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Protein

Ras-related protein Rab-18

Gene

Rab18

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes. Plays a key role in eye and brain development and neurodegeneration (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 23GTPBy similarity9
Nucleotide bindingi63 – 67GTPBy similarity5
Nucleotide bindingi122 – 125GTPBy similarity4
Nucleotide bindingi151 – 153GTPBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation
R-MMU-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-MMU-8873719 RAB geranylgeranylation
R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-18
Gene namesi
Name:Rab18
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:102790 Rab18

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001211941 – 203Ras-related protein Rab-18Add BLAST203
PropeptideiPRO_0000370762204 – 206Removed in mature formSequence analysis3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei144PhosphoserineCombined sources1
Lipidationi199S-palmitoyl cysteineSequence analysis1
Modified residuei203Cysteine methyl esterSequence analysis1
Lipidationi203S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Palmitate, Phosphoprotein, Prenylation

Proteomic databases

EPDiP35293
PaxDbiP35293
PeptideAtlasiP35293
PRIDEiP35293

PTM databases

iPTMnetiP35293
PhosphoSitePlusiP35293
SwissPalmiP35293

Expressioni

Tissue specificityi

Expression is high in the brain, moderate in the pituitary, and low in the liver. Detected in all tissues.

Gene expression databases

BgeeiENSMUSG00000073639
CleanExiMM_RAB18
ExpressionAtlasiP35293 baseline and differential
GenevisibleiP35293 MM

Interactioni

Protein-protein interaction databases

BioGridi202536, 2 interactors
IntActiP35293, 11 interactors
MINTiP35293
STRINGi10090.ENSMUSP00000095285

Structurei

3D structure databases

ProteinModelPortaliP35293
SMRiP35293
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi37 – 45Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0080 Eukaryota
ENOG410XPD0 LUCA
GeneTreeiENSGT00760000119101
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiP35293
KOiK07910
OMAiCCFEELV
OrthoDBiEOG091G0MOO
PhylomeDBiP35293
TreeFamiTF313448

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR025662 Sigma_54_int_dom_ATP-bd_1
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35293-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEDVLTTLK ILIIGESGVG KSSLLLRFTD DTFDPELAAT IGVDFKVKTI
60 70 80 90 100
SVDGNKAKLA IWDTAGQERF RTLTPSYYRG AQGVILVYDV TRRDTFVKLD
110 120 130 140 150
NWLNELETYC TRNDIVNMLV GNKIDKENRE VDRNEGLKFA RKHSMLFIEA
160 170 180 190 200
SAKTCDGVQC AFEELVEKII QTPGLWESEN QNKGVKLSHR EESRGGGACG

GYCSVL
Length:206
Mass (Da):23,035
Last modified:October 1, 1996 - v2
Checksum:iD1B0F48666999B77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80333 mRNA Translation: CAA56583.1
L04966 mRNA Translation: AAC37632.1
AK045514 mRNA Translation: BAC32402.1
AK140901 mRNA Translation: BAE24512.1
AK143673 mRNA Translation: BAE25489.1
AK146177 mRNA Translation: BAE26955.1
AK146397 mRNA Translation: BAE27140.1
AK154920 mRNA Translation: BAE32926.1
BC056351 mRNA Translation: AAH56351.1
M79308 mRNA Translation: AAK14832.1
CCDSiCCDS29044.1
PIRiJN0874
RefSeqiNP_851415.1, NM_181070.6
UniGeneiMm.132802

Genome annotation databases

EnsembliENSMUST00000097680; ENSMUSP00000095285; ENSMUSG00000073639
GeneIDi19330
KEGGimmu:19330
UCSCiuc008dzo.2 mouse

Similar proteinsi

Entry informationi

Entry nameiRAB18_MOUSE
AccessioniPrimary (citable) accession number: P35293
Secondary accession number(s): Q543V0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 166 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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