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P35295

- RAB20_MOUSE

UniProt

P35295 - RAB20_MOUSE

Protein

Ras-related protein Rab-20

Gene

Rab20

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 2 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium. Plays a role in the fusion of phagosomes with lysosomes By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi12 – 198GTPBy similarity
    Nucleotide bindingi55 – 595GTPBy similarity
    Nucleotide bindingi113 – 1164GTPBy similarity

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW

    GO - Biological processi

    1. phagosome acidification Source: UniProtKB
    2. phagosome-lysosome fusion Source: UniProtKB
    3. protein transport Source: UniProtKB-KW
    4. small GTPase mediated signal transduction Source: InterPro

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras-related protein Rab-20
    Gene namesi
    Name:Rab20
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:102789. Rab20.

    Subcellular locationi

    Golgi apparatus By similarity. Cytoplasmic vesiclephagosome By similarity. Cytoplasmic vesiclephagosome membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity
    Note: Recruited to phagosomes containing S.aureus or Mycobacterium By similarity. Highly enriched on apical endocytic structures in polarized epithelial cells of kidney proximal tubules.By similarity

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB-SubCell
    2. phagocytic vesicle Source: UniProtKB
    3. phagocytic vesicle membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 233233Ras-related protein Rab-20PRO_0000121203Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi231 – 2311S-geranylgeranyl cysteineBy similarity
    Lipidationi232 – 2321S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Prenylation

    Proteomic databases

    PRIDEiP35295.

    PTM databases

    PhosphoSiteiP35295.

    Expressioni

    Tissue specificityi

    Present in a variety of tissues, but not in brain.

    Gene expression databases

    ArrayExpressiP35295.
    BgeeiP35295.
    CleanExiMM_RAB20.
    GenevestigatoriP35295.

    Structurei

    3D structure databases

    ProteinModelPortaliP35295.
    SMRiP35295. Positions 7-193.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi33 – 419Effector regionBy similarity

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rab family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    HOGENOMiHOG000233968.
    HOVERGENiHBG097927.
    InParanoidiP35295.
    KOiK07911.
    OMAiMRKPDGK.
    OrthoDBiEOG78D7MT.
    PhylomeDBiP35295.
    TreeFamiTF331574.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SUPFAMiSSF52540. SSF52540. 2 hits.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51419. RAB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P35295-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRKPDGKIVL LGDMNVGKTS LLQRYMERRF PDTVSTVGGA FYLKQWRSFN    50
    ISIWDTAGRE QFHGLGSLYC RGAAAIILTY DVNHPQSLFE LEDRFLGLTE 100
    TANNDCLFAI VGNKVDLTSE RDTEGGEKEG PASGKVGSCV STKVPKQVQP 150
    EDAVALYKKI LKYKMLDERE MPAAEQMCFE TSAKTGYNVD LLFETLFDLV 200
    VPMIMRQRAE ESDQTVDIAS CKTPKQTRSG CCA 233
    Length:233
    Mass (Da):25,989
    Last modified:October 1, 1996 - v2
    Checksum:i3A2E70A18D5280A9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X80332 mRNA. Translation: CAA56582.1.
    M79310 mRNA. Translation: AAK14834.1.
    CCDSiCCDS22095.1.
    PIRiI48728. S46950.
    RefSeqiNP_035357.1. NM_011227.1.
    UniGeneiMm.37632.
    Mm.390014.

    Genome annotation databases

    EnsembliENSMUST00000033900; ENSMUSP00000033900; ENSMUSG00000031504.
    GeneIDi19332.
    KEGGimmu:19332.
    UCSCiuc009kvd.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X80332 mRNA. Translation: CAA56582.1 .
    M79310 mRNA. Translation: AAK14834.1 .
    CCDSi CCDS22095.1.
    PIRi I48728. S46950.
    RefSeqi NP_035357.1. NM_011227.1.
    UniGenei Mm.37632.
    Mm.390014.

    3D structure databases

    ProteinModelPortali P35295.
    SMRi P35295. Positions 7-193.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P35295.

    Proteomic databases

    PRIDEi P35295.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000033900 ; ENSMUSP00000033900 ; ENSMUSG00000031504 .
    GeneIDi 19332.
    KEGGi mmu:19332.
    UCSCi uc009kvd.1. mouse.

    Organism-specific databases

    CTDi 55647.
    MGIi MGI:102789. Rab20.

    Phylogenomic databases

    eggNOGi COG1100.
    HOGENOMi HOG000233968.
    HOVERGENi HBG097927.
    InParanoidi P35295.
    KOi K07911.
    OMAi MRKPDGK.
    OrthoDBi EOG78D7MT.
    PhylomeDBi P35295.
    TreeFami TF331574.

    Miscellaneous databases

    ChiTaRSi RAB20. mouse.
    NextBioi 296315.
    PROi P35295.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P35295.
    Bgeei P35295.
    CleanExi MM_RAB20.
    Genevestigatori P35295.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SUPFAMi SSF52540. SSF52540. 2 hits.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and subcellular localization of novel rab proteins reveals polarized and cell type-specific expression."
      Luetcke A., Parton R.G., Murphy C., Olkkonen V.M., Dupree P., Valencia A., Simons K., Zerial M.
      J. Cell Sci. 107:3437-3448(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Kidney.
    2. "The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach."
      Chavrier P., Simons K., Zerial M.
      Gene 112:261-264(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-60.
      Tissue: Kidney.

    Entry informationi

    Entry nameiRAB20_MOUSE
    AccessioniPrimary (citable) accession number: P35295
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 112 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3