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Protein

C-X-C chemokine receptor type 2

Gene

Cxcr2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

ReactomeiREACT_288802. Chemokine receptors bind chemokines.
REACT_331048. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C chemokine receptor type 2
Short name:
CXC-R2
Short name:
CXCR-2
Alternative name(s):
GRO/MGSA receptor
High affinity interleukin-8 receptor B
Short name:
IL-8R B
CD_antigen: CD182
Gene namesi
Name:Cxcr2
Synonyms:Cmkar2, Gpcr16, Il8rb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:105303. Cxcr2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4747ExtracellularSequence AnalysisAdd
BLAST
Transmembranei48 – 7427Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini75 – 839CytoplasmicSequence Analysis
Transmembranei84 – 10421Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini105 – 11915ExtracellularSequence AnalysisAdd
BLAST
Transmembranei120 – 14122Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini142 – 16221CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei163 – 18220Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini183 – 20725ExtracellularSequence AnalysisAdd
BLAST
Transmembranei208 – 23023Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini231 – 25020CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei251 – 27222Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini273 – 29321ExtracellularSequence AnalysisAdd
BLAST
Transmembranei294 – 31421Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini315 – 35945CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359C-X-C chemokine receptor type 2PRO_0000069339Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi23 – 231N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi118 ↔ 195PROSITE-ProRule annotation

Post-translational modificationi

Phosphorylated upon ligand binding; which is required for desensitization.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiP35343.

PTM databases

PhosphoSiteiP35343.

Expressioni

Gene expression databases

BgeeiP35343.
CleanExiMM_IL8RB.
GenevisibleiP35343. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027372.

Structurei

3D structure databases

ProteinModelPortaliP35343.
SMRiP35343. Positions 37-332.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146068.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP35343.
KOiK05050.
OMAiKLIKETC.
OrthoDBiEOG7ZPNK9.
PhylomeDBiP35343.
TreeFamiTF330966.

Family and domain databases

InterProiIPR000057. Chemokine_CXCR2.
IPR000174. Chemokine_CXCR_1/2.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00427. INTRLEUKIN8R.
PR00573. INTRLEUKN8BR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35343-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEFKVDKFN IEDFFSGDLD IFNYSSGMPS ILPDAVPCHS ENLEINSYAV
60 70 80 90 100
VVIYVLVTLL SLVGNSLVML VILYNRSTCS VTDVYLLNLA IADLFFALTL
110 120 130 140 150
PVWAASKVNG WTFGSTLCKI FSYVKEVTFY SSVLLLACIS MDRYLAIVHA
160 170 180 190 200
TSTLIQKRHL VKFVCIAMWL LSVILALPIL ILRNPVKVNL STLVCYEDVG
210 220 230 240 250
NNTSRLRVVL RILPQTFGFL VPLLIMLFCY GFTLRTLFKA HMGQKHRAMR
260 270 280 290 300
VIFAVVLVFL LCWLPYNLVL FTDTLMRTKL IKETCERRDD IDKALNATEI
310 320 330 340 350
LGFLHSCLNP IIYAFIGQKF RHGLLKIMAT YGLVSKEFLA KEGRPSFVSS

SSANTSTTL
Length:359
Mass (Da):40,425
Last modified:June 1, 1994 - v1
Checksum:i74BD166E9B679F88
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23637 Genomic DNA. Translation: AAA39305.1.
L26549 Genomic DNA. Translation: AAL31314.1.
L13239 Genomic DNA. Translation: AAA62109.1.
U31207 Genomic DNA. Translation: AAC52239.1.
D17630 mRNA. Translation: BAA04536.1.
AK158234 mRNA. Translation: BAE34417.1.
CH466548 Genomic DNA. Translation: EDL00307.1.
BC051677 mRNA. Translation: AAH51677.1.
L20337 mRNA. Translation: AAA16853.1.
CCDSiCCDS15040.1.
PIRiA48921.
RefSeqiNP_034039.1. NM_009909.3.
XP_006495701.1. XM_006495638.2.
UniGeneiMm.234466.

Genome annotation databases

EnsembliENSMUST00000027372; ENSMUSP00000027372; ENSMUSG00000026180.
ENSMUST00000106899; ENSMUSP00000102512; ENSMUSG00000026180.
GeneIDi12765.
KEGGimmu:12765.
UCSCiuc007bll.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23637 Genomic DNA. Translation: AAA39305.1.
L26549 Genomic DNA. Translation: AAL31314.1.
L13239 Genomic DNA. Translation: AAA62109.1.
U31207 Genomic DNA. Translation: AAC52239.1.
D17630 mRNA. Translation: BAA04536.1.
AK158234 mRNA. Translation: BAE34417.1.
CH466548 Genomic DNA. Translation: EDL00307.1.
BC051677 mRNA. Translation: AAH51677.1.
L20337 mRNA. Translation: AAA16853.1.
CCDSiCCDS15040.1.
PIRiA48921.
RefSeqiNP_034039.1. NM_009909.3.
XP_006495701.1. XM_006495638.2.
UniGeneiMm.234466.

3D structure databases

ProteinModelPortaliP35343.
SMRiP35343. Positions 37-332.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027372.

Chemistry

GuidetoPHARMACOLOGYi69.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP35343.

Proteomic databases

PRIDEiP35343.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027372; ENSMUSP00000027372; ENSMUSG00000026180.
ENSMUST00000106899; ENSMUSP00000102512; ENSMUSG00000026180.
GeneIDi12765.
KEGGimmu:12765.
UCSCiuc007bll.1. mouse.

Organism-specific databases

CTDi3579.
MGIiMGI:105303. Cxcr2.

Phylogenomic databases

eggNOGiNOG146068.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP35343.
KOiK05050.
OMAiKLIKETC.
OrthoDBiEOG7ZPNK9.
PhylomeDBiP35343.
TreeFamiTF330966.

Enzyme and pathway databases

ReactomeiREACT_288802. Chemokine receptors bind chemokines.
REACT_331048. G alpha (i) signalling events.

Miscellaneous databases

NextBioi282122.
PROiP35343.
SOURCEiSearch...

Gene expression databases

BgeeiP35343.
CleanExiMM_IL8RB.
GenevisibleiP35343. MM.

Family and domain databases

InterProiIPR000057. Chemokine_CXCR2.
IPR000174. Chemokine_CXCR_1/2.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00427. INTRLEUKIN8R.
PR00573. INTRLEUKN8BR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The murine homologue of the human interleukin-8 receptor type B maps near the Ity-Lsh-Bcg disease resistance locus."
    Cerretti D.P., Nelson N., Kozlosky C.J., Morrissey P.J., Copeland N.G., Gilbert D.J., Jenkins N.A., Dosik J.K., Mock B.A.
    Genomics 18:410-413(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The N-terminus of interleukin-8 (IL-8) receptor confers high affinity binding to human IL-8."
    Suzuki H., Prado G.N., Wilkinson N., Navarro J.
    J. Biol. Chem. 269:18263-18266(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The murine interleukin 8 type B receptor homologue and its ligands. Expression and biological characterization."
    Bozic C.R., Gerard N.P., von Uexkull-Guldenband C., Kolakowski L.F. Jr., Conklyn M.J., Breslow R., Showell H.J., Gerard C.
    J. Biol. Chem. 269:29355-29358(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/c.
  4. "Chemokine binding and activities mediated by the mouse IL-8 receptor."
    Lee J., Cacalano G., Camerato T., Toy K., Moore M.W., Wood W.I.
    J. Immunol. 155:2158-2164(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  5. "Cloning of a cDNA encoding a mouse homolog of the interleukin-8 receptor."
    Harada A., Kuno K., Nomura H., Mukaida N., Murakami S., Matsushima K.
    Gene 142:297-300(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  6. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Inner ear.
  7. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Trophoblast.
  9. "Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors."
    Wilkie T.M., Chen Y., Gilbert D.J., Moore K.J., Yu L., Simon M.I., Copeland N.G., Jenkins N.A.
    Genomics 18:175-184(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 145-258.
    Tissue: Testis.
  10. "IL-10-conditioned dendritic cells, decommissioned for recruitment of adaptive immunity, elicit innate inflammatory gene products in response to danger signals."
    Nolan K.F., Strong V., Soler D., Fairchild P.J., Cobbold S.P., Croxton R., Gonzalo J.-A., Rubio A., Wells M., Waldmann H.
    J. Immunol. 172:2201-2209(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiCXCR2_MOUSE
AccessioniPrimary (citable) accession number: P35343
Secondary accession number(s): Q53X27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: June 24, 2015
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.