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P35289 (RAB15_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ras-related protein Rab-15
Gene names
Name:Rab15
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length212 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May act in concert with RAB3A in regulating aspects of synaptic vesicle membrane flow within the nerve terminal.

Subunit structure

The GTP bound form of RAB15 interacts with REP15 By similarity.

Subcellular location

Cell membrane; Lipid-anchor; Cytoplasmic side Potential.

Tissue specificity

Expressed predominantly in neural tissues.

Sequence similarities

Belongs to the small GTPase superfamily. Rab family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 212212Ras-related protein Rab-15
PRO_0000121190

Regions

Nucleotide binding15 – 228GTP By similarity
Nucleotide binding63 – 675GTP By similarity
Nucleotide binding121 – 1244GTP By similarity

Amino acid modifications

Modified residue2121Cysteine methyl ester By similarity
Lipidation2101S-geranylgeranyl cysteine By similarity
Lipidation2121S-geranylgeranyl cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
P35289 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 04817DDA66CADE12

FASTA21224,283
        10         20         30         40         50         60 
MAKQYDVLFR LLLIGDSGVG KTCLLCRFTD NEFHSSHIST IGVDFKMKTI EVDGIKVRIQ 

        70         80         90        100        110        120 
IWDTAGQERY QTITKQYYRR AQGIFLVYDI SSERSYQHIM KWVSDVDEYA PEGVQKILIG 

       130        140        150        160        170        180 
NKADEEQKRQ VGREQGQQLA KEYGMDFYET SACTNLNIKE SFTRLTELVL QAHRKELDGL 

       190        200        210 
RTCASNELAL AELEEDEGKT EGPANSSKTC WC 

« Hide

References

« Hide 'large scale' references
[1]"Rab15, a novel low molecular weight GTP-binding protein specifically expressed in rat brain."
Elferink L.A., Anzai K., Scheller R.H.
J. Biol. Chem. 267:5768-5775(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Brain.
[2]Erratum
Elferink L.A., Anzai K., Scheller R.H.
J. Biol. Chem. 267:22693-22693(1992) [PubMed] [Europe PMC] [Abstract]
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M83679 mRNA. Translation: AAA41995.1.
BC094954 mRNA. Translation: AAH94954.1.
PIRF42148.
RefSeqNP_942044.1. NM_198749.2.
UniGeneRn.24234.

3D structure databases

ProteinModelPortalP35289.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid256132. 1 interaction.
STRING10116.ENSRNOP00000010043.

PTM databases

PhosphoSiteP35289.

Proteomic databases

PaxDbP35289.
PRIDEP35289.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000010043; ENSRNOP00000010043; ENSRNOG00000007364.
GeneID299156.
KEGGrno:299156.
UCSCRGD:735172. rat.

Organism-specific databases

CTD376267.
RGD735172. Rab15.

Phylogenomic databases

eggNOGCOG1100.
GeneTreeENSGT00750000117504.
HOGENOMHOG000233968.
HOVERGENHBG009351.
InParanoidP35289.
KOK07908.
OMAITETFTR.
OrthoDBEOG7V4B0R.
PhylomeDBP35289.
TreeFamTF314097.

Gene expression databases

GenevestigatorP35289.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamPF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio644892.
PROP35289.

Entry information

Entry nameRAB15_RAT
AccessionPrimary (citable) accession number: P35289
Secondary accession number(s): Q504L6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: April 16, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families