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Protein

Ras-related protein Rab-24

Gene

Rab24

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in autophagy-related processes.

Miscellaneous

The unusual Ser-67, instead of a conserved Gln in other family members, is the cause of low GTPase activity. As a result, the predominant nucleotide associated with the protein is GTP.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 22GTPBy similarity9
Nucleotide bindingi63 – 67GTPBy similarity5
Nucleotide bindingi120 – 123GTPBy similarity4
Nucleotide bindingi154 – 156GTPBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAutophagy, Protein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation
R-MMU-8873719 RAB geranylgeranylation

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-24
Alternative name(s):
Rab-16
Gene namesi
Name:Rab24
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:105065 Rab24

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi22S → N: Predominantly in the GTP-bound state. No effect on subcellular location. 1 Publication1
Mutagenesisi67S → Q: Increase in GTPase activity. No effect neither on prenylation, nor on subcellular location. 1 Publication1
Mutagenesisi120T → A or I: Accumulates in punctate structures in both cytoplasmic and nuclear compartments. 1 Publication1
Mutagenesisi123D → I: Accumulates in punctate structures in both cytoplasmic and nuclear compartments. Disruptes the integrity of the nuclear envelope. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001212141 – 203Ras-related protein Rab-24Add BLAST203

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi200S-geranylgeranyl cysteineBy similarity1
Lipidationi201S-geranylgeranyl cysteineBy similarity1

Post-translational modificationi

Isoprenylation is inefficient compared to other Rab family members.1 Publication

Keywords - PTMi

Lipoprotein, Prenylation

Proteomic databases

EPDiP35290
PaxDbiP35290
PeptideAtlasiP35290
PRIDEiP35290

PTM databases

iPTMnetiP35290
PhosphoSitePlusiP35290

Expressioni

Tissue specificityi

Widely expressed, with highest expression in brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000034789
CleanExiMM_RAB24
ExpressionAtlasiP35290 baseline and differential
GenevisibleiP35290 MM

Interactioni

Subunit structurei

Unlike other Rab family members, does not interact with GDP dissociation inhibitors (GDIs), including ARHGDIA and ARHGDIB.

Protein-protein interaction databases

IntActiP35290, 4 interactors
MINTiP35290
STRINGi10090.ENSMUSP00000046188

Structurei

3D structure databases

ProteinModelPortaliP35290
SMRiP35290
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi37 – 45Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0092 Eukaryota
ENOG410YCCP LUCA
GeneTreeiENSGT00910000144316
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiP35290
KOiK07912
OMAiVERYVHH
OrthoDBiEOG091G0NNJ
PhylomeDBiP35290
TreeFamiTF300199

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequencei

Sequence statusi: Complete.

P35290-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGQRVDVKV VMLGKEYVGK TSLVERYVHD RFLVGPYQNT IGAAFVAKVM
60 70 80 90 100
CVGDRTVTLG IWDTAGSERY EAMSRIYYRG AKAAIVCYDL TDSSSFERAK
110 120 130 140 150
FWVKELRSLE EGCQIYLCGT KSDLLEEDRR RRRVDFHDVQ DYADNIKAQL
160 170 180 190 200
FETSSKTGQS VDELFQKVAE DYVSVAAFQV MTEDKGVDLS QKANPYFYSC

CHH
Length:203
Mass (Da):23,144
Last modified:October 1, 1996 - v2
Checksum:i872EA5E2E7B5B0F0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti67S → Q in AAK14830 (PubMed:1555775).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22819 mRNA Translation: CAA80472.1
BC019950 mRNA Translation: AAH19950.1
BC054466 mRNA Translation: AAH54466.1
BC055894 mRNA Translation: AAH55894.1
M79306 mRNA Translation: AAK14830.1
CCDSiCCDS26541.1
PIRiJH0646
S40235
RefSeqiNP_033026.1, NM_009000.3
UniGeneiMm.220923

Genome annotation databases

EnsembliENSMUST00000035242; ENSMUSP00000046188; ENSMUSG00000034789
GeneIDi19336
KEGGimmu:19336
UCSCiuc007qqk.1 mouse

Similar proteinsi

Entry informationi

Entry nameiRAB24_MOUSE
AccessioniPrimary (citable) accession number: P35290
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 161 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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