Somatostatin receptor type 5 - Homo sapiens (Human)

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Names and origin

Protein names

Recommended name:
Somatostatin receptor type 5
Alternative name(s):
SS5R

Gene names

Name:

SSTR5

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	364 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Adult pituitary gland, heart, small intestine, adrenal gland, cerebellum and fetal hypothalamus. No expression in fetal or adult kidney, liver, pancreas, uterus, spleen, lung, thyroid or ovary.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

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Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate Phosphoprotein
Gene Ontology (GO)
Biological process	G-protein signaling, coupled to cyclic nucleotide second messenger Ref.1 Traceable author statement. Source: ProtInc negative regulation of cell proliferation Traceable author statement. Source: ProtInc
Cellular component	integral to plasma membrane Ref.1 Traceable author statement. Source: ProtInc
Molecular function	somatostatin receptor activity Traceable author statement. Source: ProtInc
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 364

364

Somatostatin receptor type 5

PRO_0000070130

Regions

Topological domain

1 – 38

38

Extracellular Potential

Transmembrane

39 – 66

28

1 Potential

Topological domain

67 – 76

10

Cytoplasmic Potential

Transmembrane

77 – 101

25

2 Potential

Topological domain

102 – 113

12

Extracellular Potential

Transmembrane

114 – 135

22

3 Potential

Topological domain

136 – 157

22

Cytoplasmic Potential

Transmembrane

158 – 178

21

4 Potential

Topological domain

179 – 197

19

Extracellular Potential

Transmembrane

198 – 222

25

5 Potential

Topological domain

223 – 247

25

Cytoplasmic Potential

Transmembrane

248 – 273

26

6 Potential

Topological domain

274 – 283

10

Extracellular Potential

Transmembrane

284 – 308

25

7 Potential

Topological domain

309 – 364

56

Cytoplasmic Potential

Amino acid modifications

Modified residue

325

1

Phosphoserine; by PKA Potential

Lipidation

320

1

S-palmitoyl cysteine Potential

Glycosylation

13

1

N-linked (GlcNAc...) Potential

Glycosylation

26

1

N-linked (GlcNAc...) Potential

Glycosylation

187

1

N-linked (GlcNAc...) Potential

Disulfide bond

112 ↔ 186

By similarity

Natural variations

Natural variant

37

1

G → R: dbSNP rs4988482.

VAR_029222

Natural variant

48

1

L → M: dbSNP rs4988483.

VAR_029223

Natural variant

52

1

A → V: dbSNP rs4988484.

VAR_029224

Natural variant

105

1

W → R: dbSNP rs34803074.

VAR_033484

Natural variant

109

1

P → S: dbSNP rs4988487.

VAR_029225

Natural variant

234

1

R → C: dbSNP rs34070276.

VAR_049442

Natural variant

251

1

L → S: dbSNP rs34474910.

VAR_033485

Natural variant

267

1

V → I: dbSNP rs35125411.

VAR_049443

Natural variant

333

1

T → M: dbSNP rs12596873.

VAR_029226

Natural variant

335

1

P → L: dbSNP rs169068. Ref.4 Ref.5

VAR_020073

Natural variant

339

1

R → K: dbSNP rs35072648.

VAR_033486

Natural variant

357

1

G → R: dbSNP rs34947461.

VAR_049444

Experimental info

Sequence conflict

348 – 352

5

PPAHR → RPRT in AAA20828. Ref.1

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Sequences

Sequence

Length

Mass (Da)

Tools

P35346-1 [UniParc].

Last modified December 1, 2000. Version 3.
Checksum: 905744715F31121C
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FASTA

364

39,202

        10         20         30         40         50         60 
MEPLFPASTP SWNASSPGAA SGGGDNRTLV GPAPSAGARA VLVPVLYLLV CAAGLGGNTL 

        70         80         90        100        110        120 
VIYVVLRFAK MKTVTNIYIL NLAVADVLYM LGLPFLATQN AASFWPFGPV LCRLVMTLDG 

       130        140        150        160        170        180 
VNQFTSVFCL TVMSVDRYLA VVHPLSSARW RRPRVAKLAS AAAWVLSLCM SLPLLVFADV 

       190        200        210        220        230        240 
QEGGTCNASW PEPVGLWGAV FIIYTAVLGF FAPLLVICLC YLLIVVKVRA AGVRVGCVRR 

       250        260        270        280        290        300 
RSERKVTRMV LVVVLVFAGC WLPFFTVNIV NLAVALPQEP ASAGLYFFVV ILSYANSCAN 

       310        320        330        340        350        360 
PVLYGFLSDN FRQSFQKVLC LRKGSGAKDA DATEPRPDRI RQQQEATPPA HRAAANGLMQ 


TSKL

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning, functional characterization, and chromosomal localization of a human somatostatin receptor (somatostatin receptor type 5) with preferential affinity for somatostatin-28." Panetta R., Greenwood M.T., Warszynska A., Demchyshyn L.L., Day R., Niznik H.B., Srikant C.B., Patel Y.C. Mol. Pharmacol. 45:417-427(1994) [PubMed: 7908405] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype." Yamada Y., Kagimoto S., Kubota A., Yasuda K., Masuda K., Someya Y., Ihara Y., Li Q., Imura H., Seino S., Seino Y. Biochem. Biophys. Res. Commun. 195:844-852(1993) [PubMed: 8373420] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Characterization of cloned human somatostatin receptor SSTR5." O'Carroll A.-M., Raynor K., Lolait S.J., Reisine T. Mol. Pharmacol. 46:291-298(1994) [PubMed: 8078491] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16." Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R. Hum. Mol. Genet. 10:339-352(2001) [PubMed: 11157797] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LEU-335.
[5]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. Pennacchio L.A. Nature 432:988-994(2004) [PubMed: 15616553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LEU-335.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
	L14865 Genomic DNA. Translation: AAA20828.1. D16827 Genomic DNA. Translation: BAA04107.1. AE006466 Genomic DNA. Translation: AAK61266.1. AL031713 Genomic DNA. No translation available.
IPI	IPI00018079.
PIR	I57955. JN0763.
RefSeq	NP_001044.1.
UniGene	Hs.449840
3D structure databases
HSSP	HSSP built from PDB template 1F88 based on UniProtKB P02699.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Genome annotation databases
Ensembl	ENSG00000162009. Homo sapiens. [Contig view]
GeneID	6755.
KEGG	hsa:6755.
Organism-specific databases
GeneCards	GC16P001068.
H-InvDB	HIX0038653.
HGNC	HGNC:11334. SSTR5.
HPA	CAB005615.
MIM	182455. gene.
Orphanet	963. Acromegaly.
PharmGKB	PA36158.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P35346.
HOVERGEN	P35346.
OMA	P35346. NAVSYWP.
Enzyme and pathway databases
Reactome	REACT_14797. Signaling by GPCR.
Gene expression databases
ArrayExpress	P35346.
Bgee	P35346.
CleanEx	HS_SSTR5.
GermOnline	ENSG00000162009. Homo sapiens.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR000586. Somatstn_rcpt. IPR001184. Somatstn_rcpt_5. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00246. SOMATOSTATNR. PR00591. SOMATOSTTN5R.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
DrugBank	DB00104. Octreotide.
NextBio	26352.
SOURCE	Search...

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Entry information

Entry name

SSR5_HUMAN

Accession

Primary (citable) accession number: P35346
Secondary accession number(s): P34988, Q9UJI5

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	December 1, 2000
Last modified:	June 16, 2009
This is version 83 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein family/group databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents