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P35351 (AGTR2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Type-2 angiotensin II receptor
Alternative name(s):
Angiotensin II type-2 receptor
Short name=AT2
Gene names
Name:Agtr2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length363 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation By similarity.

Subunit structure

Interacts with MTUS1 By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Abundant expression in fetal tissues, immature brain, skin wound and atretic ovarian follicles.

Developmental stage

Abundant in whole fetus but decreases rapidly after birth. In adults is highly expressed in the adrenal, present in the brain and uterus but undetectable in the heart.

Post-translational modification

C-terminal Ser or Thr residues may be phosphorylated.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
Phosphoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger

Inferred from electronic annotation. Source: Ensembl

aldosterone secretion

Inferred from mutant phenotype PubMed 1566502. Source: RGD

angiotensin-activated signaling pathway

Traceable author statement PubMed 14664700. Source: GOC

behavior

Inferred from electronic annotation. Source: Ensembl

brain renin-angiotensin system

Inferred from electronic annotation. Source: Ensembl

cell growth involved in cardiac muscle cell development

Inferred from mutant phenotype PubMed 21173078. Source: RGD

cellular response to dexamethasone stimulus

Inferred from direct assay PubMed 17537984. Source: UniProtKB

cellular sodium ion homeostasis

Inferred from mutant phenotype PubMed 16380540. Source: RGD

cerebellar cortex development

Inferred from mutant phenotype PubMed 19682991. Source: RGD

dopamine biosynthetic process

Inferred from mutant phenotype PubMed 20097214. Source: RGD

inflammatory response

Inferred from direct assay PubMed 21209001. Source: RGD

kidney development

Inferred from expression pattern PubMed 11924718. Source: RGD

kidney morphogenesis

Inferred from mutant phenotype PubMed 18495111. Source: RGD

negative regulation of fibroblast proliferation

Inferred from mutant phenotype PubMed 22184331. Source: RGD

negative regulation of heart rate

Inferred from electronic annotation. Source: Ensembl

negative regulation of icosanoid secretion

Inferred from mutant phenotype PubMed 18799632. Source: RGD

negative regulation of neurotrophin TRK receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

negative regulation of norepinephrine secretion

Inferred from direct assay PubMed 18670361. Source: RGD

neuron differentiation

Traceable author statement PubMed 14664700. Source: RGD

positive regulation of branching involved in ureteric bud morphogenesis

Inferred from mutant phenotype PubMed 17537984. Source: UniProtKB

positive regulation of cell proliferation

Inferred from mutant phenotype PubMed 22645419. Source: RGD

positive regulation of cytokine secretion

Inferred from mutant phenotype PubMed 19033105. Source: RGD

positive regulation of extrinsic apoptotic signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of metanephric glomerulus development

Inferred from electronic annotation. Source: Ensembl

positive regulation of nitric-oxide synthase activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of phosphoprotein phosphatase activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of renal sodium excretion

Inferred from mutant phenotype PubMed 16380540. Source: RGD

positive regulation of transcription, DNA-templated

Inferred from electronic annotation. Source: Ensembl

positive regulation of vasodilation

Inferred from mutant phenotype PubMed 18463192PubMed 23718715. Source: RGD

regulation of metanephros size

Inferred from electronic annotation. Source: Ensembl

regulation of systemic arterial blood pressure by circulatory renin-angiotensin

Inferred from electronic annotation. Source: Ensembl

regulation of transcription factor import into nucleus

Inferred from direct assay PubMed 14657020. Source: RGD

renin-angiotensin regulation of aldosterone production

Inferred from mutant phenotype PubMed 21318332. Source: RGD

response to organonitrogen compound

Inferred from expression pattern PubMed 16025228. Source: RGD

vasodilation by angiotensin involved in regulation of systemic arterial blood pressure

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

perinuclear region of cytoplasm

Inferred from direct assay PubMed 14657020. Source: RGD

plasma membrane

Inferred from direct assay PubMed 14657020. Source: RGD

   Molecular_functionG-protein alpha-subunit binding

Traceable author statement PubMed 14657020. Source: RGD

angiotensin type II receptor activity

Traceable author statement PubMed 14664700. Source: RGD

peptide hormone binding

Inferred from mutant phenotype PubMed 14568903. Source: RGD

protein binding

Inferred from physical interaction PubMed 16754789. Source: RGD

transcription factor binding

Inferred from physical interaction PubMed 14657020. Source: RGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 363363Type-2 angiotensin II receptor
PRO_0000069170

Regions

Topological domain1 – 4545Extracellular Potential
Transmembrane46 – 7126Helical; Name=1; Potential
Topological domain72 – 809Cytoplasmic Potential
Transmembrane81 – 10222Helical; Name=2; Potential
Topological domain103 – 11917Extracellular Potential
Transmembrane120 – 14021Helical; Name=3; Potential
Topological domain141 – 16020Cytoplasmic Potential
Transmembrane161 – 17919Helical; Name=4; Potential
Topological domain180 – 20829Extracellular Potential
Transmembrane209 – 23426Helical; Name=5; Potential
Topological domain235 – 25622Cytoplasmic Potential
Transmembrane257 – 27822Helical; Name=6; Potential
Topological domain279 – 29719Extracellular Potential
Transmembrane298 – 31821Helical; Name=7; Potential
Topological domain319 – 36345Cytoplasmic Potential

Amino acid modifications

Modified residue3541Phosphoserine; by PKC Potential
Glycosylation41N-linked (GlcNAc...) Potential
Glycosylation131N-linked (GlcNAc...) Potential
Glycosylation241N-linked (GlcNAc...) Potential
Glycosylation291N-linked (GlcNAc...) Potential
Glycosylation341N-linked (GlcNAc...) Potential
Disulfide bond35 ↔ 290 Ref.6
Disulfide bond117 ↔ 195 Ref.6

Sequences

Sequence LengthMass (Da)Tools
P35351 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 4FE4551A41336650

FASTA36341,331
        10         20         30         40         50         60 
MKDNFSFAAT SRNITSSLPF DNLNATGTNE SAFNCSHKPA DKHLEAIPVL YYMIFVIGFA 

        70         80         90        100        110        120 
VNIVVVSLFC CQKGPKKVSS IYIFNLAVAD LLLLATLPLW ATYYSYRYDW LFGPVMCKVF 

       130        140        150        160        170        180 
GSFLTLNMFA SIFFITCMSV DRYQSVIYPF LSQRRNPWQA SYVVPLVWCM ACLSSLPTFY 

       190        200        210        220        230        240 
FRDVRTIEYL GVNACIMAFP PEKYAQWSAG IALMKNILGF IIPLIFIATC YFGIRKHLLK 

       250        260        270        280        290        300 
TNSYGKNRIT RDQVLKMAAA VVLAFIICWL PFHVLTFLDA LTWMGIINSC EVIAVIDLAL 

       310        320        330        340        350        360 
PFAILLGFTN SCVNPFLYCF VGNRFQQKLR SVFRVPITWL QGKRETMSCR KSSSLREMDT 


FVS 

« Hide

References

[1]"Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibition."
Kambayashi Y., Bardhan S., Takahashi K., Tsuzuki S., Inui H., Hamakubo T., Inagami T.
J. Biol. Chem. 268:24543-24546(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Expression cloning of type 2 angiotensin II receptor reveals a unique class of seven-transmembrane receptors."
Mukoyama M., Nakajima M., Horiuchi M., Sasamura H., Pratt R.E., Dzau V.J.
J. Biol. Chem. 268:24539-24542(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Sprague-Dawley.
Tissue: Fetus.
[3]"Cloning, characterization, and genetic mapping of the rat type 2 angiotensin II receptor gene."
Koike G., Winer E.S., Horiuchi M., Brown D.M., Szpirer C., Dzau V.J., Jacob H.J.
Hypertension 26:998-1002(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Fischer.
Tissue: Liver.
[4]"Cloning, expression and regulation of angiotensin II receptors."
Inagami T., Iwai N., Sasaki K., Yamano Y., Bardhan S., Chaki S., Guo D.F., Furuta H., Ohyama K., Kambayashi Y., Takahashi K., Ichiki T.
Eur. Heart J. 15:104-107(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[5]"Cloning of the rat angiotensin II type 2 receptor gene and identification of its functional promoter region."
Kobayashi S., Ohnishi J., Nibu Y., Nishimatsu S., Umemura S., Ishii M., Murakami K., Miyazaki H.
Biochim. Biophys. Acta 1262:155-158(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-143.
Strain: Sprague-Dawley.
[6]"Reversible inactivation of AT(2) angiotensin II receptor from cysteine-disulfide bond exchange."
Feng Y.H., Saad Y., Karnik S.S.
FEBS Lett. 484:133-138(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: DISULFIDE BONDS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D16840 mRNA. Translation: BAA04116.1.
U01908 Genomic DNA. Translation: AAC52126.1.
U22663 Genomic DNA. Translation: AAA86509.1.
D43778 Genomic DNA. Translation: BAA07833.1.
PIRA49092.
RefSeqNP_036626.1. NM_012494.3.
XP_006257494.1. XM_006257432.1.
UniGeneRn.162367.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2G2Amodel-A1-363[»]
ProteinModelPortalP35351.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-204597.

Chemistry

BindingDBP35351.
ChEMBLCHEMBL257.
GuidetoPHARMACOLOGY35.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP35351.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000074269; ENSRNOP00000064709; ENSRNOG00000050006.
GeneID24182.
KEGGrno:24182.

Organism-specific databases

CTD186.
RGD2072. Agtr2.

Phylogenomic databases

GeneTreeENSGT00720000108671.
HOVERGENHBG104998.
KOK04167.
OMANCSHKPS.
OrthoDBEOG7TQV1F.
PhylomeDBP35351.

Gene expression databases

GenevestigatorP35351.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000147. ATII_AT2_rcpt.
IPR000248. ATII_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00241. ANGIOTENSINR.
PR00636. ANGIOTENSN2R.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio602529.
PROP35351.

Entry information

Entry nameAGTR2_RAT
AccessionPrimary (citable) accession number: P35351
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: June 11, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries