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Protein

Cornifin-A

Gene

SPRR1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.

GO - Molecular functioni

  • protein binding, bridging Source: UniProtKB
  • structural molecule activity Source: UniProtKB

GO - Biological processi

  • epidermis development Source: ProtInc
  • keratinization Source: UniProtKB-KW
  • keratinocyte differentiation Source: UniProtKB
  • peptide cross-linking Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Keratinization

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169474-MONOMER.
ReactomeiR-HSA-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Cornifin-A
Alternative name(s):
19 kDa pancornulin
SPRK
Small proline-rich protein IA
Short name:
SPR-IA
Gene namesi
Name:SPRR1A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:11259. SPRR1A.

Subcellular locationi

GO - Cellular componenti

  • cornified envelope Source: UniProtKB
  • cytoplasm Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi6698.
OpenTargetsiENSG00000169474.
PharmGKBiPA36088.

Polymorphism and mutation databases

BioMutaiSPRR1A.
DMDMi215273890.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001499951 – 89Cornifin-AAdd BLAST89

Proteomic databases

PaxDbiP35321.
PeptideAtlasiP35321.
PRIDEiP35321.

2D gel databases

UCD-2DPAGEP35321.

PTM databases

iPTMnetiP35321.
PhosphoSitePlusiP35321.

Expressioni

Inductioni

During squamous differentiation of epidermal keratinocytes.

Gene expression databases

BgeeiENSG00000169474.
CleanExiHS_SPRR1A.
GenevisibleiP35321. HS.

Organism-specific databases

HPAiCAB011237.

Interactioni

GO - Molecular functioni

  • protein binding, bridging Source: UniProtKB

Protein-protein interaction databases

BioGridi112576. 3 interactors.
IntActiP35321. 4 interactors.
STRINGi9606.ENSP00000307340.

Structurei

3D structure databases

ProteinModelPortaliP35321.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati3 – 141Add BLAST12
Repeati18 – 292Add BLAST12
Repeati31 – 3818
Repeati39 – 4628
Repeati47 – 5438
Repeati55 – 6248
Repeati63 – 7058
Repeati71 – 7868

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni3 – 292 X 12 AA approximate repeatsAdd BLAST27
Regioni31 – 786 X 8 AA approximate tandem repeatsAdd BLAST48

Sequence similaritiesi

Belongs to the cornifin (SPRR) family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410JH2M. Eukaryota.
ENOG410XUVY. LUCA.
GeneTreeiENSGT00730000111065.
HOGENOMiHOG000059526.
HOVERGENiHBG079213.
InParanoidiP35321.
OMAiLEPCQPK.
OrthoDBiEOG091G15WJ.
PhylomeDBiP35321.
TreeFamiTF338205.

Family and domain databases

InterProiIPR003302. Cornifin.
IPR026075. SPRR/LCE.
[Graphical view]
PANTHERiPTHR23263. PTHR23263. 1 hit.
PTHR23263:SF49. PTHR23263:SF49. 1 hit.

Sequencei

Sequence statusi: Complete.

P35321-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSQQQKQPC TPPPQPQQQQ VKQPCQPPPQ EPCIPKTKEP CHPKVPEPCH
60 70 80
PKVPEPCQPK VPEPCQPKVP EPCPSTVTPA PAQQKTKQK
Length:89
Mass (Da):9,877
Last modified:November 25, 2008 - v2
Checksum:iC79E79931794D3D4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti53V → I AA sequence (PubMed:7829876).Curated1
Sequence conflicti65Missing AA sequence (PubMed:7829876).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02109742H → Q.3 PublicationsCorresponds to variant rs1611762dbSNPEnsembl.1
Natural variantiVAR_02109861V → I.3 PublicationsCorresponds to variant rs1611764dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05187 Genomic DNA. Translation: AAC26838.1.
AY755659 Genomic DNA. Translation: AAU88143.1.
AL356867 Genomic DNA. Translation: CAI19801.1.
CH471121 Genomic DNA. Translation: EAW53355.1.
CH471121 Genomic DNA. Translation: EAW53356.1.
BC105081 mRNA. Translation: AAI05082.1.
BC105083 mRNA. Translation: AAI05084.1.
CCDSiCCDS1032.1.
PIRiI54187.
RefSeqiNP_001186757.1. NM_001199828.1.
NP_005978.2. NM_005987.3.
UniGeneiHs.46320.

Genome annotation databases

EnsembliENST00000368762; ENSP00000357751; ENSG00000169474.
GeneIDi6698.
KEGGihsa:6698.
UCSCiuc057lan.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05187 Genomic DNA. Translation: AAC26838.1.
AY755659 Genomic DNA. Translation: AAU88143.1.
AL356867 Genomic DNA. Translation: CAI19801.1.
CH471121 Genomic DNA. Translation: EAW53355.1.
CH471121 Genomic DNA. Translation: EAW53356.1.
BC105081 mRNA. Translation: AAI05082.1.
BC105083 mRNA. Translation: AAI05084.1.
CCDSiCCDS1032.1.
PIRiI54187.
RefSeqiNP_001186757.1. NM_001199828.1.
NP_005978.2. NM_005987.3.
UniGeneiHs.46320.

3D structure databases

ProteinModelPortaliP35321.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112576. 3 interactors.
IntActiP35321. 4 interactors.
STRINGi9606.ENSP00000307340.

PTM databases

iPTMnetiP35321.
PhosphoSitePlusiP35321.

Polymorphism and mutation databases

BioMutaiSPRR1A.
DMDMi215273890.

2D gel databases

UCD-2DPAGEP35321.

Proteomic databases

PaxDbiP35321.
PeptideAtlasiP35321.
PRIDEiP35321.

Protocols and materials databases

DNASUi6698.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368762; ENSP00000357751; ENSG00000169474.
GeneIDi6698.
KEGGihsa:6698.
UCSCiuc057lan.1. human.

Organism-specific databases

CTDi6698.
DisGeNETi6698.
GeneCardsiSPRR1A.
H-InvDBHIX0028873.
HGNCiHGNC:11259. SPRR1A.
HPAiCAB011237.
MIMi182265. gene.
neXtProtiNX_P35321.
OpenTargetsiENSG00000169474.
PharmGKBiPA36088.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JH2M. Eukaryota.
ENOG410XUVY. LUCA.
GeneTreeiENSGT00730000111065.
HOGENOMiHOG000059526.
HOVERGENiHBG079213.
InParanoidiP35321.
OMAiLEPCQPK.
OrthoDBiEOG091G15WJ.
PhylomeDBiP35321.
TreeFamiTF338205.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169474-MONOMER.
ReactomeiR-HSA-6809371. Formation of the cornified envelope.

Miscellaneous databases

ChiTaRSiSPRR1A. human.
GeneWikiiSPRR1A.
GenomeRNAii6698.
PROiP35321.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169474.
CleanExiHS_SPRR1A.
GenevisibleiP35321. HS.

Family and domain databases

InterProiIPR003302. Cornifin.
IPR026075. SPRR/LCE.
[Graphical view]
PANTHERiPTHR23263. PTHR23263. 1 hit.
PTHR23263:SF49. PTHR23263:SF49. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSPR1A_HUMAN
AccessioniPrimary (citable) accession number: P35321
Secondary accession number(s): B1AN47
, D3DV31, Q2M303, Q9UDG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: November 25, 2008
Last modified: November 30, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.