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Protein

Somatostatin receptor type 5

Gene

SSTR5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerization.4 Publications

GO - Molecular functioni

  • neuropeptide binding Source: GO_Central
  • somatostatin receptor activity Source: ProtInc

GO - Biological processi

  • cellular response to glucocorticoid stimulus Source: GO_Central
  • chemical synaptic transmission Source: GO_Central
  • glucose homeostasis Source: Ensembl
  • G-protein coupled receptor signaling pathway Source: ProtInc
  • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
  • negative regulation of cell proliferation Source: ProtInc
  • positive regulation of cytokinesis Source: UniProtKB
  • regulation of insulin secretion Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000162009-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Somatostatin receptor type 5
Short name:
SS-5-R
Short name:
SS5-R
Short name:
SS5R
Gene namesi
Name:SSTR5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:11334. SSTR5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38ExtracellularSequence analysisAdd BLAST38
Transmembranei39 – 66Helical; Name=1Sequence analysisAdd BLAST28
Topological domaini67 – 76CytoplasmicSequence analysis10
Transmembranei77 – 101Helical; Name=2Sequence analysisAdd BLAST25
Topological domaini102 – 113ExtracellularSequence analysisAdd BLAST12
Transmembranei114 – 135Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini136 – 157CytoplasmicSequence analysisAdd BLAST22
Transmembranei158 – 178Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini179 – 197ExtracellularSequence analysisAdd BLAST19
Transmembranei198 – 222Helical; Name=5Sequence analysisAdd BLAST25
Topological domaini223 – 247CytoplasmicSequence analysisAdd BLAST25
Transmembranei248 – 273Helical; Name=6Sequence analysisAdd BLAST26
Topological domaini274 – 283ExtracellularSequence analysis10
Transmembranei284 – 308Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini309 – 364CytoplasmicSequence analysisAdd BLAST56

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • neuron projection Source: GO_Central
  • nucleus Source: HPA
  • plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6755.
MalaCardsiSSTR5.
OpenTargetsiENSG00000162009.
PharmGKBiPA36158.

Chemistry databases

ChEMBLiCHEMBL1792.
DrugBankiDB06791. Lanreotide.
DB00104. Octreotide.
DB06663. Pasireotide.
DB04894. Vapreotide.
GuidetoPHARMACOLOGYi359.

Polymorphism and mutation databases

BioMutaiSSTR5.
DMDMi12644225.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000701301 – 364Somatostatin receptor type 5Add BLAST364

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi13N-linked (GlcNAc...)Sequence analysis1
Glycosylationi26N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi112 ↔ 186PROSITE-ProRule annotation
Glycosylationi187N-linked (GlcNAc...)Sequence analysis1
Lipidationi320S-palmitoyl cysteine; by ZDHHC5By similarity1
Modified residuei325Phosphoserine; by PKASequence analysis1

Post-translational modificationi

Palmitoylated by ZDHHC5, but not ZDHHC3, nor ZDHHC8. Palmitoylation creates an additional intracellular loop which is thought to be important for efficient coupling to G-proteins and may target the protein to lipid rafts.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP35346.
PeptideAtlasiP35346.
PRIDEiP35346.

PTM databases

iPTMnetiP35346.
PhosphoSitePlusiP35346.

Expressioni

Tissue specificityi

Adult pituitary gland, heart, small intestine, adrenal gland, cerebellum and fetal hypothalamus. No expression in fetal or adult kidney, liver, pancreas, uterus, spleen, lung, thyroid or ovary.3 Publications

Gene expression databases

BgeeiENSG00000162009.
CleanExiHS_SSTR5.
GenevisibleiP35346. HS.

Organism-specific databases

HPAiHPA066503.

Interactioni

Subunit structurei

Heterodimer with SSTR2. Heterodimerization with SSTR2 increases cell growth inhibition activity of SSTR2.1 Publication

Protein-protein interaction databases

BioGridi112633. 3 interactors.
STRINGi9606.ENSP00000293897.

Chemistry databases

BindingDBiP35346.

Structurei

3D structure databases

ProteinModelPortaliP35346.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118797.
HOGENOMiHOG000230485.
HOVERGENiHBG106919.
InParanoidiP35346.
KOiK04221.
OMAiQEGWDTC.
OrthoDBiEOG091G0HEN.
PhylomeDBiP35346.
TreeFamiTF315737.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000586. Somatstn_rcpt.
IPR001184. Somatstn_rcpt_5.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00246. SOMATOSTATNR.
PR00591. SOMATOSTTN5R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35346-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPLFPASTP SWNASSPGAA SGGGDNRTLV GPAPSAGARA VLVPVLYLLV
60 70 80 90 100
CAAGLGGNTL VIYVVLRFAK MKTVTNIYIL NLAVADVLYM LGLPFLATQN
110 120 130 140 150
AASFWPFGPV LCRLVMTLDG VNQFTSVFCL TVMSVDRYLA VVHPLSSARW
160 170 180 190 200
RRPRVAKLAS AAAWVLSLCM SLPLLVFADV QEGGTCNASW PEPVGLWGAV
210 220 230 240 250
FIIYTAVLGF FAPLLVICLC YLLIVVKVRA AGVRVGCVRR RSERKVTRMV
260 270 280 290 300
LVVVLVFAGC WLPFFTVNIV NLAVALPQEP ASAGLYFFVV ILSYANSCAN
310 320 330 340 350
PVLYGFLSDN FRQSFQKVLC LRKGSGAKDA DATEPRPDRI RQQQEATPPA
360
HRAAANGLMQ TSKL
Length:364
Mass (Da):39,202
Last modified:December 1, 2000 - v3
Checksum:i905744715F31121C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti348 – 352PPAHR → RPRT in AAA20828 (PubMed:7908405).Curated5

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02922237G → R.Corresponds to variant rs4988482dbSNPEnsembl.1
Natural variantiVAR_02922348L → M.Corresponds to variant rs4988483dbSNPEnsembl.1
Natural variantiVAR_02922452A → V.Corresponds to variant rs4988484dbSNPEnsembl.1
Natural variantiVAR_033484105W → R.Corresponds to variant rs34803074dbSNPEnsembl.1
Natural variantiVAR_029225109P → S.Corresponds to variant rs4988487dbSNPEnsembl.1
Natural variantiVAR_049442234R → C.Corresponds to variant rs34070276dbSNPEnsembl.1
Natural variantiVAR_033485251L → S.Corresponds to variant rs34474910dbSNPEnsembl.1
Natural variantiVAR_049443267V → I.Corresponds to variant rs35125411dbSNPEnsembl.1
Natural variantiVAR_029226333T → M.Corresponds to variant rs12596873dbSNPEnsembl.1
Natural variantiVAR_020073335P → L.2 PublicationsCorresponds to variant rs169068dbSNPEnsembl.1
Natural variantiVAR_033486339R → K.Corresponds to variant rs35072648dbSNPEnsembl.1
Natural variantiVAR_049444357G → R.Corresponds to variant rs34947461dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14865 Genomic DNA. Translation: AAA20828.1.
D16827 Genomic DNA. Translation: BAA04107.1.
AY081193 Genomic DNA. Translation: AAL88744.1.
AE006466 Genomic DNA. Translation: AAK61266.1.
AL031713 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85687.1.
CCDSiCCDS10429.1.
PIRiI57955.
JN0763.
RefSeqiNP_001044.1. NM_001053.3.
NP_001166031.1. NM_001172560.1.
UniGeneiHs.449840.

Genome annotation databases

EnsembliENST00000293897; ENSP00000293897; ENSG00000162009.
GeneIDi6755.
KEGGihsa:6755.
UCSCiuc002ckq.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14865 Genomic DNA. Translation: AAA20828.1.
D16827 Genomic DNA. Translation: BAA04107.1.
AY081193 Genomic DNA. Translation: AAL88744.1.
AE006466 Genomic DNA. Translation: AAK61266.1.
AL031713 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85687.1.
CCDSiCCDS10429.1.
PIRiI57955.
JN0763.
RefSeqiNP_001044.1. NM_001053.3.
NP_001166031.1. NM_001172560.1.
UniGeneiHs.449840.

3D structure databases

ProteinModelPortaliP35346.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112633. 3 interactors.
STRINGi9606.ENSP00000293897.

Chemistry databases

BindingDBiP35346.
ChEMBLiCHEMBL1792.
DrugBankiDB06791. Lanreotide.
DB00104. Octreotide.
DB06663. Pasireotide.
DB04894. Vapreotide.
GuidetoPHARMACOLOGYi359.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP35346.
PhosphoSitePlusiP35346.

Polymorphism and mutation databases

BioMutaiSSTR5.
DMDMi12644225.

Proteomic databases

PaxDbiP35346.
PeptideAtlasiP35346.
PRIDEiP35346.

Protocols and materials databases

DNASUi6755.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000293897; ENSP00000293897; ENSG00000162009.
GeneIDi6755.
KEGGihsa:6755.
UCSCiuc002ckq.4. human.

Organism-specific databases

CTDi6755.
DisGeNETi6755.
GeneCardsiSSTR5.
HGNCiHGNC:11334. SSTR5.
HPAiHPA066503.
MalaCardsiSSTR5.
MIMi182455. gene.
neXtProtiNX_P35346.
OpenTargetsiENSG00000162009.
PharmGKBiPA36158.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118797.
HOGENOMiHOG000230485.
HOVERGENiHBG106919.
InParanoidiP35346.
KOiK04221.
OMAiQEGWDTC.
OrthoDBiEOG091G0HEN.
PhylomeDBiP35346.
TreeFamiTF315737.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000162009-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-418594. G alpha (i) signalling events.

Miscellaneous databases

GeneWikiiSomatostatin_receptor_5.
GenomeRNAii6755.
PROiP35346.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162009.
CleanExiHS_SSTR5.
GenevisibleiP35346. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000586. Somatstn_rcpt.
IPR001184. Somatstn_rcpt_5.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00246. SOMATOSTATNR.
PR00591. SOMATOSTTN5R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSSR5_HUMAN
AccessioniPrimary (citable) accession number: P35346
Secondary accession number(s): P34988, Q541E0, Q9UJI5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: December 1, 2000
Last modified: November 2, 2016
This is version 159 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.