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Protein

Cornifin-A

Gene

SPRR1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.

GO - Molecular functioni

  • protein binding, bridging Source: UniProtKB
  • structural molecule activity Source: UniProtKB

GO - Biological processi

  • epidermis development Source: ProtInc
  • keratinization Source: UniProtKB-KW
  • keratinocyte differentiation Source: UniProtKB
  • peptide cross-linking Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Keratinization

Names & Taxonomyi

Protein namesi
Recommended name:
Cornifin-A
Alternative name(s):
19 kDa pancornulin
SPRK
Small proline-rich protein IA
Short name:
SPR-IA
Gene namesi
Name:SPRR1A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:11259. SPRR1A.

Subcellular locationi

GO - Cellular componenti

  • cornified envelope Source: UniProtKB
  • cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36088.

Polymorphism and mutation databases

BioMutaiSPRR1A.
DMDMi215273890.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8989Cornifin-APRO_0000149995Add
BLAST

Proteomic databases

PaxDbiP35321.
PRIDEiP35321.

2D gel databases

UCD-2DPAGEP35321.

PTM databases

PhosphoSiteiP35321.

Expressioni

Inductioni

During squamous differentiation of epidermal keratinocytes.

Gene expression databases

BgeeiP35321.
CleanExiHS_SPRR1A.
GenevisibleiP35321. HS.

Organism-specific databases

HPAiCAB011237.

Interactioni

Protein-protein interaction databases

BioGridi112576. 2 interactions.
IntActiP35321. 2 interactions.
STRINGi9606.ENSP00000307340.

Structurei

3D structure databases

ProteinModelPortaliP35321.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati3 – 14121Add
BLAST
Repeati18 – 29122Add
BLAST
Repeati31 – 3881
Repeati39 – 4682
Repeati47 – 5483
Repeati55 – 6284
Repeati63 – 7085
Repeati71 – 7886

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni3 – 29272 X 12 AA approximate repeatsAdd
BLAST
Regioni31 – 78486 X 8 AA approximate tandem repeatsAdd
BLAST

Sequence similaritiesi

Belongs to the cornifin (SPRR) family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG39062.
GeneTreeiENSGT00730000111065.
HOGENOMiHOG000059526.
HOVERGENiHBG079213.
InParanoidiP35321.
OMAiLEPCQPK.
OrthoDBiEOG773XKP.
PhylomeDBiP35321.
TreeFamiTF338205.

Family and domain databases

InterProiIPR003302. Cornifin.
IPR026075. SPRR/LCE.
[Graphical view]
PANTHERiPTHR23263. PTHR23263. 1 hit.
PfamiPF02389. Cornifin. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35321-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSQQQKQPC TPPPQPQQQQ VKQPCQPPPQ EPCIPKTKEP CHPKVPEPCH
60 70 80
PKVPEPCQPK VPEPCQPKVP EPCPSTVTPA PAQQKTKQK
Length:89
Mass (Da):9,877
Last modified:November 25, 2008 - v2
Checksum:iC79E79931794D3D4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti53 – 531V → I AA sequence (PubMed:7829876).Curated
Sequence conflicti65 – 651Missing AA sequence (PubMed:7829876).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti42 – 421H → Q.3 Publications
Corresponds to variant rs1611762 [ dbSNP | Ensembl ].
VAR_021097
Natural varianti61 – 611V → I.3 Publications
Corresponds to variant rs1611764 [ dbSNP | Ensembl ].
VAR_021098

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05187 Genomic DNA. Translation: AAC26838.1.
AY755659 Genomic DNA. Translation: AAU88143.1.
AL356867 Genomic DNA. Translation: CAI19801.1.
CH471121 Genomic DNA. Translation: EAW53355.1.
CH471121 Genomic DNA. Translation: EAW53356.1.
BC105081 mRNA. Translation: AAI05082.1.
BC105083 mRNA. Translation: AAI05084.1.
CCDSiCCDS1032.1.
PIRiI54187.
RefSeqiNP_001186757.1. NM_001199828.1.
NP_005978.2. NM_005987.3.
UniGeneiHs.46320.

Genome annotation databases

EnsembliENST00000368762; ENSP00000357751; ENSG00000169474.
GeneIDi6698.
KEGGihsa:6698.
UCSCiuc001faw.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05187 Genomic DNA. Translation: AAC26838.1.
AY755659 Genomic DNA. Translation: AAU88143.1.
AL356867 Genomic DNA. Translation: CAI19801.1.
CH471121 Genomic DNA. Translation: EAW53355.1.
CH471121 Genomic DNA. Translation: EAW53356.1.
BC105081 mRNA. Translation: AAI05082.1.
BC105083 mRNA. Translation: AAI05084.1.
CCDSiCCDS1032.1.
PIRiI54187.
RefSeqiNP_001186757.1. NM_001199828.1.
NP_005978.2. NM_005987.3.
UniGeneiHs.46320.

3D structure databases

ProteinModelPortaliP35321.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112576. 2 interactions.
IntActiP35321. 2 interactions.
STRINGi9606.ENSP00000307340.

PTM databases

PhosphoSiteiP35321.

Polymorphism and mutation databases

BioMutaiSPRR1A.
DMDMi215273890.

2D gel databases

UCD-2DPAGEP35321.

Proteomic databases

PaxDbiP35321.
PRIDEiP35321.

Protocols and materials databases

DNASUi6698.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368762; ENSP00000357751; ENSG00000169474.
GeneIDi6698.
KEGGihsa:6698.
UCSCiuc001faw.3. human.

Organism-specific databases

CTDi6698.
GeneCardsiGC01P152956.
H-InvDBHIX0028873.
HGNCiHGNC:11259. SPRR1A.
HPAiCAB011237.
MIMi182265. gene.
neXtProtiNX_P35321.
PharmGKBiPA36088.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG39062.
GeneTreeiENSGT00730000111065.
HOGENOMiHOG000059526.
HOVERGENiHBG079213.
InParanoidiP35321.
OMAiLEPCQPK.
OrthoDBiEOG773XKP.
PhylomeDBiP35321.
TreeFamiTF338205.

Miscellaneous databases

ChiTaRSiSPRR1A. human.
GeneWikiiSPRR1A.
GenomeRNAii6698.
NextBioi26115.
PROiP35321.
SOURCEiSearch...

Gene expression databases

BgeeiP35321.
CleanExiHS_SPRR1A.
GenevisibleiP35321. HS.

Family and domain databases

InterProiIPR003302. Cornifin.
IPR026075. SPRR/LCE.
[Graphical view]
PANTHERiPTHR23263. PTHR23263. 1 hit.
PfamiPF02389. Cornifin. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins."
    Gibbs S., Fijneman R., Wiegant J., Geurts van Kessel A., van de Putte P., Backendorf C.
    Genomics 16:630-637(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS GLN-42 AND ILE-61.
    Tissue: Skin.
  2. "Differential expression of protease inhibitor and small proline-rich protein genes between normal human oral tissue and odontogenic keratocysts."
    Robinson P.A., Marley J.J., High A.S., Hume W.J.
    Arch. Oral Biol. 39:251-259(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. NIEHS SNPs program
    Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS GLN-42 AND ILE-61.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLN-42 AND ILE-61.
  7. "The pancornulins: a group of small proline rich-related cornified envelope precursors with bifunctional capabilities in isopeptide bond formation."
    Greco M.A., Lorand L., Lane W.S., Baden H.P., Parameswaran K.N.P., Kvedar J.C.
    J. Invest. Dermatol. 104:204-210(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 8-31 AND 53-85.
    Tissue: Keratinocyte.

Entry informationi

Entry nameiSPR1A_HUMAN
AccessioniPrimary (citable) accession number: P35321
Secondary accession number(s): B1AN47
, D3DV31, Q2M303, Q9UDG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: November 25, 2008
Last modified: June 24, 2015
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.