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Protein

Sodium/potassium-transporting ATPase subunit alpha

Gene
N/A
Organism
Hydra vulgaris (Hydra) (Hydra attenuata)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

Catalytic activityi

ATP + H2O + Na+(In) + K+(Out) = ADP + phosphate + Na+(Out) + K+(In).

Enzyme regulationi

This alpha subunit is resistant to ouabain.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei3824-aspartylphosphate intermediateCurated1
Binding sitei512ATPBy similarity1
Metal bindingi725MagnesiumBy similarity1
Metal bindingi729MagnesiumBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit alpha (EC:3.6.3.9)
Short name:
Na(+)/K(+) ATPase alpha subunit
Alternative name(s):
Sodium pump subunit alpha
OrganismiHydra vulgaris (Hydra) (Hydra attenuata)
Taxonomic identifieri6087 [NCBI]
Taxonomic lineageiEukaryotaMetazoaCnidariaHydrozoaHydroidolinaAnthoathecataAplanulataHydridaeHydra

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei102 – 123HelicalBy similarityAdd BLAST22
Transmembranei136 – 155HelicalBy similarityAdd BLAST20
Transmembranei297 – 319HelicalBy similarityAdd BLAST23
Transmembranei326 – 354HelicalBy similarityAdd BLAST29
Transmembranei795 – 818HelicalBy similarityAdd BLAST24
Transmembranei857 – 882HelicalBy similarityAdd BLAST26
Transmembranei924 – 944HelicalBy similarityAdd BLAST21
Transmembranei961 – 986HelicalBy similarityAdd BLAST26

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000463081 – 1031Sodium/potassium-transporting ATPase subunit alphaAdd BLAST1031

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP35317.

Interactioni

Subunit structurei

Composed of three subunits: alpha (catalytic), beta and gamma.

Structurei

3D structure databases

ProteinModelPortaliP35317.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK01539.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR005775. P-type_ATPase_IIC.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35317-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADPGDLESR GKADSYSVAE KKSAPKKISK KNANKAKLED LKKELEMTEH
60 70 80 90 100
SMKLESLLSM YETSLEKGLS ENIVARNLER DGLNALTPPK QTPEWVKFCK
110 120 130 140 150
QMFGGFSMLL WIGAILCFFA FGIRAVRDTN PNMDELYLGI VLSVVVIITG
160 170 180 190 200
CFSYYQESKS SKIMESFKKM IPQEALVLRD GKKITINAEQ CVVGDVVFVK
210 220 230 240 250
FGDRIPADIR IVECKGLKVD NSSLTGESEP QSRAVDFTHE NPIETKNLAF
260 270 280 290 300
FSTNAVEGTA TGIVVRIGDN TVMGRIANLA SGLGSGKTPI ALEIEHFIHI
310 320 330 340 350
VTGVAVFLGV SFLIISLAMG YHWLEAIIFL IGIIVANVPE GLLATVTVCL
360 370 380 390 400
TLTAKKMAKK NCLVKHLEAV ETLGSTSVIC SDKTGTLTQN RMTVAHMWFD
410 420 430 440 450
KMIVEADTTE DQSGIAHDKG SLTWKSLAKV AALCSRAEFK PNQNDVAVLR
460 470 480 490 500
KECTGDASET AILKFVELSV GNVMDIRAKN KKVTEIPFNS TNKYQVSVHE
510 520 530 540 550
QENSSGYLLV MKGAPEKVLE RCSTILINGE EQPLKDDVIE IYNKAYDELG
560 570 580 590 600
GLGERVLGFC HYYLPVDQYP KGFLFKTEEE QNFPLEGLCF LGLLSMIDPP
610 620 630 640 650
RAAVPDAVSK CRSAGIKVIM VTGDHPITAK AIAKGVGIIS EGNECEEDIA
660 670 680 690 700
LRLNIPLEDL SEDQKKSAKA CVIHGAKLKD IKNEELDKIL CDHTEIVFAR
710 720 730 740 750
TSPQQKLIIV EGCQRQGAIV AVTGDGVNDS PALKKADIGV AMGIAGSDVS
760 770 780 790 800
KQAADMILLD DNFASIVTGV EEGRLIFDNL KKSIVYTLTS NIPEISPFLM
810 820 830 840 850
FILFGIPLPL GTITILCIDL GTDMVPAISL AYEKAESDIM KRHPRNPIRD
860 870 880 890 900
KLVNERLISL AYGQIGMMQA TAGFFTYFII LAENGFLPSY LFGLRSQWDD
910 920 930 940 950
MSNNNLLDSF GSEWTYFQRK EIELTCQTAF FTTIVVVQWA DLIISKTRRL
960 970 980 990 1000
SLFQQGMTNW FLNFGLFFET ALAAFLQYTP GVNTGLRLRP MNFTWWLPGL
1010 1020 1030
PFSLLIFVYD EIRRYLLRKN PGGWVEKETY Y
Length:1,031
Mass (Da):114,161
Last modified:February 1, 1994 - v1
Checksum:iD2F4A07B811B356F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M75140 mRNA. Translation: AAA29207.1.
RefSeqiNP_001296716.1. NM_001309787.1.
UniGeneiHma.2843.

Genome annotation databases

GeneIDi105846521.
KEGGihmg:105846521.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M75140 mRNA. Translation: AAA29207.1.
RefSeqiNP_001296716.1. NM_001309787.1.
UniGeneiHma.2843.

3D structure databases

ProteinModelPortaliP35317.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP35317.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi105846521.
KEGGihmg:105846521.

Phylogenomic databases

KOiK01539.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR005775. P-type_ATPase_IIC.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAT1A_HYDVU
AccessioniPrimary (citable) accession number: P35317
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 2, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.