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P35289

- RAB15_RAT

UniProt

P35289 - RAB15_RAT

Protein

Ras-related protein Rab-15

Gene

Rab15

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    May act in concert with RAB3A in regulating aspects of synaptic vesicle membrane flow within the nerve terminal.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi15 – 228GTPBy similarity
    Nucleotide bindingi63 – 675GTPBy similarity
    Nucleotide bindingi121 – 1244GTPBy similarity

    GO - Molecular functioni

    1. GTP binding Source: RGD

    GO - Biological processi

    1. neurotransmitter secretion Source: RGD
    2. protein transport Source: UniProtKB-KW
    3. small GTPase mediated signal transduction Source: InterPro

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras-related protein Rab-15
    Gene namesi
    Name:Rab15
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 6

    Organism-specific databases

    RGDi735172. Rab15.

    Subcellular locationi

    Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

    GO - Cellular componenti

    1. membrane Source: RGD
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 212212Ras-related protein Rab-15PRO_0000121190Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi210 – 2101S-geranylgeranyl cysteineBy similarity
    Modified residuei212 – 2121Cysteine methyl esterBy similarity
    Lipidationi212 – 2121S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Methylation, Prenylation

    Proteomic databases

    PaxDbiP35289.
    PRIDEiP35289.

    PTM databases

    PhosphoSiteiP35289.

    Expressioni

    Tissue specificityi

    Expressed predominantly in neural tissues.

    Gene expression databases

    GenevestigatoriP35289.

    Interactioni

    Subunit structurei

    The GTP bound form of RAB15 interacts with REP15.By similarity

    Protein-protein interaction databases

    BioGridi256132. 1 interaction.
    STRINGi10116.ENSRNOP00000010043.

    Structurei

    3D structure databases

    ProteinModelPortaliP35289.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rab family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    GeneTreeiENSGT00750000117504.
    HOGENOMiHOG000233968.
    HOVERGENiHBG009351.
    InParanoidiP35289.
    KOiK07908.
    OMAiITETFTR.
    OrthoDBiEOG7V4B0R.
    PhylomeDBiP35289.
    TreeFamiTF314097.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00175. RAB. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51419. RAB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P35289-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKQYDVLFR LLLIGDSGVG KTCLLCRFTD NEFHSSHIST IGVDFKMKTI    50
    EVDGIKVRIQ IWDTAGQERY QTITKQYYRR AQGIFLVYDI SSERSYQHIM 100
    KWVSDVDEYA PEGVQKILIG NKADEEQKRQ VGREQGQQLA KEYGMDFYET 150
    SACTNLNIKE SFTRLTELVL QAHRKELDGL RTCASNELAL AELEEDEGKT 200
    EGPANSSKTC WC 212
    Length:212
    Mass (Da):24,283
    Last modified:February 1, 1994 - v1
    Checksum:i04817DDA66CADE12
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M83679 mRNA. Translation: AAA41995.1.
    BC094954 mRNA. Translation: AAH94954.1.
    PIRiF42148.
    RefSeqiNP_942044.1. NM_198749.2.
    UniGeneiRn.24234.

    Genome annotation databases

    EnsembliENSRNOT00000010043; ENSRNOP00000010043; ENSRNOG00000007364.
    GeneIDi299156.
    KEGGirno:299156.
    UCSCiRGD:735172. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M83679 mRNA. Translation: AAA41995.1 .
    BC094954 mRNA. Translation: AAH94954.1 .
    PIRi F42148.
    RefSeqi NP_942044.1. NM_198749.2.
    UniGenei Rn.24234.

    3D structure databases

    ProteinModelPortali P35289.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 256132. 1 interaction.
    STRINGi 10116.ENSRNOP00000010043.

    PTM databases

    PhosphoSitei P35289.

    Proteomic databases

    PaxDbi P35289.
    PRIDEi P35289.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000010043 ; ENSRNOP00000010043 ; ENSRNOG00000007364 .
    GeneIDi 299156.
    KEGGi rno:299156.
    UCSCi RGD:735172. rat.

    Organism-specific databases

    CTDi 376267.
    RGDi 735172. Rab15.

    Phylogenomic databases

    eggNOGi COG1100.
    GeneTreei ENSGT00750000117504.
    HOGENOMi HOG000233968.
    HOVERGENi HBG009351.
    InParanoidi P35289.
    KOi K07908.
    OMAi ITETFTR.
    OrthoDBi EOG7V4B0R.
    PhylomeDBi P35289.
    TreeFami TF314097.

    Miscellaneous databases

    NextBioi 644892.
    PROi P35289.

    Gene expression databases

    Genevestigatori P35289.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00175. RAB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Rab15, a novel low molecular weight GTP-binding protein specifically expressed in rat brain."
      Elferink L.A., Anzai K., Scheller R.H.
      J. Biol. Chem. 267:5768-5775(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Brain.
    2. Erratum
      Elferink L.A., Anzai K., Scheller R.H.
      J. Biol. Chem. 267:22693-22693(1992) [PubMed] [Europe PMC] [Abstract]
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiRAB15_RAT
    AccessioniPrimary (citable) accession number: P35289
    Secondary accession number(s): Q504L6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3