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P35349

- GRM6_RAT

UniProt

P35349 - GRM6_RAT

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Protein

Metabotropic glutamate receptor 6

Gene

Grm6

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca2+ uptake. Required for normal vision.By similarity1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei148 – 1481GlutamateBy similarity
Binding sitei219 – 2191GlutamateBy similarity
Binding sitei301 – 3011GlutamateBy similarity
Binding sitei394 – 3941GlutamateBy similarity

GO - Molecular functioni

  1. adenylate cyclase inhibiting G-protein coupled glutamate receptor activity Source: RGD
  2. glutamate receptor activity Source: UniProtKB
  3. group III metabotropic glutamate receptor activity Source: RefGenome

GO - Biological processi

  1. adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway Source: RGD
  2. detection of light stimulus involved in visual perception Source: UniProtKB
  3. G-protein coupled glutamate receptor signaling pathway Source: UniProtKB
  4. locomotory behavior Source: Ensembl
  5. positive regulation of calcium ion import Source: UniProtKB
  6. regulation of synaptic transmission, glutamatergic Source: RefGenome
  7. retina development in camera-type eye Source: Ensembl
  8. synaptic transmission Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Vision

Names & Taxonomyi

Protein namesi
Recommended name:
Metabotropic glutamate receptor 6
Short name:
mGluR6
Gene namesi
Name:Grm6
Synonyms:Gprc1f, Mglur6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 10

Organism-specific databases

RGDi2747. Grm6.

Subcellular locationi

Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity. Golgi apparatus membrane By similarity; Multi-pass membrane protein By similarity. Cell projectiondendrite By similarity
Note: Subject to trafficking from the endoplasmic reticulum to the Golgi apparatus and then to the cell membrane. Detected at dendritic tips of bipolar cells (By similarity).By similarity

GO - Cellular componenti

  1. cell projection Source: UniProtKB-KW
  2. endoplasmic reticulum membrane Source: UniProtKB
  3. Golgi membrane Source: UniProtKB
  4. integral component of membrane Source: RGD
  5. integral component of plasma membrane Source: UniProtKB
  6. new growing cell tip Source: Ensembl
  7. presynaptic membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 871848Metabotropic glutamate receptor 6PRO_0000012937Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi51 ↔ 93By similarity
Disulfide bondi238 ↔ 530By similarity
Glycosylationi290 – 2901N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi361 ↔ 377By similarity
Disulfide bondi417 ↔ 424By similarity
Glycosylationi445 – 4451N-linked (GlcNAc...)Sequence Analysis
Glycosylationi473 – 4731N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi512 ↔ 531By similarity
Disulfide bondi516 ↔ 534By similarity
Disulfide bondi537 ↔ 549By similarity
Disulfide bondi552 ↔ 565By similarity
Glycosylationi561 – 5611N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP35349.
PRIDEiP35349.

PTM databases

PhosphoSiteiP35349.

Expressioni

Tissue specificityi

Restricted expression in the inner nuclear layer of the retina.1 Publication

Gene expression databases

GenevestigatoriP35349.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi246584. 5 interactions.
IntActiP35349. 2 interactions.
MINTiMINT-1777333.
STRINGi10116.ENSRNOP00000000249.

Structurei

3D structure databases

ProteinModelPortaliP35349.
SMRiP35349. Positions 26-500.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 579556ExtracellularSequence AnalysisAdd
BLAST
Topological domaini603 – 61614CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini638 – 64811ExtracellularSequence AnalysisAdd
BLAST
Topological domaini668 – 69124CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini713 – 74230ExtracellularSequence AnalysisAdd
BLAST
Topological domaini765 – 77713CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini801 – 81313ExtracellularSequence AnalysisAdd
BLAST
Topological domaini840 – 87132CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei580 – 60223Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei617 – 63721Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei649 – 66719Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei692 – 71221Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei743 – 76422Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei778 – 80023Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei814 – 83926Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni169 – 1713Glutamate bindingBy similarity

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG295200.
GeneTreeiENSGT00760000118884.
HOGENOMiHOG000218635.
HOVERGENiHBG107965.
InParanoidiP35349.
KOiK04608.
OMAiVCIAQSI.
OrthoDBiEOG7Z0JXG.
PhylomeDBiP35349.
TreeFamiTF313240.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR000162. GPCR_3_mtglu_rcpt.
IPR000112. GPCR_3_mtglu_rcpt_6.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
PR01056. MTABOTROPC6R.
PR00593. MTABOTROPICR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35349 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGRLPVLLLW LAWWLSQAGI ACGAGSVRLA GGLTLGGLFP VHARGAAGRA
60 70 80 90 100
CGALKKEQGV HRLEAMLYAL DRVNADPELL PGVRLGARLL DTCSRDTYAL
110 120 130 140 150
EQALSFVQAL IRGRGDGDEA SVRCPGGVPP LRSAPPERVV AVVGASASSV
160 170 180 190 200
SIMVANVLRL FAIPQISYAS TAPELSDSTR YDFFSRVVPP DSYQAQAMVD
210 220 230 240 250
IVRALGWNYV STLASEGNYG ESGVEAFVQI SREAGGVCIA QSIKIPREPK
260 270 280 290 300
PGEFHKVIRR LMETPNARGI IIFANEDDIR RVLEATRQAN LTGHFLWVGS
310 320 330 340 350
DSWGSKISPI LNLEEEAVGA ITILPKRASI DGFDQYFMTR SLENNRRNIW
360 370 380 390 400
FAEFWEENFN CKLTSSGGQS DDSTRKCTGE ERIGQDSAYE QEGKVQFVID
410 420 430 440 450
AVYAIAHALH SMHQALCPGH TGLCPAMEPT DGRTLLHYIR AVRFNGSAGT
460 470 480 490 500
PVMFNENGDA PGRYDIFQYQ ATNGSASSGG YQAVGQWAEA LRLDMEVLRW
510 520 530 540 550
SGDPHEVPPS QCSLPCGPGE RKKMVKGVPC CWHCEACDGY RFQVDEFTCE
560 570 580 590 600
ACPGDMRPTP NHTGCRPTPV VRLTWSSPWA ALPLLLAVLG IMATTTIMAT
610 620 630 640 650
FMRHNDTPIV RASGRELSYV LLTGIFLIYA ITFLMVAEPC AAICAARRLL
660 670 680 690 700
LGLGTTLSYS ALLTKTNRIY RIFEQGKRSV TPPPFISPTS QLVITFGLTS
710 720 730 740 750
LQVVGVIAWL GAQPPHSVID YEEQRTVDPE QARGVLKCDM SDLSLIGCLG
760 770 780 790 800
YSLLLMVTCT VYAIKARGVP ETFNEAKPIG FTMYTTCIIW LAFVPIFFGT
810 820 830 840 850
AQSAEKIYIQ TTTLTVSLSL SASVSLGMLY VPKTYVILFH PEQNVQKRKR
860 870
SLKKTSTMAA PPQNENAEDA K
Length:871
Mass (Da):95,089
Last modified:June 1, 1994 - v1
Checksum:i9F70B4D6A13B186D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D13963 mRNA. Translation: BAA03066.1.
PIRiA46742.
RefSeqiNP_075209.1. NM_022920.1.
UniGeneiRn.44615.

Genome annotation databases

EnsembliENSRNOT00000000249; ENSRNOP00000000249; ENSRNOG00000000233.
GeneIDi24419.
KEGGirno:24419.
UCSCiRGD:2747. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D13963 mRNA. Translation: BAA03066.1 .
PIRi A46742.
RefSeqi NP_075209.1. NM_022920.1.
UniGenei Rn.44615.

3D structure databases

ProteinModelPortali P35349.
SMRi P35349. Positions 26-500.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 246584. 5 interactions.
IntActi P35349. 2 interactions.
MINTi MINT-1777333.
STRINGi 10116.ENSRNOP00000000249.

Chemistry

BindingDBi P35349.
ChEMBLi CHEMBL2111335.
GuidetoPHARMACOLOGYi 294.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P35349.

Proteomic databases

PaxDbi P35349.
PRIDEi P35349.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000000249 ; ENSRNOP00000000249 ; ENSRNOG00000000233 .
GeneIDi 24419.
KEGGi rno:24419.
UCSCi RGD:2747. rat.

Organism-specific databases

CTDi 2916.
RGDi 2747. Grm6.

Phylogenomic databases

eggNOGi NOG295200.
GeneTreei ENSGT00760000118884.
HOGENOMi HOG000218635.
HOVERGENi HBG107965.
InParanoidi P35349.
KOi K04608.
OMAi VCIAQSI.
OrthoDBi EOG7Z0JXG.
PhylomeDBi P35349.
TreeFami TF313240.

Miscellaneous databases

NextBioi 603271.

Gene expression databases

Genevestigatori P35349.

Family and domain databases

InterProi IPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR000162. GPCR_3_mtglu_rcpt.
IPR000112. GPCR_3_mtglu_rcpt_6.
IPR028082. Peripla_BP_I.
[Graphical view ]
Pfami PF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view ]
PRINTSi PR00248. GPCRMGR.
PR01056. MTABOTROPC6R.
PR00593. MTABOTROPICR.
SUPFAMi SSF53822. SSF53822. 1 hit.
PROSITEi PS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular characterization of a novel retinal metabotropic glutamate receptor mGluR6 with a high agonist selectivity for L-2-amino-4-phosphonobutyrate."
    Nakajima Y., Iwakabe H., Akazawa C., Nawa H., Shigemoto R., Nakanishi S.
    J. Biol. Chem. 268:11868-11873(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
    Tissue: Retina.

Entry informationi

Entry nameiGRM6_RAT
AccessioniPrimary (citable) accession number: P35349
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: October 29, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3