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P35321

- SPR1A_HUMAN

UniProt

P35321 - SPR1A_HUMAN

Protein

Cornifin-A

Gene

SPRR1A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. protein binding, bridging Source: UniProtKB
    3. structural molecule activity Source: UniProtKB

    GO - Biological processi

    1. epidermis development Source: ProtInc
    2. keratinization Source: UniProtKB-KW
    3. keratinocyte differentiation Source: UniProtKB
    4. peptide cross-linking Source: UniProtKB

    Keywords - Biological processi

    Keratinization

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cornifin-A
    Alternative name(s):
    19 kDa pancornulin
    SPRK
    Small proline-rich protein IA
    Short name:
    SPR-IA
    Gene namesi
    Name:SPRR1A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:11259. SPRR1A.

    Subcellular locationi

    GO - Cellular componenti

    1. cornified envelope Source: UniProtKB
    2. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36088.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 8989Cornifin-APRO_0000149995Add
    BLAST

    Proteomic databases

    PaxDbiP35321.
    PRIDEiP35321.

    2D gel databases

    UCD-2DPAGEP35321.

    PTM databases

    PhosphoSiteiP35321.

    Expressioni

    Inductioni

    During squamous differentiation of epidermal keratinocytes.

    Gene expression databases

    BgeeiP35321.
    CleanExiHS_SPRR1A.
    GenevestigatoriP35321.

    Organism-specific databases

    HPAiCAB011237.

    Interactioni

    Protein-protein interaction databases

    BioGridi112576. 2 interactions.
    IntActiP35321. 2 interactions.
    STRINGi9606.ENSP00000307340.

    Structurei

    3D structure databases

    ProteinModelPortaliP35321.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati3 – 14121Add
    BLAST
    Repeati18 – 29122Add
    BLAST
    Repeati31 – 3881
    Repeati39 – 4682
    Repeati47 – 5483
    Repeati55 – 6284
    Repeati63 – 7085
    Repeati71 – 7886

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni3 – 29272 X 12 AA approximate repeatsAdd
    BLAST
    Regioni31 – 78486 X 8 AA approximate tandem repeatsAdd
    BLAST

    Sequence similaritiesi

    Belongs to the cornifin (SPRR) family.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG39062.
    HOGENOMiHOG000059526.
    HOVERGENiHBG079213.
    InParanoidiP35321.
    OMAiCHPKEPC.
    OrthoDBiEOG773XKP.
    PhylomeDBiP35321.
    TreeFamiTF338205.

    Family and domain databases

    InterProiIPR003302. Cornifin.
    IPR026075. SPRR/LCE.
    [Graphical view]
    PANTHERiPTHR23263. PTHR23263. 1 hit.
    PfamiPF02389. Cornifin. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P35321-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSQQQKQPC TPPPQPQQQQ VKQPCQPPPQ EPCIPKTKEP CHPKVPEPCH   50
    PKVPEPCQPK VPEPCQPKVP EPCPSTVTPA PAQQKTKQK 89
    Length:89
    Mass (Da):9,877
    Last modified:November 25, 2008 - v2
    Checksum:iC79E79931794D3D4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti53 – 531V → I AA sequence (PubMed:7829876)Curated
    Sequence conflicti65 – 651Missing AA sequence (PubMed:7829876)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti42 – 421H → Q.3 Publications
    Corresponds to variant rs1611762 [ dbSNP | Ensembl ].
    VAR_021097
    Natural varianti61 – 611V → I.3 Publications
    Corresponds to variant rs1611764 [ dbSNP | Ensembl ].
    VAR_021098

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L05187 Genomic DNA. Translation: AAC26838.1.
    AY755659 Genomic DNA. Translation: AAU88143.1.
    AL356867 Genomic DNA. Translation: CAI19801.1.
    CH471121 Genomic DNA. Translation: EAW53355.1.
    CH471121 Genomic DNA. Translation: EAW53356.1.
    BC105081 mRNA. Translation: AAI05082.1.
    BC105083 mRNA. Translation: AAI05084.1.
    CCDSiCCDS1032.1.
    PIRiI54187.
    RefSeqiNP_001186757.1. NM_001199828.1.
    NP_005978.2. NM_005987.3.
    UniGeneiHs.46320.

    Genome annotation databases

    EnsembliENST00000368762; ENSP00000357751; ENSG00000169474.
    GeneIDi6698.
    KEGGihsa:6698.
    UCSCiuc001faw.3. human.

    Polymorphism databases

    DMDMi215273890.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L05187 Genomic DNA. Translation: AAC26838.1 .
    AY755659 Genomic DNA. Translation: AAU88143.1 .
    AL356867 Genomic DNA. Translation: CAI19801.1 .
    CH471121 Genomic DNA. Translation: EAW53355.1 .
    CH471121 Genomic DNA. Translation: EAW53356.1 .
    BC105081 mRNA. Translation: AAI05082.1 .
    BC105083 mRNA. Translation: AAI05084.1 .
    CCDSi CCDS1032.1.
    PIRi I54187.
    RefSeqi NP_001186757.1. NM_001199828.1.
    NP_005978.2. NM_005987.3.
    UniGenei Hs.46320.

    3D structure databases

    ProteinModelPortali P35321.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112576. 2 interactions.
    IntActi P35321. 2 interactions.
    STRINGi 9606.ENSP00000307340.

    PTM databases

    PhosphoSitei P35321.

    Polymorphism databases

    DMDMi 215273890.

    2D gel databases

    UCD-2DPAGE P35321.

    Proteomic databases

    PaxDbi P35321.
    PRIDEi P35321.

    Protocols and materials databases

    DNASUi 6698.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000368762 ; ENSP00000357751 ; ENSG00000169474 .
    GeneIDi 6698.
    KEGGi hsa:6698.
    UCSCi uc001faw.3. human.

    Organism-specific databases

    CTDi 6698.
    GeneCardsi GC01P152956.
    H-InvDB HIX0028873.
    HGNCi HGNC:11259. SPRR1A.
    HPAi CAB011237.
    MIMi 182265. gene.
    neXtProti NX_P35321.
    PharmGKBi PA36088.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG39062.
    HOGENOMi HOG000059526.
    HOVERGENi HBG079213.
    InParanoidi P35321.
    OMAi CHPKEPC.
    OrthoDBi EOG773XKP.
    PhylomeDBi P35321.
    TreeFami TF338205.

    Miscellaneous databases

    ChiTaRSi SPRR1A. human.
    GeneWikii SPRR1A.
    GenomeRNAii 6698.
    NextBioi 26115.
    PROi P35321.
    SOURCEi Search...

    Gene expression databases

    Bgeei P35321.
    CleanExi HS_SPRR1A.
    Genevestigatori P35321.

    Family and domain databases

    InterProi IPR003302. Cornifin.
    IPR026075. SPRR/LCE.
    [Graphical view ]
    PANTHERi PTHR23263. PTHR23263. 1 hit.
    Pfami PF02389. Cornifin. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins."
      Gibbs S., Fijneman R., Wiegant J., Geurts van Kessel A., van de Putte P., Backendorf C.
      Genomics 16:630-637(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS GLN-42 AND ILE-61.
      Tissue: Skin.
    2. "Differential expression of protease inhibitor and small proline-rich protein genes between normal human oral tissue and odontogenic keratocysts."
      Robinson P.A., Marley J.J., High A.S., Hume W.J.
      Arch. Oral Biol. 39:251-259(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. NIEHS SNPs program
      Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS GLN-42 AND ILE-61.
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLN-42 AND ILE-61.
    7. "The pancornulins: a group of small proline rich-related cornified envelope precursors with bifunctional capabilities in isopeptide bond formation."
      Greco M.A., Lorand L., Lane W.S., Baden H.P., Parameswaran K.N.P., Kvedar J.C.
      J. Invest. Dermatol. 104:204-210(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 8-31 AND 53-85.
      Tissue: Keratinocyte.

    Entry informationi

    Entry nameiSPR1A_HUMAN
    AccessioniPrimary (citable) accession number: P35321
    Secondary accession number(s): B1AN47
    , D3DV31, Q2M303, Q9UDG4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 119 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3