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P35349

- GRM6_RAT

UniProt

P35349 - GRM6_RAT

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Protein

Metabotropic glutamate receptor 6

Gene
Grm6, Gprc1f, Mglur6
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity By similarity. Signaling stimulates TRPM1 channel activity and Ca2+ uptake. Required for normal vision.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei148 – 1481Glutamate By similarity
Binding sitei219 – 2191Glutamate By similarity
Binding sitei301 – 3011Glutamate By similarity
Binding sitei394 – 3941Glutamate By similarity

GO - Molecular functioni

  1. adenylate cyclase inhibiting G-protein coupled glutamate receptor activity Source: RGD
  2. glutamate receptor activity Source: UniProtKB
  3. group III metabotropic glutamate receptor activity Source: RefGenome

GO - Biological processi

  1. adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway Source: RGD
  2. detection of light stimulus involved in visual perception Source: UniProtKB
  3. G-protein coupled glutamate receptor signaling pathway Source: UniProtKB
  4. locomotory behavior Source: Ensembl
  5. positive regulation of calcium ion import Source: UniProtKB
  6. regulation of synaptic transmission, glutamatergic Source: RefGenome
  7. retina development in camera-type eye Source: Ensembl
  8. synaptic transmission Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Sensory transduction, Vision

Names & Taxonomyi

Protein namesi
Recommended name:
Metabotropic glutamate receptor 6
Short name:
mGluR6
Gene namesi
Name:Grm6
Synonyms:Gprc1f, Mglur6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 10

Organism-specific databases

RGDi2747. Grm6.

Subcellular locationi

Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity. Golgi apparatus membrane; Multi-pass membrane protein By similarity. Cell projectiondendrite By similarity
Note: Subject to trafficking from the endoplasmic reticulum to the Golgi apparatus and then to the cell membrane. Detected at dendritic tips of bipolar cells By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 579556Extracellular Reviewed predictionAdd
BLAST
Transmembranei580 – 60223Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini603 – 61614Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei617 – 63721Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini638 – 64811Extracellular Reviewed predictionAdd
BLAST
Transmembranei649 – 66719Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini668 – 69124Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei692 – 71221Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini713 – 74230Extracellular Reviewed predictionAdd
BLAST
Transmembranei743 – 76422Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini765 – 77713Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei778 – 80023Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini801 – 81313Extracellular Reviewed predictionAdd
BLAST
Transmembranei814 – 83926Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini840 – 87132Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. dendrite Source: UniProtKB-SubCell
  2. endoplasmic reticulum membrane Source: UniProtKB
  3. Golgi membrane Source: UniProtKB
  4. integral component of membrane Source: RGD
  5. integral component of plasma membrane Source: UniProtKB
  6. new growing cell tip Source: Ensembl
  7. presynaptic membrane Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed predictionAdd
BLAST
Chaini24 – 871848Metabotropic glutamate receptor 6PRO_0000012937Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi51 ↔ 93 By similarity
Disulfide bondi238 ↔ 530 By similarity
Glycosylationi290 – 2901N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi361 ↔ 377 By similarity
Disulfide bondi417 ↔ 424 By similarity
Glycosylationi445 – 4451N-linked (GlcNAc...) Reviewed prediction
Glycosylationi473 – 4731N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi512 ↔ 531 By similarity
Disulfide bondi516 ↔ 534 By similarity
Disulfide bondi537 ↔ 549 By similarity
Disulfide bondi552 ↔ 565 By similarity
Glycosylationi561 – 5611N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP35349.
PRIDEiP35349.

PTM databases

PhosphoSiteiP35349.

Expressioni

Tissue specificityi

Restricted expression in the inner nuclear layer of the retina.1 Publication

Gene expression databases

GenevestigatoriP35349.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

BioGridi246584. 5 interactions.
IntActiP35349. 2 interactions.
MINTiMINT-1777333.
STRINGi10116.ENSRNOP00000000249.

Structurei

3D structure databases

ProteinModelPortaliP35349.
SMRiP35349. Positions 26-500.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni169 – 1713Glutamate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG295200.
GeneTreeiENSGT00750000117581.
HOGENOMiHOG000218635.
HOVERGENiHBG107965.
InParanoidiP35349.
KOiK04608.
OMAiVCIAQSI.
OrthoDBiEOG7Z0JXG.
PhylomeDBiP35349.
TreeFamiTF313240.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR000162. GPCR_3_mtglu_rcpt.
IPR000112. GPCR_3_mtglu_rcpt_6.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
PR01056. MTABOTROPC6R.
PR00593. MTABOTROPICR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35349-1 [UniParc]FASTAAdd to Basket

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MGRLPVLLLW LAWWLSQAGI ACGAGSVRLA GGLTLGGLFP VHARGAAGRA    50
CGALKKEQGV HRLEAMLYAL DRVNADPELL PGVRLGARLL DTCSRDTYAL 100
EQALSFVQAL IRGRGDGDEA SVRCPGGVPP LRSAPPERVV AVVGASASSV 150
SIMVANVLRL FAIPQISYAS TAPELSDSTR YDFFSRVVPP DSYQAQAMVD 200
IVRALGWNYV STLASEGNYG ESGVEAFVQI SREAGGVCIA QSIKIPREPK 250
PGEFHKVIRR LMETPNARGI IIFANEDDIR RVLEATRQAN LTGHFLWVGS 300
DSWGSKISPI LNLEEEAVGA ITILPKRASI DGFDQYFMTR SLENNRRNIW 350
FAEFWEENFN CKLTSSGGQS DDSTRKCTGE ERIGQDSAYE QEGKVQFVID 400
AVYAIAHALH SMHQALCPGH TGLCPAMEPT DGRTLLHYIR AVRFNGSAGT 450
PVMFNENGDA PGRYDIFQYQ ATNGSASSGG YQAVGQWAEA LRLDMEVLRW 500
SGDPHEVPPS QCSLPCGPGE RKKMVKGVPC CWHCEACDGY RFQVDEFTCE 550
ACPGDMRPTP NHTGCRPTPV VRLTWSSPWA ALPLLLAVLG IMATTTIMAT 600
FMRHNDTPIV RASGRELSYV LLTGIFLIYA ITFLMVAEPC AAICAARRLL 650
LGLGTTLSYS ALLTKTNRIY RIFEQGKRSV TPPPFISPTS QLVITFGLTS 700
LQVVGVIAWL GAQPPHSVID YEEQRTVDPE QARGVLKCDM SDLSLIGCLG 750
YSLLLMVTCT VYAIKARGVP ETFNEAKPIG FTMYTTCIIW LAFVPIFFGT 800
AQSAEKIYIQ TTTLTVSLSL SASVSLGMLY VPKTYVILFH PEQNVQKRKR 850
SLKKTSTMAA PPQNENAEDA K 871
Length:871
Mass (Da):95,089
Last modified:June 1, 1994 - v1
Checksum:i9F70B4D6A13B186D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D13963 mRNA. Translation: BAA03066.1.
PIRiA46742.
RefSeqiNP_075209.1. NM_022920.1.
UniGeneiRn.44615.

Genome annotation databases

EnsembliENSRNOT00000000249; ENSRNOP00000000249; ENSRNOG00000000233.
GeneIDi24419.
KEGGirno:24419.
UCSCiRGD:2747. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D13963 mRNA. Translation: BAA03066.1 .
PIRi A46742.
RefSeqi NP_075209.1. NM_022920.1.
UniGenei Rn.44615.

3D structure databases

ProteinModelPortali P35349.
SMRi P35349. Positions 26-500.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 246584. 5 interactions.
IntActi P35349. 2 interactions.
MINTi MINT-1777333.
STRINGi 10116.ENSRNOP00000000249.

Chemistry

BindingDBi P35349.
ChEMBLi CHEMBL3842.
GuidetoPHARMACOLOGYi 294.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P35349.

Proteomic databases

PaxDbi P35349.
PRIDEi P35349.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000000249 ; ENSRNOP00000000249 ; ENSRNOG00000000233 .
GeneIDi 24419.
KEGGi rno:24419.
UCSCi RGD:2747. rat.

Organism-specific databases

CTDi 2916.
RGDi 2747. Grm6.

Phylogenomic databases

eggNOGi NOG295200.
GeneTreei ENSGT00750000117581.
HOGENOMi HOG000218635.
HOVERGENi HBG107965.
InParanoidi P35349.
KOi K04608.
OMAi VCIAQSI.
OrthoDBi EOG7Z0JXG.
PhylomeDBi P35349.
TreeFami TF313240.

Miscellaneous databases

NextBioi 603271.

Gene expression databases

Genevestigatori P35349.

Family and domain databases

InterProi IPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR000162. GPCR_3_mtglu_rcpt.
IPR000112. GPCR_3_mtglu_rcpt_6.
IPR028082. Peripla_BP_I.
[Graphical view ]
Pfami PF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view ]
PRINTSi PR00248. GPCRMGR.
PR01056. MTABOTROPC6R.
PR00593. MTABOTROPICR.
SUPFAMi SSF53822. SSF53822. 1 hit.
PROSITEi PS00979. G_PROTEIN_RECEP_F3_1. 1 hit.
PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS00981. G_PROTEIN_RECEP_F3_3. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular characterization of a novel retinal metabotropic glutamate receptor mGluR6 with a high agonist selectivity for L-2-amino-4-phosphonobutyrate."
    Nakajima Y., Iwakabe H., Akazawa C., Nawa H., Shigemoto R., Nakanishi S.
    J. Biol. Chem. 268:11868-11873(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
    Tissue: Retina.

Entry informationi

Entry nameiGRM6_RAT
AccessioniPrimary (citable) accession number: P35349
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: June 11, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi