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Protein

Ras-related protein Rab-24

Gene

Rab24

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in autophagy-related processes.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 22GTPBy similarity9
Nucleotide bindingi63 – 67GTPBy similarity5
Nucleotide bindingi120 – 123GTPBy similarity4
Nucleotide bindingi154 – 156GTPBy similarity3

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Autophagy, Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-24
Alternative name(s):
Rab-16
Gene namesi
Name:Rab24
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:105065. Rab24.

Subcellular locationi

GO - Cellular componenti

  • autophagosome Source: MGI
  • cytosol Source: UniProtKB-SubCell
  • membrane Source: UniProtKB-SubCell
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi22S → N: Predominantly in the GTP-bound state. No effect on subcellular location. 1 Publication1
Mutagenesisi67S → Q: Increase in GTPase activity. No effect neither on prenylation, nor on subcellular location. 1 Publication1
Mutagenesisi120T → A or I: Accumulates in punctate structures in both cytoplasmic and nuclear compartments. 1 Publication1
Mutagenesisi123D → I: Accumulates in punctate structures in both cytoplasmic and nuclear compartments. Disruptes the integrity of the nuclear envelope. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001212141 – 203Ras-related protein Rab-24Add BLAST203

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi200S-geranylgeranyl cysteineBy similarity1
Lipidationi201S-geranylgeranyl cysteineBy similarity1

Post-translational modificationi

Isoprenylation is inefficient compared to other Rab family members.

Keywords - PTMi

Lipoprotein, Prenylation

Proteomic databases

EPDiP35290.
PaxDbiP35290.
PeptideAtlasiP35290.
PRIDEiP35290.

PTM databases

iPTMnetiP35290.
PhosphoSitePlusiP35290.

Expressioni

Tissue specificityi

Widely expressed, with highest expression in brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000034789.
CleanExiMM_RAB24.
ExpressionAtlasiP35290. baseline and differential.
GenevisibleiP35290. MM.

Interactioni

Subunit structurei

Unlike other Rab family members, does not interact with GDP dissociation inhibitors (GDIs), including ARHGDIA and ARHGDIB.

Protein-protein interaction databases

IntActiP35290. 4 interactors.
MINTiMINT-7899035.
STRINGi10090.ENSMUSP00000046188.

Structurei

3D structure databases

ProteinModelPortaliP35290.
SMRiP35290.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi37 – 45Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0092. Eukaryota.
ENOG410YCCP. LUCA.
GeneTreeiENSGT00760000119101.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP35290.
KOiK07912.
OMAiRFWVKEL.
OrthoDBiEOG091G0NNJ.
PhylomeDBiP35290.
TreeFamiTF300199.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35290-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGQRVDVKV VMLGKEYVGK TSLVERYVHD RFLVGPYQNT IGAAFVAKVM
60 70 80 90 100
CVGDRTVTLG IWDTAGSERY EAMSRIYYRG AKAAIVCYDL TDSSSFERAK
110 120 130 140 150
FWVKELRSLE EGCQIYLCGT KSDLLEEDRR RRRVDFHDVQ DYADNIKAQL
160 170 180 190 200
FETSSKTGQS VDELFQKVAE DYVSVAAFQV MTEDKGVDLS QKANPYFYSC

CHH
Length:203
Mass (Da):23,144
Last modified:October 1, 1996 - v2
Checksum:i872EA5E2E7B5B0F0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti67S → Q in AAK14830 (PubMed:1555775).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22819 mRNA. Translation: CAA80472.1.
BC019950 mRNA. Translation: AAH19950.1.
BC054466 mRNA. Translation: AAH54466.1.
BC055894 mRNA. Translation: AAH55894.1.
M79306 mRNA. Translation: AAK14830.1.
CCDSiCCDS26541.1.
PIRiJH0646.
S40235.
RefSeqiNP_033026.1. NM_009000.3.
UniGeneiMm.220923.

Genome annotation databases

EnsembliENSMUST00000035242; ENSMUSP00000046188; ENSMUSG00000034789.
GeneIDi19336.
KEGGimmu:19336.
UCSCiuc007qqk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22819 mRNA. Translation: CAA80472.1.
BC019950 mRNA. Translation: AAH19950.1.
BC054466 mRNA. Translation: AAH54466.1.
BC055894 mRNA. Translation: AAH55894.1.
M79306 mRNA. Translation: AAK14830.1.
CCDSiCCDS26541.1.
PIRiJH0646.
S40235.
RefSeqiNP_033026.1. NM_009000.3.
UniGeneiMm.220923.

3D structure databases

ProteinModelPortaliP35290.
SMRiP35290.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP35290. 4 interactors.
MINTiMINT-7899035.
STRINGi10090.ENSMUSP00000046188.

PTM databases

iPTMnetiP35290.
PhosphoSitePlusiP35290.

Proteomic databases

EPDiP35290.
PaxDbiP35290.
PeptideAtlasiP35290.
PRIDEiP35290.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035242; ENSMUSP00000046188; ENSMUSG00000034789.
GeneIDi19336.
KEGGimmu:19336.
UCSCiuc007qqk.1. mouse.

Organism-specific databases

CTDi53917.
MGIiMGI:105065. Rab24.

Phylogenomic databases

eggNOGiKOG0092. Eukaryota.
ENOG410YCCP. LUCA.
GeneTreeiENSGT00760000119101.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP35290.
KOiK07912.
OMAiRFWVKEL.
OrthoDBiEOG091G0NNJ.
PhylomeDBiP35290.
TreeFamiTF300199.

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiP35290.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034789.
CleanExiMM_RAB24.
ExpressionAtlasiP35290. baseline and differential.
GenevisibleiP35290. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAB24_MOUSE
AccessioniPrimary (citable) accession number: P35290
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 153 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The unusual Ser-67, instead of a conserved Gln in other family members, is the cause of low GTPase activity. As a result, the predominant nucleotide associated with the protein is GTP.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.