Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P35295 (RAB20_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ras-related protein Rab-20
Gene names
Name:Rab20
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length233 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium. Plays a role in the fusion of phagosomes with lysosomes By similarity.

Subcellular location

Golgi apparatus By similarity. Cytoplasmic vesiclephagosome By similarity. Cytoplasmic vesiclephagosome membrane; Lipid-anchor; Cytoplasmic side By similarity. Note: Recruited to phagosomes containing S.aureus or Mycobacterium By similarity. Highly enriched on apical endocytic structures in polarized epithelial cells of kidney proximal tubules.

Tissue specificity

Present in a variety of tissues, but not in brain.

Sequence similarities

Belongs to the small GTPase superfamily. Rab family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 233233Ras-related protein Rab-20
PRO_0000121203

Regions

Nucleotide binding12 – 198GTP By similarity
Nucleotide binding55 – 595GTP By similarity
Nucleotide binding113 – 1164GTP By similarity
Motif33 – 419Effector region By similarity

Amino acid modifications

Lipidation2311S-geranylgeranyl cysteine By similarity
Lipidation2321S-geranylgeranyl cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
P35295 [UniParc].

Last modified October 1, 1996. Version 2.
Checksum: 3A2E70A18D5280A9

FASTA23325,989
        10         20         30         40         50         60 
MRKPDGKIVL LGDMNVGKTS LLQRYMERRF PDTVSTVGGA FYLKQWRSFN ISIWDTAGRE 

        70         80         90        100        110        120 
QFHGLGSLYC RGAAAIILTY DVNHPQSLFE LEDRFLGLTE TANNDCLFAI VGNKVDLTSE 

       130        140        150        160        170        180 
RDTEGGEKEG PASGKVGSCV STKVPKQVQP EDAVALYKKI LKYKMLDERE MPAAEQMCFE 

       190        200        210        220        230 
TSAKTGYNVD LLFETLFDLV VPMIMRQRAE ESDQTVDIAS CKTPKQTRSG CCA 

« Hide

References

[1]"Cloning and subcellular localization of novel rab proteins reveals polarized and cell type-specific expression."
Luetcke A., Parton R.G., Murphy C., Olkkonen V.M., Dupree P., Valencia A., Simons K., Zerial M.
J. Cell Sci. 107:3437-3448(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Kidney.
[2]"The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach."
Chavrier P., Simons K., Zerial M.
Gene 112:261-264(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-60.
Tissue: Kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X80332 mRNA. Translation: CAA56582.1.
M79310 mRNA. Translation: AAK14834.1.
PIRS46950. I48728.
RefSeqNP_035357.1. NM_011227.1.
UniGeneMm.37632.
Mm.390014.

3D structure databases

ProteinModelPortalP35295.
SMRP35295. Positions 5-232.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP35295.

Proteomic databases

PRIDEP35295.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000033900; ENSMUSP00000033900; ENSMUSG00000031504.
GeneID19332.
KEGGmmu:19332.
UCSCuc009kvd.1. mouse.

Organism-specific databases

CTD55647.
MGIMGI:102789. Rab20.

Phylogenomic databases

eggNOGCOG1100.
HOGENOMHOG000233968.
HOVERGENHBG097927.
InParanoidP35295.
KOK07911.
OMAMRKPDGK.
OrthoDBEOG78D7MT.
PhylomeDBP35295.
TreeFamTF331574.

Gene expression databases

ArrayExpressP35295.
BgeeP35295.
CleanExMM_RAB20.
GenevestigatorP35295.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamPF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SUPFAMSSF52540. SSF52540. 2 hits.
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSRAB20. mouse.
NextBio296315.
PROP35295.
SOURCESearch...

Entry information

Entry nameRAB20_MOUSE
AccessionPrimary (citable) accession number: P35295
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot