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Protein

Hippocalcin-like protein 4

Gene

Hpcal4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.

Miscellaneous

Probably binds two or three calcium ions.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi73 – 841PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi109 – 1202PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi159 – 1703PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • calcium channel regulator activity Source: RGD
  • calcium ion binding Source: InterPro
  • protein C-terminus binding Source: RGD
  • protein domain specific binding Source: RGD

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hippocalcin-like protein 4
Alternative name(s):
Neural visinin-like protein 2
Short name:
NVL-2
Short name:
NVP-2
Visinin-like protein 2
Short name:
VILIP-2
Gene namesi
Name:Hpcal4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi708491 Hpcal4

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00000737802 – 191Hippocalcin-like protein 4Add BLAST190

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PaxDbiP35332
PRIDEiP35332

PTM databases

iPTMnetiP35332
PhosphoSitePlusiP35332

Expressioni

Tissue specificityi

Neuron-specific in the central and peripheral nervous system.

Gene expression databases

BgeeiENSRNOG00000050983
GenevisibleiP35332 RN

Interactioni

GO - Molecular functioni

  • protein C-terminus binding Source: RGD
  • protein domain specific binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066655

Structurei

3D structure databases

ProteinModelPortaliP35332
SMRiP35332
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 59EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini60 – 95EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini96 – 131EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini146 – 181EF-hand 4PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the recoverin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0044 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00760000118820
HOGENOMiHOG000233019
HOVERGENiHBG108179
InParanoidiP35332
OMAiCDIDLYK
OrthoDBiEOG091G11T4
PhylomeDBiP35332
TreeFamiTF300009

Family and domain databases

CDDicd00051 EFh, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR029534 VILIP-2
PANTHERiPTHR23055:SF84 PTHR23055:SF84, 1 hit
PfamiView protein in Pfam
PF00036 EF-hand_1, 1 hit
PF13499 EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 3 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 3 hits
PS50222 EF_HAND_2, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35332-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKNNSKLAP EELEDLVQNT EFSEQELKQW YKGFLKDCPS GILNLEEFQQ
60 70 80 90 100
LYIKFFPYGD ASKFAQHAFR TFDKNGDGTI DFREFICALS VTSRGSFEQK
110 120 130 140 150
LNWAFEMYDL DGDGRITRLE MLEIIEAIYK MVGTVIMMRM NQDGLTPQQR
160 170 180 190
VDKIFKKMDQ DKDDQITLEE FKEAAKSDPS IVLLLQCDMQ K
Length:191
Mass (Da):22,245
Last modified:January 23, 2007 - v2
Checksum:i23E500B4D871103A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13125 mRNA Translation: BAA02427.1
PIRiJH0815
RefSeqiNP_059053.1, NM_017357.1
XP_006238891.1, XM_006238829.3
UniGeneiRn.34529

Genome annotation databases

EnsembliENSRNOT00000074347; ENSRNOP00000066655; ENSRNOG00000050983
GeneIDi50872
KEGGirno:50872
UCSCiRGD:708491 rat

Similar proteinsi

Entry informationi

Entry nameiHPCL4_RAT
AccessioniPrimary (citable) accession number: P35332
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health