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P35295

- RAB20_MOUSE

UniProt

P35295 - RAB20_MOUSE

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Protein

Ras-related protein Rab-20

Gene

Rab20

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium. Plays a role in the fusion of phagosomes with lysosomes (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 198GTPBy similarity
Nucleotide bindingi55 – 595GTPBy similarity
Nucleotide bindingi113 – 1164GTPBy similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW

GO - Biological processi

  1. phagosome acidification Source: UniProtKB
  2. phagosome-lysosome fusion Source: UniProtKB
  3. protein transport Source: UniProtKB-KW
  4. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-20
Gene namesi
Name:Rab20
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:102789. Rab20.

Subcellular locationi

Golgi apparatus By similarity. Cytoplasmic vesiclephagosome By similarity. Cytoplasmic vesiclephagosome membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity
Note: Recruited to phagosomes containing S.aureus or Mycobacterium (By similarity). Highly enriched on apical endocytic structures in polarized epithelial cells of kidney proximal tubules.By similarity

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
  3. phagocytic vesicle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 233233Ras-related protein Rab-20PRO_0000121203Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi231 – 2311S-geranylgeranyl cysteineBy similarity
Lipidationi232 – 2321S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Prenylation

Proteomic databases

PRIDEiP35295.

PTM databases

PhosphoSiteiP35295.

Expressioni

Tissue specificityi

Present in a variety of tissues, but not in brain.

Gene expression databases

BgeeiP35295.
CleanExiMM_RAB20.
ExpressionAtlasiP35295. baseline and differential.
GenevestigatoriP35295.

Structurei

3D structure databases

ProteinModelPortaliP35295.
SMRiP35295. Positions 7-193.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi33 – 419Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiCOG1100.
HOGENOMiHOG000233968.
HOVERGENiHBG097927.
InParanoidiP35295.
KOiK07911.
OMAiMRKPDGK.
OrthoDBiEOG78D7MT.
PhylomeDBiP35295.
TreeFamiTF331574.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SUPFAMiSSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35295 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRKPDGKIVL LGDMNVGKTS LLQRYMERRF PDTVSTVGGA FYLKQWRSFN
60 70 80 90 100
ISIWDTAGRE QFHGLGSLYC RGAAAIILTY DVNHPQSLFE LEDRFLGLTE
110 120 130 140 150
TANNDCLFAI VGNKVDLTSE RDTEGGEKEG PASGKVGSCV STKVPKQVQP
160 170 180 190 200
EDAVALYKKI LKYKMLDERE MPAAEQMCFE TSAKTGYNVD LLFETLFDLV
210 220 230
VPMIMRQRAE ESDQTVDIAS CKTPKQTRSG CCA
Length:233
Mass (Da):25,989
Last modified:October 1, 1996 - v2
Checksum:i3A2E70A18D5280A9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X80332 mRNA. Translation: CAA56582.1.
M79310 mRNA. Translation: AAK14834.1.
CCDSiCCDS22095.1.
PIRiI48728. S46950.
RefSeqiNP_035357.1. NM_011227.1.
UniGeneiMm.37632.
Mm.390014.

Genome annotation databases

EnsembliENSMUST00000033900; ENSMUSP00000033900; ENSMUSG00000031504.
GeneIDi19332.
KEGGimmu:19332.
UCSCiuc009kvd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X80332 mRNA. Translation: CAA56582.1 .
M79310 mRNA. Translation: AAK14834.1 .
CCDSi CCDS22095.1.
PIRi I48728. S46950.
RefSeqi NP_035357.1. NM_011227.1.
UniGenei Mm.37632.
Mm.390014.

3D structure databases

ProteinModelPortali P35295.
SMRi P35295. Positions 7-193.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P35295.

Proteomic databases

PRIDEi P35295.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033900 ; ENSMUSP00000033900 ; ENSMUSG00000031504 .
GeneIDi 19332.
KEGGi mmu:19332.
UCSCi uc009kvd.1. mouse.

Organism-specific databases

CTDi 55647.
MGIi MGI:102789. Rab20.

Phylogenomic databases

eggNOGi COG1100.
HOGENOMi HOG000233968.
HOVERGENi HBG097927.
InParanoidi P35295.
KOi K07911.
OMAi MRKPDGK.
OrthoDBi EOG78D7MT.
PhylomeDBi P35295.
TreeFami TF331574.

Miscellaneous databases

ChiTaRSi RAB20. mouse.
NextBioi 296315.
PROi P35295.
SOURCEi Search...

Gene expression databases

Bgeei P35295.
CleanExi MM_RAB20.
ExpressionAtlasi P35295. baseline and differential.
Genevestigatori P35295.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SUPFAMi SSF52540. SSF52540. 2 hits.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51419. RAB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and subcellular localization of novel rab proteins reveals polarized and cell type-specific expression."
    Luetcke A., Parton R.G., Murphy C., Olkkonen V.M., Dupree P., Valencia A., Simons K., Zerial M.
    J. Cell Sci. 107:3437-3448(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.
  2. "The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach."
    Chavrier P., Simons K., Zerial M.
    Gene 112:261-264(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-60.
    Tissue: Kidney.

Entry informationi

Entry nameiRAB20_MOUSE
AccessioniPrimary (citable) accession number: P35295
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3