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Protein

Ras-related protein Rab-21

Gene

Rab21

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general. As a result, may regulate cell adhesion and migration. During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis. Involved in neurite growth (By similarity).By similarity2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi24 – 32GTPBy similarity9
Nucleotide bindingi72 – 76GTPBy similarity5
Nucleotide bindingi130 – 133GTPBy similarity4
Nucleotide bindingi160 – 162GTPBy similarity3

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-8876198. RAB GEFs exchange GTP for GDP on RABs.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-21
Alternative name(s):
Rab-12
Gene namesi
Name:Rab21
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:894308. Rab21.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi31T → N: Defects in GTP-binding. Decrease in integrin-binding. 1 Publication1
Mutagenesisi76Q → L: Defects in GTP hydrolysis. Increase in integrin-binding. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001212062 – 219Ras-related protein Rab-21Add BLAST218
PropeptideiPRO_0000370769220 – 222Removed in mature formSequence analysis3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Lipidationi218S-geranylgeranyl cysteineBy similarity1
Modified residuei219Cysteine methyl esterSequence analysis1
Lipidationi219S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiP35282.
PaxDbiP35282.
PeptideAtlasiP35282.
PRIDEiP35282.

PTM databases

iPTMnetiP35282.
PhosphoSitePlusiP35282.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020132.
CleanExiMM_RAB21.
ExpressionAtlasiP35282. baseline and differential.
GenevisibleiP35282. MM.

Interactioni

Subunit structurei

Interacts with the cytoplasmic tail of integrins ITGA1, ITGA2, ITGA5, ITGA6, ITGA11 and ITGB1; this interaction is dependent upon its GDP/GTP cycle. Interacts with ANKRD27 (By similarity).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ITGA2P173017EBI-1993555,EBI-702960From a different organism.
ITGB1P055563EBI-1993555,EBI-703066From a different organism.

Protein-protein interaction databases

IntActiP35282. 34 interactors.
MINTiMINT-1863390.
STRINGi10090.ENSMUSP00000020343.

Structurei

3D structure databases

ProteinModelPortaliP35282.
SMRiP35282.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi46 – 54Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0088. Eukaryota.
ENOG410XQT5. LUCA.
GeneTreeiENSGT00760000119101.
HOVERGENiHBG009351.
InParanoidiP35282.
KOiK07890.
OMAiMDARMRE.
OrthoDBiEOG091G0HKN.
TreeFamiTF300199.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35282-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAGGGAAA AAGRAYSFKV VLLGEGCVGK TSLVLRYCEN KFNDKHITTL
60 70 80 90 100
QASFLTKKLN IGGKRVNLAI WDTAGQERFH ALGPIYYRDS NGAILVYDVT
110 120 130 140 150
DEDSFQKVKN WVKELRKMLG NEICLCIVGN KIDLEKERHV SIQEAESYAE
160 170 180 190 200
SVGAKHYHTS AKQNKGIEEL FLDLCKRMIE TAQVDERAKG NGSSQAGAAR
210 220
RGVQIIDDEP QAQSSGGCCS SG
Length:222
Mass (Da):24,106
Last modified:January 23, 2007 - v4
Checksum:i7FB005C28E8D6954
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC055042 mRNA. Translation: AAH55042.1.
M79302 mRNA. Translation: AAK14826.1.
CCDSiCCDS24177.1.
PIRiA38879.
RefSeqiNP_077774.1. NM_024454.1.
UniGeneiMm.21936.

Genome annotation databases

EnsembliENSMUST00000020343; ENSMUSP00000020343; ENSMUSG00000020132.
GeneIDi216344.
KEGGimmu:216344.
UCSCiuc007haz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC055042 mRNA. Translation: AAH55042.1.
M79302 mRNA. Translation: AAK14826.1.
CCDSiCCDS24177.1.
PIRiA38879.
RefSeqiNP_077774.1. NM_024454.1.
UniGeneiMm.21936.

3D structure databases

ProteinModelPortaliP35282.
SMRiP35282.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP35282. 34 interactors.
MINTiMINT-1863390.
STRINGi10090.ENSMUSP00000020343.

PTM databases

iPTMnetiP35282.
PhosphoSitePlusiP35282.

Proteomic databases

EPDiP35282.
PaxDbiP35282.
PeptideAtlasiP35282.
PRIDEiP35282.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020343; ENSMUSP00000020343; ENSMUSG00000020132.
GeneIDi216344.
KEGGimmu:216344.
UCSCiuc007haz.1. mouse.

Organism-specific databases

CTDi23011.
MGIiMGI:894308. Rab21.

Phylogenomic databases

eggNOGiKOG0088. Eukaryota.
ENOG410XQT5. LUCA.
GeneTreeiENSGT00760000119101.
HOVERGENiHBG009351.
InParanoidiP35282.
KOiK07890.
OMAiMDARMRE.
OrthoDBiEOG091G0HKN.
TreeFamiTF300199.

Enzyme and pathway databases

ReactomeiR-MMU-8876198. RAB GEFs exchange GTP for GDP on RABs.

Miscellaneous databases

PROiP35282.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020132.
CleanExiMM_RAB21.
ExpressionAtlasiP35282. baseline and differential.
GenevisibleiP35282. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAB21_MOUSE
AccessioniPrimary (citable) accession number: P35282
Secondary accession number(s): Q7TPN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 144 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.