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Protein

Intercellular adhesion molecule 2

Gene

Icam2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiR-MMU-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-MMU-216083. Integrin cell surface interactions.
R-MMU-5621575. CD209 (DC-SIGN) signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Intercellular adhesion molecule 2
Short name:
ICAM-2
Alternative name(s):
Lymphocyte function-associated AG-1 counter-receptor
CD_antigen: CD102
Gene namesi
Name:Icam2
Synonyms:Icam-2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:96394. Icam2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 222200ExtracellularSequence analysisAdd
BLAST
Transmembranei223 – 24725HelicalSequence analysisAdd
BLAST
Topological domaini248 – 27730CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell periphery Source: MGI
  • extracellular exosome Source: MGI
  • integral component of plasma membrane Source: MGI
  • membrane Source: MGI
  • plasma membrane Source: MGI
  • uropod Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222By similarityAdd
BLAST
Chaini23 – 277255Intercellular adhesion molecule 2PRO_0000014791Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi45 – 451N-linked (GlcNAc...)Sequence analysis
Disulfide bondi46 ↔ 91By similarity
Disulfide bondi50 ↔ 95By similarity
Glycosylationi82 – 821N-linked (GlcNAc...)Sequence analysis
Disulfide bondi134 ↔ 189By similarity
Glycosylationi158 – 1581N-linked (GlcNAc...)Sequence analysis
Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence analysis
Glycosylationi186 – 1861N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP35330.
MaxQBiP35330.
PaxDbiP35330.
PRIDEiP35330.

PTM databases

PhosphoSiteiP35330.
SwissPalmiP35330.

Expressioni

Tissue specificityi

Expressed in endothelial cells and leukocytes. High levels found in lung.

Gene expression databases

BgeeiP35330.
CleanExiMM_ICAM2.
ExpressionAtlasiP35330. baseline and differential.
GenevisibleiP35330. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-29094N.
IntActiP35330. 1 interaction.
STRINGi10090.ENSMUSP00000001055.

Structurei

Secondary structure

1
277
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi256 – 2594Combined sources
Helixi262 – 2643Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1J19X-ray2.40B253-268[»]
ProteinModelPortaliP35330.
SMRiP35330. Positions 23-215.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP35330.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 9860Ig-like C2-type 1Add
BLAST
Domaini127 – 19670Ig-like C2-type 2Add
BLAST

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. ICAM family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH57. Eukaryota.
ENOG410Z9H1. LUCA.
GeneTreeiENSGT00530000063246.
HOGENOMiHOG000049136.
HOVERGENiHBG052075.
InParanoidiP35330.
KOiK06523.
OMAiNFSCLAV.
OrthoDBiEOG790G21.
PhylomeDBiP35330.
TreeFamiTF333745.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR015653. ICAM2.
IPR013768. ICAM_N.
IPR003987. ICAM_VCAM_N.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
[Graphical view]
PANTHERiPTHR13771:SF3. PTHR13771:SF3. 1 hit.
PfamiPF03921. ICAM_N. 1 hit.
[Graphical view]
PRINTSiPR01472. ICAMVCAM1.
SUPFAMiSSF48726. SSF48726. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35330-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSFACWSLS LLILFYSPGS GEKAFEVYIW SEKQIVEATE SWKINCSTNC
60 70 80 90 100
AAPDMGGLET PTNKIMLEEH PQGKWKQFLV SNVSKDTVFF CHFTCSGKQH
110 120 130 140 150
SESLNIRVYQ PPAQVTLKLQ PPRVFVGEDF TIECTVSPVQ PLERLTLSLL
160 170 180 190 200
RGRETLKNQT FGGAETVPQE ATATFNSTAL KKDGLNFSCQ AELDLRPHGG
210 220 230 240 250
YIIRSISEYQ ILEVYEPMQD NQMVIIIVVV SILLFLFVTS VLLCFIFGQH
260 270
WHRRRTGTYG VLAAWRRLPR AFRARPV
Length:277
Mass (Da):31,390
Last modified:February 1, 1994 - v1
Checksum:iCBB2FFBCF207DA48
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti272 – 2721F → S in BAB25266 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65493 mRNA. Translation: CAA46474.1.
X65490, X65491, X65492 Genomic DNA. Translation: CAA46473.1.
AK007801 mRNA. Translation: BAB25266.1.
BC039128 mRNA. Translation: AAH39128.1.
BC039970 mRNA. Translation: AAH39970.1.
CCDSiCCDS25555.1.
PIRiA46510.
RefSeqiNP_034624.1. NM_010494.1.
XP_006532366.1. XM_006532303.1.
UniGeneiMm.394.

Genome annotation databases

EnsembliENSMUST00000001055; ENSMUSP00000001055; ENSMUSG00000001029.
GeneIDi15896.
KEGGimmu:15896.
UCSCiuc007lyx.1. mouse.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

ICAM-2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65493 mRNA. Translation: CAA46474.1.
X65490, X65491, X65492 Genomic DNA. Translation: CAA46473.1.
AK007801 mRNA. Translation: BAB25266.1.
BC039128 mRNA. Translation: AAH39128.1.
BC039970 mRNA. Translation: AAH39970.1.
CCDSiCCDS25555.1.
PIRiA46510.
RefSeqiNP_034624.1. NM_010494.1.
XP_006532366.1. XM_006532303.1.
UniGeneiMm.394.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1J19X-ray2.40B253-268[»]
ProteinModelPortaliP35330.
SMRiP35330. Positions 23-215.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-29094N.
IntActiP35330. 1 interaction.
STRINGi10090.ENSMUSP00000001055.

PTM databases

PhosphoSiteiP35330.
SwissPalmiP35330.

Proteomic databases

EPDiP35330.
MaxQBiP35330.
PaxDbiP35330.
PRIDEiP35330.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001055; ENSMUSP00000001055; ENSMUSG00000001029.
GeneIDi15896.
KEGGimmu:15896.
UCSCiuc007lyx.1. mouse.

Organism-specific databases

CTDi3384.
MGIiMGI:96394. Icam2.

Phylogenomic databases

eggNOGiENOG410IH57. Eukaryota.
ENOG410Z9H1. LUCA.
GeneTreeiENSGT00530000063246.
HOGENOMiHOG000049136.
HOVERGENiHBG052075.
InParanoidiP35330.
KOiK06523.
OMAiNFSCLAV.
OrthoDBiEOG790G21.
PhylomeDBiP35330.
TreeFamiTF333745.

Enzyme and pathway databases

ReactomeiR-MMU-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-MMU-216083. Integrin cell surface interactions.
R-MMU-5621575. CD209 (DC-SIGN) signaling.

Miscellaneous databases

EvolutionaryTraceiP35330.
NextBioi288608.
PROiP35330.
SOURCEiSearch...

Gene expression databases

BgeeiP35330.
CleanExiMM_ICAM2.
ExpressionAtlasiP35330. baseline and differential.
GenevisibleiP35330. MM.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR015653. ICAM2.
IPR013768. ICAM_N.
IPR003987. ICAM_VCAM_N.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
[Graphical view]
PANTHERiPTHR13771:SF3. PTHR13771:SF3. 1 hit.
PfamiPF03921. ICAM_N. 1 hit.
[Graphical view]
PRINTSiPR01472. ICAMVCAM1.
SUPFAMiSSF48726. SSF48726. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation, characterization, and expression of mouse ICAM-2 complementary and genomic DNA."
    Xu H., Tong I.L., de Fougerolles A.R., Springer T.A.
    J. Immunol. 149:2650-2655(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: AKR/J.
    Tissue: B-cell.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Pancreas.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue, Heart, Lung and Spleen.

Entry informationi

Entry nameiICAM2_MOUSE
AccessioniPrimary (citable) accession number: P35330
Secondary accession number(s): Q9D8Q4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 11, 2016
This is version 145 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.