Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

C-X-C chemokine receptor type 2

Gene

Cxcr2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processChemotaxis

Enzyme and pathway databases

ReactomeiR-MMU-380108 Chemokine receptors bind chemokines
R-MMU-418594 G alpha (i) signalling events
R-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C chemokine receptor type 2
Short name:
CXC-R2
Short name:
CXCR-2
Alternative name(s):
GRO/MGSA receptor
High affinity interleukin-8 receptor B
Short name:
IL-8R B
CD_antigen: CD182
Gene namesi
Name:Cxcr2
Synonyms:Cmkar2, Gpcr16, Il8rb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:105303 Cxcr2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 47ExtracellularSequence analysisAdd BLAST47
Transmembranei48 – 74Helical; Name=1Sequence analysisAdd BLAST27
Topological domaini75 – 83CytoplasmicSequence analysis9
Transmembranei84 – 104Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini105 – 119ExtracellularSequence analysisAdd BLAST15
Transmembranei120 – 141Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini142 – 162CytoplasmicSequence analysisAdd BLAST21
Transmembranei163 – 182Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini183 – 207ExtracellularSequence analysisAdd BLAST25
Transmembranei208 – 230Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini231 – 250CytoplasmicSequence analysisAdd BLAST20
Transmembranei251 – 272Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini273 – 293ExtracellularSequence analysisAdd BLAST21
Transmembranei294 – 314Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini315 – 359CytoplasmicSequence analysisAdd BLAST45

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi69

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000693391 – 359C-X-C chemokine receptor type 2Add BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi23N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi118 ↔ 195PROSITE-ProRule annotation

Post-translational modificationi

Phosphorylated upon ligand binding; which is required for desensitization.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP35343
MaxQBiP35343
PaxDbiP35343
PRIDEiP35343

PTM databases

PhosphoSitePlusiP35343

Expressioni

Gene expression databases

BgeeiENSMUSG00000026180
CleanExiMM_IL8RB

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

CORUMiP35343
STRINGi10090.ENSMUSP00000027372

Structurei

3D structure databases

ProteinModelPortaliP35343
SMRiP35343
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEHI Eukaryota
ENOG410Y9Y6 LUCA
GeneTreeiENSGT00760000118785
HOGENOMiHOG000234122
HOVERGENiHBG106917
InParanoidiP35343
KOiK05050
OMAiINKHAVV
OrthoDBiEOG091G0C7W
PhylomeDBiP35343
TreeFamiTF330966

Family and domain databases

CDDicd15178 7tmA_CXCR1_2, 1 hit
InterProiView protein in InterPro
IPR000057 Chemokine_CXCR2
IPR000174 Chemokine_CXCR_1/2
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00427 INTRLEUKIN8R
PR00573 INTRLEUKN8BR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P35343-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEFKVDKFN IEDFFSGDLD IFNYSSGMPS ILPDAVPCHS ENLEINSYAV
60 70 80 90 100
VVIYVLVTLL SLVGNSLVML VILYNRSTCS VTDVYLLNLA IADLFFALTL
110 120 130 140 150
PVWAASKVNG WTFGSTLCKI FSYVKEVTFY SSVLLLACIS MDRYLAIVHA
160 170 180 190 200
TSTLIQKRHL VKFVCIAMWL LSVILALPIL ILRNPVKVNL STLVCYEDVG
210 220 230 240 250
NNTSRLRVVL RILPQTFGFL VPLLIMLFCY GFTLRTLFKA HMGQKHRAMR
260 270 280 290 300
VIFAVVLVFL LCWLPYNLVL FTDTLMRTKL IKETCERRDD IDKALNATEI
310 320 330 340 350
LGFLHSCLNP IIYAFIGQKF RHGLLKIMAT YGLVSKEFLA KEGRPSFVSS

SSANTSTTL
Length:359
Mass (Da):40,425
Last modified:June 1, 1994 - v1
Checksum:i74BD166E9B679F88
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23637 Genomic DNA Translation: AAA39305.1
L26549 Genomic DNA Translation: AAL31314.1
L13239 Genomic DNA Translation: AAA62109.1
U31207 Genomic DNA Translation: AAC52239.1
D17630 mRNA Translation: BAA04536.1
AK158234 mRNA Translation: BAE34417.1
CH466548 Genomic DNA Translation: EDL00307.1
BC051677 mRNA Translation: AAH51677.1
L20337 mRNA Translation: AAA16853.1
CCDSiCCDS15040.1
PIRiA48921
RefSeqiNP_034039.1, NM_009909.3
XP_006495701.1, XM_006495638.3
UniGeneiMm.234466

Genome annotation databases

EnsembliENSMUST00000027372; ENSMUSP00000027372; ENSMUSG00000026180
ENSMUST00000106899; ENSMUSP00000102512; ENSMUSG00000026180
GeneIDi12765
KEGGimmu:12765
UCSCiuc007bll.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCXCR2_MOUSE
AccessioniPrimary (citable) accession number: P35343
Secondary accession number(s): Q53X27
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: April 25, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health