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P35289

- RAB15_RAT

UniProt

P35289 - RAB15_RAT

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Protein
Ras-related protein Rab-15
Gene
Rab15
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May act in concert with RAB3A in regulating aspects of synaptic vesicle membrane flow within the nerve terminal.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 228GTP By similarity
Nucleotide bindingi63 – 675GTP By similarity
Nucleotide bindingi121 – 1244GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: RGD

GO - Biological processi

  1. neurotransmitter secretion Source: RGD
  2. protein transport Source: UniProtKB-KW
  3. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-15
Gene namesi
Name:Rab15
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 6

Organism-specific databases

RGDi735172. Rab15.

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: RGD
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 212212Ras-related protein Rab-15
PRO_0000121190Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi210 – 2101S-geranylgeranyl cysteine By similarity
Modified residuei212 – 2121Cysteine methyl ester By similarity
Lipidationi212 – 2121S-geranylgeranyl cysteine By similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiP35289.
PRIDEiP35289.

PTM databases

PhosphoSiteiP35289.

Expressioni

Tissue specificityi

Expressed predominantly in neural tissues.

Gene expression databases

GenevestigatoriP35289.

Interactioni

Subunit structurei

The GTP bound form of RAB15 interacts with REP15 By similarity.

Protein-protein interaction databases

BioGridi256132. 1 interaction.
STRINGi10116.ENSRNOP00000010043.

Structurei

3D structure databases

ProteinModelPortaliP35289.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00750000117504.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP35289.
KOiK07908.
OMAiITETFTR.
OrthoDBiEOG7V4B0R.
PhylomeDBiP35289.
TreeFamiTF314097.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35289-1 [UniParc]FASTAAdd to Basket

« Hide

MAKQYDVLFR LLLIGDSGVG KTCLLCRFTD NEFHSSHIST IGVDFKMKTI    50
EVDGIKVRIQ IWDTAGQERY QTITKQYYRR AQGIFLVYDI SSERSYQHIM 100
KWVSDVDEYA PEGVQKILIG NKADEEQKRQ VGREQGQQLA KEYGMDFYET 150
SACTNLNIKE SFTRLTELVL QAHRKELDGL RTCASNELAL AELEEDEGKT 200
EGPANSSKTC WC 212
Length:212
Mass (Da):24,283
Last modified:February 1, 1994 - v1
Checksum:i04817DDA66CADE12
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M83679 mRNA. Translation: AAA41995.1.
BC094954 mRNA. Translation: AAH94954.1.
PIRiF42148.
RefSeqiNP_942044.1. NM_198749.2.
UniGeneiRn.24234.

Genome annotation databases

EnsembliENSRNOT00000010043; ENSRNOP00000010043; ENSRNOG00000007364.
GeneIDi299156.
KEGGirno:299156.
UCSCiRGD:735172. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M83679 mRNA. Translation: AAA41995.1 .
BC094954 mRNA. Translation: AAH94954.1 .
PIRi F42148.
RefSeqi NP_942044.1. NM_198749.2.
UniGenei Rn.24234.

3D structure databases

ProteinModelPortali P35289.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 256132. 1 interaction.
STRINGi 10116.ENSRNOP00000010043.

PTM databases

PhosphoSitei P35289.

Proteomic databases

PaxDbi P35289.
PRIDEi P35289.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000010043 ; ENSRNOP00000010043 ; ENSRNOG00000007364 .
GeneIDi 299156.
KEGGi rno:299156.
UCSCi RGD:735172. rat.

Organism-specific databases

CTDi 376267.
RGDi 735172. Rab15.

Phylogenomic databases

eggNOGi COG1100.
GeneTreei ENSGT00750000117504.
HOGENOMi HOG000233968.
HOVERGENi HBG009351.
InParanoidi P35289.
KOi K07908.
OMAi ITETFTR.
OrthoDBi EOG7V4B0R.
PhylomeDBi P35289.
TreeFami TF314097.

Miscellaneous databases

NextBioi 644892.
PROi P35289.

Gene expression databases

Genevestigatori P35289.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00175. RAB. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51419. RAB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Rab15, a novel low molecular weight GTP-binding protein specifically expressed in rat brain."
    Elferink L.A., Anzai K., Scheller R.H.
    J. Biol. Chem. 267:5768-5775(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.
  2. Erratum
    Elferink L.A., Anzai K., Scheller R.H.
    J. Biol. Chem. 267:22693-22693(1992) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiRAB15_RAT
AccessioniPrimary (citable) accession number: P35289
Secondary accession number(s): Q504L6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: April 16, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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