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P35315 (ATC_TRYBB) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable calcium-transporting ATPase
EC=3.6.3.8
Alternative name(s):
Calcium pump
Gene names
Name:TBA1
OrganismTrypanosoma brucei brucei
Taxonomic identifier5702 [NCBI]
Taxonomic lineageEukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Trypanosoma

Protein attributes

Sequence length1011 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium By similarity.

Catalytic activity

ATP + H2O + Ca2+[side 1] = ADP + phosphate + Ca2+[side 2].

Subcellular location

Flagellar pocket. Cell membrane; Multi-pass membrane protein. Note: May be located in the flagellar pocket of the membrane.

Sequence similarities

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10111011Probable calcium-transporting ATPase
PRO_0000046228

Regions

Topological domain1 – 6565Cytoplasmic Potential
Transmembrane66 – 8419Helical; Potential
Topological domain85 – 906Extracellular Potential
Transmembrane91 – 11020Helical; Potential
Topological domain111 – 258148Cytoplasmic Potential
Transmembrane259 – 27820Helical; Potential
Topological domain279 – 30325Extracellular Potential
Transmembrane304 – 32118Helical; Potential
Topological domain322 – 770449Cytoplasmic Potential
Transmembrane771 – 79424Helical; Potential
Topological domain795 – 83541Extracellular Potential
Transmembrane836 – 85621Helical; Potential
Topological domain857 – 88529Cytoplasmic Potential
Transmembrane886 – 90520Helical; Potential
Topological domain906 – 92217Extracellular Potential
Transmembrane923 – 94220Helical; Potential
Topological domain943 – 101169Cytoplasmic Potential

Sites

Active site35714-aspartylphosphate intermediate By similarity
Binding site5141ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P35315 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 4F2103FED2A7D5D0

FASTA1,011110,314
        10         20         30         40         50         60 
MLPENLPTDP AAMTPAAVAA ALRVDTKVGL SSNEVEERRQ AFGINELPSE PPTPFWKLVL 

        70         80         90        100        110        120 
AQFEDTLVRI LLLAATVSFA MAVVENNAAD FVEPFIILLI LILNATVGVW QENRAEGAIE 

       130        140        150        160        170        180 
ALKSFVPKTA VVLRDGDIKT VNAEELVPGD VVEVAVGNRV PADMRVVELH STTLRADQSI 

       190        200        210        220        230        240 
LNGESVEAMK QIEAVKGRQE RFPACMVYSG TAIVYGKALC VVVRTGASTE IGTIERDVRE 

       250        260        270        280        290        300 
QEEVKTPLQV KLDEFGVLLS KVIGYICLVV FAVNLVRWYA THKPTKNETF FTRYIQPSVH 

       310        320        330        340        350        360 
CLKVAVALAV AAIPEGLPAV VTTCLALGTR RMAQHNALVR DLPSVETLGR CTVICSDKTG 

       370        380        390        400        410        420 
TLTTNMMSVL HAFTLKGDGS IKEYELKDSR FNIVSNSVTC EGRQVSSPLE QDGALTKLAN 

       430        440        450        460        470        480 
IAVLCNDASL HHNAATVQVE KIGEATEAAL LVMSEKFANI KGDSAVNAFR TLCEGKWKKN 

       490        500        510        520        530        540 
ATLEFTRKRK SMSVHVTSTV TGSPASSTNN LFVKGAPEEV LRRSTHVMQD NGAVVQLSAT 

       550        560        570        580        590        600 
HRKRIIEQLD KISGGANALR CIGFAFKPTK AVQHVRLNDP ATFEDVESDL TFVGACGMLD 

       610        620        630        640        650        660 
PPREEVRDAI VKCRTAGIRV VVITGDRKET AEAICCKLGL LSSTADTTGL SYTGQELDAM 

       670        680        690        700        710        720 
TPAQKREAVL TAVLFSRTDP SHKMQLVQLL KDERLICAMT GDGVNDAPAL KKADIGIAMG 

       730        740        750        760        770        780 
SGTEVAKSAS KMVLADDNFA TVVKAVQEGR AIYNNTKQFI RYLISSNIGE VVCILVTGLF 

       790        800        810        820        830        840 
GLPEALSPVQ LLWVNLVTDG LPATALGFNA PDRDIMEQRP RRMEEPIVNG WLFMRYMVIG 

       850        860        870        880        890        900 
VYVGLATVGG FLWWFLRHGF SWHDLTTYTA CSDMTNGTCL LLANPQTARA IALSILVVVE 

       910        920        930        940        950        960 
MLNALNALSE NASLIVSRPS SNVWLLFAIF SSLSLHLIIM YVPFFAKLFN IVPLGVDPHV 

       970        980        990       1000       1010 
VQQAQPWSIL TPTNFDDWKA VIVFSVPVIF LDELLKFITR RMEKAQEKKK D

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References

[1]"Structure and transcription of a P-ATPase gene from Trypanosoma brucei."
Revelard P., Pays E.
Mol. Biochem. Parasitol. 46:241-251(1991) [PubMed: 1833643] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M73769 Genomic DNA. Translation: AAA30227.1.

3D structure databases

ProteinModelPortalP35315.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR023306. ATPase_cation_domN.
IPR008250. ATPase_P-typ_ATPase-assoc-dom.
IPR005782. ATPase_P-typ_Ca-transp.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023300. ATPase_P-typ_cyto_domA.
IPR023299. ATPase_P-typ_cyto_domN.
IPR001757. ATPase_P-typ_ion-transptr.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR005834. Dehalogen-like_hydro.
IPR023214. HAD-like_dom.
[Graphical view]
Gene3DG3DSA:2.70.150.10. ATPase_P-typ_cyto_domA. 2 hits.
G3DSA:3.40.1110.10. ATPase_P-typ_cyto_domN. 1 hit.
G3DSA:1.20.1110.10. ATPase_P-typ_TM_dom. 2 hits.
PfamPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSPR00119. CATATPASE.
SMARTSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMSSF81660. ATPase_cation_domN. 1 hit.
SSF56784. HAD-like_dom. 1 hit.
TIGRFAMsTIGR01116. ATPase-IIA1_Ca. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameATC_TRYBB
AccessionPrimary (citable) accession number: P35315
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: January 25, 2012
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

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