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Protein

Small proline-rich protein 2B

Gene

SPRR2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.

GO - Molecular functioni

GO - Biological processi

  • epidermis development Source: UniProtKB
  • keratinization Source: UniProtKB-KW
  • keratinocyte differentiation Source: UniProtKB
  • peptide cross-linking Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Keratinization

Names & Taxonomyi

Protein namesi
Recommended name:
Small proline-rich protein 2B
Short name:
SPR-2B
Gene namesi
Name:SPRR2B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:11262. SPRR2B.

Subcellular locationi

GO - Cellular componenti

  • cornified envelope Source: UniProtKB
  • cytoplasm Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36091.

Polymorphism and mutation databases

BioMutaiSPRR2B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7272Small proline-rich protein 2BPRO_0000150009Add
BLAST

Proteomic databases

PaxDbiP35325.
PRIDEiP35325.

PTM databases

PhosphoSiteiP35325.

Expressioni

Tissue specificityi

Suprabasal layers of squamous-differentiated tissues such as epidermis, esophagus, tongue and trachea.

Developmental stagei

Expressed during differentiation of squamous cells.

Inductioni

By UV irradiation and carcinogenic agents. During squamous differentiation of epidermal keratinocytes.

Gene expression databases

BgeeiP35325.
CleanExiHS_SPRR2B.
GenevisibleiP35325. HS.

Interactioni

Protein-protein interaction databases

BioGridi112579. 3 interactions.
IntActiP35325. 4 interactions.
STRINGi9606.ENSP00000340703.

Structurei

3D structure databases

ProteinModelPortaliP35325.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati21 – 2991
Repeati30 – 3892
Repeati39 – 4793

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni21 – 47273 X 9 AA tandem repeats of P-K-C-P-[EQ]-P-C-P-PAdd
BLAST

Sequence similaritiesi

Belongs to the cornifin (SPRR) family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410KCHG. Eukaryota.
ENOG4110NYN. LUCA.
GeneTreeiENSGT00840000130291.
OMAiLKCPEPC.

Family and domain databases

InterProiIPR026075. SPRR/LCE.
IPR029142. SPRR2.
[Graphical view]
PANTHERiPTHR23263. PTHR23263. 1 hit.
PfamiPF14820. SPRR2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35325-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYQQQQCKQ PCQPPPVCPT PKCPEPCPPP KCPEPCPPPK CPQPCPPQQC
60 70
QQKYPPVTPS PPCQPKYPPK SK
Length:72
Mass (Da):7,975
Last modified:February 1, 1994 - v1
Checksum:i87B452D0F8B63448
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti39 – 391P → S.
Corresponds to variant rs1048268 [ dbSNP | Ensembl ].
VAR_034518

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05188 Genomic DNA. Translation: AAA60576.1.
AF333952 Genomic DNA. Translation: AAK70940.1.
AL356867 Genomic DNA. Translation: CAI19808.1.
CCDSiCCDS30865.1.
PIRiI68511.
RefSeqiNP_001017418.1. NM_001017418.2.
UniGeneiHs.568239.

Genome annotation databases

EnsembliENST00000368755; ENSP00000357744; ENSG00000196805.
GeneIDi6701.
KEGGihsa:6701.
UCSCiuc057lau.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05188 Genomic DNA. Translation: AAA60576.1.
AF333952 Genomic DNA. Translation: AAK70940.1.
AL356867 Genomic DNA. Translation: CAI19808.1.
CCDSiCCDS30865.1.
PIRiI68511.
RefSeqiNP_001017418.1. NM_001017418.2.
UniGeneiHs.568239.

3D structure databases

ProteinModelPortaliP35325.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112579. 3 interactions.
IntActiP35325. 4 interactions.
STRINGi9606.ENSP00000340703.

PTM databases

PhosphoSiteiP35325.

Polymorphism and mutation databases

BioMutaiSPRR2B.

Proteomic databases

PaxDbiP35325.
PRIDEiP35325.

Protocols and materials databases

DNASUi6701.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368755; ENSP00000357744; ENSG00000196805.
GeneIDi6701.
KEGGihsa:6701.
UCSCiuc057lau.1. human.

Organism-specific databases

CTDi6701.
GeneCardsiSPRR2B.
HGNCiHGNC:11262. SPRR2B.
MIMi182268. gene.
neXtProtiNX_P35325.
PharmGKBiPA36091.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KCHG. Eukaryota.
ENOG4110NYN. LUCA.
GeneTreeiENSGT00840000130291.
OMAiLKCPEPC.

Miscellaneous databases

GenomeRNAii6701.
NextBioi26129.
PROiP35325.
SOURCEiSearch...

Gene expression databases

BgeeiP35325.
CleanExiHS_SPRR2B.
GenevisibleiP35325. HS.

Family and domain databases

InterProiIPR026075. SPRR/LCE.
IPR029142. SPRR2.
[Graphical view]
PANTHERiPTHR23263. PTHR23263. 1 hit.
PfamiPF14820. SPRR2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins."
    Gibbs S., Fijneman R., Wiegant J., Geurts van Kessel A., van de Putte P., Backendorf C.
    Genomics 16:630-637(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Skin.
  2. "Structural organization and regulation of the small proline-rich family of cornified envelope precursors suggest a role in adaptive barrier function."
    Cabral A., Voskamp P., Cleton-Jansen A.-M., South A., Nizetic D., Backendorf C.
    J. Biol. Chem. 276:19231-19237(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiSPR2B_HUMAN
AccessioniPrimary (citable) accession number: P35325
Secondary accession number(s): Q5T528
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 11, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.