Metabotropic glutamate receptor 6 precursor

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P35349 (GRM6_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 94. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Metabotropic glutamate receptor 6
Short name=mGluR6

Gene names

Name:	Grm6
Synonyms:	Gprc1f, Mglur6

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	871 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Restricted expression in the inner nuclear layer of the retina.
Sequence similarities	Belongs to the G-protein coupled receptor 3 family.

Ontologies

Keywords
Biological process	Sensory transduction
Cellular component	Cell membrane Membrane
Domain	Signal Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	locomotory behavior Inferred from electronic annotation. Source: Compara retina development in camera-type eye Inferred from electronic annotation. Source: Compara sensory perception of light stimulus Inferred from electronic annotation. Source: Compara synaptic transmission Inferred from expression pattern Ref.1. Source: RGD
Cellular_component	integral to membrane Traceable author statement Ref.1. Source: RGD new growing cell tip Inferred from electronic annotation. Source: Compara plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	adenylate cyclase inhibiting G-protein coupled glutamate receptor activity Inferred from direct assay Ref.1. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 23

Potential

Chain

24 – 871

848

Metabotropic glutamate receptor 6

PRO_0000012937

Regions

Topological domain

24 – 579

556

Extracellular Potential

Transmembrane

580 – 602

Helical; Name=1; Potential

Topological domain

603 – 616

Cytoplasmic Potential

Transmembrane

617 – 637

Helical; Name=2; Potential

Topological domain

638 – 648

Extracellular Potential

Transmembrane

649 – 667

Helical; Name=3; Potential

Topological domain

668 – 691

Cytoplasmic Potential

Transmembrane

692 – 712

Helical; Name=4; Potential

Topological domain

713 – 742

Extracellular Potential

Transmembrane

743 – 764

Helical; Name=5; Potential

Topological domain

765 – 777

Cytoplasmic Potential

Transmembrane

778 – 800

Helical; Name=6; Potential

Topological domain

801 – 813

Extracellular Potential

Transmembrane

814 – 839

Helical; Name=7; Potential

Topological domain

840 – 871

Cytoplasmic Potential

Amino acid modifications

Glycosylation

290

N-linked (GlcNAc...) Potential

Glycosylation

445

N-linked (GlcNAc...) Potential

Glycosylation

473

N-linked (GlcNAc...) Potential

Glycosylation

561

N-linked (GlcNAc...) Potential

Disulfide bond

51 ↔ 93

By similarity

Disulfide bond

238 ↔ 530

By similarity

Disulfide bond

361 ↔ 377

By similarity

Disulfide bond

417 ↔ 424

By similarity

Disulfide bond

512 ↔ 531

By similarity

Disulfide bond

516 ↔ 534

By similarity

Disulfide bond

537 ↔ 549

By similarity

Disulfide bond

552 ↔ 565

By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

P35349 [UniParc].

Last modified June 1, 1994. Version 1.
Checksum: 9F70B4D6A13B186D
Show »

FASTA

871

95,089

        10         20         30         40         50         60 
MGRLPVLLLW LAWWLSQAGI ACGAGSVRLA GGLTLGGLFP VHARGAAGRA CGALKKEQGV 

        70         80         90        100        110        120 
HRLEAMLYAL DRVNADPELL PGVRLGARLL DTCSRDTYAL EQALSFVQAL IRGRGDGDEA 

       130        140        150        160        170        180 
SVRCPGGVPP LRSAPPERVV AVVGASASSV SIMVANVLRL FAIPQISYAS TAPELSDSTR 

       190        200        210        220        230        240 
YDFFSRVVPP DSYQAQAMVD IVRALGWNYV STLASEGNYG ESGVEAFVQI SREAGGVCIA 

       250        260        270        280        290        300 
QSIKIPREPK PGEFHKVIRR LMETPNARGI IIFANEDDIR RVLEATRQAN LTGHFLWVGS 

       310        320        330        340        350        360 
DSWGSKISPI LNLEEEAVGA ITILPKRASI DGFDQYFMTR SLENNRRNIW FAEFWEENFN 

       370        380        390        400        410        420 
CKLTSSGGQS DDSTRKCTGE ERIGQDSAYE QEGKVQFVID AVYAIAHALH SMHQALCPGH 

       430        440        450        460        470        480 
TGLCPAMEPT DGRTLLHYIR AVRFNGSAGT PVMFNENGDA PGRYDIFQYQ ATNGSASSGG 

       490        500        510        520        530        540 
YQAVGQWAEA LRLDMEVLRW SGDPHEVPPS QCSLPCGPGE RKKMVKGVPC CWHCEACDGY 

       550        560        570        580        590        600 
RFQVDEFTCE ACPGDMRPTP NHTGCRPTPV VRLTWSSPWA ALPLLLAVLG IMATTTIMAT 

       610        620        630        640        650        660 
FMRHNDTPIV RASGRELSYV LLTGIFLIYA ITFLMVAEPC AAICAARRLL LGLGTTLSYS 

       670        680        690        700        710        720 
ALLTKTNRIY RIFEQGKRSV TPPPFISPTS QLVITFGLTS LQVVGVIAWL GAQPPHSVID 

       730        740        750        760        770        780 
YEEQRTVDPE QARGVLKCDM SDLSLIGCLG YSLLLMVTCT VYAIKARGVP ETFNEAKPIG 

       790        800        810        820        830        840 
FTMYTTCIIW LAFVPIFFGT AQSAEKIYIQ TTTLTVSLSL SASVSLGMLY VPKTYVILFH 

       850        860        870 
PEQNVQKRKR SLKKTSTMAA PPQNENAEDA K

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References

[1]	"Molecular characterization of a novel retinal metabotropic glutamate receptor mGluR6 with a high agonist selectivity for L-2-amino-4-phosphonobutyrate." Nakajima Y., Iwakabe H., Akazawa C., Nawa H., Shigemoto R., Nakanishi S. J. Biol. Chem. 268:11868-11873(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Retina.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D13963 mRNA. Translation: BAA03066.1.
IPI	IPI00197626.
PIR	A46742.
RefSeq	NP_075209.1. NM_022920.1.
UniGene	Rn.44615.
3D structure databases
ProteinModelPortal	P35349.
SMR	P35349. Positions 26-500.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-1777333.
STRING	10116.ENSRNOP00000000249.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P35349.
Proteomic databases
PaxDb	P35349.
PRIDE	P35349.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000000249; ENSRNOP00000000249; ENSRNOG00000000233.
GeneID	24419.
KEGG	rno:24419.
UCSC	RGD:2747. rat.
Organism-specific databases
CTD	2916.
RGD	2747. Grm6.
Phylogenomic databases
eggNOG	NOG295200.
GeneTree	ENSGT00640000091090.
HOGENOM	HOG000218635.
HOVERGEN	HBG107965.
InParanoid	P35349.
KO	K04608.
OrthoDB	EOG4H4634.
Gene expression databases
Genevestigator	P35349.
Family and domain databases
InterPro	IPR001828. ANF_lig-bd_rcpt. IPR000337. GPCR_3. IPR011500. GPCR_3_9-Cys_dom. IPR017978. GPCR_3_C. IPR017979. GPCR_3_CS. IPR000162. GPCR_3_mtglu_rcpt. IPR000112. GPCR_3_mtglu_rcpt_6. [Graphical view]
Pfam	PF00003. 7tm_3. 1 hit. PF01094. ANF_receptor. 1 hit. PF07562. NCD3G. 1 hit. [Graphical view]
PRINTS	PR00248. GPCRMGR. PR01056. MTABOTROPC6R. PR00593. MTABOTROPICR.
PROSITE	PS00979. G_PROTEIN_RECEP_F3_1. 1 hit. PS00980. G_PROTEIN_RECEP_F3_2. 1 hit. PS00981. G_PROTEIN_RECEP_F3_3. 1 hit. PS50259. G_PROTEIN_RECEP_F3_4. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P35349.
ChEMBL	CHEMBL3842.
NextBio	603271.

Entry information

Entry name

GRM6_RAT

Accession

Primary (citable) accession number: P35349

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	April 3, 2013
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents