P35344 (CXCR2_RABIT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
C-X-C chemokine receptor type 2
Short name=CXC-R2
Short name=CXCR-2

Alternative name(s):
GRO/MGSA receptor
High affinity interleukin-8 receptor B
Short name=IL-8R B
CD_antigen=CD182

Gene names

Name:	CXCR2
Synonyms:	IL8RB

Organism

Oryctolagus cuniculus (Rabbit) [Reference proteome]

Taxonomic identifier

9986 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length	358 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2 By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Expressed preferentially in neutrophils.
Post-translational modification	Phosphorylated upon ligand binding; which is required for desensitization By similarity.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Chemotaxis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chemotaxis Inferred from electronic annotation. Source: UniProtKB-KW elevation of cytosolic calcium ion concentration Inferred from electronic annotation. Source: InterPro negative regulation of cAMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	C-X-C chemokine receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 358	358	C-X-C chemokine receptor type 2		PRO_0000069341
Regions
	Topological domain	1 – 46	46	Extracellular Potential
	Transmembrane	47 – 73	27	Helical; Name=1; Potential
	Topological domain	74 – 82	9	Cytoplasmic Potential
	Transmembrane	83 – 103	21	Helical; Name=2; Potential
	Topological domain	104 – 118	15	Extracellular Potential
	Transmembrane	119 – 140	22	Helical; Name=3; Potential
	Topological domain	141 – 161	21	Cytoplasmic Potential
	Transmembrane	162 – 181	20	Helical; Name=4; Potential
	Topological domain	182 – 206	25	Extracellular Potential
	Transmembrane	207 – 229	23	Helical; Name=5; Potential
	Topological domain	230 – 249	20	Cytoplasmic Potential
	Transmembrane	250 – 271	22	Helical; Name=6; Potential
	Topological domain	272 – 292	21	Extracellular Potential
	Transmembrane	293 – 313	21	Helical; Name=7; Potential
	Topological domain	314 – 358	45	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	8	1	N-linked (GlcNAc...) Potential
	Glycosylation	20	1	N-linked (GlcNAc...) Potential
	Disulfide bond	117 ↔ 194		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P35344 [UniParc]. Last modified June 1, 1994. Version 1. Checksum: 6899716944D6126A	FASTA	358	40,632
	10 20 30 40 50 60 MQEFTWENYS YEDFFGDFSN YSYSTDLPPT LLDSAPCRSE SLETNSYVVL ITYILVFLLS 70 80 90 100 110 120 LLGNSLVMLV ILYSRSTCSV TDVYLLNLAI ADLLFATTLP IWAASKVHGW TFGTPLCKVV 130 140 150 160 170 180 SLVKEVNFYS GILLLACISV DRYLAIVHAT RTMIQKRHLV KFICLSMWGV SLILSLPILL 190 200 210 220 230 240 FRNAIFPPNS SPVCYEDMGN STAKWRMVLR ILPQTFGFIL PLLVMLFCYV FTLRTLFQAH 250 260 270 280 290 300 MGQKHRAMRV IFAVVLIFLL CWLPYNLVLL TDTLMRTHVI QETCERRNDI DRALDATEIL 310 320 330 340 350 GFLHSCLNPI IYAFIGQKFR YGLLKILAAH GLISKEFLAK ESRPSFVASS SGNTSTTL

References

[1]

"Molecular characterization of a novel rabbit interleukin-8 receptor isotype." Prado G.N., Thomas K.M., Suzuki H., Larosa G.J., Wilkinson N.C., Folco E., Navarro J. J. Biol. Chem. 269:12391-12394(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Albino. Tissue: Blood.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L24445 mRNA. Translation: AAA31378.1.
PIR	A53752.
RefSeq	NP_001164561.1. NM_001171090.1.
UniGene	Ocu.1988.
3D structure databases
ProteinModelPortal	P35344.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	100328627.
Organism-specific databases
CTD	3579.
Phylogenomic databases
HOVERGEN	HBG106917.
Family and domain databases
InterPro	IPR000174. Chemokine_CXCR. IPR000057. Chemokine_CXCR2. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00427. INTRLEUKIN8R. PR00573. INTRLEUKN8BR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChEMBL	CHEMBL1075198.

Entry information

Entry name

CXCR2_RABIT

Accession

Primary (citable) accession number: P35344

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	June 1, 1994
Last modified:	May 1, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program