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Protein

C-X-C chemokine receptor type 2

Gene

Cxcr2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

ReactomeiR-MMU-380108. Chemokine receptors bind chemokines.
R-MMU-418594. G alpha (i) signalling events.
R-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C chemokine receptor type 2
Short name:
CXC-R2
Short name:
CXCR-2
Alternative name(s):
GRO/MGSA receptor
High affinity interleukin-8 receptor B
Short name:
IL-8R B
CD_antigen: CD182
Gene namesi
Name:Cxcr2
Synonyms:Cmkar2, Gpcr16, Il8rb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:105303. Cxcr2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 47ExtracellularSequence analysisAdd BLAST47
Transmembranei48 – 74Helical; Name=1Sequence analysisAdd BLAST27
Topological domaini75 – 83CytoplasmicSequence analysis9
Transmembranei84 – 104Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini105 – 119ExtracellularSequence analysisAdd BLAST15
Transmembranei120 – 141Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini142 – 162CytoplasmicSequence analysisAdd BLAST21
Transmembranei163 – 182Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini183 – 207ExtracellularSequence analysisAdd BLAST25
Transmembranei208 – 230Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini231 – 250CytoplasmicSequence analysisAdd BLAST20
Transmembranei251 – 272Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini273 – 293ExtracellularSequence analysisAdd BLAST21
Transmembranei294 – 314Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini315 – 359CytoplasmicSequence analysisAdd BLAST45

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi69.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000693391 – 359C-X-C chemokine receptor type 2Add BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi23N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi118 ↔ 195PROSITE-ProRule annotation

Post-translational modificationi

Phosphorylated upon ligand binding; which is required for desensitization.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP35343.
MaxQBiP35343.
PaxDbiP35343.
PRIDEiP35343.

PTM databases

PhosphoSitePlusiP35343.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026180.
CleanExiMM_IL8RB.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027372.

Structurei

3D structure databases

ProteinModelPortaliP35343.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEHI. Eukaryota.
ENOG410Y9Y6. LUCA.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP35343.
KOiK05050.
OMAiMRTKLIK.
OrthoDBiEOG091G0C7W.
PhylomeDBiP35343.
TreeFamiTF330966.

Family and domain databases

InterProiIPR000057. Chemokine_CXCR2.
IPR000174. Chemokine_CXCR_1/2.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00427. INTRLEUKIN8R.
PR00573. INTRLEUKN8BR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35343-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEFKVDKFN IEDFFSGDLD IFNYSSGMPS ILPDAVPCHS ENLEINSYAV
60 70 80 90 100
VVIYVLVTLL SLVGNSLVML VILYNRSTCS VTDVYLLNLA IADLFFALTL
110 120 130 140 150
PVWAASKVNG WTFGSTLCKI FSYVKEVTFY SSVLLLACIS MDRYLAIVHA
160 170 180 190 200
TSTLIQKRHL VKFVCIAMWL LSVILALPIL ILRNPVKVNL STLVCYEDVG
210 220 230 240 250
NNTSRLRVVL RILPQTFGFL VPLLIMLFCY GFTLRTLFKA HMGQKHRAMR
260 270 280 290 300
VIFAVVLVFL LCWLPYNLVL FTDTLMRTKL IKETCERRDD IDKALNATEI
310 320 330 340 350
LGFLHSCLNP IIYAFIGQKF RHGLLKIMAT YGLVSKEFLA KEGRPSFVSS

SSANTSTTL
Length:359
Mass (Da):40,425
Last modified:June 1, 1994 - v1
Checksum:i74BD166E9B679F88
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23637 Genomic DNA. Translation: AAA39305.1.
L26549 Genomic DNA. Translation: AAL31314.1.
L13239 Genomic DNA. Translation: AAA62109.1.
U31207 Genomic DNA. Translation: AAC52239.1.
D17630 mRNA. Translation: BAA04536.1.
AK158234 mRNA. Translation: BAE34417.1.
CH466548 Genomic DNA. Translation: EDL00307.1.
BC051677 mRNA. Translation: AAH51677.1.
L20337 mRNA. Translation: AAA16853.1.
CCDSiCCDS15040.1.
PIRiA48921.
RefSeqiNP_034039.1. NM_009909.3.
XP_006495701.1. XM_006495638.3.
UniGeneiMm.234466.

Genome annotation databases

EnsembliENSMUST00000027372; ENSMUSP00000027372; ENSMUSG00000026180.
ENSMUST00000106899; ENSMUSP00000102512; ENSMUSG00000026180.
GeneIDi12765.
KEGGimmu:12765.
UCSCiuc007bll.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23637 Genomic DNA. Translation: AAA39305.1.
L26549 Genomic DNA. Translation: AAL31314.1.
L13239 Genomic DNA. Translation: AAA62109.1.
U31207 Genomic DNA. Translation: AAC52239.1.
D17630 mRNA. Translation: BAA04536.1.
AK158234 mRNA. Translation: BAE34417.1.
CH466548 Genomic DNA. Translation: EDL00307.1.
BC051677 mRNA. Translation: AAH51677.1.
L20337 mRNA. Translation: AAA16853.1.
CCDSiCCDS15040.1.
PIRiA48921.
RefSeqiNP_034039.1. NM_009909.3.
XP_006495701.1. XM_006495638.3.
UniGeneiMm.234466.

3D structure databases

ProteinModelPortaliP35343.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027372.

Chemistry databases

GuidetoPHARMACOLOGYi69.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP35343.

Proteomic databases

EPDiP35343.
MaxQBiP35343.
PaxDbiP35343.
PRIDEiP35343.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027372; ENSMUSP00000027372; ENSMUSG00000026180.
ENSMUST00000106899; ENSMUSP00000102512; ENSMUSG00000026180.
GeneIDi12765.
KEGGimmu:12765.
UCSCiuc007bll.1. mouse.

Organism-specific databases

CTDi3579.
MGIiMGI:105303. Cxcr2.

Phylogenomic databases

eggNOGiENOG410IEHI. Eukaryota.
ENOG410Y9Y6. LUCA.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiP35343.
KOiK05050.
OMAiMRTKLIK.
OrthoDBiEOG091G0C7W.
PhylomeDBiP35343.
TreeFamiTF330966.

Enzyme and pathway databases

ReactomeiR-MMU-380108. Chemokine receptors bind chemokines.
R-MMU-418594. G alpha (i) signalling events.
R-MMU-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiP35343.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026180.
CleanExiMM_IL8RB.

Family and domain databases

InterProiIPR000057. Chemokine_CXCR2.
IPR000174. Chemokine_CXCR_1/2.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00427. INTRLEUKIN8R.
PR00573. INTRLEUKN8BR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCXCR2_MOUSE
AccessioniPrimary (citable) accession number: P35343
Secondary accession number(s): Q53X27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 30, 2016
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.