Reviewed, UniProtKB/Swiss-Prot P35348 (ADA1A_HUMAN)

Names and origin

Protein names

Recommended name:
    Alpha-1A adrenergic receptor
Alternative name(s):
    Alpha 1A-adrenoreceptor
    Alpha 1A-adrenoceptor
    Alpha-1C adrenergic receptor
    Alpha-adrenergic receptor 1c

Gene names

Name:	ADRA1A
Synonyms:	ADRA1C

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	466 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in heart, brain, liver and prostate, but not in kidney, lung, adrenal, aorta and pituitary. Within the prostate, expressed in the apex, base, periurethra and lateral lobe. Isoform 4 is the most abundant isoform expressed in the prostate with high levels also detected in liver and heart.
Post-translational modification	Carboxyl-terminal Ser or Thr residues may be phosphorylated By similarity.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	G-protein coupled receptor protein signaling pathway Inferred from Experiment. Source: Reactome apoptosis Traceable author statement. Source: ProtInc cell-cell signaling Ref.1 Traceable author statement. Source: ProtInc negative regulation of cell proliferation Traceable author statement. Source: ProtInc protein kinase cascade Traceable author statement. Source: ProtInc smooth muscle contraction Ref.3 Traceable author statement. Source: ProtInc
Cellular component	integral to plasma membrane Ref.1 Traceable author statement. Source: ProtInc
Molecular function	alpha1-adrenergic receptor activity Ref.5 Ref.7 Traceable author statement. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 9 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P35348-1) Also known as: Alpha 1c-1; Alpha(1A-1); This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P35348-2) Also known as: Alpha 1c-2; Alpha(1A-2); The sequence of this isoform differs from the canonical sequence as follows:      424-466: VRSKSFLQVC...ISLSENGEEV → TKSRSVTRLE...GQDDLDLLTS
Sequence annotation (Features)
	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
	Sequence conflict	463	1	T → TG in BAA06901. Ref.5
Isoform 3 (identifier: P35348-3) Also known as: Alpha 1c-3; Alpha(1A-3); The sequence of this isoform differs from the canonical sequence as follows:      424-429: VRSKSF → GHTPMT      430-466: Missing.
Isoform 4 (identifier: P35348-4) Also known as: Alpha(1A-4); The sequence of this isoform differs from the canonical sequence as follows:      424-466: VRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV → RGMDCRYFTKNCREHIKHVNFMMPPWRKGSEC
Sequence annotation (Features)
	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
	Sequence conflict	453	1	S → L in AAC06138. Ref.7
Isoform 5 (identifier: P35348-5) The sequence of this isoform differs from the canonical sequence as follows:      296-297: SF → KS      298-466: Missing.
Isoform 6 (identifier: P35348-6) The sequence of this isoform differs from the canonical sequence as follows:      295-342: GSFFPDFKPS...FKKAFQNVLR → DEETEAQEGK...VSRKDTCGVW      343-466: Missing.
Sequence annotation (Features)
	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
	Sequence conflict	302	1	E → Q in AAR84650. Ref.8
Isoform 2b/3b (identifier: P35348-7) The sequence of this isoform differs from the canonical sequence as follows:      296-324: SFFPDFKPSETVFKIVFWLGYLNSCINPI → TYILKYDVLFWRKGLSVCTRLRERKEIKN      325-466: Missing.
Isoform 2c (identifier: P35348-8) The sequence of this isoform differs from the canonical sequence as follows:      295-466: GSFFPDFKPS...ISLSENGEEV → DEVSLCHQAG...GQDDLDLLTS
Isoform 3c (identifier: P35348-9) The sequence of this isoform differs from the canonical sequence as follows:      296-466: SFFPDFKPSE...ISLSENGEEV → THTHDMKPAS...TVTDTGKTVT

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 466	466	Alpha-1A adrenergic receptor		PRO_0000069063
Regions
	Topological domain	1 – 27	27	Extracellular By similarity
	Transmembrane	28 – 51	24	1 By similarity
	Topological domain	52 – 64	13	Cytoplasmic By similarity
	Transmembrane	65 – 88	24	2 By similarity
	Topological domain	89 – 99	11	Extracellular By similarity
	Transmembrane	100 – 122	23	3 By similarity
	Topological domain	123 – 143	21	Cytoplasmic By similarity
	Transmembrane	144 – 167	24	4 By similarity
	Topological domain	168 – 181	14	Extracellular By similarity
	Transmembrane	182 – 205	24	5 By similarity
	Topological domain	206 – 273	68	Cytoplasmic By similarity
	Transmembrane	274 – 297	24	6 By similarity
	Topological domain	298 – 305	8	Extracellular By similarity
	Transmembrane	306 – 329	24	7 By similarity
	Topological domain	330 – 466	137	Cytoplasmic By similarity
Amino acid modifications
	Modified residue	215	1	Phosphoserine; by PKA Potential
	Lipidation	345	1	S-palmitoyl cysteine Potential
	Glycosylation	7	1	N-linked (GlcNAc...) Potential
	Glycosylation	13	1	N-linked (GlcNAc...) Potential
	Glycosylation	22	1	N-linked (GlcNAc...) Potential
	Disulfide bond	99 ↔ 176		By similarity
Natural variations
	Alternative sequence	295 – 466	172	GSFFP…NGEEV → DEVSLCHQAGVQWHDLGSLQ PPPPGFKRFSCLSLPSSWDY RDVPPGRRHQAQLIFVFLVE TGFHHVGQDDLDLLTS in isoform 2c.		VSP_011046
	Alternative sequence	295 – 342	48	GSFFP…QNVLR → DEETEAQEGKNDSPSFKQPV HHAAVLGLEVMEKENLEGVS RKDTCGVW in isoform 6.		VSP_011053
	Alternative sequence	296 – 466	171	SFFPD…NGEEV → THTHDMKPASRPRLLSLLPK EGEHETHHWSCDPLSLESTP GAQEPCLTLGFTSLSSIHLT KAQIQHVTVTDTGKTVT in isoform 3c.		VSP_011049
	Alternative sequence	296 – 324	29	SFFPD…CINPI → TYILKYDVLFWRKGLSVCTR LRERKEIKN in isoform 2b/3b.		VSP_011047
	Alternative sequence	296 – 297	2	SF → KS in isoform 5.		VSP_011051
	Alternative sequence	298 – 466	169	Missing in isoform 5.		VSP_011052
	Alternative sequence	325 – 466	142	Missing in isoform 2b/3b.		VSP_011048
	Alternative sequence	343 – 466	124	Missing in isoform 6.		VSP_011054
	Alternative sequence	424 – 466	43	VRSKS…NGEEV → TKSRSVTRLECSGMILAHCN LRLPGSRDSPASASQAAGTT DVPPGRRHQAQLIFVFLVET GFHHVGQDDLDLLTS in isoform 2.		VSP_011055
	Alternative sequence	424 – 466	43	VRSKS…NGEEV → RGMDCRYFTKNCREHIKHVN FMMPPWRKGSEC in isoform 4.		VSP_011050
	Alternative sequence	424 – 429	6	VRSKSF → GHTPMT in isoform 3.		VSP_011044
	Alternative sequence	430 – 466	37	Missing in isoform 3.		VSP_011045
	Natural variant	40	1	G → W in a breast cancer sample; somatic mutation. Ref.18		VAR_035756
	Natural variant	200	1	I → S: dbSNP rs2229125.		VAR_049370
	Natural variant	347	1	C → R Frequent polymorphism. dbSNP rs1048101. Ref.5 Ref.1 Ref.2 Ref.4 Ref.6 Ref.16 Ref.17		VAR_019509
	Natural variant	414	1	K → R: dbSNP rs3730247.		VAR_049371
	Natural variant	465	1	E → D: dbSNP rs2229126.		VAR_049372
Experimental info
	Sequence conflict	43	1	G → C in AAA93114. Ref.4
	Sequence conflict	129	1	S → T in AAA93114. Ref.4
	Sequence conflict	130	1	Y → H in AAK77197. Ref.9
	Sequence conflict	185	1	V → A in AAH95512. Ref.14
	Sequence conflict	338	1	Q → C Ref.2
	Sequence conflict	359	1	T → P in AAA93114. Ref.4
	Sequence conflict	384	1	T → A in AAK77197. Ref.9
	Sequence conflict	387	1	R → G in AAK77197. Ref.9
	Sequence conflict	390	1	K → R in AAK77197. Ref.9
	Sequence conflict	431	1	Q → E in BAA04960. Ref.1
	Sequence conflict	437	1	G → E in AAK77197. Ref.9
	Sequence conflict	442	1	S → C in AAA93114. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Alpha 1c-1) (Alpha(1A-1)) [UniParc]. Last modified November 1, 1995. Version 2. Checksum: 1A50487531DECDF0	FASTA	466	51,487
	10 20 30 40 50 60 MVFLSGNASD SSNCTQPPAP VNISKAILLG VILGGLILFG VLGNILVILS VACHRHLHSV 70 80 90 100 110 120 THYYIVNLAV ADLLLTSTVL PFSAIFEVLG YWAFGRVFCN IWAAVDVLCC TASIMGLCII 130 140 150 160 170 180 SIDRYIGVSY PLRYPTIVTQ RRGLMALLCV WALSLVISIG PLFGWRQPAP EDETICQINE 190 200 210 220 230 240 EPGYVLFSAL GSFYLPLAII LVMYCRVYVV AKRESRGLKS GLKTDKSDSE QVTLRIHRKN 250 260 270 280 290 300 APAGGSGMAS AKTKTHFSVR LLKFSREKKA AKTLGIVVGC FVLCWLPFFL VMPIGSFFPD 310 320 330 340 350 360 FKPSETVFKI VFWLGYLNSC INPIIYPCSS QEFKKAFQNV LRIQCLCRKQ SSKHALGYTL 370 380 390 400 410 420 HPPSQAVEGQ HKDMVRIPVG SRETFYRISK TDGVCEWKFF SSMPRGSARI TVSKDQSSCT 430 440 450 460 TARVRSKSFL QVCCCVGPST PSLDKNHQVP TIKVHTISLS ENGEEV
	Isoform 2 (Alpha 1c-2) (Alpha(1A-2)). Checksum: 8E69F2C2BF8BC445	FASTA	498	54,890
	10 20 30 40 50 60 MVFLSGNASD SSNCTQPPAP VNISKAILLG VILGGLILFG VLGNILVILS VACHRHLHSV 70 80 90 100 110 120 THYYIVNLAV ADLLLTSTVL PFSAIFEVLG YWAFGRVFCN IWAAVDVLCC TASIMGLCII 130 140 150 160 170 180 SIDRYIGVSY PLRYPTIVTQ RRGLMALLCV WALSLVISIG PLFGWRQPAP EDETICQINE 190 200 210 220 230 240 EPGYVLFSAL GSFYLPLAII LVMYCRVYVV AKRESRGLKS GLKTDKSDSE QVTLRIHRKN 250 260 270 280 290 300 APAGGSGMAS AKTKTHFSVR LLKFSREKKA AKTLGIVVGC FVLCWLPFFL VMPIGSFFPD 310 320 330 340 350 360 FKPSETVFKI VFWLGYLNSC INPIIYPCSS QEFKKAFQNV LRIQCLCRKQ SSKHALGYTL 370 380 390 400 410 420 HPPSQAVEGQ HKDMVRIPVG SRETFYRISK TDGVCEWKFF SSMPRGSARI TVSKDQSSCT 430 440 450 460 470 480 TARTKSRSVT RLECSGMILA HCNLRLPGSR DSPASASQAA GTTDVPPGRR HQAQLIFVFL 490 VETGFHHVGQ DDLDLLTS
	Isoform 3 (Alpha 1c-3) (Alpha(1A-3)). Checksum: E67B19B5CA668687	FASTA	429	47,461
	10 20 30 40 50 60 MVFLSGNASD SSNCTQPPAP VNISKAILLG VILGGLILFG VLGNILVILS VACHRHLHSV 70 80 90 100 110 120 THYYIVNLAV ADLLLTSTVL PFSAIFEVLG YWAFGRVFCN IWAAVDVLCC TASIMGLCII 130 140 150 160 170 180 SIDRYIGVSY PLRYPTIVTQ RRGLMALLCV WALSLVISIG PLFGWRQPAP EDETICQINE 190 200 210 220 230 240 EPGYVLFSAL GSFYLPLAII LVMYCRVYVV AKRESRGLKS GLKTDKSDSE QVTLRIHRKN 250 260 270 280 290 300 APAGGSGMAS AKTKTHFSVR LLKFSREKKA AKTLGIVVGC FVLCWLPFFL VMPIGSFFPD 310 320 330 340 350 360 FKPSETVFKI VFWLGYLNSC INPIIYPCSS QEFKKAFQNV LRIQCLCRKQ SSKHALGYTL 370 380 390 400 410 420 HPPSQAVEGQ HKDMVRIPVG SRETFYRISK TDGVCEWKFF SSMPRGSARI TVSKDQSSCT TARGHTPMT
	Isoform 4 (Alpha(1A-4)). Checksum: 80C61B88FA608B6C	FASTA	455	50,777
	10 20 30 40 50 60 MVFLSGNASD SSNCTQPPAP VNISKAILLG VILGGLILFG VLGNILVILS VACHRHLHSV 70 80 90 100 110 120 THYYIVNLAV ADLLLTSTVL PFSAIFEVLG YWAFGRVFCN IWAAVDVLCC TASIMGLCII 130 140 150 160 170 180 SIDRYIGVSY PLRYPTIVTQ RRGLMALLCV WALSLVISIG PLFGWRQPAP EDETICQINE 190 200 210 220 230 240 EPGYVLFSAL GSFYLPLAII LVMYCRVYVV AKRESRGLKS GLKTDKSDSE QVTLRIHRKN 250 260 270 280 290 300 APAGGSGMAS AKTKTHFSVR LLKFSREKKA AKTLGIVVGC FVLCWLPFFL VMPIGSFFPD 310 320 330 340 350 360 FKPSETVFKI VFWLGYLNSC INPIIYPCSS QEFKKAFQNV LRIQCLCRKQ SSKHALGYTL 370 380 390 400 410 420 HPPSQAVEGQ HKDMVRIPVG SRETFYRISK TDGVCEWKFF SSMPRGSARI TVSKDQSSCT 430 440 450 TARRGMDCRY FTKNCREHIK HVNFMMPPWR KGSEC
	Isoform 5. Checksum: 4871F9BE42A87D6E	FASTA	297	32,433
	10 20 30 40 50 60 MVFLSGNASD SSNCTQPPAP VNISKAILLG VILGGLILFG VLGNILVILS VACHRHLHSV 70 80 90 100 110 120 THYYIVNLAV ADLLLTSTVL PFSAIFEVLG YWAFGRVFCN IWAAVDVLCC TASIMGLCII 130 140 150 160 170 180 SIDRYIGVSY PLRYPTIVTQ RRGLMALLCV WALSLVISIG PLFGWRQPAP EDETICQINE 190 200 210 220 230 240 EPGYVLFSAL GSFYLPLAII LVMYCRVYVV AKRESRGLKS GLKTDKSDSE QVTLRIHRKN 250 260 270 280 290 APAGGSGMAS AKTKTHFSVR LLKFSREKKA AKTLGIVVGC FVLCWLPFFL VMPIGKS
	Isoform 6. Checksum: 2B6E7CC81B9CBE50	FASTA	342	37,468
	10 20 30 40 50 60 MVFLSGNASD SSNCTQPPAP VNISKAILLG VILGGLILFG VLGNILVILS VACHRHLHSV 70 80 90 100 110 120 THYYIVNLAV ADLLLTSTVL PFSAIFEVLG YWAFGRVFCN IWAAVDVLCC TASIMGLCII 130 140 150 160 170 180 SIDRYIGVSY PLRYPTIVTQ RRGLMALLCV WALSLVISIG PLFGWRQPAP EDETICQINE 190 200 210 220 230 240 EPGYVLFSAL GSFYLPLAII LVMYCRVYVV AKRESRGLKS GLKTDKSDSE QVTLRIHRKN 250 260 270 280 290 300 APAGGSGMAS AKTKTHFSVR LLKFSREKKA AKTLGIVVGC FVLCWLPFFL VMPIDEETEA 310 320 330 340 QEGKNDSPSF KQPVHHAAVL GLEVMEKENL EGVSRKDTCG VW
	Isoform 2b/3b. Checksum: 608DACD5497EE83E	FASTA	324	35,829
	10 20 30 40 50 60 MVFLSGNASD SSNCTQPPAP VNISKAILLG VILGGLILFG VLGNILVILS VACHRHLHSV 70 80 90 100 110 120 THYYIVNLAV ADLLLTSTVL PFSAIFEVLG YWAFGRVFCN IWAAVDVLCC TASIMGLCII 130 140 150 160 170 180 SIDRYIGVSY PLRYPTIVTQ RRGLMALLCV WALSLVISIG PLFGWRQPAP EDETICQINE 190 200 210 220 230 240 EPGYVLFSAL GSFYLPLAII LVMYCRVYVV AKRESRGLKS GLKTDKSDSE QVTLRIHRKN 250 260 270 280 290 300 APAGGSGMAS AKTKTHFSVR LLKFSREKKA AKTLGIVVGC FVLCWLPFFL VMPIGTYILK 310 320 YDVLFWRKGL SVCTRLRERK EIKN
	Isoform 2c. Checksum: F00E717A4C4A59AC	FASTA	370	40,725
	10 20 30 40 50 60 MVFLSGNASD SSNCTQPPAP VNISKAILLG VILGGLILFG VLGNILVILS VACHRHLHSV 70 80 90 100 110 120 THYYIVNLAV ADLLLTSTVL PFSAIFEVLG YWAFGRVFCN IWAAVDVLCC TASIMGLCII 130 140 150 160 170 180 SIDRYIGVSY PLRYPTIVTQ RRGLMALLCV WALSLVISIG PLFGWRQPAP EDETICQINE 190 200 210 220 230 240 EPGYVLFSAL GSFYLPLAII LVMYCRVYVV AKRESRGLKS GLKTDKSDSE QVTLRIHRKN 250 260 270 280 290 300 APAGGSGMAS AKTKTHFSVR LLKFSREKKA AKTLGIVVGC FVLCWLPFFL VMPIDEVSLC 310 320 330 340 350 360 HQAGVQWHDL GSLQPPPPGF KRFSCLSLPS SWDYRDVPPG RRHQAQLIFV FLVETGFHHV 370 GQDDLDLLTS
	Isoform 3c. Checksum: 839C5750F9B428F5	FASTA	372	40,638
	10 20 30 40 50 60 MVFLSGNASD SSNCTQPPAP VNISKAILLG VILGGLILFG VLGNILVILS VACHRHLHSV 70 80 90 100 110 120 THYYIVNLAV ADLLLTSTVL PFSAIFEVLG YWAFGRVFCN IWAAVDVLCC TASIMGLCII 130 140 150 160 170 180 SIDRYIGVSY PLRYPTIVTQ RRGLMALLCV WALSLVISIG PLFGWRQPAP EDETICQINE 190 200 210 220 230 240 EPGYVLFSAL GSFYLPLAII LVMYCRVYVV AKRESRGLKS GLKTDKSDSE QVTLRIHRKN 250 260 270 280 290 300 APAGGSGMAS AKTKTHFSVR LLKFSREKKA AKTLGIVVGC FVLCWLPFFL VMPIGTHTHD 310 320 330 340 350 360 MKPASRPRLL SLLPKEGEHE THHWSCDPLS LESTPGAQEP CLTLGFTSLS SIHLTKAQIQ 370 HVTVTDTGKT VT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, functional expression and tissue distribution of human cDNA for the alpha 1C-adrenergic receptor." Hirasawa A., Horie K., Tanaka T., Takagaki K., Murai M., Yano J., Tsujimoto G. Biochem. Biophys. Res. Commun. 195:902-909(1993) [PubMed: 8396931] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), VARIANT ARG-347. Tissue: Prostate.
[2]	"Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c." Weinberg D.H., Trivedi P., Tan C.P., Mitra S., Perkins-Barrow A., Borkowski D., Strader C.D., Bayne M. Biochem. Biophys. Res. Commun. 201:1296-1304(1994) [PubMed: 8024574] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-347. Tissue: Heart.
[3]	"The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype." Forray C., Bard J.A., Wetzel J.M., Chiu G., Shapiro E., Tang R., Lepor H., Hartig P.R., Weinshank R.L., Branchek T.A., Gluchowski C. Mol. Pharmacol. 45:703-708(1994) [PubMed: 8183249] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1). Tissue: Hippocampus and Lymphocyte.
[4]	"The alpha 1C-adrenoceptor in human prostate: cloning, functional expression, and localization to specific prostatic cell types." Tseng-Crank J., Kost T., Goetz A., Hazum S., Roberson K.M., Haizlip J., Godinot N., Robertson C.N., Saussy D. Br. J. Pharmacol. 115:1475-1485(1995) [PubMed: 8564208] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-347.
[5]	"Cloning, functional expression and tissue distribution of human alpha 1c-adrenoceptor splice variants." Hirasawa A., Shibata K., Horie K., Takei Y., Obika K., Tanaka T., Muramoto N., Takagaki K., Yano J., Tsujimoto G. FEBS Lett. 363:256-260(1995) [PubMed: 7737411] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), VARIANT ARG-347, TISSUE SPECIFICITY. Tissue: Prostate.
[6]	"Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues." Schwinn D.A., Johnston G.I., Page S.O., Mosley M.J., Wilson K.H., Worman N.P., Campbell S., Fidock M.D., Furness L.M., Parry-Smith D.J., Peter B., Bailey D.S. J. Pharmacol. Exp. Ther. 272:134-142(1995) [PubMed: 7815325] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-347.
[7]	"Molecular cloning, genomic characterization and expression of novel human alpha1A-adrenoceptor isoforms." Chang D.J., Chang T.K., Yamanishi S.S., Salazar F.H.R., Kosaka A.H., Khare R., Bhakta S., Jasper J.R., Shieh I.-S., Lesnick J.D., Ford A.P.D.W., Daniels D.V., Clarke D.E., Bach C.T., Chan H.W. FEBS Lett. 422:279-283(1998) [PubMed: 9490024] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), TISSUE SPECIFICITY. Tissue: Prostate.
[8]	"Truncated isoforms inhibit [3H]prazosin binding and cellular trafficking of native human alpha1A-adrenoceptors." Coge F., Guenin S.P., Renouard-Try A., Rique H., Ouvry C., Fabry N., Beauverger P., Nicolas J.P., Galizzi J.-P., Boutin J.A., Canet E. Biochem. J. 343:231-239(1999) [PubMed: 10493934] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2B/3B; 2C; 3C; 5 AND 6). Tissue: Liver.
[9]	"RT-PCR cloning and sequence analysis of adrenergic receptor subtype-alpha-1a cDNA from human prostrate cell-line DU-145." Banerjee A.G.N., Aarti A. Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[10]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[11]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Kopatz S.A., Aronstam R.S., Sharma S.V. Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[12]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Cerebellum.
[13]	NHLBI resequencing and genotyping service (RS&G) Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[14]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-347.
[15]	"Identification of alpha 1-adrenoceptor subtypes present in the human prostate." Faure C., Pimoule C., Vallancien G., Langer S.Z., Graham D. Life Sci. 54:1595-1605(1994) [PubMed: 8196478] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 52-400 (ISOFORMS 1/2/3/4), TISSUE SPECIFICITY, VARIANT ARG-347. Tissue: Prostate.
[16]	"Alpha 1a-adrenoceptor polymorphism: pharmacological characterization and association with benign prostatic hypertrophy." Shibata K., Hirasawa A., Moriyama N., Kawabe K., Ogawa S., Tsujimoto G. Br. J. Pharmacol. 118:1403-1408(1996) [PubMed: 8832064] [Abstract] Cited for: VARIANT ARG-347.
[17]	"Alpha 1A-adrenergic receptor polymorphism and vascular response." Sofowora G.G., Dishy V., Landau R., Xie H.G., Prasad H.C., Byrne D.W., Smiley R.M., Kim R.B., Wood A.J., Stein C.M. Clin. Pharmacol. Ther. 75:539-545(2004) [PubMed: 15179408] [Abstract] Cited for: VARIANT ARG-347.
[18]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] TRP-40.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D25235 mRNA. Translation: BAA04960.1. U03866 Genomic DNA. Translation: AAB60353.1. U02569 mRNA. Translation: AAA93114.1. D32201 mRNA. Translation: BAA06900.1. D32202 mRNA. Translation: BAA06901.1. L31774 mRNA. Translation: AAB59486.1. AF013261 mRNA. Translation: AAC06138.1. AY491775 mRNA. Translation: AAR84644.1. AY491776 mRNA. Translation: AAR84645.1. AY491777 mRNA. Translation: AAR84646.1. AY491778 mRNA. Translation: AAR84647.1. AY491779 mRNA. Translation: AAR84648.1. AY491780 mRNA. Translation: AAR84649.1. AY491781 mRNA. Translation: AAR84650.1. AF395806 mRNA. Translation: AAK77197.1. AB065703 Genomic DNA. Translation: BAC05926.1. AY389505 Genomic DNA. Translation: AAQ91331.1. AK289548 mRNA. Translation: BAF82237.1. EU326301 Genomic DNA. Translation: ACA05899.1. EU326301 Genomic DNA. Translation: ACA05900.1. EU326301 Genomic DNA. Translation: ACA05902.1. EU326301 Genomic DNA. Translation: ACA05903.1. EU326301 Genomic DNA. Translation: ACA05904.1. EU326301 Genomic DNA. Translation: ACA05905.1. EU326301 Genomic DNA. Translation: ACA05906.1. EU326301 Genomic DNA. Translation: ACA05907.1. BC095512 mRNA. Translation: AAH95512.1.
IPI	IPI00430195. IPI00430196. IPI00430197. IPI00430199. IPI00430201. IPI00430202. IPI00430203. IPI00430204. IPI00430205.
PIR	JN0765. S65656. S65657.
RefSeq	NP_000671.2. NP_150645.2. NP_150646.3. NP_150647.2.
UniGene	Hs.709175
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P35348. 3 interactions.
STRING	P35348.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P35348.
Proteomic databases
PRIDE	P35348.
Genome annotation databases
Ensembl	ENST00000276393; ENSP00000276393; ENSG00000120907; Homo sapiens. [Genome view]
GeneID	148.
KEGG	hsa:148.
UCSC	uc003xfe.1. human. uc003xfh.1. human. uc010lul.1. human. uc010lum.1. human.
Organism-specific databases
CTD	148.
GeneCards	GC08M026661.
H-InvDB	HIX0034243.
HGNC	HGNC:277. ADRA1A.
MIM	104221. gene.
PharmGKB	PA34.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	P35348.
Enzyme and pathway databases
Reactome	REACT_14797. Signaling by GPCR.
Gene expression databases
ArrayExpress	P35348.
Bgee	P35348.
CleanEx	HS_ADRA1A.
Genevestigator	P35348.
GermOnline	ENSG00000120907. Homo sapiens.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR001004. Adrene_rcpt_A1Cs. IPR002233. Adrnrgc_rcpt. IPR017452. GPCR_Rhodpsn_supfam. [Graphical view]
PANTHER	PTHR19266:SF89. Adrene_rcpt_A1Cs. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR01103. ADRENERGICR. PR00557. ADRENRGCA1AR. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
DrugBank	DB00346. Alfuzosin. DB01118. Amiodarone. DB00182. Amphetamine. DB00865. Benzphetamine. DB00217. Bethanidine. DB01136. Carvedilol. DB00298. Dapiprazole. DB04840. Debrisoquin. DB01576. Dextroamphetamine. DB00590. Doxazosin. DB00751. Epinastine. DB00668. Epinephrine. DB00696. Ergotamine. DB00875. Flupenthixol. DB00226. Guanadrel Sulfate. DB01170. Guanethidine. DB00598. Labetalol. DB01255. Lisdexamfetamine. DB00934. Maprotiline. DB01365. Mephentermine. DB00610. Metaraminol. DB01577. Methamphetamine. DB01403. Methotrimeprazine. DB00723. Methoxamine. DB00211. Midodrine. DB01149. Nefazodone. DB00699. Nicergoline. DB00665. Nilutamide. DB00368. Norepinephrine. DB00506. Norgestrel. DB00935. Oxymetazoline. DB00850. Perphenazine. DB01579. Phendimetrazine. DB00925. Phenoxybenzamine. DB00388. Phenylephrine. DB00397. Phenylpropanolamine. DB00457. Prazosin. DB00420. Promazine. DB01069. Promethazine. DB01608. Propericiazine. DB00777. Propiomazine. DB00852. Pseudoephedrine. DB00734. Risperidone. DB06144. Sertindole. DB00706. Tamsulosin. DB01162. Terazosin. DB00679. Thioridazine. DB00797. Tolazoline. DB00656. Trazodone. DB00831. Trifluoperazine. DB00246. Ziprasidone.
NextBio	585.
SOURCE	Search...

Entry information

Entry name

ADA1A_HUMAN

Accession

Primary (citable) accession number: P35348
Secondary accession number(s): A8K0I3 , B0ZBD1, B0ZBD2, B0ZBD4, B0ZBD5, B0ZBD6, B0ZBD8, B0ZBD9, O60451, Q13675, Q13729, Q4VBM7, Q6RUJ4, Q6RUJ5, Q6RUJ7, Q6RUJ8, Q6RUJ9, Q96RE8, Q9UD63, Q9UD67

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	November 1, 1995
Last modified:	November 24, 2009
This is version 100 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.