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P35351

- AGTR2_RAT

UniProt

P35351 - AGTR2_RAT

Protein

Type-2 angiotensin II receptor

Gene

Agtr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation By similarity.By similarity

    GO - Molecular functioni

    1. angiotensin type II receptor activity Source: RGD
    2. G-protein alpha-subunit binding Source: RGD
    3. peptide hormone binding Source: RGD
    4. protein binding Source: RGD
    5. transcription factor binding Source: RGD

    GO - Biological processi

    1. aldosterone secretion Source: RGD
    2. angiotensin-activated signaling pathway Source: GOC
    3. behavior Source: Ensembl
    4. brain renin-angiotensin system Source: Ensembl
    5. cell growth involved in cardiac muscle cell development Source: RGD
    6. cellular response to dexamethasone stimulus Source: UniProtKB
    7. cellular sodium ion homeostasis Source: RGD
    8. cerebellar cortex development Source: RGD
    9. dopamine biosynthetic process Source: RGD
    10. G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger Source: Ensembl
    11. inflammatory response Source: RGD
    12. kidney development Source: RGD
    13. kidney morphogenesis Source: RGD
    14. negative regulation of fibroblast proliferation Source: RGD
    15. negative regulation of heart rate Source: Ensembl
    16. negative regulation of icosanoid secretion Source: RGD
    17. negative regulation of neurotrophin TRK receptor signaling pathway Source: Ensembl
    18. negative regulation of norepinephrine secretion Source: RGD
    19. neuron differentiation Source: RGD
    20. positive regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
    21. positive regulation of cell proliferation Source: RGD
    22. positive regulation of cytokine secretion Source: RGD
    23. positive regulation of extrinsic apoptotic signaling pathway Source: Ensembl
    24. positive regulation of metanephric glomerulus development Source: Ensembl
    25. positive regulation of nitric-oxide synthase activity Source: Ensembl
    26. positive regulation of phosphoprotein phosphatase activity Source: Ensembl
    27. positive regulation of renal sodium excretion Source: RGD
    28. positive regulation of transcription, DNA-templated Source: Ensembl
    29. positive regulation of vasodilation Source: RGD
    30. regulation of metanephros size Source: Ensembl
    31. regulation of systemic arterial blood pressure by circulatory renin-angiotensin Source: Ensembl
    32. regulation of transcription factor import into nucleus Source: RGD
    33. renin-angiotensin regulation of aldosterone production Source: RGD
    34. response to organonitrogen compound Source: RGD
    35. vasodilation by angiotensin involved in regulation of systemic arterial blood pressure Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Type-2 angiotensin II receptor
    Alternative name(s):
    Angiotensin II type-2 receptor
    Short name:
    AT2
    Gene namesi
    Name:Agtr2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome X

    Organism-specific databases

    RGDi2072. Agtr2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. perinuclear region of cytoplasm Source: RGD
    3. plasma membrane Source: RGD

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 363363Type-2 angiotensin II receptorPRO_0000069170Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi13 – 131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi24 – 241N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi29 – 291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi34 – 341N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi35 ↔ 2901 PublicationPROSITE-ProRule annotation
    Disulfide bondi117 ↔ 1951 PublicationPROSITE-ProRule annotation
    Modified residuei354 – 3541Phosphoserine; by PKCSequence Analysis

    Post-translational modificationi

    C-terminal Ser or Thr residues may be phosphorylated.

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    PTM databases

    PhosphoSiteiP35351.

    Expressioni

    Tissue specificityi

    Abundant expression in fetal tissues, immature brain, skin wound and atretic ovarian follicles.

    Developmental stagei

    Abundant in whole fetus but decreases rapidly after birth. In adults is highly expressed in the adrenal, present in the brain and uterus but undetectable in the heart.

    Gene expression databases

    GenevestigatoriP35351.

    Interactioni

    Subunit structurei

    Interacts with MTUS1.By similarity

    Protein-protein interaction databases

    MINTiMINT-204597.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2G2Amodel-A1-363[»]
    ProteinModelPortaliP35351.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4545ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini72 – 809CytoplasmicSequence Analysis
    Topological domaini103 – 11917ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini141 – 16020CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini180 – 20829ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini235 – 25622CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini279 – 29719ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini319 – 36345CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei46 – 7126Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei81 – 10222Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei120 – 14021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei161 – 17919Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei209 – 23426Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei257 – 27822Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei298 – 31821Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    GeneTreeiENSGT00720000108671.
    HOVERGENiHBG104998.
    KOiK04167.
    OMAiNCSHKPS.
    OrthoDBiEOG7TQV1F.
    PhylomeDBiP35351.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000147. ATII_AT2_rcpt.
    IPR000248. ATII_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00241. ANGIOTENSINR.
    PR00636. ANGIOTENSN2R.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P35351-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKDNFSFAAT SRNITSSLPF DNLNATGTNE SAFNCSHKPA DKHLEAIPVL    50
    YYMIFVIGFA VNIVVVSLFC CQKGPKKVSS IYIFNLAVAD LLLLATLPLW 100
    ATYYSYRYDW LFGPVMCKVF GSFLTLNMFA SIFFITCMSV DRYQSVIYPF 150
    LSQRRNPWQA SYVVPLVWCM ACLSSLPTFY FRDVRTIEYL GVNACIMAFP 200
    PEKYAQWSAG IALMKNILGF IIPLIFIATC YFGIRKHLLK TNSYGKNRIT 250
    RDQVLKMAAA VVLAFIICWL PFHVLTFLDA LTWMGIINSC EVIAVIDLAL 300
    PFAILLGFTN SCVNPFLYCF VGNRFQQKLR SVFRVPITWL QGKRETMSCR 350
    KSSSLREMDT FVS 363
    Length:363
    Mass (Da):41,331
    Last modified:June 1, 1994 - v1
    Checksum:i4FE4551A41336650
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D16840 mRNA. Translation: BAA04116.1.
    U01908 Genomic DNA. Translation: AAC52126.1.
    U22663 Genomic DNA. Translation: AAA86509.1.
    D43778 Genomic DNA. Translation: BAA07833.1.
    PIRiA49092.
    RefSeqiNP_036626.1. NM_012494.3.
    XP_006257494.1. XM_006257432.1.
    UniGeneiRn.162367.

    Genome annotation databases

    EnsembliENSRNOT00000074269; ENSRNOP00000064709; ENSRNOG00000050006.
    GeneIDi24182.
    KEGGirno:24182.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D16840 mRNA. Translation: BAA04116.1 .
    U01908 Genomic DNA. Translation: AAC52126.1 .
    U22663 Genomic DNA. Translation: AAA86509.1 .
    D43778 Genomic DNA. Translation: BAA07833.1 .
    PIRi A49092.
    RefSeqi NP_036626.1. NM_012494.3.
    XP_006257494.1. XM_006257432.1.
    UniGenei Rn.162367.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2G2A model - A 1-363 [» ]
    ProteinModelPortali P35351.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-204597.

    Chemistry

    BindingDBi P35351.
    ChEMBLi CHEMBL257.
    GuidetoPHARMACOLOGYi 35.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P35351.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000074269 ; ENSRNOP00000064709 ; ENSRNOG00000050006 .
    GeneIDi 24182.
    KEGGi rno:24182.

    Organism-specific databases

    CTDi 186.
    RGDi 2072. Agtr2.

    Phylogenomic databases

    GeneTreei ENSGT00720000108671.
    HOVERGENi HBG104998.
    KOi K04167.
    OMAi NCSHKPS.
    OrthoDBi EOG7TQV1F.
    PhylomeDBi P35351.

    Miscellaneous databases

    NextBioi 602529.
    PROi P35351.

    Gene expression databases

    Genevestigatori P35351.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000147. ATII_AT2_rcpt.
    IPR000248. ATII_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00241. ANGIOTENSINR.
    PR00636. ANGIOTENSN2R.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibition."
      Kambayashi Y., Bardhan S., Takahashi K., Tsuzuki S., Inui H., Hamakubo T., Inagami T.
      J. Biol. Chem. 268:24543-24546(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Expression cloning of type 2 angiotensin II receptor reveals a unique class of seven-transmembrane receptors."
      Mukoyama M., Nakajima M., Horiuchi M., Sasamura H., Pratt R.E., Dzau V.J.
      J. Biol. Chem. 268:24539-24542(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Sprague-Dawley.
      Tissue: Fetus.
    3. "Cloning, characterization, and genetic mapping of the rat type 2 angiotensin II receptor gene."
      Koike G., Winer E.S., Horiuchi M., Brown D.M., Szpirer C., Dzau V.J., Jacob H.J.
      Hypertension 26:998-1002(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Fischer.
      Tissue: Liver.
    4. "Cloning, expression and regulation of angiotensin II receptors."
      Inagami T., Iwai N., Sasaki K., Yamano Y., Bardhan S., Chaki S., Guo D.F., Furuta H., Ohyama K., Kambayashi Y., Takahashi K., Ichiki T.
      Eur. Heart J. 15:104-107(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    5. "Cloning of the rat angiotensin II type 2 receptor gene and identification of its functional promoter region."
      Kobayashi S., Ohnishi J., Nibu Y., Nishimatsu S., Umemura S., Ishii M., Murakami K., Miyazaki H.
      Biochim. Biophys. Acta 1262:155-158(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-143.
      Strain: Sprague-Dawley.
    6. "Reversible inactivation of AT(2) angiotensin II receptor from cysteine-disulfide bond exchange."
      Feng Y.H., Saad Y., Karnik S.S.
      FEBS Lett. 484:133-138(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISULFIDE BONDS.

    Entry informationi

    Entry nameiAGTR2_RAT
    AccessioniPrimary (citable) accession number: P35351
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3