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P35293

- RAB18_MOUSE

UniProt

P35293 - RAB18_MOUSE

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Protein

Ras-related protein Rab-18

Gene

Rab18

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes. Plays a key role in eye and brain development and neurodegeneration (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 239GTPBy similarity
Nucleotide bindingi63 – 675GTPBy similarity
Nucleotide bindingi122 – 1254GTPBy similarity
Nucleotide bindingi151 – 1533GTPBy similarity

GO - Molecular functioni

  1. GDP binding Source: UniProtKB
  2. GTP binding Source: UniProtKB-KW

GO - Biological processi

  1. brain development Source: UniProtKB
  2. eye development Source: UniProtKB
  3. lipid particle organization Source: MGI
  4. protein transport Source: UniProtKB-KW
  5. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-18
Gene namesi
Name:Rab18
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:102790. Rab18.

Subcellular locationi

Apical cell membrane Curated; Lipid-anchor Curated. Basal cell membrane Curated; Lipid-anchor Curated
Note: Highly enriched on apical endocytic structures in polarized epithelial cells of kidney proximal tubules. Detected on both the apical and basolateral domains in epithelial cells of the intestine.

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. intracellular Source: Ensembl
  3. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 203203Ras-related protein Rab-18PRO_0000121194Add
BLAST
Propeptidei204 – 2063Removed in mature formSequence AnalysisPRO_0000370762

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Lipidationi199 – 1991S-palmitoyl cysteineSequence Analysis
Modified residuei203 – 2031Cysteine methyl esterSequence Analysis
Lipidationi203 – 2031S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Palmitate, Prenylation

Proteomic databases

MaxQBiP35293.
PaxDbiP35293.
PRIDEiP35293.

PTM databases

PhosphoSiteiP35293.

Expressioni

Tissue specificityi

Expression is high in the brain, moderate in the pituitary, and low in the liver. Detected in all tissues.

Gene expression databases

BgeeiP35293.
CleanExiMM_RAB18.
ExpressionAtlasiP35293. baseline and differential.
GenevestigatoriP35293.

Interactioni

Protein-protein interaction databases

BioGridi202536. 1 interaction.
IntActiP35293. 1 interaction.
MINTiMINT-1864434.

Structurei

3D structure databases

ProteinModelPortaliP35293.
SMRiP35293. Positions 2-178.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi37 – 459Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiCOG1100.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP35293.
KOiK07910.
OMAiTYTTRND.
OrthoDBiEOG7CVQ04.
PhylomeDBiP35293.
TreeFamiTF313448.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35293-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDEDVLTTLK ILIIGESGVG KSSLLLRFTD DTFDPELAAT IGVDFKVKTI
60 70 80 90 100
SVDGNKAKLA IWDTAGQERF RTLTPSYYRG AQGVILVYDV TRRDTFVKLD
110 120 130 140 150
NWLNELETYC TRNDIVNMLV GNKIDKENRE VDRNEGLKFA RKHSMLFIEA
160 170 180 190 200
SAKTCDGVQC AFEELVEKII QTPGLWESEN QNKGVKLSHR EESRGGGACG

GYCSVL
Length:206
Mass (Da):23,035
Last modified:October 1, 1996 - v2
Checksum:iD1B0F48666999B77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80333 mRNA. Translation: CAA56583.1.
L04966 mRNA. Translation: AAC37632.1.
AK045514 mRNA. Translation: BAC32402.1.
AK140901 mRNA. Translation: BAE24512.1.
AK143673 mRNA. Translation: BAE25489.1.
AK146177 mRNA. Translation: BAE26955.1.
AK146397 mRNA. Translation: BAE27140.1.
AK154920 mRNA. Translation: BAE32926.1.
BC056351 mRNA. Translation: AAH56351.1.
M79308 mRNA. Translation: AAK14832.1.
CCDSiCCDS29044.1.
PIRiJN0874.
RefSeqiNP_851415.1. NM_181070.6.
UniGeneiMm.132802.

Genome annotation databases

EnsembliENSMUST00000097680; ENSMUSP00000095285; ENSMUSG00000073639.
GeneIDi19330.
KEGGimmu:19330.
UCSCiuc008dzo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80333 mRNA. Translation: CAA56583.1 .
L04966 mRNA. Translation: AAC37632.1 .
AK045514 mRNA. Translation: BAC32402.1 .
AK140901 mRNA. Translation: BAE24512.1 .
AK143673 mRNA. Translation: BAE25489.1 .
AK146177 mRNA. Translation: BAE26955.1 .
AK146397 mRNA. Translation: BAE27140.1 .
AK154920 mRNA. Translation: BAE32926.1 .
BC056351 mRNA. Translation: AAH56351.1 .
M79308 mRNA. Translation: AAK14832.1 .
CCDSi CCDS29044.1.
PIRi JN0874.
RefSeqi NP_851415.1. NM_181070.6.
UniGenei Mm.132802.

3D structure databases

ProteinModelPortali P35293.
SMRi P35293. Positions 2-178.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 202536. 1 interaction.
IntActi P35293. 1 interaction.
MINTi MINT-1864434.

PTM databases

PhosphoSitei P35293.

Proteomic databases

MaxQBi P35293.
PaxDbi P35293.
PRIDEi P35293.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000097680 ; ENSMUSP00000095285 ; ENSMUSG00000073639 .
GeneIDi 19330.
KEGGi mmu:19330.
UCSCi uc008dzo.1. mouse.

Organism-specific databases

CTDi 22931.
MGIi MGI:102790. Rab18.

Phylogenomic databases

eggNOGi COG1100.
HOGENOMi HOG000233968.
HOVERGENi HBG009351.
InParanoidi P35293.
KOi K07910.
OMAi TYTTRND.
OrthoDBi EOG7CVQ04.
PhylomeDBi P35293.
TreeFami TF313448.

Miscellaneous databases

NextBioi 296305.
PROi P35293.
SOURCEi Search...

Gene expression databases

Bgeei P35293.
CleanExi MM_RAB18.
ExpressionAtlasi P35293. baseline and differential.
Genevestigatori P35293.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00175. RAB. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51419. RAB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and subcellular localization of novel rab proteins reveals polarized and cell type-specific expression."
    Luetcke A., Parton R.G., Murphy C., Olkkonen V.M., Dupree P., Valencia A., Simons K., Zerial M.
    J. Cell Sci. 107:3437-3448(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.
  2. "Gene cloning and characterization of a GTP-binding Rab protein from mouse pituitary AtT-20 cells."
    Yu H., Leaf D.S., Moore H.P.
    Gene 132:273-278(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: LAF1.
    Tissue: Pituitary.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J, DBA/2 and NOD.
    Tissue: Corpora quadrigemina, Head and Spleen.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  5. "The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach."
    Chavrier P., Simons K., Zerial M.
    Gene 112:261-264(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-68.
    Tissue: Kidney.

Entry informationi

Entry nameiRAB18_MOUSE
AccessioniPrimary (citable) accession number: P35293
Secondary accession number(s): Q543V0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3