ID RAB15_RAT Reviewed; 212 AA. AC P35289; Q504L6; DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1994, sequence version 1. DT 24-JAN-2024, entry version 164. DE RecName: Full=Ras-related protein Rab-15; GN Name=Rab15; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=Sprague-Dawley; TISSUE=Brain; RX PubMed=1313420; DOI=10.1016/s0021-9258(18)42619-1; RA Elferink L.A., Anzai K., Scheller R.H.; RT "Rab15, a novel low molecular weight GTP-binding protein specifically RT expressed in rat brain."; RL J. Biol. Chem. 267:5768-5775(1992). RN [2] RP ERRATUM OF PUBMED:1313420. RX PubMed=1429617; DOI=10.1016/s0021-9258(18)41727-9; RA Elferink L.A., Anzai K., Scheller R.H.; RL J. Biol. Chem. 267:22693-22693(1992). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: May act in concert with RAB3A in regulating aspects of CC synaptic vesicle membrane flow within the nerve terminal. CC -!- SUBUNIT: The GTP bound form of RAB15 interacts with REP15. Interacts CC (GTP-bound form) with MICAL1, MICAL3, MICALCL, EHBP1 and EHBP1L1. CC {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor CC {ECO:0000305}; Cytoplasmic side {ECO:0000305}. CC -!- TISSUE SPECIFICITY: Expressed predominantly in neural tissues. CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family. CC {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M83679; AAA41995.1; -; mRNA. DR EMBL; BC094954; AAH94954.1; -; mRNA. DR PIR; F42148; F42148. DR RefSeq; NP_942044.1; NM_198749.2. DR AlphaFoldDB; P35289; -. DR SMR; P35289; -. DR BioGRID; 256132; 1. DR STRING; 10116.ENSRNOP00000010043; -. DR iPTMnet; P35289; -. DR PhosphoSitePlus; P35289; -. DR jPOST; P35289; -. DR PaxDb; 10116-ENSRNOP00000010043; -. DR Ensembl; ENSRNOT00000010043.6; ENSRNOP00000010043.3; ENSRNOG00000007364.6. DR Ensembl; ENSRNOT00055034317; ENSRNOP00055027798; ENSRNOG00055020096. DR Ensembl; ENSRNOT00060038942; ENSRNOP00060032192; ENSRNOG00060022440. DR Ensembl; ENSRNOT00065029241; ENSRNOP00065023190; ENSRNOG00065017492. DR GeneID; 299156; -. DR KEGG; rno:299156; -. DR UCSC; RGD:735172; rat. DR AGR; RGD:735172; -. DR CTD; 376267; -. DR RGD; 735172; Rab15. DR eggNOG; KOG0078; Eukaryota. DR GeneTree; ENSGT00940000157848; -. DR HOGENOM; CLU_041217_23_1_1; -. DR InParanoid; P35289; -. DR OMA; SSKNCWC; -. DR OrthoDB; 8685at2759; -. DR PhylomeDB; P35289; -. DR TreeFam; TF314097; -. DR Reactome; R-RNO-8873719; RAB geranylgeranylation. DR PRO; PR:P35289; -. DR Proteomes; UP000002494; Chromosome 6. DR Bgee; ENSRNOG00000007364; Expressed in frontal cortex and 17 other cell types or tissues. DR GO; GO:0005929; C:cilium; ISO:RGD. DR GO; GO:0005737; C:cytoplasm; ISO:RGD. DR GO; GO:0010008; C:endosome membrane; ISO:RGD. DR GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:RGD. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0098793; C:presynapse; IEA:GOC. DR GO; GO:0005525; F:GTP binding; TAS:RGD. DR GO; GO:0003924; F:GTPase activity; IEA:InterPro. DR GO; GO:0007269; P:neurotransmitter secretion; TAS:RGD. DR GO; GO:1903307; P:positive regulation of regulated secretory pathway; ISO:RGD. DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW. DR GO; GO:0032482; P:Rab protein signal transduction; IEA:InterPro. DR CDD; cd04117; Rab15; 1. DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR041826; Rab15. DR InterPro; IPR005225; Small_GTP-bd_dom. DR InterPro; IPR001806; Small_GTPase. DR NCBIfam; TIGR00231; small_GTP; 1. DR PANTHER; PTHR47980; LD44762P; 1. DR PANTHER; PTHR47980:SF4; RAS-RELATED PROTEIN RAB-15; 1. DR Pfam; PF00071; Ras; 1. DR PRINTS; PR00449; RASTRNSFRMNG. DR SMART; SM00175; RAB; 1. DR SMART; SM00176; RAN; 1. DR SMART; SM00173; RAS; 1. DR SMART; SM00174; RHO; 1. DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1. DR PROSITE; PS51419; RAB; 1. DR Genevisible; P35289; RN. PE 2: Evidence at transcript level; KW Cell membrane; GTP-binding; Lipoprotein; Membrane; Methylation; KW Nucleotide-binding; Prenylation; Protein transport; Reference proteome; KW Transport. FT CHAIN 1..212 FT /note="Ras-related protein Rab-15" FT /id="PRO_0000121190" FT BINDING 15..22 FT /ligand="GTP" FT /ligand_id="ChEBI:CHEBI:37565" FT /evidence="ECO:0000250" FT BINDING 63..67 FT /ligand="GTP" FT /ligand_id="ChEBI:CHEBI:37565" FT /evidence="ECO:0000250" FT BINDING 121..124 FT /ligand="GTP" FT /ligand_id="ChEBI:CHEBI:37565" FT /evidence="ECO:0000250" FT MOD_RES 212 FT /note="Cysteine methyl ester" FT /evidence="ECO:0000250" FT LIPID 210 FT /note="S-geranylgeranyl cysteine" FT /evidence="ECO:0000250" FT LIPID 212 FT /note="S-geranylgeranyl cysteine" FT /evidence="ECO:0000250" SQ SEQUENCE 212 AA; 24283 MW; 04817DDA66CADE12 CRC64; MAKQYDVLFR LLLIGDSGVG KTCLLCRFTD NEFHSSHIST IGVDFKMKTI EVDGIKVRIQ IWDTAGQERY QTITKQYYRR AQGIFLVYDI SSERSYQHIM KWVSDVDEYA PEGVQKILIG NKADEEQKRQ VGREQGQQLA KEYGMDFYET SACTNLNIKE SFTRLTELVL QAHRKELDGL RTCASNELAL AELEEDEGKT EGPANSSKTC WC //