P35348 (ADA1A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alpha-1A adrenergic receptor

Alternative name(s):
Alpha-1A adrenoreceptor
Short name=Alpha-1A adrenoceptor
Alpha-1C adrenergic receptor
Alpha-adrenergic receptor 1c

Gene names

Name:	ADRA1A
Synonyms:	ADRA1C

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	466 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G11 proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. Ref.16 Ref.17
Subunit structure	Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes. Ref.17
Subcellular location	Nucleus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note: Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes. Ref.16 Ref.17
Tissue specificity	Expressed in heart, brain, liver and prostate, but not in kidney, lung, adrenal, aorta and pituitary. Within the prostate, expressed in the apex, base, periurethral and lateral lobe. Isoform 4 is the most abundant isoform expressed in the prostate with high levels also detected in liver and heart. Ref.5 Ref.7 Ref.15
Post-translational modification	C-terminal Ser or Thr residues may be phosphorylated By similarity.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily.
Sequence caution	Isoform 2: The sequence BAA06901.1 differs from that shown. Reason: Frameshift at position 465. Isoform 2: The sequence ACA05900.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Cell membrane Membrane Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	activation of phospholipase C activity Inferred from sequence or structural similarity. Source: BHF-UCL adult heart development Inferred from electronic annotation. Source: Compara aging Inferred from sequence or structural similarity. Source: BHF-UCL apoptotic process Traceable author statement PubMed 10671514. Source: ProtInc calcium ion transport into cytosol Inferred from sequence or structural similarity. Source: BHF-UCL cell growth Inferred from electronic annotation. Source: Compara cell-cell signaling Traceable author statement Ref.1. Source: ProtInc intracellular protein kinase cascade Traceable author statement PubMed 10671514. Source: ProtInc micturition Inferred from electronic annotation. Source: Compara negative regulation of Rho protein signal transduction Inferred from sequence or structural similarity. Source: BHF-UCL negative regulation of cell proliferation Traceable author statement PubMed 10860850. Source: ProtInc negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure Inferred from electronic annotation. Source: Compara negative regulation of synaptic transmission, GABAergic Inferred from sequence or structural similarity. Source: BHF-UCL norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure Inferred from electronic annotation. Source: Compara organ growth Inferred from electronic annotation. Source: Compara phospholipase C-activating G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: Compara pilomotor reflex Inferred from electronic annotation. Source: Compara positive regulation of ERK1 and ERK2 cascade Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of action potential Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of cardiac muscle contraction Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of heart rate by epinephrine-norepinephrine Inferred from electronic annotation. Source: Compara positive regulation of protein kinase C signaling cascade Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of smooth muscle contraction Inferred from electronic annotation. Source: Compara positive regulation of systemic arterial blood pressure Inferred from electronic annotation. Source: Compara positive regulation of the force of heart contraction by epinephrine-norepinephrine Inferred from electronic annotation. Source: Compara positive regulation of vasoconstriction Inferred from sequence or structural similarity. Source: BHF-UCL response to drug Inferred from sequence or structural similarity. Source: BHF-UCL response to hormone stimulus Inferred from sequence or structural similarity. Source: BHF-UCL response to stress Inferred from sequence or structural similarity. Source: BHF-UCL smooth muscle contraction Traceable author statement Ref.3. Source: ProtInc
Cellular_component	T-tubule Inferred from electronic annotation. Source: Compara Z disc Inferred from electronic annotation. Source: Compara integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc nuclear membrane Inferred from direct assay Ref.17. Source: UniProtKB
Molecular_function	alpha1-adrenergic receptor activity Non-traceable author statement Ref.7. Source: UniProtKB protein heterodimerization activity Inferred from direct assay Ref.17. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 9 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P35348-1)

Also known as: Alpha 1c-1; Alpha(1A-1);

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P35348-2)

Also known as: Alpha 1c-2; Alpha(1A-2);

The sequence of this isoform differs from the canonical sequence as follows:
     424-466: VRSKSFLQVC...ISLSENGEEV → TKSRSVTRLE...CHQADATRPS

Isoform 3 (identifier: P35348-3)

Also known as: Alpha 1c-3; Alpha(1A-3);

The sequence of this isoform differs from the canonical sequence as follows:
     424-429: VRSKSF → GHTPMT
     430-466: Missing.

Isoform 4 (identifier: P35348-4)

Also known as: Alpha(1A-4);

The sequence of this isoform differs from the canonical sequence as follows:
     424-466: VRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV → RGMDCRYFTKNCREHIKHVNFMMPPWRKGSEC

Isoform 5 (identifier: P35348-5)

The sequence of this isoform differs from the canonical sequence as follows:
     296-297: SF → KS
     298-466: Missing.

Isoform 6 (identifier: P35348-6)

The sequence of this isoform differs from the canonical sequence as follows:
     295-342: GSFFPDFKPS...FKKAFQNVLR → DEETEAQEGK...VSRKDTCGVW
     343-466: Missing.

Isoform 7 (identifier: P35348-7)

Also known as: 2b/3b;

The sequence of this isoform differs from the canonical sequence as follows:
     296-324: SFFPDFKPSETVFKIVFWLGYLNSCINPI → TYILKYDVLFWRKGLSVCTRLRERKEIKN
     325-466: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 8 (identifier: P35348-8)

Also known as: 2c;

The sequence of this isoform differs from the canonical sequence as follows:
     295-466: GSFFPDFKPS...ISLSENGEEV → DEVSLCHQAG...GQDDLDLLTS

Isoform 9 (identifier: P35348-9)

Also known as: 3c;

The sequence of this isoform differs from the canonical sequence as follows:
     296-466: SFFPDFKPSE...ISLSENGEEV → THTHDMKPAS...TVTDTGKTVT

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 466	466	Alpha-1A adrenergic receptor		PRO_0000069063
Regions
	Topological domain	1 – 27	27	Extracellular By similarity
	Transmembrane	28 – 51	24	Helical; Name=1; By similarity
	Topological domain	52 – 64	13	Cytoplasmic By similarity
	Transmembrane	65 – 88	24	Helical; Name=2; By similarity
	Topological domain	89 – 99	11	Extracellular By similarity
	Transmembrane	100 – 122	23	Helical; Name=3; By similarity
	Topological domain	123 – 143	21	Cytoplasmic By similarity
	Transmembrane	144 – 167	24	Helical; Name=4; By similarity
	Topological domain	168 – 181	14	Extracellular By similarity
	Transmembrane	182 – 205	24	Helical; Name=5; By similarity
	Topological domain	206 – 273	68	Cytoplasmic By similarity
	Transmembrane	274 – 297	24	Helical; Name=6; By similarity
	Topological domain	298 – 305	8	Extracellular By similarity
	Transmembrane	306 – 329	24	Helical; Name=7; By similarity
	Topological domain	330 – 466	137	Cytoplasmic By similarity
	Region	334 – 349	16	Nuclear localization signal
Amino acid modifications
	Modified residue	215	1	Phosphoserine; by PKA Potential
	Lipidation	345	1	S-palmitoyl cysteine Potential
	Glycosylation	7	1	N-linked (GlcNAc...) Potential
	Glycosylation	13	1	N-linked (GlcNAc...) Potential
	Glycosylation	22	1	N-linked (GlcNAc...) Potential
	Disulfide bond	99 ↔ 176		By similarity
Natural variations
	Alternative sequence	295 – 466	172	GSFFP…NGEEV → DEVSLCHQAGVQWHDLGSLQ PPPPGFKRFSCLSLPSSWDY RDVPPGRRHQAQLIFVFLVE TGFHHVGQDDLDLLTS in isoform 8.		VSP_011046
	Alternative sequence	295 – 342	48	GSFFP…QNVLR → DEETEAQEGKNDSPSFKQPV HHAAVLGLEVMEKENLEGVS RKDTCGVW in isoform 6.		VSP_011053
	Alternative sequence	296 – 466	171	SFFPD…NGEEV → THTHDMKPASRPRLLSLLPK EGEHETHHWSCDPLSLESTP GAQEPCLTLGFTSLSSIHLT KAQIQHVTVTDTGKTVT in isoform 9.		VSP_011049
	Alternative sequence	296 – 324	29	SFFPD…CINPI → TYILKYDVLFWRKGLSVCTR LRERKEIKN in isoform 7.		VSP_011047
	Alternative sequence	296 – 297	2	SF → KS in isoform 5.		VSP_011051
	Alternative sequence	298 – 466	169	Missing in isoform 5.		VSP_011052
	Alternative sequence	325 – 466	142	Missing in isoform 7.		VSP_011048
	Alternative sequence	343 – 466	124	Missing in isoform 6.		VSP_011054
	Alternative sequence	424 – 466	43	VRSKS…NGEEV → TKSRSVTRLECSGMILAHCN LRLPGSRDSPASASQAAGTT GMCHQADATRPS in isoform 2.		VSP_011055
	Alternative sequence	424 – 466	43	VRSKS…NGEEV → RGMDCRYFTKNCREHIKHVN FMMPPWRKGSEC in isoform 4.		VSP_011050
	Alternative sequence	424 – 429	6	VRSKSF → GHTPMT in isoform 3.		VSP_011044
	Alternative sequence	430 – 466	37	Missing in isoform 3.		VSP_011045
	Natural variant	40	1	G → W in a breast cancer sample; somatic mutation. Ref.20		VAR_035756
	Natural variant	200	1	I → S. Corresponds to variant rs2229125 [ dbSNP | Ensembl ].		VAR_049370
	Natural variant	347	1	C → R Frequent polymorphism. Ref.1 Ref.2 Ref.4 Ref.5 Ref.6 Ref.14 Ref.15 Ref.18 Ref.19 Corresponds to variant rs1048101 [ dbSNP | Ensembl ].		VAR_019509
	Natural variant	414	1	K → R. Corresponds to variant rs3730247 [ dbSNP | Ensembl ].		VAR_049371
	Natural variant	465	1	E → D. Corresponds to variant rs2229126 [ dbSNP | Ensembl ].		VAR_049372
Experimental info
	Mutagenesis	334	1	K → A: Abolishes targeting to the nuclear membrane of cardiac myocytes; when associated with A-335; A-342; A-348 and A-349. Ref.17
	Mutagenesis	335	1	K → A: Abolishes targeting to the nuclear membrane of cardiac myocytes; when associated with A-334; A-342; A-348 and A-349. Ref.17
	Mutagenesis	342	1	R → A: Abolishes targeting to the nuclear membrane of cardiac myocytes; when associated with A-334; A-335; A-348 and A-349. Ref.17
	Mutagenesis	348	1	R → A: Abolishes targeting to the nuclear membrane of cardiac myocytes; when associated with A-334; A-335; A-342 and A-349. Ref.17
	Mutagenesis	349	1	K → A: Abolishes targeting to the nuclear membrane of cardiac myocytes; when associated with A-334; A-335; A-342 and A-348. Ref.17
	Sequence conflict	43	1	G → C in AAA93114. Ref.4
	Sequence conflict	129	1	S → T in AAA93114. Ref.4
	Sequence conflict	130	1	Y → H in AAK77197. Ref.9
	Sequence conflict	185	1	V → A in AAH95512. Ref.14
	Sequence conflict	338	1	Q → C Ref.2
	Sequence conflict	359	1	T → P in AAA93114. Ref.4
	Sequence conflict	384	1	T → A in AAK77197. Ref.9
	Sequence conflict	387	1	R → G in AAK77197. Ref.9
	Sequence conflict	390	1	K → R in AAK77197. Ref.9
	Sequence conflict	431	1	Q → E in BAA04960. Ref.1
	Sequence conflict	437	1	G → E in AAK77197. Ref.9
	Sequence conflict	442	1	S → C in AAA93114. Ref.4
Isoform 4:
	Sequence conflict	453	1	S → L in AAC06138. Ref.7
Isoform 6:
	Sequence conflict	302	1	E → Q in AAR84650. Ref.8

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Alpha 1c-1) (Alpha(1A-1)) [UniParc]. Last modified November 1, 1995. Version 2. Checksum: 1A50487531DECDF0	FASTA	466	51,487
	10 20 30 40 50 60 MVFLSGNASD SSNCTQPPAP VNISKAILLG VILGGLILFG VLGNILVILS VACHRHLHSV 70 80 90 100 110 120 THYYIVNLAV ADLLLTSTVL PFSAIFEVLG YWAFGRVFCN IWAAVDVLCC TASIMGLCII 130 140 150 160 170 180 SIDRYIGVSY PLRYPTIVTQ RRGLMALLCV WALSLVISIG PLFGWRQPAP EDETICQINE 190 200 210 220 230 240 EPGYVLFSAL GSFYLPLAII LVMYCRVYVV AKRESRGLKS GLKTDKSDSE QVTLRIHRKN 250 260 270 280 290 300 APAGGSGMAS AKTKTHFSVR LLKFSREKKA AKTLGIVVGC FVLCWLPFFL VMPIGSFFPD 310 320 330 340 350 360 FKPSETVFKI VFWLGYLNSC INPIIYPCSS QEFKKAFQNV LRIQCLCRKQ SSKHALGYTL 370 380 390 400 410 420 HPPSQAVEGQ HKDMVRIPVG SRETFYRISK TDGVCEWKFF SSMPRGSARI TVSKDQSSCT 430 440 450 460 TARVRSKSFL QVCCCVGPST PSLDKNHQVP TIKVHTISLS ENGEEV
	Isoform 2 (Alpha 1c-2) (Alpha(1A-2)) [UniParc]. Checksum: DE3CEEDD1AB3E56D	FASTA	475	52,205
	10 20 30 40 50 60 MVFLSGNASD SSNCTQPPAP VNISKAILLG VILGGLILFG VLGNILVILS VACHRHLHSV 70 80 90 100 110 120 THYYIVNLAV ADLLLTSTVL PFSAIFEVLG YWAFGRVFCN IWAAVDVLCC TASIMGLCII 130 140 150 160 170 180 SIDRYIGVSY PLRYPTIVTQ RRGLMALLCV WALSLVISIG PLFGWRQPAP EDETICQINE 190 200 210 220 230 240 EPGYVLFSAL GSFYLPLAII LVMYCRVYVV AKRESRGLKS GLKTDKSDSE QVTLRIHRKN 250 260 270 280 290 300 APAGGSGMAS AKTKTHFSVR LLKFSREKKA AKTLGIVVGC FVLCWLPFFL VMPIGSFFPD 310 320 330 340 350 360 FKPSETVFKI VFWLGYLNSC INPIIYPCSS QEFKKAFQNV LRIQCLCRKQ SSKHALGYTL 370 380 390 400 410 420 HPPSQAVEGQ HKDMVRIPVG SRETFYRISK TDGVCEWKFF SSMPRGSARI TVSKDQSSCT 430 440 450 460 470 TARTKSRSVT RLECSGMILA HCNLRLPGSR DSPASASQAA GTTGMCHQAD ATRPS
	Isoform 3 (Alpha 1c-3) (Alpha(1A-3)) [UniParc]. Checksum: E67B19B5CA668687	FASTA	429	47,461
	10 20 30 40 50 60 MVFLSGNASD SSNCTQPPAP VNISKAILLG VILGGLILFG VLGNILVILS VACHRHLHSV 70 80 90 100 110 120 THYYIVNLAV ADLLLTSTVL PFSAIFEVLG YWAFGRVFCN IWAAVDVLCC TASIMGLCII 130 140 150 160 170 180 SIDRYIGVSY PLRYPTIVTQ RRGLMALLCV WALSLVISIG PLFGWRQPAP EDETICQINE 190 200 210 220 230 240 EPGYVLFSAL GSFYLPLAII LVMYCRVYVV AKRESRGLKS GLKTDKSDSE QVTLRIHRKN 250 260 270 280 290 300 APAGGSGMAS AKTKTHFSVR LLKFSREKKA AKTLGIVVGC FVLCWLPFFL VMPIGSFFPD 310 320 330 340 350 360 FKPSETVFKI VFWLGYLNSC INPIIYPCSS QEFKKAFQNV LRIQCLCRKQ SSKHALGYTL 370 380 390 400 410 420 HPPSQAVEGQ HKDMVRIPVG SRETFYRISK TDGVCEWKFF SSMPRGSARI TVSKDQSSCT TARGHTPMT
	Isoform 4 (Alpha(1A-4)) [UniParc]. Checksum: 80C61B88FA608B6C	FASTA	455	50,777
	10 20 30 40 50 60 MVFLSGNASD SSNCTQPPAP VNISKAILLG VILGGLILFG VLGNILVILS VACHRHLHSV 70 80 90 100 110 120 THYYIVNLAV ADLLLTSTVL PFSAIFEVLG YWAFGRVFCN IWAAVDVLCC TASIMGLCII 130 140 150 160 170 180 SIDRYIGVSY PLRYPTIVTQ RRGLMALLCV WALSLVISIG PLFGWRQPAP EDETICQINE 190 200 210 220 230 240 EPGYVLFSAL GSFYLPLAII LVMYCRVYVV AKRESRGLKS GLKTDKSDSE QVTLRIHRKN 250 260 270 280 290 300 APAGGSGMAS AKTKTHFSVR LLKFSREKKA AKTLGIVVGC FVLCWLPFFL VMPIGSFFPD 310 320 330 340 350 360 FKPSETVFKI VFWLGYLNSC INPIIYPCSS QEFKKAFQNV LRIQCLCRKQ SSKHALGYTL 370 380 390 400 410 420 HPPSQAVEGQ HKDMVRIPVG SRETFYRISK TDGVCEWKFF SSMPRGSARI TVSKDQSSCT 430 440 450 TARRGMDCRY FTKNCREHIK HVNFMMPPWR KGSEC
	Isoform 5 [UniParc]. Checksum: 4871F9BE42A87D6E	FASTA	297	32,433
	10 20 30 40 50 60 MVFLSGNASD SSNCTQPPAP VNISKAILLG VILGGLILFG VLGNILVILS VACHRHLHSV 70 80 90 100 110 120 THYYIVNLAV ADLLLTSTVL PFSAIFEVLG YWAFGRVFCN IWAAVDVLCC TASIMGLCII 130 140 150 160 170 180 SIDRYIGVSY PLRYPTIVTQ RRGLMALLCV WALSLVISIG PLFGWRQPAP EDETICQINE 190 200 210 220 230 240 EPGYVLFSAL GSFYLPLAII LVMYCRVYVV AKRESRGLKS GLKTDKSDSE QVTLRIHRKN 250 260 270 280 290 APAGGSGMAS AKTKTHFSVR LLKFSREKKA AKTLGIVVGC FVLCWLPFFL VMPIGKS
	Isoform 6 [UniParc]. Checksum: 2B6E7CC81B9CBE50	FASTA	342	37,468
	10 20 30 40 50 60 MVFLSGNASD SSNCTQPPAP VNISKAILLG VILGGLILFG VLGNILVILS VACHRHLHSV 70 80 90 100 110 120 THYYIVNLAV ADLLLTSTVL PFSAIFEVLG YWAFGRVFCN IWAAVDVLCC TASIMGLCII 130 140 150 160 170 180 SIDRYIGVSY PLRYPTIVTQ RRGLMALLCV WALSLVISIG PLFGWRQPAP EDETICQINE 190 200 210 220 230 240 EPGYVLFSAL GSFYLPLAII LVMYCRVYVV AKRESRGLKS GLKTDKSDSE QVTLRIHRKN 250 260 270 280 290 300 APAGGSGMAS AKTKTHFSVR LLKFSREKKA AKTLGIVVGC FVLCWLPFFL VMPIDEETEA 310 320 330 340 QEGKNDSPSF KQPVHHAAVL GLEVMEKENL EGVSRKDTCG VW
	Isoform 7 (2b/3b) [UniParc]. Checksum: 608DACD5497EE83E	FASTA	324	35,829
	10 20 30 40 50 60 MVFLSGNASD SSNCTQPPAP VNISKAILLG VILGGLILFG VLGNILVILS VACHRHLHSV 70 80 90 100 110 120 THYYIVNLAV ADLLLTSTVL PFSAIFEVLG YWAFGRVFCN IWAAVDVLCC TASIMGLCII 130 140 150 160 170 180 SIDRYIGVSY PLRYPTIVTQ RRGLMALLCV WALSLVISIG PLFGWRQPAP EDETICQINE 190 200 210 220 230 240 EPGYVLFSAL GSFYLPLAII LVMYCRVYVV AKRESRGLKS GLKTDKSDSE QVTLRIHRKN 250 260 270 280 290 300 APAGGSGMAS AKTKTHFSVR LLKFSREKKA AKTLGIVVGC FVLCWLPFFL VMPIGTYILK 310 320 YDVLFWRKGL SVCTRLRERK EIKN
	Isoform 8 (2c) [UniParc]. Checksum: F00E717A4C4A59AC	FASTA	370	40,725
	10 20 30 40 50 60 MVFLSGNASD SSNCTQPPAP VNISKAILLG VILGGLILFG VLGNILVILS VACHRHLHSV 70 80 90 100 110 120 THYYIVNLAV ADLLLTSTVL PFSAIFEVLG YWAFGRVFCN IWAAVDVLCC TASIMGLCII 130 140 150 160 170 180 SIDRYIGVSY PLRYPTIVTQ RRGLMALLCV WALSLVISIG PLFGWRQPAP EDETICQINE 190 200 210 220 230 240 EPGYVLFSAL GSFYLPLAII LVMYCRVYVV AKRESRGLKS GLKTDKSDSE QVTLRIHRKN 250 260 270 280 290 300 APAGGSGMAS AKTKTHFSVR LLKFSREKKA AKTLGIVVGC FVLCWLPFFL VMPIDEVSLC 310 320 330 340 350 360 HQAGVQWHDL GSLQPPPPGF KRFSCLSLPS SWDYRDVPPG RRHQAQLIFV FLVETGFHHV 370 GQDDLDLLTS
	Isoform 9 (3c) [UniParc]. Checksum: 839C5750F9B428F5	FASTA	372	40,638
	10 20 30 40 50 60 MVFLSGNASD SSNCTQPPAP VNISKAILLG VILGGLILFG VLGNILVILS VACHRHLHSV 70 80 90 100 110 120 THYYIVNLAV ADLLLTSTVL PFSAIFEVLG YWAFGRVFCN IWAAVDVLCC TASIMGLCII 130 140 150 160 170 180 SIDRYIGVSY PLRYPTIVTQ RRGLMALLCV WALSLVISIG PLFGWRQPAP EDETICQINE 190 200 210 220 230 240 EPGYVLFSAL GSFYLPLAII LVMYCRVYVV AKRESRGLKS GLKTDKSDSE QVTLRIHRKN 250 260 270 280 290 300 APAGGSGMAS AKTKTHFSVR LLKFSREKKA AKTLGIVVGC FVLCWLPFFL VMPIGTHTHD 310 320 330 340 350 360 MKPASRPRLL SLLPKEGEHE THHWSCDPLS LESTPGAQEP CLTLGFTSLS SIHLTKAQIQ 370 HVTVTDTGKT VT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, functional expression and tissue distribution of human cDNA for the alpha 1C-adrenergic receptor." Hirasawa A., Horie K., Tanaka T., Takagaki K., Murai M., Yano J., Tsujimoto G. Biochem. Biophys. Res. Commun. 195:902-909(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), VARIANT ARG-347. Tissue: Prostate.
[2]	"Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c." Weinberg D.H., Trivedi P., Tan C.P., Mitra S., Perkins-Barrow A., Borkowski D., Strader C.D., Bayne M. Biochem. Biophys. Res. Commun. 201:1296-1304(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-347. Tissue: Heart.
[3]	"The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype." Forray C., Bard J.A., Wetzel J.M., Chiu G., Shapiro E., Tang R., Lepor H., Hartig P.R., Weinshank R.L., Branchek T.A., Gluchowski C. Mol. Pharmacol. 45:703-708(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1). Tissue: Hippocampus and Lymphocyte.
[4]	"The alpha 1C-adrenoceptor in human prostate: cloning, functional expression, and localization to specific prostatic cell types." Tseng-Crank J., Kost T., Goetz A., Hazum S., Roberson K.M., Haizlip J., Godinot N., Robertson C.N., Saussy D. Br. J. Pharmacol. 115:1475-1485(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-347.
[5]	"Cloning, functional expression and tissue distribution of human alpha 1c-adrenoceptor splice variants." Hirasawa A., Shibata K., Horie K., Takei Y., Obika K., Tanaka T., Muramoto N., Takagaki K., Yano J., Tsujimoto G. FEBS Lett. 363:256-260(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), VARIANT ARG-347, TISSUE SPECIFICITY. Tissue: Prostate.
[6]	"Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues." Schwinn D.A., Johnston G.I., Page S.O., Mosley M.J., Wilson K.H., Worman N.P., Campbell S., Fidock M.D., Furness L.M., Parry-Smith D.J., Peter B., Bailey D.S. J. Pharmacol. Exp. Ther. 272:134-142(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-347.
[7]	"Molecular cloning, genomic characterization and expression of novel human alpha1A-adrenoceptor isoforms." Chang D.J., Chang T.K., Yamanishi S.S., Salazar F.H.R., Kosaka A.H., Khare R., Bhakta S., Jasper J.R., Shieh I.-S., Lesnick J.D., Ford A.P.D.W., Daniels D.V., Clarke D.E., Bach C.T., Chan H.W. FEBS Lett. 422:279-283(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), TISSUE SPECIFICITY. Tissue: Prostate.
[8]	"Truncated isoforms inhibit [3H]prazosin binding and cellular trafficking of native human alpha1A-adrenoceptors." Coge F., Guenin S.P., Renouard-Try A., Rique H., Ouvry C., Fabry N., Beauverger P., Nicolas J.P., Galizzi J.-P., Boutin J.A., Canet E. Biochem. J. 343:231-239(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 5; 6; 7; 8 AND 9). Tissue: Liver.
[9]	"RT-PCR cloning and sequence analysis of adrenergic receptor subtype-alpha-1a cDNA from human prostrate cell-line DU-145." Banerjee A.G.N., Aarti A. Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[10]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[11]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Kopatz S.A., Aronstam R.S., Sharma S.V. Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[12]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Cerebellum.
[13]	NHLBI resequencing and genotyping service (RS&G) Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[14]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-347.
[15]	"Identification of alpha 1-adrenoceptor subtypes present in the human prostate." Faure C., Pimoule C., Vallancien G., Langer S.Z., Graham D. Life Sci. 54:1595-1605(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 52-400 (ISOFORMS 1/2/3/4), TISSUE SPECIFICITY, VARIANT ARG-347. Tissue: Prostate.
[16]	"Nuclear alpha1-adrenergic receptors signal activated ERK localization to caveolae in adult cardiac myocytes." Wright C.D., Chen Q., Baye N.L., Huang Y., Healy C.L., Kasinathan S., O'Connell T.D. Circ. Res. 103:992-1000(2008) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, FUNCTION.
[17]	"Nuclear localization drives alpha1-adrenergic receptor oligomerization and signaling in cardiac myocytes." Wright C.D., Wu S.C., Dahl E.F., Sazama A.J., O'Connell T.D. Cell. Signal. 24:794-802(2012) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, SUBUNIT, FUNCTION, MUTAGENESIS OF LYS-334; LYS-335; ARG-342; ARG-348 AND LYS-349.
[18]	"Alpha 1a-adrenoceptor polymorphism: pharmacological characterization and association with benign prostatic hypertrophy." Shibata K., Hirasawa A., Moriyama N., Kawabe K., Ogawa S., Tsujimoto G. Br. J. Pharmacol. 118:1403-1408(1996) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT ARG-347.
[19]	"Alpha 1A-adrenergic receptor polymorphism and vascular response." Sofowora G.G., Dishy V., Landau R., Xie H.G., Prasad H.C., Byrne D.W., Smiley R.M., Kim R.B., Wood A.J., Stein C.M. Clin. Pharmacol. Ther. 75:539-545(2004) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT ARG-347.
[20]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] TRP-40.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D25235 mRNA. Translation: BAA04960.1. U03866 Genomic DNA. Translation: AAB60353.1. U02569 mRNA. Translation: AAA93114.1. D32201 mRNA. Translation: BAA06900.1. D32202 mRNA. Translation: BAA06901.1. Frameshift. L31774 mRNA. Translation: AAB59486.1. AF013261 mRNA. Translation: AAC06138.1. AY491775 mRNA. Translation: AAR84644.1. AY491776 mRNA. Translation: AAR84645.1. AY491777 mRNA. Translation: AAR84646.1. AY491778 mRNA. Translation: AAR84647.1. AY491779 mRNA. Translation: AAR84648.1. AY491780 mRNA. Translation: AAR84649.1. AY491781 mRNA. Translation: AAR84650.1. AF395806 mRNA. Translation: AAK77197.1. AB065703 Genomic DNA. Translation: BAC05926.1. AY389505 Genomic DNA. Translation: AAQ91331.1. AK289548 mRNA. Translation: BAF82237.1. EU326301 Genomic DNA. Translation: ACA05899.1. EU326301 Genomic DNA. Translation: ACA05900.1. Sequence problems. EU326301 Genomic DNA. Translation: ACA05902.1. EU326301 Genomic DNA. Translation: ACA05903.1. EU326301 Genomic DNA. Translation: ACA05904.1. EU326301 Genomic DNA. Translation: ACA05905.1. EU326301 Genomic DNA. Translation: ACA05906.1. EU326301 Genomic DNA. Translation: ACA05907.1. BC095512 mRNA. Translation: AAH95512.1.
IPI	IPI00430195. IPI00430197. IPI00430199. IPI00430201. IPI00430202. IPI00430203. IPI00430204. IPI00430205. IPI00954300.
PIR	JN0765. S65656. S65657.
RefSeq	NP_000671.2. NM_000680.2. NP_150645.2. NM_033302.2. NP_150646.3. NM_033303.3. NP_150647.2. NM_033304.2.
UniGene	Hs.709175.
3D structure databases
ProteinModelPortal	P35348.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-33401N.
IntAct	P35348. 3 interactions.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P35348.
Polymorphism databases
DMDM	1168246.
Proteomic databases
PaxDb	P35348.
PRIDE	P35348.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000276393; ENSP00000276393; ENSG00000120907. ENST00000354550; ENSP00000346557; ENSG00000120907. ENST00000358857; ENSP00000351725; ENSG00000120907. ENST00000380572; ENSP00000369946; ENSG00000120907. ENST00000380573; ENSP00000369947; ENSG00000120907. ENST00000380581; ENSP00000369955; ENSG00000120907. ENST00000380582; ENSP00000369956; ENSG00000120907. ENST00000380586; ENSP00000369960; ENSG00000120907. ENST00000380587; ENSP00000369961; ENSG00000120907. ENST00000519096; ENSP00000431073; ENSG00000120907. ENST00000521711; ENSP00000430414; ENSG00000120907.
GeneID	148.
KEGG	hsa:148.
UCSC	uc003xfe.1. human. uc003xfg.1. human. uc003xfh.1. human. uc010lul.1. human. uc010lum.1. human. uc022atd.1. human.
Organism-specific databases
CTD	148.
GeneCards	GC08M026605.
HGNC	HGNC:277. ADRA1A.
HPA	HPA029678.
MIM	104221. gene.
neXtProt	NX_P35348.
PharmGKB	PA34.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG253615.
HOVERGEN	HBG106962.
KO	K04135.
OMA	NCTHPPA.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
SignaLink	P35348.
Gene expression databases
ArrayExpress	P35348.
Bgee	P35348.
CleanEx	HS_ADRA1A.
Genevestigator	P35348.
GermOnline	ENSG00000120907. Homo sapiens.
Family and domain databases
InterPro	IPR001004. Adrene_rcpt_A1Cs. IPR002233. Adrnrgc_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR01103. ADRENERGICR. PR00557. ADRENRGCA1AR. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P35348.
ChEMBL	CHEMBL229.
DrugBank	DB00346. Alfuzosin. DB01118. Amiodarone. DB00182. Amphetamine. DB00865. Benzphetamine. DB00217. Bethanidine. DB01136. Carvedilol. DB00298. Dapiprazole. DB04840. Debrisoquin. DB01576. Dextroamphetamine. DB00590. Doxazosin. DB00751. Epinastine. DB00668. Epinephrine. DB00696. Ergotamine. DB00875. Flupenthixol. DB00226. Guanadrel Sulfate. DB01170. Guanethidine. DB00598. Labetalol. DB01255. Lisdexamfetamine. DB00934. Maprotiline. DB01365. Mephentermine. DB00610. Metaraminol. DB01577. Methamphetamine. DB01403. Methotrimeprazine. DB00723. Methoxamine. DB00211. Midodrine. DB01149. Nefazodone. DB00699. Nicergoline. DB00665. Nilutamide. DB00368. Norepinephrine. DB00506. Norgestrel. DB00935. Oxymetazoline. DB00850. Perphenazine. DB01579. Phendimetrazine. DB00925. Phenoxybenzamine. DB00388. Phenylephrine. DB00397. Phenylpropanolamine. DB00457. Prazosin. DB00420. Promazine. DB01069. Promethazine. DB01608. Propericiazine. DB00777. Propiomazine. DB00852. Pseudoephedrine. DB00734. Risperidone. DB06144. Sertindole. DB00706. Tamsulosin. DB01162. Terazosin. DB00679. Thioridazine. DB00797. Tolazoline. DB00656. Trazodone. DB00831. Trifluoperazine. DB00246. Ziprasidone.
GenomeRNAi	148.
NextBio	585.
SOURCE	Search...

Entry information

Entry name

ADA1A_HUMAN

Accession

Primary (citable) accession number: P35348
Secondary accession number(s): A8K0I3 , B0ZBD1, B0ZBD2, B0ZBD4, B0ZBD5, B0ZBD6, B0ZBD8, B0ZBD9, O60451, Q13675, Q13729, Q4VBM7, Q6RUJ4, Q6RUJ5, Q6RUJ7, Q6RUJ8, Q6RUJ9, Q96RE8, Q9UD63, Q9UD67

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	November 1, 1995
Last modified:	May 29, 2013
This is version 135 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.