Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Small proline-rich protein 2A

Gene

SPRR2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.

GO - Molecular functioni

GO - Biological processi

  • epidermis development Source: UniProtKB
  • keratinization Source: UniProtKB-KW
  • keratinocyte differentiation Source: UniProtKB
  • peptide cross-linking Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Keratinization

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163212-MONOMER.
ReactomeiR-HSA-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Small proline-rich protein 2A
Short name:
SPR-2A
Alternative name(s):
2-1
Gene namesi
Name:SPRR2A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:11261. SPRR2A.

Subcellular locationi

GO - Cellular componenti

  • cornified envelope Source: UniProtKB
  • cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi6700.
OpenTargetsiENSG00000241794.
PharmGKBiPA36090.

Polymorphism and mutation databases

BioMutaiSPRR2A.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001500081 – 72Small proline-rich protein 2AAdd BLAST72

Proteomic databases

MaxQBiP35326.
PaxDbiP35326.
PeptideAtlasiP35326.
PRIDEiP35326.

Expressioni

Inductioni

During squamous differentiation of epidermal keratinocytes.

Gene expression databases

BgeeiENSG00000241794.
CleanExiHS_SPRR2A.
GenevisibleiP35326. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SRCP129313EBI-1047940,EBI-621482

Protein-protein interaction databases

BioGridi112578. 11 interactors.
IntActiP35326. 15 interactors.
MINTiMINT-7303756.
STRINGi9606.ENSP00000376423.

Structurei

3D structure databases

ProteinModelPortaliP35326.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati21 – 2919
Repeati30 – 3829
Repeati39 – 4739

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 473 X 9 AA tandem repeats of P-K-C-P-[EQ]-P-C-P-PAdd BLAST27

Sequence similaritiesi

Belongs to the cornifin (SPRR) family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410KCJJ. Eukaryota.
ENOG4110NWC. LUCA.
GeneTreeiENSGT00810000126124.
HOGENOMiHOG000059530.
InParanoidiP35326.
OMAiPECPEPC.

Family and domain databases

InterProiIPR026075. SPRR/LCE.
IPR029142. SPRR2.
[Graphical view]
PANTHERiPTHR23263. PTHR23263. 1 hit.
PfamiPF14820. SPRR2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35326-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYQQQQCKQ PCQPPPVCPT PKCPEPCPPP KCPEPCPPPK CPQPCPPQQC
60 70
QQKYPPVTPS PPCQSKYPPK SK
Length:72
Mass (Da):7,965
Last modified:February 1, 1994 - v1
Checksum:i28B452D0F8B6344A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53064 Genomic DNA. Translation: CAA37239.1.
AL356867 Genomic DNA. Translation: CAI19807.1.
AK311939 mRNA. Translation: BAG34880.1.
CH471121 Genomic DNA. Translation: EAW53346.1.
CH471121 Genomic DNA. Translation: EAW53347.1.
BC096108 mRNA. Translation: AAH96108.1.
BC096109 mRNA. Translation: AAH96109.1.
BC096110 mRNA. Translation: AAH96110.1.
BC096111 mRNA. Translation: AAH96111.1.
BC128049 mRNA. Translation: AAI28050.1.
CCDSiCCDS1034.1.
PIRiS12712.
RefSeqiNP_005979.1. NM_005988.2.
UniGeneiHs.355542.

Genome annotation databases

EnsembliENST00000392653; ENSP00000376423; ENSG00000241794.
GeneIDi6700.
KEGGihsa:6700.
UCSCiuc001fbd.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53064 Genomic DNA. Translation: CAA37239.1.
AL356867 Genomic DNA. Translation: CAI19807.1.
AK311939 mRNA. Translation: BAG34880.1.
CH471121 Genomic DNA. Translation: EAW53346.1.
CH471121 Genomic DNA. Translation: EAW53347.1.
BC096108 mRNA. Translation: AAH96108.1.
BC096109 mRNA. Translation: AAH96109.1.
BC096110 mRNA. Translation: AAH96110.1.
BC096111 mRNA. Translation: AAH96111.1.
BC128049 mRNA. Translation: AAI28050.1.
CCDSiCCDS1034.1.
PIRiS12712.
RefSeqiNP_005979.1. NM_005988.2.
UniGeneiHs.355542.

3D structure databases

ProteinModelPortaliP35326.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112578. 11 interactors.
IntActiP35326. 15 interactors.
MINTiMINT-7303756.
STRINGi9606.ENSP00000376423.

Polymorphism and mutation databases

BioMutaiSPRR2A.

Proteomic databases

MaxQBiP35326.
PaxDbiP35326.
PeptideAtlasiP35326.
PRIDEiP35326.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000392653; ENSP00000376423; ENSG00000241794.
GeneIDi6700.
KEGGihsa:6700.
UCSCiuc001fbd.4. human.

Organism-specific databases

CTDi6700.
DisGeNETi6700.
GeneCardsiSPRR2A.
HGNCiHGNC:11261. SPRR2A.
MIMi182267. gene.
neXtProtiNX_P35326.
OpenTargetsiENSG00000241794.
PharmGKBiPA36090.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KCJJ. Eukaryota.
ENOG4110NWC. LUCA.
GeneTreeiENSGT00810000126124.
HOGENOMiHOG000059530.
InParanoidiP35326.
OMAiPECPEPC.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163212-MONOMER.
ReactomeiR-HSA-6809371. Formation of the cornified envelope.

Miscellaneous databases

ChiTaRSiSPRR2A. human.
GeneWikiiSPRR2A.
GenomeRNAii6700.
PROiP35326.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000241794.
CleanExiHS_SPRR2A.
GenevisibleiP35326. HS.

Family and domain databases

InterProiIPR026075. SPRR/LCE.
IPR029142. SPRR2.
[Graphical view]
PANTHERiPTHR23263. PTHR23263. 1 hit.
PfamiPF14820. SPRR2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSPR2A_HUMAN
AccessioniPrimary (citable) accession number: P35326
Secondary accession number(s): B2R4T3, D3DV35, Q5T529
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 30, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.