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Protein

Ras-related protein Rab-20

Gene

Rab20

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium. Plays a role in the fusion of phagosomes with lysosomes (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 19GTPBy similarity8
Nucleotide bindingi55 – 59GTPBy similarity5
Nucleotide bindingi113 – 116GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-20
Gene namesi
Name:Rab20
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:102789. Rab20.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001212031 – 233Ras-related protein Rab-20Add BLAST233

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi231S-geranylgeranyl cysteineBy similarity1
Lipidationi232S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Prenylation

Proteomic databases

PaxDbiP35295.
PRIDEiP35295.

PTM databases

iPTMnetiP35295.
PhosphoSitePlusiP35295.

Expressioni

Tissue specificityi

Present in a variety of tissues, but not in brain.

Gene expression databases

BgeeiENSMUSG00000031504.
CleanExiMM_RAB20.
ExpressionAtlasiP35295. baseline and differential.
GenevisibleiP35295. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033900.

Structurei

3D structure databases

ProteinModelPortaliP35295.
SMRiP35295.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi33 – 41Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0092. Eukaryota.
ENOG410YCCP. LUCA.
GeneTreeiENSGT00760000119101.
HOGENOMiHOG000233968.
HOVERGENiHBG097927.
InParanoidiP35295.
KOiK07911.
OMAiHRYMERR.
OrthoDBiEOG091G0XVL.
PhylomeDBiP35295.
TreeFamiTF331574.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
PfamiView protein in Pfam
PF00071. Ras. 1 hit.
SUPFAMiSSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51419. RAB. 1 hit.

Sequencei

Sequence statusi: Complete.

P35295-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKPDGKIVL LGDMNVGKTS LLQRYMERRF PDTVSTVGGA FYLKQWRSFN
60 70 80 90 100
ISIWDTAGRE QFHGLGSLYC RGAAAIILTY DVNHPQSLFE LEDRFLGLTE
110 120 130 140 150
TANNDCLFAI VGNKVDLTSE RDTEGGEKEG PASGKVGSCV STKVPKQVQP
160 170 180 190 200
EDAVALYKKI LKYKMLDERE MPAAEQMCFE TSAKTGYNVD LLFETLFDLV
210 220 230
VPMIMRQRAE ESDQTVDIAS CKTPKQTRSG CCA
Length:233
Mass (Da):25,989
Last modified:October 1, 1996 - v2
Checksum:i3A2E70A18D5280A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80332 mRNA. Translation: CAA56582.1.
M79310 mRNA. Translation: AAK14834.1.
CCDSiCCDS22095.1.
PIRiI48728. S46950.
RefSeqiNP_035357.1. NM_011227.1.
UniGeneiMm.37632.
Mm.390014.

Genome annotation databases

EnsembliENSMUST00000033900; ENSMUSP00000033900; ENSMUSG00000031504.
GeneIDi19332.
KEGGimmu:19332.
UCSCiuc009kvd.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiRAB20_MOUSE
AccessioniPrimary (citable) accession number: P35295
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: October 1, 1996
Last modified: August 30, 2017
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families