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P35343

- CXCR2_MOUSE

UniProt

P35343 - CXCR2_MOUSE

Protein

C-X-C chemokine receptor type 2

Gene

Cxcr2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 1 (01 Jun 1994)
      Previous versions | rss
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    Functioni

    Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.1 Publication

    GO - Molecular functioni

    1. chemokine receptor activity Source: MGI
    2. interleukin-8 receptor activity Source: MGI
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. acute inflammatory response to antigenic stimulus Source: Ensembl
    2. cellular defense response Source: Ensembl
    3. chemokine-mediated signaling pathway Source: GOC
    4. chemotaxis Source: MGI
    5. metanephric tubule morphogenesis Source: Ensembl
    6. midbrain development Source: Ensembl
    7. negative regulation of apoptotic process Source: MGI
    8. negative regulation of neutrophil apoptotic process Source: Ensembl
    9. neutrophil activation Source: Ensembl
    10. neutrophil chemotaxis Source: Ensembl
    11. phospholipase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
    12. positive regulation of angiogenesis Source: Ensembl
    13. positive regulation of cardiac muscle cell apoptotic process Source: Ensembl
    14. positive regulation of cell proliferation Source: Ensembl
    15. positive regulation of cytosolic calcium ion concentration Source: Ensembl
    16. positive regulation of neutrophil chemotaxis Source: Ensembl
    17. positive regulation of vascular permeability Source: Ensembl
    18. receptor internalization Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Chemotaxis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-X-C chemokine receptor type 2
    Short name:
    CXC-R2
    Short name:
    CXCR-2
    Alternative name(s):
    GRO/MGSA receptor
    High affinity interleukin-8 receptor B
    Short name:
    IL-8R B
    CD_antigen: CD182
    Gene namesi
    Name:Cxcr2
    Synonyms:Cmkar2, Gpcr16, Il8rb
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:105303. Cxcr2.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW
    3. mast cell granule Source: Ensembl
    4. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 359359C-X-C chemokine receptor type 2PRO_0000069339Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi23 – 231N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi118 ↔ 195PROSITE-ProRule annotation

    Post-translational modificationi

    Phosphorylated upon ligand binding; which is required for desensitization.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PRIDEiP35343.

    PTM databases

    PhosphoSiteiP35343.

    Expressioni

    Gene expression databases

    BgeeiP35343.
    CleanExiMM_IL8RB.
    GenevestigatoriP35343.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000027372.

    Structurei

    3D structure databases

    ProteinModelPortaliP35343.
    SMRiP35343. Positions 37-332.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4747ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini75 – 839CytoplasmicSequence Analysis
    Topological domaini105 – 11915ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini142 – 16221CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini183 – 20725ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini231 – 25020CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini273 – 29321ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini315 – 35945CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei48 – 7427Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei84 – 10421Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei120 – 14122Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei163 – 18220Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei208 – 23023Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei251 – 27222Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei294 – 31421Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG146068.
    GeneTreeiENSGT00730000110292.
    HOGENOMiHOG000234122.
    HOVERGENiHBG106917.
    InParanoidiQ53X27.
    KOiK05050.
    OMAiLFRRTIY.
    OrthoDBiEOG7ZPNK9.
    PhylomeDBiP35343.
    TreeFamiTF330966.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000057. Chemokine_CXCR2.
    IPR000174. Chemokine_CXCR_1/2.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24227. PTHR24227. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00427. INTRLEUKIN8R.
    PR00573. INTRLEUKN8BR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P35343-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGEFKVDKFN IEDFFSGDLD IFNYSSGMPS ILPDAVPCHS ENLEINSYAV    50
    VVIYVLVTLL SLVGNSLVML VILYNRSTCS VTDVYLLNLA IADLFFALTL 100
    PVWAASKVNG WTFGSTLCKI FSYVKEVTFY SSVLLLACIS MDRYLAIVHA 150
    TSTLIQKRHL VKFVCIAMWL LSVILALPIL ILRNPVKVNL STLVCYEDVG 200
    NNTSRLRVVL RILPQTFGFL VPLLIMLFCY GFTLRTLFKA HMGQKHRAMR 250
    VIFAVVLVFL LCWLPYNLVL FTDTLMRTKL IKETCERRDD IDKALNATEI 300
    LGFLHSCLNP IIYAFIGQKF RHGLLKIMAT YGLVSKEFLA KEGRPSFVSS 350
    SSANTSTTL 359
    Length:359
    Mass (Da):40,425
    Last modified:June 1, 1994 - v1
    Checksum:i74BD166E9B679F88
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L23637 Genomic DNA. Translation: AAA39305.1.
    L26549 Genomic DNA. Translation: AAL31314.1.
    L13239 Genomic DNA. Translation: AAA62109.1.
    U31207 Genomic DNA. Translation: AAC52239.1.
    D17630 mRNA. Translation: BAA04536.1.
    AK158234 mRNA. Translation: BAE34417.1.
    CH466548 Genomic DNA. Translation: EDL00307.1.
    BC051677 mRNA. Translation: AAH51677.1.
    L20337 mRNA. Translation: AAA16853.1.
    CCDSiCCDS15040.1.
    PIRiA48921.
    RefSeqiNP_034039.1. NM_009909.3.
    XP_006495701.1. XM_006495638.1.
    UniGeneiMm.234466.

    Genome annotation databases

    EnsembliENSMUST00000027372; ENSMUSP00000027372; ENSMUSG00000026180.
    ENSMUST00000106899; ENSMUSP00000102512; ENSMUSG00000026180.
    GeneIDi12765.
    KEGGimmu:12765.
    UCSCiuc007bll.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L23637 Genomic DNA. Translation: AAA39305.1 .
    L26549 Genomic DNA. Translation: AAL31314.1 .
    L13239 Genomic DNA. Translation: AAA62109.1 .
    U31207 Genomic DNA. Translation: AAC52239.1 .
    D17630 mRNA. Translation: BAA04536.1 .
    AK158234 mRNA. Translation: BAE34417.1 .
    CH466548 Genomic DNA. Translation: EDL00307.1 .
    BC051677 mRNA. Translation: AAH51677.1 .
    L20337 mRNA. Translation: AAA16853.1 .
    CCDSi CCDS15040.1.
    PIRi A48921.
    RefSeqi NP_034039.1. NM_009909.3.
    XP_006495701.1. XM_006495638.1.
    UniGenei Mm.234466.

    3D structure databases

    ProteinModelPortali P35343.
    SMRi P35343. Positions 37-332.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000027372.

    Chemistry

    GuidetoPHARMACOLOGYi 69.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P35343.

    Proteomic databases

    PRIDEi P35343.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000027372 ; ENSMUSP00000027372 ; ENSMUSG00000026180 .
    ENSMUST00000106899 ; ENSMUSP00000102512 ; ENSMUSG00000026180 .
    GeneIDi 12765.
    KEGGi mmu:12765.
    UCSCi uc007bll.1. mouse.

    Organism-specific databases

    CTDi 3579.
    MGIi MGI:105303. Cxcr2.

    Phylogenomic databases

    eggNOGi NOG146068.
    GeneTreei ENSGT00730000110292.
    HOGENOMi HOG000234122.
    HOVERGENi HBG106917.
    InParanoidi Q53X27.
    KOi K05050.
    OMAi LFRRTIY.
    OrthoDBi EOG7ZPNK9.
    PhylomeDBi P35343.
    TreeFami TF330966.

    Miscellaneous databases

    NextBioi 282122.
    PROi P35343.
    SOURCEi Search...

    Gene expression databases

    Bgeei P35343.
    CleanExi MM_IL8RB.
    Genevestigatori P35343.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000057. Chemokine_CXCR2.
    IPR000174. Chemokine_CXCR_1/2.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24227. PTHR24227. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00427. INTRLEUKIN8R.
    PR00573. INTRLEUKN8BR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The murine homologue of the human interleukin-8 receptor type B maps near the Ity-Lsh-Bcg disease resistance locus."
      Cerretti D.P., Nelson N., Kozlosky C.J., Morrissey P.J., Copeland N.G., Gilbert D.J., Jenkins N.A., Dosik J.K., Mock B.A.
      Genomics 18:410-413(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The N-terminus of interleukin-8 (IL-8) receptor confers high affinity binding to human IL-8."
      Suzuki H., Prado G.N., Wilkinson N., Navarro J.
      J. Biol. Chem. 269:18263-18266(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The murine interleukin 8 type B receptor homologue and its ligands. Expression and biological characterization."
      Bozic C.R., Gerard N.P., von Uexkull-Guldenband C., Kolakowski L.F. Jr., Conklyn M.J., Breslow R., Showell H.J., Gerard C.
      J. Biol. Chem. 269:29355-29358(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: BALB/c.
    4. "Chemokine binding and activities mediated by the mouse IL-8 receptor."
      Lee J., Cacalano G., Camerato T., Toy K., Moore M.W., Wood W.I.
      J. Immunol. 155:2158-2164(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
    5. "Cloning of a cDNA encoding a mouse homolog of the interleukin-8 receptor."
      Harada A., Kuno K., Nomura H., Mukaida N., Murakami S., Matsushima K.
      Gene 142:297-300(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    6. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Inner ear.
    7. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Trophoblast.
    9. "Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors."
      Wilkie T.M., Chen Y., Gilbert D.J., Moore K.J., Yu L., Simon M.I., Copeland N.G., Jenkins N.A.
      Genomics 18:175-184(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 145-258.
      Tissue: Testis.
    10. "IL-10-conditioned dendritic cells, decommissioned for recruitment of adaptive immunity, elicit innate inflammatory gene products in response to danger signals."
      Nolan K.F., Strong V., Soler D., Fairchild P.J., Cobbold S.P., Croxton R., Gonzalo J.-A., Rubio A., Wells M., Waldmann H.
      J. Immunol. 172:2201-2209(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiCXCR2_MOUSE
    AccessioniPrimary (citable) accession number: P35343
    Secondary accession number(s): Q53X27
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 1994
    Last sequence update: June 1, 1994
    Last modified: October 1, 2014
    This is version 125 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3