P35346 (SSR5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Somatostatin receptor type 5
Short name=SS-5-R
Short name=SS5-R
Short name=SS5R

Gene names

Name:

SSTR5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	364 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Adult pituitary gland, heart, small intestine, adrenal gland, cerebellum and fetal hypothalamus. No expression in fetal or adult kidney, liver, pancreas, uterus, spleen, lung, thyroid or ovary.
Post-translational modification	Palmitoylated by ZDHHC5, but not ZDHHC3, nor ZDHHC8. Palmitoylation creates an additional intracellular loop which is thought to be important for efficient coupling to G-proteins and may target the protein to lipid rafts. Ref.8
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Traceable author statement Ref.1. Source: ProtInc glucose homeostasis Inferred from electronic annotation. Source: Compara negative regulation of cell proliferation Traceable author statement PubMed 9892014. Source: ProtInc regulation of insulin secretion Inferred from electronic annotation. Source: Compara
Cellular_component	integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Molecular_function	somatostatin receptor activity Traceable author statement PubMed 9892014. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 364	364	Somatostatin receptor type 5		PRO_0000070130
Regions
	Topological domain	1 – 38	38	Extracellular Potential
	Transmembrane	39 – 66	28	Helical; Name=1; Potential
	Topological domain	67 – 76	10	Cytoplasmic Potential
	Transmembrane	77 – 101	25	Helical; Name=2; Potential
	Topological domain	102 – 113	12	Extracellular Potential
	Transmembrane	114 – 135	22	Helical; Name=3; Potential
	Topological domain	136 – 157	22	Cytoplasmic Potential
	Transmembrane	158 – 178	21	Helical; Name=4; Potential
	Topological domain	179 – 197	19	Extracellular Potential
	Transmembrane	198 – 222	25	Helical; Name=5; Potential
	Topological domain	223 – 247	25	Cytoplasmic Potential
	Transmembrane	248 – 273	26	Helical; Name=6; Potential
	Topological domain	274 – 283	10	Extracellular Potential
	Transmembrane	284 – 308	25	Helical; Name=7; Potential
	Topological domain	309 – 364	56	Cytoplasmic Potential
Amino acid modifications
	Modified residue	325	1	Phosphoserine; by PKA Potential
	Lipidation	320	1	S-palmitoyl cysteine; by ZDHHC5 By similarity
	Glycosylation	13	1	N-linked (GlcNAc...) Potential
	Glycosylation	26	1	N-linked (GlcNAc...) Potential
	Glycosylation	187	1	N-linked (GlcNAc...) Potential
	Disulfide bond	112 ↔ 186		By similarity
Natural variations
	Natural variant	37	1	G → R. Corresponds to variant rs4988482 [ dbSNP | Ensembl ].		VAR_029222
	Natural variant	48	1	L → M. Corresponds to variant rs4988483 [ dbSNP | Ensembl ].		VAR_029223
	Natural variant	52	1	A → V. Corresponds to variant rs4988484 [ dbSNP | Ensembl ].		VAR_029224
	Natural variant	105	1	W → R. Corresponds to variant rs34803074 [ dbSNP | Ensembl ].		VAR_033484
	Natural variant	109	1	P → S. Corresponds to variant rs4988487 [ dbSNP | Ensembl ].		VAR_029225
	Natural variant	234	1	R → C. Corresponds to variant rs34070276 [ dbSNP | Ensembl ].		VAR_049442
	Natural variant	251	1	L → S. Corresponds to variant rs34474910 [ dbSNP | Ensembl ].		VAR_033485
	Natural variant	267	1	V → I. Corresponds to variant rs35125411 [ dbSNP | Ensembl ].		VAR_049443
	Natural variant	333	1	T → M. Corresponds to variant rs12596873 [ dbSNP | Ensembl ].		VAR_029226
	Natural variant	335	1	P → L. Ref.5 Ref.6 Corresponds to variant rs169068 [ dbSNP | Ensembl ].		VAR_020073
	Natural variant	339	1	R → K. Corresponds to variant rs35072648 [ dbSNP | Ensembl ].		VAR_033486
	Natural variant	357	1	G → R. Corresponds to variant rs34947461 [ dbSNP | Ensembl ].		VAR_049444
Experimental info
	Sequence conflict	348 – 352	5	PPAHR → RPRT in AAA20828. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P35346 [UniParc]. Last modified December 1, 2000. Version 3. Checksum: 905744715F31121C	FASTA	364	39,202
	10 20 30 40 50 60 MEPLFPASTP SWNASSPGAA SGGGDNRTLV GPAPSAGARA VLVPVLYLLV CAAGLGGNTL 70 80 90 100 110 120 VIYVVLRFAK MKTVTNIYIL NLAVADVLYM LGLPFLATQN AASFWPFGPV LCRLVMTLDG 130 140 150 160 170 180 VNQFTSVFCL TVMSVDRYLA VVHPLSSARW RRPRVAKLAS AAAWVLSLCM SLPLLVFADV 190 200 210 220 230 240 QEGGTCNASW PEPVGLWGAV FIIYTAVLGF FAPLLVICLC YLLIVVKVRA AGVRVGCVRR 250 260 270 280 290 300 RSERKVTRMV LVVVLVFAGC WLPFFTVNIV NLAVALPQEP ASAGLYFFVV ILSYANSCAN 310 320 330 340 350 360 PVLYGFLSDN FRQSFQKVLC LRKGSGAKDA DATEPRPDRI RQQQEATPPA HRAAANGLMQ TSKL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning, functional characterization, and chromosomal localization of a human somatostatin receptor (somatostatin receptor type 5) with preferential affinity for somatostatin-28." Panetta R., Greenwood M.T., Warszynska A., Demchyshyn L.L., Day R., Niznik H.B., Srikant C.B., Patel Y.C. Mol. Pharmacol. 45:417-427(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype." Yamada Y., Kagimoto S., Kubota A., Yasuda K., Masuda K., Someya Y., Ihara Y., Li Q., Imura H., Seino S., Seino Y. Biochem. Biophys. Res. Commun. 195:844-852(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Characterization of cloned human somatostatin receptor SSTR5." O'Carroll A.-M., Raynor K., Lolait S.J., Reisine T. Mol. Pharmacol. 46:291-298(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Identification of an upstream pituitary-active promoter of human somatostatin receptor subtype 5." Petersenn S., Rasch A.C., Bohnke C., Schulte H.M. Endocrinology 143:2626-2634(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]	"Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16." Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R. Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LEU-335.
[6]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LEU-335.
[7]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"Somatostatin receptor 5 is palmitoylated by the interacting ZDHHC5 palmitoyltransferase." Kokkola T., Kruse C., Roy-Pogodzik E.M., Pekkinen J., Bauch C., Honck H.H., Hennemann H., Kreienkamp H.J. FEBS Lett. 585:2665-2670(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PALMITOYLATION BY ZDHHC5.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L14865 Genomic DNA. Translation: AAA20828.1. D16827 Genomic DNA. Translation: BAA04107.1. AY081193 Genomic DNA. Translation: AAL88744.1. AE006466 Genomic DNA. Translation: AAK61266.1. AL031713 Genomic DNA. No translation available. CH471112 Genomic DNA. Translation: EAW85687.1.
IPI	IPI00018079.
PIR	I57955. JN0763.
RefSeq	NP_001044.1. NM_001053.3. NP_001166031.1. NM_001172560.1.
UniGene	Hs.449840.
3D structure databases
ProteinModelPortal	P35346.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000293897.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P35346.
Polymorphism databases
DMDM	12644225.
Proteomic databases
PaxDb	P35346.
PRIDE	P35346.
Protocols and materials databases
DNASU	6755.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000293897; ENSP00000293897; ENSG00000162009. ENST00000397547; ENSP00000380680; ENSG00000162009.
GeneID	6755.
KEGG	hsa:6755.
UCSC	uc002ckq.3. human.
Organism-specific databases
CTD	6755.
GeneCards	GC16P001122.
HGNC	HGNC:11334. SSTR5.
MIM	182455. gene.
neXtProt	NX_P35346.
Orphanet	963. Acromegaly.
PharmGKB	PA36158.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG274661.
HOGENOM	HOG000230485.
HOVERGEN	HBG106919.
InParanoid	P35346.
KO	K04221.
OMA	GLMQTSK.
OrthoDB	EOG4Q84Z1.
PhylomeDB	P35346.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	P35346.
Bgee	P35346.
CleanEx	HS_SSTR5.
Genevestigator	P35346.
GermOnline	ENSG00000162009. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000586. Somatstn_rcpt. IPR001184. Somatstn_rcpt_5. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00246. SOMATOSTATNR. PR00591. SOMATOSTTN5R.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P35346.
ChEMBL	CHEMBL1792.
DrugBank	DB00104. Octreotide.
GenomeRNAi	6755.
NextBio	26352.
SOURCE	Search...

Entry information

Entry name

SSR5_HUMAN

Accession

Primary (citable) accession number: P35346
Secondary accession number(s): P34988, Q541E0, Q9UJI5

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	December 1, 2000
Last modified:	May 1, 2013
This is version 123 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.