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P35317

- AT1A_HYDVU

UniProt

P35317 - AT1A_HYDVU

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Protein
Sodium/potassium-transporting ATPase subunit alpha
Gene
N/A
Organism
Hydra vulgaris (Hydra) (Hydra attenuata)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

Catalytic activityi

ATP + H2O + Na+(In) + K+(Out) = ADP + phosphate + Na+(Out) + K+(In).

Enzyme regulationi

This alpha subunit is resistant to ouabain.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei382 – 38214-aspartylphosphate intermediate Inferred
Binding sitei512 – 5121ATP By similarity
Metal bindingi725 – 7251Magnesium By similarity
Metal bindingi729 – 7291Magnesium By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sodium:potassium-exchanging ATPase activity Source: UniProtKB-EC

GO - Biological processi

  1. ATP biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit alpha (EC:3.6.3.9)
Short name:
Na(+)/K(+) ATPase alpha subunit
Alternative name(s):
Sodium pump subunit alpha
OrganismiHydra vulgaris (Hydra) (Hydra attenuata)
Taxonomic identifieri6087 [NCBI]
Taxonomic lineageiEukaryotaMetazoaCnidariaHydrozoaHydroidaAnthomedusaeHydridaeHydra

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei102 – 12322Helical; By similarity
Add
BLAST
Transmembranei136 – 15520Helical; By similarity
Add
BLAST
Transmembranei297 – 31923Helical; By similarity
Add
BLAST
Transmembranei326 – 35429Helical; By similarity
Add
BLAST
Transmembranei795 – 81824Helical; By similarity
Add
BLAST
Transmembranei857 – 88226Helical; By similarity
Add
BLAST
Transmembranei924 – 94421Helical; By similarity
Add
BLAST
Transmembranei961 – 98626Helical; By similarity
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10311031Sodium/potassium-transporting ATPase subunit alpha
PRO_0000046308Add
BLAST

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP35317.

Interactioni

Subunit structurei

Composed of three subunits: alpha (catalytic), beta and gamma.

Structurei

3D structure databases

ProteinModelPortaliP35317.
SMRiP35317. Positions 38-1031.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35317-1 [UniParc]FASTAAdd to Basket

« Hide

MADPGDLESR GKADSYSVAE KKSAPKKISK KNANKAKLED LKKELEMTEH     50
SMKLESLLSM YETSLEKGLS ENIVARNLER DGLNALTPPK QTPEWVKFCK 100
QMFGGFSMLL WIGAILCFFA FGIRAVRDTN PNMDELYLGI VLSVVVIITG 150
CFSYYQESKS SKIMESFKKM IPQEALVLRD GKKITINAEQ CVVGDVVFVK 200
FGDRIPADIR IVECKGLKVD NSSLTGESEP QSRAVDFTHE NPIETKNLAF 250
FSTNAVEGTA TGIVVRIGDN TVMGRIANLA SGLGSGKTPI ALEIEHFIHI 300
VTGVAVFLGV SFLIISLAMG YHWLEAIIFL IGIIVANVPE GLLATVTVCL 350
TLTAKKMAKK NCLVKHLEAV ETLGSTSVIC SDKTGTLTQN RMTVAHMWFD 400
KMIVEADTTE DQSGIAHDKG SLTWKSLAKV AALCSRAEFK PNQNDVAVLR 450
KECTGDASET AILKFVELSV GNVMDIRAKN KKVTEIPFNS TNKYQVSVHE 500
QENSSGYLLV MKGAPEKVLE RCSTILINGE EQPLKDDVIE IYNKAYDELG 550
GLGERVLGFC HYYLPVDQYP KGFLFKTEEE QNFPLEGLCF LGLLSMIDPP 600
RAAVPDAVSK CRSAGIKVIM VTGDHPITAK AIAKGVGIIS EGNECEEDIA 650
LRLNIPLEDL SEDQKKSAKA CVIHGAKLKD IKNEELDKIL CDHTEIVFAR 700
TSPQQKLIIV EGCQRQGAIV AVTGDGVNDS PALKKADIGV AMGIAGSDVS 750
KQAADMILLD DNFASIVTGV EEGRLIFDNL KKSIVYTLTS NIPEISPFLM 800
FILFGIPLPL GTITILCIDL GTDMVPAISL AYEKAESDIM KRHPRNPIRD 850
KLVNERLISL AYGQIGMMQA TAGFFTYFII LAENGFLPSY LFGLRSQWDD 900
MSNNNLLDSF GSEWTYFQRK EIELTCQTAF FTTIVVVQWA DLIISKTRRL 950
SLFQQGMTNW FLNFGLFFET ALAAFLQYTP GVNTGLRLRP MNFTWWLPGL 1000
PFSLLIFVYD EIRRYLLRKN PGGWVEKETY Y 1031
Length:1,031
Mass (Da):114,161
Last modified:February 1, 1994 - v1
Checksum:iD2F4A07B811B356F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M75140 mRNA. Translation: AAA29207.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M75140 mRNA. Translation: AAA29207.1 .

3D structure databases

ProteinModelPortali P35317.
SMRi P35317. Positions 38-1031.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P35317.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProi IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view ]
Pfami PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view ]
PRINTSi PR00119. CATATPASE.
SMARTi SM00831. Cation_ATPase_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsi TIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and characterization of Na,K-ATPase from Hydra vulgaris: implications for enzyme evolution and ouabain sensitivity."
    Canfield V.A., Xu K.Y., D'Aquila T., Shyjan A.W., Levenson R.
    New Biol. 4:339-348(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiAT1A_HYDVU
AccessioniPrimary (citable) accession number: P35317
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: April 16, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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