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Protein

Hippocalcin-like protein 4

Gene

Hpcal4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi73 – 84121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi109 – 120122PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi159 – 170123PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • calcium channel regulator activity Source: RGD
  • calcium ion binding Source: InterPro
  • protein C-terminus binding Source: RGD
  • protein domain specific binding Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hippocalcin-like protein 4
Alternative name(s):
Neural visinin-like protein 2
Short name:
NVL-2
Short name:
NVP-2
Visinin-like protein 2
Short name:
VILIP-2
Gene namesi
Name:Hpcal4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi708491. Hpcal4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved
Chaini2 – 191190Hippocalcin-like protein 4PRO_0000073780Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineBy similarity

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PaxDbiP35332.
PRIDEiP35332.

PTM databases

iPTMnetiP35332.
PhosphoSiteiP35332.

Expressioni

Tissue specificityi

Neuron-specific in the central and peripheral nervous system.

Gene expression databases

GenevisibleiP35332. RN.

Interactioni

GO - Molecular functioni

  • protein C-terminus binding Source: RGD
  • protein domain specific binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066655.

Structurei

3D structure databases

ProteinModelPortaliP35332.
SMRiP35332. Positions 5-187.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 5936EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini60 – 9536EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini96 – 13136EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini146 – 18136EF-hand 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the recoverin family.Curated
Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0044. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118820.
HOGENOMiHOG000233019.
HOVERGENiHBG108179.
InParanoidiP35332.
OMAiQQLYIKX.
OrthoDBiEOG7GJ6F3.
PhylomeDBiP35332.
TreeFamiTF300009.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028846. Recoverin.
IPR029534. VILIP-2.
[Graphical view]
PANTHERiPTHR23055. PTHR23055. 1 hit.
PTHR23055:SF84. PTHR23055:SF84. 1 hit.
PfamiPF00036. EF-hand_1. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35332-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKNNSKLAP EELEDLVQNT EFSEQELKQW YKGFLKDCPS GILNLEEFQQ
60 70 80 90 100
LYIKFFPYGD ASKFAQHAFR TFDKNGDGTI DFREFICALS VTSRGSFEQK
110 120 130 140 150
LNWAFEMYDL DGDGRITRLE MLEIIEAIYK MVGTVIMMRM NQDGLTPQQR
160 170 180 190
VDKIFKKMDQ DKDDQITLEE FKEAAKSDPS IVLLLQCDMQ K
Length:191
Mass (Da):22,245
Last modified:January 23, 2007 - v2
Checksum:i23E500B4D871103A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13125 mRNA. Translation: BAA02427.1.
PIRiJH0815.
RefSeqiNP_059053.1. NM_017357.1.
XP_006238891.1. XM_006238829.2.
UniGeneiRn.34529.

Genome annotation databases

EnsembliENSRNOT00000074347; ENSRNOP00000066655; ENSRNOG00000050983.
GeneIDi50872.
KEGGirno:50872.
UCSCiRGD:708491. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13125 mRNA. Translation: BAA02427.1.
PIRiJH0815.
RefSeqiNP_059053.1. NM_017357.1.
XP_006238891.1. XM_006238829.2.
UniGeneiRn.34529.

3D structure databases

ProteinModelPortaliP35332.
SMRiP35332. Positions 5-187.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066655.

PTM databases

iPTMnetiP35332.
PhosphoSiteiP35332.

Proteomic databases

PaxDbiP35332.
PRIDEiP35332.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000074347; ENSRNOP00000066655; ENSRNOG00000050983.
GeneIDi50872.
KEGGirno:50872.
UCSCiRGD:708491. rat.

Organism-specific databases

CTDi51440.
RGDi708491. Hpcal4.

Phylogenomic databases

eggNOGiKOG0044. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118820.
HOGENOMiHOG000233019.
HOVERGENiHBG108179.
InParanoidiP35332.
OMAiQQLYIKX.
OrthoDBiEOG7GJ6F3.
PhylomeDBiP35332.
TreeFamiTF300009.

Miscellaneous databases

NextBioi610594.
PROiP35332.

Gene expression databases

GenevisibleiP35332. RN.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028846. Recoverin.
IPR029534. VILIP-2.
[Graphical view]
PANTHERiPTHR23055. PTHR23055. 1 hit.
PTHR23055:SF84. PTHR23055:SF84. 1 hit.
PfamiPF00036. EF-hand_1. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of two additional members of the neural visinin-like Ca(2+)-binding protein gene family."
    Kajimoto Y., Shirai Y., Mukai H., Kuno T., Tanaka C.
    J. Neurochem. 61:1091-1096(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiHPCL4_RAT
AccessioniPrimary (citable) accession number: P35332
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 23, 2007
Last modified: January 20, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Probably binds two or three calcium ions.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.