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P35346

- SSR5_HUMAN

UniProt

P35346 - SSR5_HUMAN

Protein

Somatostatin receptor type 5

Gene

SSTR5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 137 (01 Oct 2014)
      Sequence version 3 (01 Dec 2000)
      Previous versions | rss
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    Functioni

    Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerization.4 Publications

    GO - Molecular functioni

    1. somatostatin receptor activity Source: ProtInc

    GO - Biological processi

    1. glucose homeostasis Source: Ensembl
    2. G-protein coupled receptor signaling pathway Source: ProtInc
    3. G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
    4. negative regulation of cell proliferation Source: ProtInc
    5. positive regulation of cytokinesis Source: UniProt
    6. regulation of insulin secretion Source: Ensembl
    7. somatostatin signaling pathway Source: GOC

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_14819. Peptide ligand-binding receptors.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Somatostatin receptor type 5
    Short name:
    SS-5-R
    Short name:
    SS5-R
    Short name:
    SS5R
    Gene namesi
    Name:SSTR5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:11334. SSTR5.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36158.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 364364Somatostatin receptor type 5PRO_0000070130Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi13 – 131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi26 – 261N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi112 ↔ 186PROSITE-ProRule annotation
    Glycosylationi187 – 1871N-linked (GlcNAc...)Sequence Analysis
    Lipidationi320 – 3201S-palmitoyl cysteine; by ZDHHC5By similarity
    Modified residuei325 – 3251Phosphoserine; by PKASequence Analysis

    Post-translational modificationi

    Palmitoylated by ZDHHC5, but not ZDHHC3, nor ZDHHC8. Palmitoylation creates an additional intracellular loop which is thought to be important for efficient coupling to G-proteins and may target the protein to lipid rafts.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

    Proteomic databases

    PaxDbiP35346.
    PRIDEiP35346.

    PTM databases

    PhosphoSiteiP35346.

    Expressioni

    Tissue specificityi

    Adult pituitary gland, heart, small intestine, adrenal gland, cerebellum and fetal hypothalamus. No expression in fetal or adult kidney, liver, pancreas, uterus, spleen, lung, thyroid or ovary.3 Publications

    Gene expression databases

    ArrayExpressiP35346.
    BgeeiP35346.
    CleanExiHS_SSTR5.
    GenevestigatoriP35346.

    Interactioni

    Subunit structurei

    Heterodimer with SSTR2. Heterodimerization with SSTR2 increases cell growth inhibition activity of SSTR2.1 Publication

    Protein-protein interaction databases

    BioGridi112633. 3 interactions.
    STRINGi9606.ENSP00000293897.

    Structurei

    3D structure databases

    ProteinModelPortaliP35346.
    SMRiP35346. Positions 46-317.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3838ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini67 – 7610CytoplasmicSequence Analysis
    Topological domaini102 – 11312ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini136 – 15722CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini179 – 19719ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini223 – 24725CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini274 – 28310ExtracellularSequence Analysis
    Topological domaini309 – 36456CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei39 – 6628Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei77 – 10125Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei114 – 13522Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei158 – 17821Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei198 – 22225Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei248 – 27326Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei284 – 30825Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG274661.
    HOGENOMiHOG000230485.
    HOVERGENiHBG106919.
    InParanoidiP35346.
    KOiK04221.
    OMAiNAVSYWP.
    PhylomeDBiP35346.
    TreeFamiTF315737.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000586. Somatstn_rcpt.
    IPR001184. Somatstn_rcpt_5.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00246. SOMATOSTATNR.
    PR00591. SOMATOSTTN5R.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P35346-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPLFPASTP SWNASSPGAA SGGGDNRTLV GPAPSAGARA VLVPVLYLLV    50
    CAAGLGGNTL VIYVVLRFAK MKTVTNIYIL NLAVADVLYM LGLPFLATQN 100
    AASFWPFGPV LCRLVMTLDG VNQFTSVFCL TVMSVDRYLA VVHPLSSARW 150
    RRPRVAKLAS AAAWVLSLCM SLPLLVFADV QEGGTCNASW PEPVGLWGAV 200
    FIIYTAVLGF FAPLLVICLC YLLIVVKVRA AGVRVGCVRR RSERKVTRMV 250
    LVVVLVFAGC WLPFFTVNIV NLAVALPQEP ASAGLYFFVV ILSYANSCAN 300
    PVLYGFLSDN FRQSFQKVLC LRKGSGAKDA DATEPRPDRI RQQQEATPPA 350
    HRAAANGLMQ TSKL 364
    Length:364
    Mass (Da):39,202
    Last modified:December 1, 2000 - v3
    Checksum:i905744715F31121C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti348 – 3525PPAHR → RPRT in AAA20828. (PubMed:7908405)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti37 – 371G → R.
    Corresponds to variant rs4988482 [ dbSNP | Ensembl ].
    VAR_029222
    Natural varianti48 – 481L → M.
    Corresponds to variant rs4988483 [ dbSNP | Ensembl ].
    VAR_029223
    Natural varianti52 – 521A → V.
    Corresponds to variant rs4988484 [ dbSNP | Ensembl ].
    VAR_029224
    Natural varianti105 – 1051W → R.
    Corresponds to variant rs34803074 [ dbSNP | Ensembl ].
    VAR_033484
    Natural varianti109 – 1091P → S.
    Corresponds to variant rs4988487 [ dbSNP | Ensembl ].
    VAR_029225
    Natural varianti234 – 2341R → C.
    Corresponds to variant rs34070276 [ dbSNP | Ensembl ].
    VAR_049442
    Natural varianti251 – 2511L → S.
    Corresponds to variant rs34474910 [ dbSNP | Ensembl ].
    VAR_033485
    Natural varianti267 – 2671V → I.
    Corresponds to variant rs35125411 [ dbSNP | Ensembl ].
    VAR_049443
    Natural varianti333 – 3331T → M.
    Corresponds to variant rs12596873 [ dbSNP | Ensembl ].
    VAR_029226
    Natural varianti335 – 3351P → L.2 Publications
    Corresponds to variant rs169068 [ dbSNP | Ensembl ].
    VAR_020073
    Natural varianti339 – 3391R → K.
    Corresponds to variant rs35072648 [ dbSNP | Ensembl ].
    VAR_033486
    Natural varianti357 – 3571G → R.
    Corresponds to variant rs34947461 [ dbSNP | Ensembl ].
    VAR_049444

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L14865 Genomic DNA. Translation: AAA20828.1.
    D16827 Genomic DNA. Translation: BAA04107.1.
    AY081193 Genomic DNA. Translation: AAL88744.1.
    AE006466 Genomic DNA. Translation: AAK61266.1.
    AL031713 Genomic DNA. No translation available.
    CH471112 Genomic DNA. Translation: EAW85687.1.
    CCDSiCCDS10429.1.
    PIRiI57955.
    JN0763.
    RefSeqiNP_001044.1. NM_001053.3.
    NP_001166031.1. NM_001172560.1.
    XP_006720999.1. XM_006720936.1.
    UniGeneiHs.449840.

    Genome annotation databases

    EnsembliENST00000293897; ENSP00000293897; ENSG00000162009.
    GeneIDi6755.
    KEGGihsa:6755.
    UCSCiuc002ckq.3. human.

    Polymorphism databases

    DMDMi12644225.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L14865 Genomic DNA. Translation: AAA20828.1 .
    D16827 Genomic DNA. Translation: BAA04107.1 .
    AY081193 Genomic DNA. Translation: AAL88744.1 .
    AE006466 Genomic DNA. Translation: AAK61266.1 .
    AL031713 Genomic DNA. No translation available.
    CH471112 Genomic DNA. Translation: EAW85687.1 .
    CCDSi CCDS10429.1.
    PIRi I57955.
    JN0763.
    RefSeqi NP_001044.1. NM_001053.3.
    NP_001166031.1. NM_001172560.1.
    XP_006720999.1. XM_006720936.1.
    UniGenei Hs.449840.

    3D structure databases

    ProteinModelPortali P35346.
    SMRi P35346. Positions 46-317.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112633. 3 interactions.
    STRINGi 9606.ENSP00000293897.

    Chemistry

    BindingDBi P35346.
    ChEMBLi CHEMBL1792.
    DrugBanki DB00104. Octreotide.
    GuidetoPHARMACOLOGYi 359.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P35346.

    Polymorphism databases

    DMDMi 12644225.

    Proteomic databases

    PaxDbi P35346.
    PRIDEi P35346.

    Protocols and materials databases

    DNASUi 6755.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000293897 ; ENSP00000293897 ; ENSG00000162009 .
    GeneIDi 6755.
    KEGGi hsa:6755.
    UCSCi uc002ckq.3. human.

    Organism-specific databases

    CTDi 6755.
    GeneCardsi GC16P001122.
    HGNCi HGNC:11334. SSTR5.
    MIMi 182455. gene.
    neXtProti NX_P35346.
    PharmGKBi PA36158.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG274661.
    HOGENOMi HOG000230485.
    HOVERGENi HBG106919.
    InParanoidi P35346.
    KOi K04221.
    OMAi NAVSYWP.
    PhylomeDBi P35346.
    TreeFami TF315737.

    Enzyme and pathway databases

    Reactomei REACT_14819. Peptide ligand-binding receptors.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii Somatostatin_receptor_5.
    GenomeRNAii 6755.
    NextBioi 26352.
    PROi P35346.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P35346.
    Bgeei P35346.
    CleanExi HS_SSTR5.
    Genevestigatori P35346.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000586. Somatstn_rcpt.
    IPR001184. Somatstn_rcpt_5.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00246. SOMATOSTATNR.
    PR00591. SOMATOSTTN5R.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning, functional characterization, and chromosomal localization of a human somatostatin receptor (somatostatin receptor type 5) with preferential affinity for somatostatin-28."
      Panetta R., Greenwood M.T., Warszynska A., Demchyshyn L.L., Day R., Niznik H.B., Srikant C.B., Patel Y.C.
      Mol. Pharmacol. 45:417-427(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY.
    2. "Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype."
      Yamada Y., Kagimoto S., Kubota A., Yasuda K., Masuda K., Someya Y., Ihara Y., Li Q., Imura H., Seino S., Seino Y.
      Biochem. Biophys. Res. Commun. 195:844-852(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
    3. "Characterization of cloned human somatostatin receptor SSTR5."
      O'Carroll A.-M., Raynor K., Lolait S.J., Reisine T.
      Mol. Pharmacol. 46:291-298(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY.
    4. "Identification of an upstream pituitary-active promoter of human somatostatin receptor subtype 5."
      Petersenn S., Rasch A.C., Bohnke C., Schulte H.M.
      Endocrinology 143:2626-2634(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY.
    5. "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
      Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.
      Hum. Mol. Genet. 10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LEU-335.
    6. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LEU-335.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "Cell growth inhibition and functioning of human somatostatin receptor type 2 are modulated by receptor heterodimerization."
      Grant M., Alturaihi H., Jaquet P., Collier B., Kumar U.
      Mol. Endocrinol. 22:2278-2292(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT.
    9. "Somatostatin receptor 5 is palmitoylated by the interacting ZDHHC5 palmitoyltransferase."
      Kokkola T., Kruse C., Roy-Pogodzik E.M., Pekkinen J., Bauch C., Honck H.H., Hennemann H., Kreienkamp H.J.
      FEBS Lett. 585:2665-2670(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PALMITOYLATION BY ZDHHC5.

    Entry informationi

    Entry nameiSSR5_HUMAN
    AccessioniPrimary (citable) accession number: P35346
    Secondary accession number(s): P34988, Q541E0, Q9UJI5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 137 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3