylomeDBiP35364.
TreeFamiTF316350.

Enzyme and pathway databases

ReactomeiREACT_233455. G alpha (i) signalling events.
REACT_246144. Serotonin receptors.

Miscellaneous databases

NextBioi607685.
PROiP35364.

Gene expression databases

GenevestigatoriP35364.

Family and domain databases

InterProiIPR001397. 5HT5A_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24247:SF14. PTHR24247:SF14. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00518. 5HT5ARECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Two members of a distinct subfamily of 5-hydroxytryptamine receptors differentially expressed in rat brain."
    Erlander M.G., Lovenberg T.W., Baron B.M., de Lecea L., Danielson P.E., Racke M., Slone A.L., Siegel B.W., Foye P.E., Cannon K., Burns J.E., Sutcliffe G.J.
    Proc. Natl. Acad. Sci. U.S.A. 90:3452-3456(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry namei5HT5A_RAT
AccessioniPrimary (citable) accession number: P35364
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: January 7, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.