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P35349

- GRM6_RAT

UniProt

P35349 - GRM6_RAT

Protein

Metabotropic glutamate receptor 6

Gene

Grm6

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity By similarity. Signaling stimulates TRPM1 channel activity and Ca2+ uptake. Required for normal vision.By similarity1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei148 – 1481GlutamateBy similarity
    Binding sitei219 – 2191GlutamateBy similarity
    Binding sitei301 – 3011GlutamateBy similarity
    Binding sitei394 – 3941GlutamateBy similarity

    GO - Molecular functioni

    1. adenylate cyclase inhibiting G-protein coupled glutamate receptor activity Source: RGD
    2. glutamate receptor activity Source: UniProtKB
    3. group III metabotropic glutamate receptor activity Source: RefGenome

    GO - Biological processi

    1. adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway Source: RGD
    2. detection of light stimulus involved in visual perception Source: UniProtKB
    3. G-protein coupled glutamate receptor signaling pathway Source: UniProtKB
    4. locomotory behavior Source: Ensembl
    5. positive regulation of calcium ion import Source: UniProtKB
    6. regulation of synaptic transmission, glutamatergic Source: RefGenome
    7. retina development in camera-type eye Source: Ensembl
    8. synaptic transmission Source: RGD

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Sensory transduction, Vision

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Metabotropic glutamate receptor 6
    Short name:
    mGluR6
    Gene namesi
    Name:Grm6
    Synonyms:Gprc1f, Mglur6
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 10

    Organism-specific databases

    RGDi2747. Grm6.

    Subcellular locationi

    Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity. Golgi apparatus membrane By similarity; Multi-pass membrane protein By similarity. Cell projectiondendrite By similarity
    Note: Subject to trafficking from the endoplasmic reticulum to the Golgi apparatus and then to the cell membrane. Detected at dendritic tips of bipolar cells By similarity.By similarity

    GO - Cellular componenti

    1. dendrite Source: UniProtKB-SubCell
    2. endoplasmic reticulum membrane Source: UniProtKB
    3. Golgi membrane Source: UniProtKB
    4. integral component of membrane Source: RGD
    5. integral component of plasma membrane Source: UniProtKB
    6. new growing cell tip Source: Ensembl
    7. presynaptic membrane Source: RefGenome

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Endoplasmic reticulum, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 871848Metabotropic glutamate receptor 6PRO_0000012937Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi51 ↔ 93By similarity
    Disulfide bondi238 ↔ 530By similarity
    Glycosylationi290 – 2901N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi361 ↔ 377By similarity
    Disulfide bondi417 ↔ 424By similarity
    Glycosylationi445 – 4451N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi473 – 4731N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi512 ↔ 531By similarity
    Disulfide bondi516 ↔ 534By similarity
    Disulfide bondi537 ↔ 549By similarity
    Disulfide bondi552 ↔ 565By similarity
    Glycosylationi561 – 5611N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP35349.
    PRIDEiP35349.

    PTM databases

    PhosphoSiteiP35349.

    Expressioni

    Tissue specificityi

    Restricted expression in the inner nuclear layer of the retina.1 Publication

    Gene expression databases

    GenevestigatoriP35349.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    BioGridi246584. 5 interactions.
    IntActiP35349. 2 interactions.
    MINTiMINT-1777333.
    STRINGi10116.ENSRNOP00000000249.

    Structurei

    3D structure databases

    ProteinModelPortaliP35349.
    SMRiP35349. Positions 26-500.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini24 – 579556ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini603 – 61614CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini638 – 64811ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini668 – 69124CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini713 – 74230ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini765 – 77713CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini801 – 81313ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini840 – 87132CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei580 – 60223Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei617 – 63721Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei649 – 66719Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei692 – 71221Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei743 – 76422Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei778 – 80023Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei814 – 83926Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni169 – 1713Glutamate bindingBy similarity

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG295200.
    GeneTreeiENSGT00750000117581.
    HOGENOMiHOG000218635.
    HOVERGENiHBG107965.
    InParanoidiP35349.
    KOiK04608.
    OMAiVCIAQSI.
    OrthoDBiEOG7Z0JXG.
    PhylomeDBiP35349.
    TreeFamiTF313240.

    Family and domain databases

    InterProiIPR001828. ANF_lig-bd_rcpt.
    IPR000337. GPCR_3.
    IPR011500. GPCR_3_9-Cys_dom.
    IPR017978. GPCR_3_C.
    IPR017979. GPCR_3_CS.
    IPR000162. GPCR_3_mtglu_rcpt.
    IPR000112. GPCR_3_mtglu_rcpt_6.
    IPR028082. Peripla_BP_I.
    [Graphical view]
    PfamiPF00003. 7tm_3. 1 hit.
    PF01094. ANF_receptor. 1 hit.
    PF07562. NCD3G. 1 hit.
    [Graphical view]
    PRINTSiPR00248. GPCRMGR.
    PR01056. MTABOTROPC6R.
    PR00593. MTABOTROPICR.
    SUPFAMiSSF53822. SSF53822. 1 hit.
    PROSITEiPS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
    PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
    PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
    PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P35349-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGRLPVLLLW LAWWLSQAGI ACGAGSVRLA GGLTLGGLFP VHARGAAGRA    50
    CGALKKEQGV HRLEAMLYAL DRVNADPELL PGVRLGARLL DTCSRDTYAL 100
    EQALSFVQAL IRGRGDGDEA SVRCPGGVPP LRSAPPERVV AVVGASASSV 150
    SIMVANVLRL FAIPQISYAS TAPELSDSTR YDFFSRVVPP DSYQAQAMVD 200
    IVRALGWNYV STLASEGNYG ESGVEAFVQI SREAGGVCIA QSIKIPREPK 250
    PGEFHKVIRR LMETPNARGI IIFANEDDIR RVLEATRQAN LTGHFLWVGS 300
    DSWGSKISPI LNLEEEAVGA ITILPKRASI DGFDQYFMTR SLENNRRNIW 350
    FAEFWEENFN CKLTSSGGQS DDSTRKCTGE ERIGQDSAYE QEGKVQFVID 400
    AVYAIAHALH SMHQALCPGH TGLCPAMEPT DGRTLLHYIR AVRFNGSAGT 450
    PVMFNENGDA PGRYDIFQYQ ATNGSASSGG YQAVGQWAEA LRLDMEVLRW 500
    SGDPHEVPPS QCSLPCGPGE RKKMVKGVPC CWHCEACDGY RFQVDEFTCE 550
    ACPGDMRPTP NHTGCRPTPV VRLTWSSPWA ALPLLLAVLG IMATTTIMAT 600
    FMRHNDTPIV RASGRELSYV LLTGIFLIYA ITFLMVAEPC AAICAARRLL 650
    LGLGTTLSYS ALLTKTNRIY RIFEQGKRSV TPPPFISPTS QLVITFGLTS 700
    LQVVGVIAWL GAQPPHSVID YEEQRTVDPE QARGVLKCDM SDLSLIGCLG 750
    YSLLLMVTCT VYAIKARGVP ETFNEAKPIG FTMYTTCIIW LAFVPIFFGT 800
    AQSAEKIYIQ TTTLTVSLSL SASVSLGMLY VPKTYVILFH PEQNVQKRKR 850
    SLKKTSTMAA PPQNENAEDA K 871
    Length:871
    Mass (Da):95,089
    Last modified:June 1, 1994 - v1
    Checksum:i9F70B4D6A13B186D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D13963 mRNA. Translation: BAA03066.1.
    PIRiA46742.
    RefSeqiNP_075209.1. NM_022920.1.
    UniGeneiRn.44615.

    Genome annotation databases

    EnsembliENSRNOT00000000249; ENSRNOP00000000249; ENSRNOG00000000233.
    GeneIDi24419.
    KEGGirno:24419.
    UCSCiRGD:2747. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D13963 mRNA. Translation: BAA03066.1 .
    PIRi A46742.
    RefSeqi NP_075209.1. NM_022920.1.
    UniGenei Rn.44615.

    3D structure databases

    ProteinModelPortali P35349.
    SMRi P35349. Positions 26-500.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 246584. 5 interactions.
    IntActi P35349. 2 interactions.
    MINTi MINT-1777333.
    STRINGi 10116.ENSRNOP00000000249.

    Chemistry

    BindingDBi P35349.
    ChEMBLi CHEMBL3842.
    GuidetoPHARMACOLOGYi 294.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P35349.

    Proteomic databases

    PaxDbi P35349.
    PRIDEi P35349.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000000249 ; ENSRNOP00000000249 ; ENSRNOG00000000233 .
    GeneIDi 24419.
    KEGGi rno:24419.
    UCSCi RGD:2747. rat.

    Organism-specific databases

    CTDi 2916.
    RGDi 2747. Grm6.

    Phylogenomic databases

    eggNOGi NOG295200.
    GeneTreei ENSGT00750000117581.
    HOGENOMi HOG000218635.
    HOVERGENi HBG107965.
    InParanoidi P35349.
    KOi K04608.
    OMAi VCIAQSI.
    OrthoDBi EOG7Z0JXG.
    PhylomeDBi P35349.
    TreeFami TF313240.

    Miscellaneous databases

    NextBioi 603271.

    Gene expression databases

    Genevestigatori P35349.

    Family and domain databases

    InterProi IPR001828. ANF_lig-bd_rcpt.
    IPR000337. GPCR_3.
    IPR011500. GPCR_3_9-Cys_dom.
    IPR017978. GPCR_3_C.
    IPR017979. GPCR_3_CS.
    IPR000162. GPCR_3_mtglu_rcpt.
    IPR000112. GPCR_3_mtglu_rcpt_6.
    IPR028082. Peripla_BP_I.
    [Graphical view ]
    Pfami PF00003. 7tm_3. 1 hit.
    PF01094. ANF_receptor. 1 hit.
    PF07562. NCD3G. 1 hit.
    [Graphical view ]
    PRINTSi PR00248. GPCRMGR.
    PR01056. MTABOTROPC6R.
    PR00593. MTABOTROPICR.
    SUPFAMi SSF53822. SSF53822. 1 hit.
    PROSITEi PS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
    PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
    PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
    PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of a novel retinal metabotropic glutamate receptor mGluR6 with a high agonist selectivity for L-2-amino-4-phosphonobutyrate."
      Nakajima Y., Iwakabe H., Akazawa C., Nawa H., Shigemoto R., Nakanishi S.
      J. Biol. Chem. 268:11868-11873(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Strain: Sprague-Dawley.
      Tissue: Retina.

    Entry informationi

    Entry nameiGRM6_RAT
    AccessioniPrimary (citable) accession number: P35349
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3