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Protein

Ras-related protein Rab-18

Gene

Rab18

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes. Plays a key role in eye and brain development and neurodegeneration (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 23GTPBy similarity9
Nucleotide bindingi63 – 67GTPBy similarity5
Nucleotide bindingi122 – 125GTPBy similarity4
Nucleotide bindingi151 – 153GTPBy similarity3

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.
R-MMU-6811436. COPI-independent Golgi-to-ER retrograde traffic.
R-MMU-8876198. RAB GEFs exchange GTP for GDP on RABs.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-18
Gene namesi
Name:Rab18
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:102790. Rab18.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001211941 – 203Ras-related protein Rab-18Add BLAST203
PropeptideiPRO_0000370762204 – 206Removed in mature formSequence analysis3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei144PhosphoserineCombined sources1
Lipidationi199S-palmitoyl cysteineSequence analysis1
Modified residuei203Cysteine methyl esterSequence analysis1
Lipidationi203S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Palmitate, Phosphoprotein, Prenylation

Proteomic databases

EPDiP35293.
PaxDbiP35293.
PeptideAtlasiP35293.
PRIDEiP35293.

PTM databases

iPTMnetiP35293.
PhosphoSitePlusiP35293.
SwissPalmiP35293.

Expressioni

Tissue specificityi

Expression is high in the brain, moderate in the pituitary, and low in the liver. Detected in all tissues.

Gene expression databases

BgeeiENSMUSG00000073639.
CleanExiMM_RAB18.
ExpressionAtlasiP35293. baseline and differential.
GenevisibleiP35293. MM.

Interactioni

Protein-protein interaction databases

BioGridi202536. 1 interactor.
IntActiP35293. 11 interactors.
MINTiMINT-1864434.
STRINGi10090.ENSMUSP00000095285.

Structurei

3D structure databases

ProteinModelPortaliP35293.
SMRiP35293.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi37 – 45Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0080. Eukaryota.
ENOG410XPD0. LUCA.
GeneTreeiENSGT00860000133677.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP35293.
KOiK07910.
OMAiRKIMETD.
OrthoDBiEOG091G0MOO.
PhylomeDBiP35293.
TreeFamiTF313448.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35293-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEDVLTTLK ILIIGESGVG KSSLLLRFTD DTFDPELAAT IGVDFKVKTI
60 70 80 90 100
SVDGNKAKLA IWDTAGQERF RTLTPSYYRG AQGVILVYDV TRRDTFVKLD
110 120 130 140 150
NWLNELETYC TRNDIVNMLV GNKIDKENRE VDRNEGLKFA RKHSMLFIEA
160 170 180 190 200
SAKTCDGVQC AFEELVEKII QTPGLWESEN QNKGVKLSHR EESRGGGACG

GYCSVL
Length:206
Mass (Da):23,035
Last modified:October 1, 1996 - v2
Checksum:iD1B0F48666999B77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80333 mRNA. Translation: CAA56583.1.
L04966 mRNA. Translation: AAC37632.1.
AK045514 mRNA. Translation: BAC32402.1.
AK140901 mRNA. Translation: BAE24512.1.
AK143673 mRNA. Translation: BAE25489.1.
AK146177 mRNA. Translation: BAE26955.1.
AK146397 mRNA. Translation: BAE27140.1.
AK154920 mRNA. Translation: BAE32926.1.
BC056351 mRNA. Translation: AAH56351.1.
M79308 mRNA. Translation: AAK14832.1.
CCDSiCCDS29044.1.
PIRiJN0874.
RefSeqiNP_851415.1. NM_181070.6.
UniGeneiMm.132802.

Genome annotation databases

EnsembliENSMUST00000097680; ENSMUSP00000095285; ENSMUSG00000073639.
GeneIDi19330.
KEGGimmu:19330.
UCSCiuc008dzo.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80333 mRNA. Translation: CAA56583.1.
L04966 mRNA. Translation: AAC37632.1.
AK045514 mRNA. Translation: BAC32402.1.
AK140901 mRNA. Translation: BAE24512.1.
AK143673 mRNA. Translation: BAE25489.1.
AK146177 mRNA. Translation: BAE26955.1.
AK146397 mRNA. Translation: BAE27140.1.
AK154920 mRNA. Translation: BAE32926.1.
BC056351 mRNA. Translation: AAH56351.1.
M79308 mRNA. Translation: AAK14832.1.
CCDSiCCDS29044.1.
PIRiJN0874.
RefSeqiNP_851415.1. NM_181070.6.
UniGeneiMm.132802.

3D structure databases

ProteinModelPortaliP35293.
SMRiP35293.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202536. 1 interactor.
IntActiP35293. 11 interactors.
MINTiMINT-1864434.
STRINGi10090.ENSMUSP00000095285.

PTM databases

iPTMnetiP35293.
PhosphoSitePlusiP35293.
SwissPalmiP35293.

Proteomic databases

EPDiP35293.
PaxDbiP35293.
PeptideAtlasiP35293.
PRIDEiP35293.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000097680; ENSMUSP00000095285; ENSMUSG00000073639.
GeneIDi19330.
KEGGimmu:19330.
UCSCiuc008dzo.2. mouse.

Organism-specific databases

CTDi22931.
MGIiMGI:102790. Rab18.

Phylogenomic databases

eggNOGiKOG0080. Eukaryota.
ENOG410XPD0. LUCA.
GeneTreeiENSGT00860000133677.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP35293.
KOiK07910.
OMAiRKIMETD.
OrthoDBiEOG091G0MOO.
PhylomeDBiP35293.
TreeFamiTF313448.

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.
R-MMU-6811436. COPI-independent Golgi-to-ER retrograde traffic.
R-MMU-8876198. RAB GEFs exchange GTP for GDP on RABs.

Miscellaneous databases

PROiP35293.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000073639.
CleanExiMM_RAB18.
ExpressionAtlasiP35293. baseline and differential.
GenevisibleiP35293. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAB18_MOUSE
AccessioniPrimary (citable) accession number: P35293
Secondary accession number(s): Q543V0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 155 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.