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P35289

- RAB15_RAT

UniProt

P35289 - RAB15_RAT

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Protein

Ras-related protein Rab-15

Gene

Rab15

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May act in concert with RAB3A in regulating aspects of synaptic vesicle membrane flow within the nerve terminal.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 228GTPBy similarity
Nucleotide bindingi63 – 675GTPBy similarity
Nucleotide bindingi121 – 1244GTPBy similarity

GO - Molecular functioni

  1. GTP binding Source: RGD

GO - Biological processi

  1. neurotransmitter secretion Source: RGD
  2. protein transport Source: UniProtKB-KW
  3. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-15
Gene namesi
Name:Rab15
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 6

Organism-specific databases

RGDi735172. Rab15.

Subcellular locationi

Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

GO - Cellular componenti

  1. membrane Source: RGD
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 212212Ras-related protein Rab-15PRO_0000121190Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi210 – 2101S-geranylgeranyl cysteineBy similarity
Modified residuei212 – 2121Cysteine methyl esterBy similarity
Lipidationi212 – 2121S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiP35289.
PRIDEiP35289.

PTM databases

PhosphoSiteiP35289.

Expressioni

Tissue specificityi

Expressed predominantly in neural tissues.

Gene expression databases

GenevestigatoriP35289.

Interactioni

Subunit structurei

The GTP bound form of RAB15 interacts with REP15.By similarity

Protein-protein interaction databases

BioGridi256132. 1 interaction.
STRINGi10116.ENSRNOP00000010043.

Structurei

3D structure databases

ProteinModelPortaliP35289.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00760000118937.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP35289.
KOiK07908.
OMAiITETFTR.
OrthoDBiEOG7V4B0R.
PhylomeDBiP35289.
TreeFamiTF314097.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35289-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKQYDVLFR LLLIGDSGVG KTCLLCRFTD NEFHSSHIST IGVDFKMKTI
60 70 80 90 100
EVDGIKVRIQ IWDTAGQERY QTITKQYYRR AQGIFLVYDI SSERSYQHIM
110 120 130 140 150
KWVSDVDEYA PEGVQKILIG NKADEEQKRQ VGREQGQQLA KEYGMDFYET
160 170 180 190 200
SACTNLNIKE SFTRLTELVL QAHRKELDGL RTCASNELAL AELEEDEGKT
210
EGPANSSKTC WC
Length:212
Mass (Da):24,283
Last modified:February 1, 1994 - v1
Checksum:i04817DDA66CADE12
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83679 mRNA. Translation: AAA41995.1.
BC094954 mRNA. Translation: AAH94954.1.
PIRiF42148.
RefSeqiNP_942044.1. NM_198749.2.
UniGeneiRn.24234.

Genome annotation databases

EnsembliENSRNOT00000010043; ENSRNOP00000010043; ENSRNOG00000007364.
GeneIDi299156.
KEGGirno:299156.
UCSCiRGD:735172. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83679 mRNA. Translation: AAA41995.1 .
BC094954 mRNA. Translation: AAH94954.1 .
PIRi F42148.
RefSeqi NP_942044.1. NM_198749.2.
UniGenei Rn.24234.

3D structure databases

ProteinModelPortali P35289.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 256132. 1 interaction.
STRINGi 10116.ENSRNOP00000010043.

PTM databases

PhosphoSitei P35289.

Proteomic databases

PaxDbi P35289.
PRIDEi P35289.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000010043 ; ENSRNOP00000010043 ; ENSRNOG00000007364 .
GeneIDi 299156.
KEGGi rno:299156.
UCSCi RGD:735172. rat.

Organism-specific databases

CTDi 376267.
RGDi 735172. Rab15.

Phylogenomic databases

eggNOGi COG1100.
GeneTreei ENSGT00760000118937.
HOGENOMi HOG000233968.
HOVERGENi HBG009351.
InParanoidi P35289.
KOi K07908.
OMAi ITETFTR.
OrthoDBi EOG7V4B0R.
PhylomeDBi P35289.
TreeFami TF314097.

Miscellaneous databases

NextBioi 644892.
PROi P35289.

Gene expression databases

Genevestigatori P35289.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00175. RAB. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51419. RAB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Rab15, a novel low molecular weight GTP-binding protein specifically expressed in rat brain."
    Elferink L.A., Anzai K., Scheller R.H.
    J. Biol. Chem. 267:5768-5775(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.
  2. Erratum
    Elferink L.A., Anzai K., Scheller R.H.
    J. Biol. Chem. 267:22693-22693(1992) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiRAB15_RAT
AccessioniPrimary (citable) accession number: P35289
Secondary accession number(s): Q504L6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: October 29, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3