Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P35346 (SSR5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 135. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Somatostatin receptor type 5

Short name=SS-5-R
Short name=SS5-R
Short name=SS5R
Gene names
Name:SSTR5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length364 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerization. Ref.1 Ref.2 Ref.3 Ref.4

Subunit structure

Heterodimer with SSTR2. Heterodimerization with SSTR2 increases cell growth inhibition activity of SSTR2. Ref.8

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Adult pituitary gland, heart, small intestine, adrenal gland, cerebellum and fetal hypothalamus. No expression in fetal or adult kidney, liver, pancreas, uterus, spleen, lung, thyroid or ovary. Ref.1 Ref.3 Ref.4

Post-translational modification

Palmitoylated by ZDHHC5, but not ZDHHC3, nor ZDHHC8. Palmitoylation creates an additional intracellular loop which is thought to be important for efficient coupling to G-proteins and may target the protein to lipid rafts. Ref.9

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 364364Somatostatin receptor type 5
PRO_0000070130

Regions

Topological domain1 – 3838Extracellular Potential
Transmembrane39 – 6628Helical; Name=1; Potential
Topological domain67 – 7610Cytoplasmic Potential
Transmembrane77 – 10125Helical; Name=2; Potential
Topological domain102 – 11312Extracellular Potential
Transmembrane114 – 13522Helical; Name=3; Potential
Topological domain136 – 15722Cytoplasmic Potential
Transmembrane158 – 17821Helical; Name=4; Potential
Topological domain179 – 19719Extracellular Potential
Transmembrane198 – 22225Helical; Name=5; Potential
Topological domain223 – 24725Cytoplasmic Potential
Transmembrane248 – 27326Helical; Name=6; Potential
Topological domain274 – 28310Extracellular Potential
Transmembrane284 – 30825Helical; Name=7; Potential
Topological domain309 – 36456Cytoplasmic Potential

Amino acid modifications

Modified residue3251Phosphoserine; by PKA Potential
Lipidation3201S-palmitoyl cysteine; by ZDHHC5 By similarity
Glycosylation131N-linked (GlcNAc...) Potential
Glycosylation261N-linked (GlcNAc...) Potential
Glycosylation1871N-linked (GlcNAc...) Potential
Disulfide bond112 ↔ 186 By similarity

Natural variations

Natural variant371G → R.
Corresponds to variant rs4988482 [ dbSNP | Ensembl ].
VAR_029222
Natural variant481L → M.
Corresponds to variant rs4988483 [ dbSNP | Ensembl ].
VAR_029223
Natural variant521A → V.
Corresponds to variant rs4988484 [ dbSNP | Ensembl ].
VAR_029224
Natural variant1051W → R.
Corresponds to variant rs34803074 [ dbSNP | Ensembl ].
VAR_033484
Natural variant1091P → S.
Corresponds to variant rs4988487 [ dbSNP | Ensembl ].
VAR_029225
Natural variant2341R → C.
Corresponds to variant rs34070276 [ dbSNP | Ensembl ].
VAR_049442
Natural variant2511L → S.
Corresponds to variant rs34474910 [ dbSNP | Ensembl ].
VAR_033485
Natural variant2671V → I.
Corresponds to variant rs35125411 [ dbSNP | Ensembl ].
VAR_049443
Natural variant3331T → M.
Corresponds to variant rs12596873 [ dbSNP | Ensembl ].
VAR_029226
Natural variant3351P → L. Ref.5 Ref.6
Corresponds to variant rs169068 [ dbSNP | Ensembl ].
VAR_020073
Natural variant3391R → K.
Corresponds to variant rs35072648 [ dbSNP | Ensembl ].
VAR_033486
Natural variant3571G → R.
Corresponds to variant rs34947461 [ dbSNP | Ensembl ].
VAR_049444

Experimental info

Sequence conflict348 – 3525PPAHR → RPRT in AAA20828. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P35346 [UniParc].

Last modified December 1, 2000. Version 3.
Checksum: 905744715F31121C

FASTA36439,202
        10         20         30         40         50         60 
MEPLFPASTP SWNASSPGAA SGGGDNRTLV GPAPSAGARA VLVPVLYLLV CAAGLGGNTL 

        70         80         90        100        110        120 
VIYVVLRFAK MKTVTNIYIL NLAVADVLYM LGLPFLATQN AASFWPFGPV LCRLVMTLDG 

       130        140        150        160        170        180 
VNQFTSVFCL TVMSVDRYLA VVHPLSSARW RRPRVAKLAS AAAWVLSLCM SLPLLVFADV 

       190        200        210        220        230        240 
QEGGTCNASW PEPVGLWGAV FIIYTAVLGF FAPLLVICLC YLLIVVKVRA AGVRVGCVRR 

       250        260        270        280        290        300 
RSERKVTRMV LVVVLVFAGC WLPFFTVNIV NLAVALPQEP ASAGLYFFVV ILSYANSCAN 

       310        320        330        340        350        360 
PVLYGFLSDN FRQSFQKVLC LRKGSGAKDA DATEPRPDRI RQQQEATPPA HRAAANGLMQ 


TSKL 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning, functional characterization, and chromosomal localization of a human somatostatin receptor (somatostatin receptor type 5) with preferential affinity for somatostatin-28."
Panetta R., Greenwood M.T., Warszynska A., Demchyshyn L.L., Day R., Niznik H.B., Srikant C.B., Patel Y.C.
Mol. Pharmacol. 45:417-427(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY.
[2]"Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype."
Yamada Y., Kagimoto S., Kubota A., Yasuda K., Masuda K., Someya Y., Ihara Y., Li Q., Imura H., Seino S., Seino Y.
Biochem. Biophys. Res. Commun. 195:844-852(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
[3]"Characterization of cloned human somatostatin receptor SSTR5."
O'Carroll A.-M., Raynor K., Lolait S.J., Reisine T.
Mol. Pharmacol. 46:291-298(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY.
[4]"Identification of an upstream pituitary-active promoter of human somatostatin receptor subtype 5."
Petersenn S., Rasch A.C., Bohnke C., Schulte H.M.
Endocrinology 143:2626-2634(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY.
[5]"Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.
Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LEU-335.
[6]"The sequence and analysis of duplication-rich human chromosome 16."
Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. expand/collapse author list , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LEU-335.
[7]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"Cell growth inhibition and functioning of human somatostatin receptor type 2 are modulated by receptor heterodimerization."
Grant M., Alturaihi H., Jaquet P., Collier B., Kumar U.
Mol. Endocrinol. 22:2278-2292(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBUNIT.
[9]"Somatostatin receptor 5 is palmitoylated by the interacting ZDHHC5 palmitoyltransferase."
Kokkola T., Kruse C., Roy-Pogodzik E.M., Pekkinen J., Bauch C., Honck H.H., Hennemann H., Kreienkamp H.J.
FEBS Lett. 585:2665-2670(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PALMITOYLATION BY ZDHHC5.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L14865 Genomic DNA. Translation: AAA20828.1.
D16827 Genomic DNA. Translation: BAA04107.1.
AY081193 Genomic DNA. Translation: AAL88744.1.
AE006466 Genomic DNA. Translation: AAK61266.1.
AL031713 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85687.1.
CCDSCCDS10429.1.
PIRI57955.
JN0763.
RefSeqNP_001044.1. NM_001053.3.
NP_001166031.1. NM_001172560.1.
XP_006720999.1. XM_006720936.1.
UniGeneHs.449840.

3D structure databases

ProteinModelPortalP35346.
SMRP35346. Positions 46-317.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112633. 3 interactions.
STRING9606.ENSP00000293897.

Chemistry

BindingDBP35346.
ChEMBLCHEMBL1792.
DrugBankDB00104. Octreotide.
GuidetoPHARMACOLOGY359.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP35346.

Polymorphism databases

DMDM12644225.

Proteomic databases

PaxDbP35346.
PRIDEP35346.

Protocols and materials databases

DNASU6755.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000293897; ENSP00000293897; ENSG00000162009.
ENST00000397547; ENSP00000380680; ENSG00000162009.
GeneID6755.
KEGGhsa:6755.
UCSCuc002ckq.3. human.

Organism-specific databases

CTD6755.
GeneCardsGC16P001122.
HGNCHGNC:11334. SSTR5.
MIM182455. gene.
neXtProtNX_P35346.
PharmGKBPA36158.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG274661.
HOGENOMHOG000230485.
HOVERGENHBG106919.
InParanoidP35346.
KOK04221.
OMANAVSYWP.
PhylomeDBP35346.
TreeFamTF315737.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressP35346.
BgeeP35346.
CleanExHS_SSTR5.
GenevestigatorP35346.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000586. Somatstn_rcpt.
IPR001184. Somatstn_rcpt_5.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00246. SOMATOSTATNR.
PR00591. SOMATOSTTN5R.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSomatostatin_receptor_5.
GenomeRNAi6755.
NextBio26352.
PROP35346.
SOURCESearch...

Entry information

Entry nameSSR5_HUMAN
AccessionPrimary (citable) accession number: P35346
Secondary accession number(s): P34988, Q541E0, Q9UJI5
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: December 1, 2000
Last modified: July 9, 2014
This is version 135 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries