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P35351

- AGTR2_RAT

UniProt

P35351 - AGTR2_RAT

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Protein
Type-2 angiotensin II receptor
Gene
Agtr2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation By similarity.

GO - Molecular functioni

  1. G-protein alpha-subunit binding Source: RGD
  2. angiotensin type II receptor activity Source: RGD
  3. peptide hormone binding Source: RGD
  4. protein binding Source: RGD
  5. transcription factor binding Source: RGD

GO - Biological processi

  1. G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger Source: Ensembl
  2. aldosterone secretion Source: RGD
  3. angiotensin-activated signaling pathway Source: GOC
  4. behavior Source: Ensembl
  5. brain renin-angiotensin system Source: Ensembl
  6. cell growth involved in cardiac muscle cell development Source: RGD
  7. cellular response to dexamethasone stimulus Source: UniProtKB
  8. cellular sodium ion homeostasis Source: RGD
  9. cerebellar cortex development Source: RGD
  10. dopamine biosynthetic process Source: RGD
  11. inflammatory response Source: RGD
  12. kidney development Source: RGD
  13. kidney morphogenesis Source: RGD
  14. negative regulation of fibroblast proliferation Source: RGD
  15. negative regulation of heart rate Source: Ensembl
  16. negative regulation of icosanoid secretion Source: RGD
  17. negative regulation of neurotrophin TRK receptor signaling pathway Source: Ensembl
  18. negative regulation of norepinephrine secretion Source: RGD
  19. neuron differentiation Source: RGD
  20. positive regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
  21. positive regulation of cell proliferation Source: RGD
  22. positive regulation of cytokine secretion Source: RGD
  23. positive regulation of extrinsic apoptotic signaling pathway Source: Ensembl
  24. positive regulation of metanephric glomerulus development Source: Ensembl
  25. positive regulation of nitric-oxide synthase activity Source: Ensembl
  26. positive regulation of phosphoprotein phosphatase activity Source: Ensembl
  27. positive regulation of renal sodium excretion Source: RGD
  28. positive regulation of transcription, DNA-templated Source: Ensembl
  29. positive regulation of vasodilation Source: RGD
  30. regulation of metanephros size Source: Ensembl
  31. regulation of systemic arterial blood pressure by circulatory renin-angiotensin Source: Ensembl
  32. regulation of transcription factor import into nucleus Source: RGD
  33. renin-angiotensin regulation of aldosterone production Source: RGD
  34. response to organonitrogen compound Source: RGD
  35. vasodilation by angiotensin involved in regulation of systemic arterial blood pressure Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Type-2 angiotensin II receptor
Alternative name(s):
Angiotensin II type-2 receptor
Short name:
AT2
Gene namesi
Name:Agtr2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome X

Organism-specific databases

RGDi2072. Agtr2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4545Extracellular Reviewed prediction
Add
BLAST
Transmembranei46 – 7126Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini72 – 809Cytoplasmic Reviewed prediction
Transmembranei81 – 10222Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini103 – 11917Extracellular Reviewed prediction
Add
BLAST
Transmembranei120 – 14021Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini141 – 16020Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei161 – 17919Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini180 – 20829Extracellular Reviewed prediction
Add
BLAST
Transmembranei209 – 23426Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini235 – 25622Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei257 – 27822Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini279 – 29719Extracellular Reviewed prediction
Add
BLAST
Transmembranei298 – 31821Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini319 – 36345Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. perinuclear region of cytoplasm Source: RGD
  3. plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 363363Type-2 angiotensin II receptor
PRO_0000069170Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...) Reviewed prediction
Glycosylationi13 – 131N-linked (GlcNAc...) Reviewed prediction
Glycosylationi24 – 241N-linked (GlcNAc...) Reviewed prediction
Glycosylationi29 – 291N-linked (GlcNAc...) Reviewed prediction
Glycosylationi34 – 341N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi35 ↔ 2901 Publication
Disulfide bondi117 ↔ 1951 Publication
Modified residuei354 – 3541Phosphoserine; by PKC Reviewed prediction

Post-translational modificationi

C-terminal Ser or Thr residues may be phosphorylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

PTM databases

PhosphoSiteiP35351.

Expressioni

Tissue specificityi

Abundant expression in fetal tissues, immature brain, skin wound and atretic ovarian follicles.

Developmental stagei

Abundant in whole fetus but decreases rapidly after birth. In adults is highly expressed in the adrenal, present in the brain and uterus but undetectable in the heart.

Gene expression databases

GenevestigatoriP35351.

Interactioni

Subunit structurei

Interacts with MTUS1 By similarity.

Protein-protein interaction databases

MINTiMINT-204597.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2G2Amodel-A1-363[»]
ProteinModelPortaliP35351.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00720000108671.
HOVERGENiHBG104998.
KOiK04167.
OMAiNCSHKPS.
OrthoDBiEOG7TQV1F.
PhylomeDBiP35351.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000147. ATII_AT2_rcpt.
IPR000248. ATII_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00241. ANGIOTENSINR.
PR00636. ANGIOTENSN2R.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35351-1 [UniParc]FASTAAdd to Basket

« Hide

MKDNFSFAAT SRNITSSLPF DNLNATGTNE SAFNCSHKPA DKHLEAIPVL    50
YYMIFVIGFA VNIVVVSLFC CQKGPKKVSS IYIFNLAVAD LLLLATLPLW 100
ATYYSYRYDW LFGPVMCKVF GSFLTLNMFA SIFFITCMSV DRYQSVIYPF 150
LSQRRNPWQA SYVVPLVWCM ACLSSLPTFY FRDVRTIEYL GVNACIMAFP 200
PEKYAQWSAG IALMKNILGF IIPLIFIATC YFGIRKHLLK TNSYGKNRIT 250
RDQVLKMAAA VVLAFIICWL PFHVLTFLDA LTWMGIINSC EVIAVIDLAL 300
PFAILLGFTN SCVNPFLYCF VGNRFQQKLR SVFRVPITWL QGKRETMSCR 350
KSSSLREMDT FVS 363
Length:363
Mass (Da):41,331
Last modified:June 1, 1994 - v1
Checksum:i4FE4551A41336650
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D16840 mRNA. Translation: BAA04116.1.
U01908 Genomic DNA. Translation: AAC52126.1.
U22663 Genomic DNA. Translation: AAA86509.1.
D43778 Genomic DNA. Translation: BAA07833.1.
PIRiA49092.
RefSeqiNP_036626.1. NM_012494.3.
XP_006257494.1. XM_006257432.1.
UniGeneiRn.162367.

Genome annotation databases

EnsembliENSRNOT00000074269; ENSRNOP00000064709; ENSRNOG00000050006.
GeneIDi24182.
KEGGirno:24182.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D16840 mRNA. Translation: BAA04116.1 .
U01908 Genomic DNA. Translation: AAC52126.1 .
U22663 Genomic DNA. Translation: AAA86509.1 .
D43778 Genomic DNA. Translation: BAA07833.1 .
PIRi A49092.
RefSeqi NP_036626.1. NM_012494.3.
XP_006257494.1. XM_006257432.1.
UniGenei Rn.162367.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2G2A model - A 1-363 [» ]
ProteinModelPortali P35351.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-204597.

Chemistry

BindingDBi P35351.
ChEMBLi CHEMBL257.
GuidetoPHARMACOLOGYi 35.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P35351.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000074269 ; ENSRNOP00000064709 ; ENSRNOG00000050006 .
GeneIDi 24182.
KEGGi rno:24182.

Organism-specific databases

CTDi 186.
RGDi 2072. Agtr2.

Phylogenomic databases

GeneTreei ENSGT00720000108671.
HOVERGENi HBG104998.
KOi K04167.
OMAi NCSHKPS.
OrthoDBi EOG7TQV1F.
PhylomeDBi P35351.

Miscellaneous databases

NextBioi 602529.
PROi P35351.

Gene expression databases

Genevestigatori P35351.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000147. ATII_AT2_rcpt.
IPR000248. ATII_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00241. ANGIOTENSINR.
PR00636. ANGIOTENSN2R.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibition."
    Kambayashi Y., Bardhan S., Takahashi K., Tsuzuki S., Inui H., Hamakubo T., Inagami T.
    J. Biol. Chem. 268:24543-24546(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Expression cloning of type 2 angiotensin II receptor reveals a unique class of seven-transmembrane receptors."
    Mukoyama M., Nakajima M., Horiuchi M., Sasamura H., Pratt R.E., Dzau V.J.
    J. Biol. Chem. 268:24539-24542(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Sprague-Dawley.
    Tissue: Fetus.
  3. "Cloning, characterization, and genetic mapping of the rat type 2 angiotensin II receptor gene."
    Koike G., Winer E.S., Horiuchi M., Brown D.M., Szpirer C., Dzau V.J., Jacob H.J.
    Hypertension 26:998-1002(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Fischer.
    Tissue: Liver.
  4. "Cloning, expression and regulation of angiotensin II receptors."
    Inagami T., Iwai N., Sasaki K., Yamano Y., Bardhan S., Chaki S., Guo D.F., Furuta H., Ohyama K., Kambayashi Y., Takahashi K., Ichiki T.
    Eur. Heart J. 15:104-107(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  5. "Cloning of the rat angiotensin II type 2 receptor gene and identification of its functional promoter region."
    Kobayashi S., Ohnishi J., Nibu Y., Nishimatsu S., Umemura S., Ishii M., Murakami K., Miyazaki H.
    Biochim. Biophys. Acta 1262:155-158(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-143.
    Strain: Sprague-Dawley.
  6. "Reversible inactivation of AT(2) angiotensin II receptor from cysteine-disulfide bond exchange."
    Feng Y.H., Saad Y., Karnik S.S.
    FEBS Lett. 484:133-138(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISULFIDE BONDS.

Entry informationi

Entry nameiAGTR2_RAT
AccessioniPrimary (citable) accession number: P35351
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: June 11, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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