P35286 (RAB13_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ras-related protein Rab-13

Gene names

Name:

Rab13

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	203 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in vesicular trafficking and neurotransmitter release.
Subunit structure	Interacts with CCDC64B/BICDR2 By similarity.
Subcellular location	Cell junction › tight junction By similarity. Cell membrane; Lipid-anchor; Cytoplasmic side By similarity. Cytoplasmic vesicle membrane; Lipid-anchor; Cytoplasmic side By similarity. Note: Cytoplasmic tight junctions or associated with vesicles scattered throughout the cytoplasm in cells lacking tight junctions By similarity.
Tissue specificity	Highest levels found in lung, kidney, whole brain and spinal cord.
Sequence similarities	Belongs to the small GTPase superfamily. Rab family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Cell junction Cell membrane Cytoplasmic vesicle Membrane Tight junction
Ligand	GTP-binding Nucleotide-binding
PTM	Lipoprotein Methylation Phosphoprotein Prenylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein transport Inferred from electronic annotation. Source: UniProtKB-KW small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	Golgi apparatus Inferred from electronic annotation. Source: Compara cytoplasmic vesicle membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell tight junction Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	GTP binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 200	200	Ras-related protein Rab-13		PRO_0000121184
	Propeptide	201 – 203	3	Removed in mature form Potential		PRO_0000370759
Regions
	Nucleotide binding	15 – 22	8	GTP By similarity
	Nucleotide binding	63 – 67	5	GTP By similarity
	Nucleotide binding	121 – 124	4	GTP By similarity
	Motif	37 – 45	9	Effector region By similarity
Amino acid modifications
	Modified residue	178	1	Phosphoserine By similarity
	Modified residue	200	1	Cysteine methyl ester Potential
	Lipidation	200	1	S-geranylgeranyl cysteine By similarity
Experimental info
	Sequence conflict	76	1	A → S in AAA41993. Ref.2
	Sequence conflict	113	1	G → E in AAA41993. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P35286 [UniParc]. Last modified April 26, 2004. Version 2. Checksum: B6687462C6EA95A4	FASTA	203	22,901
	10 20 30 40 50 60 MAKAYDHLFK LLLIGDSGVG KTCLIIRFAE DNFNSTYIST IGIDFKIRTV EIEGKRIKLQ 70 80 90 100 110 120 VWDTAGQERF KTITTAYYRG AMGIILVYDI TDEKSFENIQ NWMKSIKENA SAGVERLLLG 130 140 150 160 170 180 NKCDMEAKRK VQREQAERLA REHRIRFFET SAKSSVNVDE AFSSLARDIL LKTGGRRSGN 190 200 SSKPSSTDLK VSDKKNSNKC SLG

References

[1]	"Rab13 participates in Sertoli cell tight junction assembly in the testis." Lau A.S.N., Cheng C.Y., Mruk D.D. Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley.
[2]	"Rab15, a novel low molecular weight GTP-binding protein specifically expressed in rat brain." Elferink L.A., Anzai K., Scheller R.H. J. Biol. Chem. 267:5768-5775(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 40-203. Strain: Sprague-Dawley. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF525280 mRNA. Translation: AAM82588.1. M83678 mRNA. Translation: AAA41993.1.
IPI	IPI00202697.
PIR	D42148.
RefSeq	NP_112354.1. NM_031092.1.
UniGene	Rn.9819.
3D structure databases
ProteinModelPortal	P35286.
SMR	P35286. Positions 8-169.
ModBase	Search...
Protein-protein interaction databases
IntAct	P35286. 1 interaction.
MINT	MINT-2982767.
STRING	10116.ENSRNOP00000022626.
PTM databases
PhosphoSite	P35286.
Proteomic databases
PaxDb	P35286.
PRIDE	P35286.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000022627; ENSRNOP00000022626; ENSRNOG00000016733.
GeneID	81756.
KEGG	rno:81756.
UCSC	RGD:620880. rat.
Organism-specific databases
CTD	5872.
RGD	620880. Rab13.
Phylogenomic databases
eggNOG	COG1100.
GeneTree	ENSGT00700000104031.
HOGENOM	HOG000233968.
HOVERGEN	HBG009351.
InParanoid	P35286.
KO	K06109.
OMA	AMGIVLI.
OrthoDB	EOG4BVRVS.
Enzyme and pathway databases
Reactome	REACT_97881. Membrane Trafficking.
Gene expression databases
Genevestigator	P35286.
GermOnline	ENSRNOG00000016733. Rattus norvegicus.
Family and domain databases
InterPro	IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. IPR003579. Small_GTPase_Rab_type. [Graphical view]
Pfam	PF00071. Ras. 1 hit. [Graphical view]
PRINTS	PR00449. RASTRNSFRMNG.
SMART	SM00175. RAB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00231. small_GTP. 1 hit.
PROSITE	PS51419. RAB. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	615526.

Entry information

Entry name

RAB13_RAT

Accession

Primary (citable) accession number: P35286
Secondary accession number(s): Q8K3X5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	April 26, 2004
Last modified:	April 3, 2013
This is version 110 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program