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P35321 (SPR1A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cornifin-A
Alternative name(s):
19 kDa pancornulin
SPRK
Small proline-rich protein IA
Short name=SPR-IA
Gene names
Name:SPRR1A
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length89 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.

Subcellular location

Cytoplasm.

Induction

During squamous differentiation of epidermal keratinocytes.

Sequence similarities

Belongs to the cornifin (SPRR) family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 8989Cornifin-A
PRO_0000149995

Regions

Repeat3 – 14121
Repeat18 – 29122
Repeat31 – 3881
Repeat39 – 4682
Repeat47 – 5483
Repeat55 – 6284
Repeat63 – 7085
Repeat71 – 7886
Region3 – 29272 X 12 AA approximate repeats
Region31 – 78486 X 8 AA approximate tandem repeats

Natural variations

Natural variant421H → Q. Ref.1 Ref.3 Ref.6
Corresponds to variant rs1611762 [ dbSNP | Ensembl ].
VAR_021097
Natural variant611V → I. Ref.1 Ref.3 Ref.6
Corresponds to variant rs1611764 [ dbSNP | Ensembl ].
VAR_021098

Experimental info

Sequence conflict531V → I AA sequence Ref.7
Sequence conflict651Missing AA sequence Ref.7

Sequences

Sequence LengthMass (Da)Tools
P35321 [UniParc].

Last modified November 25, 2008. Version 2.
Checksum: C79E79931794D3D4

FASTA899,877
        10         20         30         40         50         60 
MNSQQQKQPC TPPPQPQQQQ VKQPCQPPPQ EPCIPKTKEP CHPKVPEPCH PKVPEPCQPK 

        70         80 
VPEPCQPKVP EPCPSTVTPA PAQQKTKQK 

« Hide

References

« Hide 'large scale' references
[1]"Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins."
Gibbs S., Fijneman R., Wiegant J., Geurts van Kessel A., van de Putte P., Backendorf C.
Genomics 16:630-637(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS GLN-42 AND ILE-61.
Tissue: Skin.
[2]"Differential expression of protease inhibitor and small proline-rich protein genes between normal human oral tissue and odontogenic keratocysts."
Robinson P.A., Marley J.J., High A.S., Hume W.J.
Arch. Oral Biol. 39:251-259(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]NIEHS SNPs program
Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS GLN-42 AND ILE-61.
[4]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLN-42 AND ILE-61.
[7]"The pancornulins: a group of small proline rich-related cornified envelope precursors with bifunctional capabilities in isopeptide bond formation."
Greco M.A., Lorand L., Lane W.S., Baden H.P., Parameswaran K.N.P., Kvedar J.C.
J. Invest. Dermatol. 104:204-210(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 8-31 AND 53-85.
Tissue: Keratinocyte.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L05187 Genomic DNA. Translation: AAC26838.1.
AY755659 Genomic DNA. Translation: AAU88143.1.
AL356867 Genomic DNA. Translation: CAI19801.1.
CH471121 Genomic DNA. Translation: EAW53355.1.
CH471121 Genomic DNA. Translation: EAW53356.1.
BC105081 mRNA. Translation: AAI05082.1.
BC105083 mRNA. Translation: AAI05084.1.
CCDSCCDS1032.1.
PIRI54187.
RefSeqNP_001186757.1. NM_001199828.1.
NP_005978.2. NM_005987.3.
UniGeneHs.46320.

3D structure databases

ProteinModelPortalP35321.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112576. 2 interactions.
IntActP35321. 2 interactions.
STRING9606.ENSP00000307340.

PTM databases

PhosphoSiteP35321.

Polymorphism databases

DMDM215273890.

2D gel databases

UCD-2DPAGEP35321.

Proteomic databases

PaxDbP35321.
PRIDEP35321.

Protocols and materials databases

DNASU6698.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000307122; ENSP00000307340; ENSG00000169474.
ENST00000368762; ENSP00000357751; ENSG00000169474.
GeneID6698.
KEGGhsa:6698.
UCSCuc001faw.3. human.

Organism-specific databases

CTD6698.
GeneCardsGC01P152956.
H-InvDBHIX0028873.
HGNCHGNC:11259. SPRR1A.
HPACAB011237.
MIM182265. gene.
neXtProtNX_P35321.
PharmGKBPA36088.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG39062.
HOGENOMHOG000059526.
HOVERGENHBG079213.
InParanoidP35321.
OMACHPKEPC.
OrthoDBEOG773XKP.
PhylomeDBP35321.
TreeFamTF338205.

Gene expression databases

BgeeP35321.
CleanExHS_SPRR1A.
GenevestigatorP35321.

Family and domain databases

InterProIPR003302. Cornifin.
IPR026075. SPRR/LCE.
[Graphical view]
PANTHERPTHR23263. PTHR23263. 1 hit.
PfamPF02389. Cornifin. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSPRR1A. human.
GeneWikiSPRR1A.
GenomeRNAi6698.
NextBio26115.
PROP35321.
SOURCESearch...

Entry information

Entry nameSPR1A_HUMAN
AccessionPrimary (citable) accession number: P35321
Secondary accession number(s): B1AN47 expand/collapse secondary AC list , D3DV31, Q2M303, Q9UDG4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: November 25, 2008
Last modified: July 9, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM