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Protein

Ras-related protein Rab-15

Gene

Rab15

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May act in concert with RAB3A in regulating aspects of synaptic vesicle membrane flow within the nerve terminal.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 228GTPBy similarity
Nucleotide bindingi63 – 675GTPBy similarity
Nucleotide bindingi121 – 1244GTPBy similarity

GO - Molecular functioni

  1. GDP binding Source: GO_Central
  2. GTPase activity Source: GO_Central
  3. GTP binding Source: RGD

GO - Biological processi

  1. intracellular protein transport Source: GO_Central
  2. metabolic process Source: GOC
  3. neurotransmitter secretion Source: RGD
  4. protein localization to plasma membrane Source: GO_Central
  5. protein secretion Source: GO_Central
  6. Rab protein signal transduction Source: GO_Central
  7. regulation of exocytosis Source: GO_Central
  8. vesicle docking involved in exocytosis Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-15
Gene namesi
Name:Rab15
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi735172. Rab15.

Subcellular locationi

Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

GO - Cellular componenti

  1. endosome membrane Source: GO_Central
  2. membrane Source: RGD
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 212212Ras-related protein Rab-15PRO_0000121190Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi210 – 2101S-geranylgeranyl cysteineBy similarity
Modified residuei212 – 2121Cysteine methyl esterBy similarity
Lipidationi212 – 2121S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiP35289.
PRIDEiP35289.

PTM databases

PhosphoSiteiP35289.

Expressioni

Tissue specificityi

Expressed predominantly in neural tissues.

Gene expression databases

GenevestigatoriP35289.

Interactioni

Subunit structurei

The GTP bound form of RAB15 interacts with REP15.By similarity

Protein-protein interaction databases

BioGridi256132. 1 interaction.
STRINGi10116.ENSRNOP00000010043.

Structurei

3D structure databases

ProteinModelPortaliP35289.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00760000118937.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP35289.
KOiK07908.
OMAiREYGMDF.
OrthoDBiEOG7V4B0R.
PhylomeDBiP35289.
TreeFamiTF314097.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35289-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKQYDVLFR LLLIGDSGVG KTCLLCRFTD NEFHSSHIST IGVDFKMKTI
60 70 80 90 100
EVDGIKVRIQ IWDTAGQERY QTITKQYYRR AQGIFLVYDI SSERSYQHIM
110 120 130 140 150
KWVSDVDEYA PEGVQKILIG NKADEEQKRQ VGREQGQQLA KEYGMDFYET
160 170 180 190 200
SACTNLNIKE SFTRLTELVL QAHRKELDGL RTCASNELAL AELEEDEGKT
210
EGPANSSKTC WC
Length:212
Mass (Da):24,283
Last modified:January 31, 1994 - v1
Checksum:i04817DDA66CADE12
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83679 mRNA. Translation: AAA41995.1.
BC094954 mRNA. Translation: AAH94954.1.
PIRiF42148.
RefSeqiNP_942044.1. NM_198749.2.
UniGeneiRn.24234.

Genome annotation databases

EnsembliENSRNOT00000010043; ENSRNOP00000010043; ENSRNOG00000007364.
GeneIDi299156.
KEGGirno:299156.
UCSCiRGD:735172. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83679 mRNA. Translation: AAA41995.1.
BC094954 mRNA. Translation: AAH94954.1.
PIRiF42148.
RefSeqiNP_942044.1. NM_198749.2.
UniGeneiRn.24234.

3D structure databases

ProteinModelPortaliP35289.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi256132. 1 interaction.
STRINGi10116.ENSRNOP00000010043.

PTM databases

PhosphoSiteiP35289.

Proteomic databases

PaxDbiP35289.
PRIDEiP35289.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000010043; ENSRNOP00000010043; ENSRNOG00000007364.
GeneIDi299156.
KEGGirno:299156.
UCSCiRGD:735172. rat.

Organism-specific databases

CTDi376267.
RGDi735172. Rab15.

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00760000118937.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP35289.
KOiK07908.
OMAiREYGMDF.
OrthoDBiEOG7V4B0R.
PhylomeDBiP35289.
TreeFamiTF314097.

Miscellaneous databases

NextBioi644892.
PROiP35289.

Gene expression databases

GenevestigatoriP35289.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Rab15, a novel low molecular weight GTP-binding protein specifically expressed in rat brain."
    Elferink L.A., Anzai K., Scheller R.H.
    J. Biol. Chem. 267:5768-5775(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.
  2. Erratum
    Elferink L.A., Anzai K., Scheller R.H.
    J. Biol. Chem. 267:22693-22693(1991) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiRAB15_RAT
AccessioniPrimary (citable) accession number: P35289
Secondary accession number(s): Q504L6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 1994
Last sequence update: January 31, 1994
Last modified: March 31, 2015
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.