Alpha-1A adrenergic receptor - Homo sapiens (Human)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Alpha-1A adrenergic receptor

Alternative name(s):
Alpha-1A adrenoreceptor
Short name=Alpha-1A adrenoceptor
Alpha-1C adrenergic receptor
Alpha-adrenergic receptor 1c

Gene names

Name:	ADRA1A
Synonyms:	ADRA1C

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	466 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in heart, brain, liver and prostate, but not in kidney, lung, adrenal, aorta and pituitary. Within the prostate, expressed in the apex, base, periurethra and lateral lobe. Isoform 4 is the most abundant isoform expressed in the prostate with high levels also detected in liver and heart. Ref.5 Ref.7 Ref.15
Post-translational modification	Carboxyl-terminal Ser or Thr residues may be phosphorylated By similarity.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily.
Sequence caution	Isoform 2: The sequence BAA06901.1 differs from that shown. Reason: Frameshift at position 465. Isoform 2: The sequence ACA05900.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	activation of phospholipase C activity Inferred from sequence or structural similarity. Source: BHF-UCL aging Inferred from sequence or structural similarity. Source: BHF-UCL apoptotic process Traceable author statement. Source: ProtInc calcium ion transport into cytosol Inferred from sequence or structural similarity. Source: BHF-UCL cell-cell signaling Traceable author statement. Source: ProtInc intracellular protein kinase cascade Traceable author statement. Source: ProtInc negative regulation of Rho protein signal transduction Inferred from sequence or structural similarity. Source: BHF-UCL negative regulation of cell proliferation Traceable author statement. Source: ProtInc negative regulation of synaptic transmission, GABAergic Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of ERK1 and ERK2 cascade Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of action potential Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of cardiac muscle contraction Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of protein kinase C signaling cascade Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of vasoconstriction Inferred from sequence or structural similarity. Source: BHF-UCL response to drug Inferred from sequence or structural similarity. Source: BHF-UCL response to hormone stimulus Inferred from sequence or structural similarity. Source: BHF-UCL response to stress Inferred from sequence or structural similarity. Source: BHF-UCL smooth muscle contraction Traceable author statement. Source: ProtInc
Cellular component	integral to plasma membrane Traceable author statement. Source: ProtInc
Molecular function	alpha1-adrenergic receptor activity Non-traceable author statement Ref.7. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 9 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P35348-1)

Also known as: Alpha 1c-1; Alpha(1A-1);

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P35348-2)

Also known as: Alpha 1c-2; Alpha(1A-2);

The sequence of this isoform differs from the canonical sequence as follows:
424-466: VRSKSFLQVC...ISLSENGEEV → TKSRSVTRLE...CHQADATRPS

Isoform 3 (identifier: P35348-3)

Also known as: Alpha 1c-3; Alpha(1A-3);

The sequence of this isoform differs from the canonical sequence as follows:
424-429: VRSKSF → GHTPMT
430-466: Missing.

Isoform 4 (identifier: P35348-4)

Also known as: Alpha(1A-4);

The sequence of this isoform differs from the canonical sequence as follows:
424-466: VRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV → RGMDCRYFTKNCREHIKHVNFMMPPWRKGSEC

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Sequence conflict

453

1

S → L in AAC06138. Ref.7

Isoform 5 (identifier: P35348-5)

The sequence of this isoform differs from the canonical sequence as follows:
296-297: SF → KS
298-466: Missing.

Isoform 6 (identifier: P35348-6)

The sequence of this isoform differs from the canonical sequence as follows:
295-342: GSFFPDFKPS...FKKAFQNVLR → DEETEAQEGK...VSRKDTCGVW
343-466: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Sequence conflict

302

1

E → Q in AAR84650. Ref.8

Isoform 7 (identifier: P35348-7)

Also known as: 2b/3b;

The sequence of this isoform differs from the canonical sequence as follows:
296-324: SFFPDFKPSETVFKIVFWLGYLNSCINPI → TYILKYDVLFWRKGLSVCTRLRERKEIKN
325-466: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 8 (identifier: P35348-8)

Also known as: 2c;

The sequence of this isoform differs from the canonical sequence as follows:
295-466: GSFFPDFKPS...ISLSENGEEV → DEVSLCHQAG...GQDDLDLLTS

Isoform 9 (identifier: P35348-9)

Also known as: 3c;

The sequence of this isoform differs from the canonical sequence as follows:
296-466: SFFPDFKPSE...ISLSENGEEV → THTHDMKPAS...TVTDTGKTVT

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 466

466

Alpha-1A adrenergic receptor

PRO_0000069063

Regions

Topological domain

1 – 27

27

Extracellular By similarity

Transmembrane

28 – 51

24

Helical; Name=1; By similarity

Topological domain

52 – 64

13

Cytoplasmic By similarity

Transmembrane

65 – 88

24

Helical; Name=2; By similarity

Topological domain

89 – 99

11

Extracellular By similarity

Transmembrane

100 – 122

23

Helical; Name=3; By similarity

Topological domain

123 – 143

21

Cytoplasmic By similarity

Transmembrane

144 – 167

24

Helical; Name=4; By similarity

Topological domain

168 – 181

14

Extracellular By similarity

Transmembrane

182 – 205

24

Helical; Name=5; By similarity

Topological domain

206 – 273

68

Cytoplasmic By similarity

Transmembrane

274 – 297

24

Helical; Name=6; By similarity

Topological domain

298 – 305

8

Extracellular By similarity

Transmembrane

306 – 329

24

Helical; Name=7; By similarity

Topological domain

330 – 466

137

Cytoplasmic By similarity

Amino acid modifications

Modified residue

215

1

Phosphoserine; by PKA Potential

Lipidation

345

1

S-palmitoyl cysteine Potential

Glycosylation

7

1

N-linked (GlcNAc...) Potential

Glycosylation

13

1

N-linked (GlcNAc...) Potential

Glycosylation

22

1

N-linked (GlcNAc...) Potential

Disulfide bond

99 ↔ 176

By similarity

Natural variations

Alternative sequence

295 – 466

172

GSFFP…NGEEV → DEVSLCHQAGVQWHDLGSLQ PPPPGFKRFSCLSLPSSWDY RDVPPGRRHQAQLIFVFLVE TGFHHVGQDDLDLLTS in isoform 8.

VSP_011046

Alternative sequence

295 – 342

48

GSFFP…QNVLR → DEETEAQEGKNDSPSFKQPV HHAAVLGLEVMEKENLEGVS RKDTCGVW in isoform 6.

VSP_011053

Alternative sequence

296 – 466

171

SFFPD…NGEEV → THTHDMKPASRPRLLSLLPK EGEHETHHWSCDPLSLESTP GAQEPCLTLGFTSLSSIHLT KAQIQHVTVTDTGKTVT in isoform 9.

VSP_011049

Alternative sequence

296 – 324

29

SFFPD…CINPI → TYILKYDVLFWRKGLSVCTR LRERKEIKN in isoform 7.

VSP_011047

Alternative sequence

296 – 297

2

SF → KS in isoform 5.

VSP_011051

Alternative sequence

298 – 466

169

Missing in isoform 5.

VSP_011052

Alternative sequence

325 – 466

142

Missing in isoform 7.

VSP_011048

Alternative sequence

343 – 466

124

Missing in isoform 6.

VSP_011054

Alternative sequence

424 – 466

43

VRSKS…NGEEV → TKSRSVTRLECSGMILAHCN LRLPGSRDSPASASQAAGTT GMCHQADATRPS in isoform 2.

VSP_011055

Alternative sequence

424 – 466

43

VRSKS…NGEEV → RGMDCRYFTKNCREHIKHVN FMMPPWRKGSEC in isoform 4.

VSP_011050

Alternative sequence

424 – 429

6

VRSKSF → GHTPMT in isoform 3.

VSP_011044

Alternative sequence

430 – 466

37

Missing in isoform 3.

VSP_011045

Natural variant

40

1

G → W in a breast cancer sample; somatic mutation. Ref.18

VAR_035756

Natural variant

200

1

I → S.
Corresponds to variant rs2229125 [ dbSNP | Ensembl ].

VAR_049370

Natural variant

347

1

C → R Frequent polymorphism. Ref.1 Ref.2 Ref.4 Ref.5 Ref.6 Ref.14 Ref.15 Ref.16 Ref.17
Corresponds to variant rs1048101 [ dbSNP | Ensembl ].

VAR_019509

Natural variant

414

1

K → R.
Corresponds to variant rs3730247 [ dbSNP | Ensembl ].

VAR_049371

Natural variant

465

1

E → D.
Corresponds to variant rs2229126 [ dbSNP | Ensembl ].

VAR_049372

Experimental info

Sequence conflict

43

1

G → C in AAA93114. Ref.4

Sequence conflict

129

1

S → T in AAA93114. Ref.4

Sequence conflict

130

1

Y → H in AAK77197. Ref.9

Sequence conflict

185

1

V → A in AAH95512. Ref.14

Sequence conflict

338

1

Q → C Ref.2

Sequence conflict

359

1

T → P in AAA93114. Ref.4

Sequence conflict

384

1

T → A in AAK77197. Ref.9

Sequence conflict

387

1

R → G in AAK77197. Ref.9

Sequence conflict

390

1

K → R in AAK77197. Ref.9

Sequence conflict

431

1

Q → E in BAA04960. Ref.1

Sequence conflict

437

1

G → E in AAK77197. Ref.9

Sequence conflict

442

1

S → C in AAA93114. Ref.4

Sequences

Sequence		Length	Mass (Da)
Isoform 1 (Alpha 1c-1) (Alpha(1A-1)) [UniParc]. Last modified November 1, 1995. Version 2. Checksum: 1A50487531DECDF0 Show »	FASTA	466	51,487
10 20 30 40 50 60 MVFLSGNASD SSNCTQPPAP VNISKAILLG VILGGLILFG VLGNILVILS VACHRHLHSV 70 80 90 100 110 120 THYYIVNLAV ADLLLTSTVL PFSAIFEVLG YWAFGRVFCN IWAAVDVLCC TASIMGLCII 130 140 150 160 170 180 SIDRYIGVSY PLRYPTIVTQ RRGLMALLCV WALSLVISIG PLFGWRQPAP EDETICQINE 190 200 210 220 230 240 EPGYVLFSAL GSFYLPLAII LVMYCRVYVV AKRESRGLKS GLKTDKSDSE QVTLRIHRKN 250 260 270 280 290 300 APAGGSGMAS AKTKTHFSVR LLKFSREKKA AKTLGIVVGC FVLCWLPFFL VMPIGSFFPD 310 320 330 340 350 360 FKPSETVFKI VFWLGYLNSC INPIIYPCSS QEFKKAFQNV LRIQCLCRKQ SSKHALGYTL 370 380 390 400 410 420 HPPSQAVEGQ HKDMVRIPVG SRETFYRISK TDGVCEWKFF SSMPRGSARI TVSKDQSSCT 430 440 450 460 TARVRSKSFL QVCCCVGPST PSLDKNHQVP TIKVHTISLS ENGEEV « Hide
Isoform 2 (Alpha 1c-2) (Alpha(1A-2)) [UniParc]. Checksum: DE3CEEDD1AB3E56D Show »	FASTA	475	52,205
10 20 30 40 50 60 MVFLSGNASD SSNCTQPPAP VNISKAILLG VILGGLILFG VLGNILVILS VACHRHLHSV 70 80 90 100 110 120 THYYIVNLAV ADLLLTSTVL PFSAIFEVLG YWAFGRVFCN IWAAVDVLCC TASIMGLCII 130 140 150 160 170 180 SIDRYIGVSY PLRYPTIVTQ RRGLMALLCV WALSLVISIG PLFGWRQPAP EDETICQINE 190 200 210 220 230 240 EPGYVLFSAL GSFYLPLAII LVMYCRVYVV AKRESRGLKS GLKTDKSDSE QVTLRIHRKN 250 260 270 280 290 300 APAGGSGMAS AKTKTHFSVR LLKFSREKKA AKTLGIVVGC FVLCWLPFFL VMPIGSFFPD 310 320 330 340 350 360 FKPSETVFKI VFWLGYLNSC INPIIYPCSS QEFKKAFQNV LRIQCLCRKQ SSKHALGYTL 370 380 390 400 410 420 HPPSQAVEGQ HKDMVRIPVG SRETFYRISK TDGVCEWKFF SSMPRGSARI TVSKDQSSCT 430 440 450 460 470 TARTKSRSVT RLECSGMILA HCNLRLPGSR DSPASASQAA GTTGMCHQAD ATRPS « Hide
Isoform 3 (Alpha 1c-3) (Alpha(1A-3)) [UniParc]. Checksum: E67B19B5CA668687 Show »	FASTA	429	47,461
10 20 30 40 50 60 MVFLSGNASD SSNCTQPPAP VNISKAILLG VILGGLILFG VLGNILVILS VACHRHLHSV 70 80 90 100 110 120 THYYIVNLAV ADLLLTSTVL PFSAIFEVLG YWAFGRVFCN IWAAVDVLCC TASIMGLCII 130 140 150 160 170 180 SIDRYIGVSY PLRYPTIVTQ RRGLMALLCV WALSLVISIG PLFGWRQPAP EDETICQINE 190 200 210 220 230 240 EPGYVLFSAL GSFYLPLAII LVMYCRVYVV AKRESRGLKS GLKTDKSDSE QVTLRIHRKN 250 260 270 280 290 300 APAGGSGMAS AKTKTHFSVR LLKFSREKKA AKTLGIVVGC FVLCWLPFFL VMPIGSFFPD 310 320 330 340 350 360 FKPSETVFKI VFWLGYLNSC INPIIYPCSS QEFKKAFQNV LRIQCLCRKQ SSKHALGYTL 370 380 390 400 410 420 HPPSQAVEGQ HKDMVRIPVG SRETFYRISK TDGVCEWKFF SSMPRGSARI TVSKDQSSCT TARGHTPMT « Hide
Isoform 4 (Alpha(1A-4)) [UniParc]. Checksum: 80C61B88FA608B6C Show »	FASTA	455	50,777
10 20 30 40 50 60 MVFLSGNASD SSNCTQPPAP VNISKAILLG VILGGLILFG VLGNILVILS VACHRHLHSV 70 80 90 100 110 120 THYYIVNLAV ADLLLTSTVL PFSAIFEVLG YWAFGRVFCN IWAAVDVLCC TASIMGLCII 130 140 150 160 170 180 SIDRYIGVSY PLRYPTIVTQ RRGLMALLCV WALSLVISIG PLFGWRQPAP EDETICQINE 190 200 210 220 230 240 EPGYVLFSAL GSFYLPLAII LVMYCRVYVV AKRESRGLKS GLKTDKSDSE QVTLRIHRKN 250 260 270 280 290 300 APAGGSGMAS AKTKTHFSVR LLKFSREKKA AKTLGIVVGC FVLCWLPFFL VMPIGSFFPD 310 320 330 340 350 360 FKPSETVFKI VFWLGYLNSC INPIIYPCSS QEFKKAFQNV LRIQCLCRKQ SSKHALGYTL 370 380 390 400 410 420 HPPSQAVEGQ HKDMVRIPVG SRETFYRISK TDGVCEWKFF SSMPRGSARI TVSKDQSSCT 430 440 450 TARRGMDCRY FTKNCREHIK HVNFMMPPWR KGSEC « Hide
Isoform 5 [UniParc]. Checksum: 4871F9BE42A87D6E Show »	FASTA	297	32,433
10 20 30 40 50 60 MVFLSGNASD SSNCTQPPAP VNISKAILLG VILGGLILFG VLGNILVILS VACHRHLHSV 70 80 90 100 110 120 THYYIVNLAV ADLLLTSTVL PFSAIFEVLG YWAFGRVFCN IWAAVDVLCC TASIMGLCII 130 140 150 160 170 180 SIDRYIGVSY PLRYPTIVTQ RRGLMALLCV WALSLVISIG PLFGWRQPAP EDETICQINE 190 200 210 220 230 240 EPGYVLFSAL GSFYLPLAII LVMYCRVYVV AKRESRGLKS GLKTDKSDSE QVTLRIHRKN 250 260 270 280 290 APAGGSGMAS AKTKTHFSVR LLKFSREKKA AKTLGIVVGC FVLCWLPFFL VMPIGKS « Hide
Isoform 6 [UniParc]. Checksum: 2B6E7CC81B9CBE50 Show »	FASTA	342	37,468
10 20 30 40 50 60 MVFLSGNASD SSNCTQPPAP VNISKAILLG VILGGLILFG VLGNILVILS VACHRHLHSV 70 80 90 100 110 120 THYYIVNLAV ADLLLTSTVL PFSAIFEVLG YWAFGRVFCN IWAAVDVLCC TASIMGLCII 130 140 150 160 170 180 SIDRYIGVSY PLRYPTIVTQ RRGLMALLCV WALSLVISIG PLFGWRQPAP EDETICQINE 190 200 210 220 230 240 EPGYVLFSAL GSFYLPLAII LVMYCRVYVV AKRESRGLKS GLKTDKSDSE QVTLRIHRKN 250 260 270 280 290 300 APAGGSGMAS AKTKTHFSVR LLKFSREKKA AKTLGIVVGC FVLCWLPFFL VMPIDEETEA 310 320 330 340 QEGKNDSPSF KQPVHHAAVL GLEVMEKENL EGVSRKDTCG VW « Hide
Isoform 7 (2b/3b) [UniParc]. Checksum: 608DACD5497EE83E Show »	FASTA	324	35,829
10 20 30 40 50 60 MVFLSGNASD SSNCTQPPAP VNISKAILLG VILGGLILFG VLGNILVILS VACHRHLHSV 70 80 90 100 110 120 THYYIVNLAV ADLLLTSTVL PFSAIFEVLG YWAFGRVFCN IWAAVDVLCC TASIMGLCII 130 140 150 160 170 180 SIDRYIGVSY PLRYPTIVTQ RRGLMALLCV WALSLVISIG PLFGWRQPAP EDETICQINE 190 200 210 220 230 240 EPGYVLFSAL GSFYLPLAII LVMYCRVYVV AKRESRGLKS GLKTDKSDSE QVTLRIHRKN 250 260 270 280 290 300 APAGGSGMAS AKTKTHFSVR LLKFSREKKA AKTLGIVVGC FVLCWLPFFL VMPIGTYILK 310 320 YDVLFWRKGL SVCTRLRERK EIKN « Hide
Isoform 8 (2c) [UniParc]. Checksum: F00E717A4C4A59AC Show »	FASTA	370	40,725
10 20 30 40 50 60 MVFLSGNASD SSNCTQPPAP VNISKAILLG VILGGLILFG VLGNILVILS VACHRHLHSV 70 80 90 100 110 120 THYYIVNLAV ADLLLTSTVL PFSAIFEVLG YWAFGRVFCN IWAAVDVLCC TASIMGLCII 130 140 150 160 170 180 SIDRYIGVSY PLRYPTIVTQ RRGLMALLCV WALSLVISIG PLFGWRQPAP EDETICQINE 190 200 210 220 230 240 EPGYVLFSAL GSFYLPLAII LVMYCRVYVV AKRESRGLKS GLKTDKSDSE QVTLRIHRKN 250 260 270 280 290 300 APAGGSGMAS AKTKTHFSVR LLKFSREKKA AKTLGIVVGC FVLCWLPFFL VMPIDEVSLC 310 320 330 340 350 360 HQAGVQWHDL GSLQPPPPGF KRFSCLSLPS SWDYRDVPPG RRHQAQLIFV FLVETGFHHV 370 GQDDLDLLTS « Hide
Isoform 9 (3c) [UniParc]. Checksum: 839C5750F9B428F5 Show »	FASTA	372	40,638
10 20 30 40 50 60 MVFLSGNASD SSNCTQPPAP VNISKAILLG VILGGLILFG VLGNILVILS VACHRHLHSV 70 80 90 100 110 120 THYYIVNLAV ADLLLTSTVL PFSAIFEVLG YWAFGRVFCN IWAAVDVLCC TASIMGLCII 130 140 150 160 170 180 SIDRYIGVSY PLRYPTIVTQ RRGLMALLCV WALSLVISIG PLFGWRQPAP EDETICQINE 190 200 210 220 230 240 EPGYVLFSAL GSFYLPLAII LVMYCRVYVV AKRESRGLKS GLKTDKSDSE QVTLRIHRKN 250 260 270 280 290 300 APAGGSGMAS AKTKTHFSVR LLKFSREKKA AKTLGIVVGC FVLCWLPFFL VMPIGTHTHD 310 320 330 340 350 360 MKPASRPRLL SLLPKEGEHE THHWSCDPLS LESTPGAQEP CLTLGFTSLS SIHLTKAQIQ 370 HVTVTDTGKT VT « Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, functional expression and tissue distribution of human cDNA for the alpha 1C-adrenergic receptor." Hirasawa A., Horie K., Tanaka T., Takagaki K., Murai M., Yano J., Tsujimoto G. Biochem. Biophys. Res. Commun. 195:902-909(1993) [PubMed: 8396931] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), VARIANT ARG-347. Tissue: Prostate.
[2]	"Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c." Weinberg D.H., Trivedi P., Tan C.P., Mitra S., Perkins-Barrow A., Borkowski D., Strader C.D., Bayne M. Biochem. Biophys. Res. Commun. 201:1296-1304(1994) [PubMed: 8024574] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-347. Tissue: Heart.
[3]	"The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype." Forray C., Bard J.A., Wetzel J.M., Chiu G., Shapiro E., Tang R., Lepor H., Hartig P.R., Weinshank R.L., Branchek T.A., Gluchowski C. Mol. Pharmacol. 45:703-708(1994) [PubMed: 8183249] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1). Tissue: Hippocampus and Lymphocyte.
[4]	"The alpha 1C-adrenoceptor in human prostate: cloning, functional expression, and localization to specific prostatic cell types." Tseng-Crank J., Kost T., Goetz A., Hazum S., Roberson K.M., Haizlip J., Godinot N., Robertson C.N., Saussy D. Br. J. Pharmacol. 115:1475-1485(1995) [PubMed: 8564208] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-347.
[5]	"Cloning, functional expression and tissue distribution of human alpha 1c-adrenoceptor splice variants." Hirasawa A., Shibata K., Horie K., Takei Y., Obika K., Tanaka T., Muramoto N., Takagaki K., Yano J., Tsujimoto G. FEBS Lett. 363:256-260(1995) [PubMed: 7737411] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), VARIANT ARG-347, TISSUE SPECIFICITY. Tissue: Prostate.
[6]	"Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues." Schwinn D.A., Johnston G.I., Page S.O., Mosley M.J., Wilson K.H., Worman N.P., Campbell S., Fidock M.D., Furness L.M., Parry-Smith D.J., Peter B., Bailey D.S. J. Pharmacol. Exp. Ther. 272:134-142(1995) [PubMed: 7815325] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ARG-347.
[7]	"Molecular cloning, genomic characterization and expression of novel human alpha1A-adrenoceptor isoforms." Chang D.J., Chang T.K., Yamanishi S.S., Salazar F.H.R., Kosaka A.H., Khare R., Bhakta S., Jasper J.R., Shieh I.-S., Lesnick J.D., Ford A.P.D.W., Daniels D.V., Clarke D.E., Bach C.T., Chan H.W. FEBS Lett. 422:279-283(1998) [PubMed: 9490024] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), TISSUE SPECIFICITY. Tissue: Prostate.
[8]	"Truncated isoforms inhibit [3H]prazosin binding and cellular trafficking of native human alpha1A-adrenoceptors." Coge F., Guenin S.P., Renouard-Try A., Rique H., Ouvry C., Fabry N., Beauverger P., Nicolas J.P., Galizzi J.-P., Boutin J.A., Canet E. Biochem. J. 343:231-239(1999) [PubMed: 10493934] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 5; 6; 7; 8 AND 9). Tissue: Liver.
[9]	"RT-PCR cloning and sequence analysis of adrenergic receptor subtype-alpha-1a cDNA from human prostrate cell-line DU-145." Banerjee A.G.N., Aarti A. Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[10]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[11]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Kopatz S.A., Aronstam R.S., Sharma S.V. Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[12]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Cerebellum.
[13]	NHLBI resequencing and genotyping service (RS&G) Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[14]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-347.
[15]	"Identification of alpha 1-adrenoceptor subtypes present in the human prostate." Faure C., Pimoule C., Vallancien G., Langer S.Z., Graham D. Life Sci. 54:1595-1605(1994) [PubMed: 8196478] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 52-400 (ISOFORMS 1/2/3/4), TISSUE SPECIFICITY, VARIANT ARG-347. Tissue: Prostate.
[16]	"Alpha 1a-adrenoceptor polymorphism: pharmacological characterization and association with benign prostatic hypertrophy." Shibata K., Hirasawa A., Moriyama N., Kawabe K., Ogawa S., Tsujimoto G. Br. J. Pharmacol. 118:1403-1408(1996) [PubMed: 8832064] [Abstract] Cited for: VARIANT ARG-347.
[17]	"Alpha 1A-adrenergic receptor polymorphism and vascular response." Sofowora G.G., Dishy V., Landau R., Xie H.G., Prasad H.C., Byrne D.W., Smiley R.M., Kim R.B., Wood A.J., Stein C.M. Clin. Pharmacol. Ther. 75:539-545(2004) [PubMed: 15179408] [Abstract] Cited for: VARIANT ARG-347.
[18]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. Velculescu V.E. Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] TRP-40.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D25235 mRNA. Translation: BAA04960.1. U03866 Genomic DNA. Translation: AAB60353.1. U02569 mRNA. Translation: AAA93114.1. D32201 mRNA. Translation: BAA06900.1. D32202 mRNA. Translation: BAA06901.1. Frameshift. L31774 mRNA. Translation: AAB59486.1. AF013261 mRNA. Translation: AAC06138.1. AY491775 mRNA. Translation: AAR84644.1. AY491776 mRNA. Translation: AAR84645.1. AY491777 mRNA. Translation: AAR84646.1. AY491778 mRNA. Translation: AAR84647.1. AY491779 mRNA. Translation: AAR84648.1. AY491780 mRNA. Translation: AAR84649.1. AY491781 mRNA. Translation: AAR84650.1. AF395806 mRNA. Translation: AAK77197.1. AB065703 Genomic DNA. Translation: BAC05926.1. AY389505 Genomic DNA. Translation: AAQ91331.1. AK289548 mRNA. Translation: BAF82237.1. EU326301 Genomic DNA. Translation: ACA05899.1. EU326301 Genomic DNA. Translation: ACA05900.1. Sequence problems. EU326301 Genomic DNA. Translation: ACA05902.1. EU326301 Genomic DNA. Translation: ACA05903.1. EU326301 Genomic DNA. Translation: ACA05904.1. EU326301 Genomic DNA. Translation: ACA05905.1. EU326301 Genomic DNA. Translation: ACA05906.1. EU326301 Genomic DNA. Translation: ACA05907.1. BC095512 mRNA. Translation: AAH95512.1.
IPI	IPI00430195. IPI00430197. IPI00430199. IPI00430201. IPI00430202. IPI00430203. IPI00430204. IPI00430205. IPI00954300.
PIR	JN0765. S65656. S65657.
RefSeq	NP_000671.2. NM_000680.2. NP_150645.2. NM_033302.2. NP_150646.3. NM_033303.3. NP_150647.2. NM_033304.2.
UniGene	Hs.709175.
3D structure databases
ProteinModelPortal	P35348.
SMR	P35348. Positions 23-343.
ModBase	Search...
Protein-protein interaction databases
IntAct	P35348. 3 interactions.
STRING	P35348.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P35348.
Polymorphism databases
DMDM	1168246.
Proteomic databases
PRIDE	P35348.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000276393; ENSP00000276393; ENSG00000120907.
GeneID	148.
KEGG	hsa:148.
UCSC	uc003xfe.1. human. uc003xfh.1. human. uc010lul.1. human. uc010lum.1. human.
Organism-specific databases
CTD	148.
GeneCards	GC08M026661.
HGNC	HGNC:277. ADRA1A.
HPA	HPA029678.
MIM	104221. gene.
neXtProt	NX_P35348.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG18099.
HOVERGEN	HBG106962.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	P35348.
Bgee	P35348.
CleanEx	HS_ADRA1A.
Genevestigator	P35348.
GermOnline	ENSG00000120907. Homo sapiens.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR001004. Adrene_rcpt_A1Cs. IPR002233. Adrnrgc_rcpt. IPR017452. GPCR_Rhodpsn_supfam. [Graphical view]
KO	K04135.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR01103. ADRENERGICR. PR00557. ADRENRGCA1AR. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
DrugBank	DB00346. Alfuzosin. DB01118. Amiodarone. DB00182. Amphetamine. DB00865. Benzphetamine. DB00217. Bethanidine. DB01136. Carvedilol. DB00298. Dapiprazole. DB04840. Debrisoquin. DB01576. Dextroamphetamine. DB00590. Doxazosin. DB00751. Epinastine. DB00668. Epinephrine. DB00696. Ergotamine. DB00875. Flupenthixol. DB00226. Guanadrel Sulfate. DB01170. Guanethidine. DB00598. Labetalol. DB01255. Lisdexamfetamine. DB00934. Maprotiline. DB01365. Mephentermine. DB00610. Metaraminol. DB01577. Methamphetamine. DB01403. Methotrimeprazine. DB00723. Methoxamine. DB00211. Midodrine. DB01149. Nefazodone. DB00699. Nicergoline. DB00665. Nilutamide. DB00368. Norepinephrine. DB00506. Norgestrel. DB00935. Oxymetazoline. DB00850. Perphenazine. DB01579. Phendimetrazine. DB00925. Phenoxybenzamine. DB00388. Phenylephrine. DB00397. Phenylpropanolamine. DB00457. Prazosin. DB00420. Promazine. DB01069. Promethazine. DB01608. Propericiazine. DB00777. Propiomazine. DB00852. Pseudoephedrine. DB00734. Risperidone. DB06144. Sertindole. DB00706. Tamsulosin. DB01162. Terazosin. DB00679. Thioridazine. DB00797. Tolazoline. DB00656. Trazodone. DB00831. Trifluoperazine. DB00246. Ziprasidone.
NextBio	585.
SOURCE	Search...

Entry information

Entry name

ADA1A_HUMAN

Accession

Primary (citable) accession number: P35348
Secondary accession number(s): A8K0I3

Q9UD67

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	November 1, 1995
Last modified:	January 25, 2012
This is version 119 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Sequence annotation (Features)

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents