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Protein

Ras-related protein Rab-6A

Gene

Rab6a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Involved in COPI-independent retrograde transport from the Golgi to the ER (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi20 – 28GTPBy similarity9
Nucleotide bindingi68 – 72GTPBy similarity5
Nucleotide bindingi126 – 129GTPBy similarity4
Nucleotide bindingi156 – 158GTPBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation
R-MMU-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-MMU-6811440 Retrograde transport at the Trans-Golgi-Network
R-MMU-8854214 TBC/RABGAPs
R-MMU-8873719 RAB geranylgeranylation
R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-6A
Short name:
Rab-6
Gene namesi
Name:Rab6a
Synonyms:Rab6
ORF Names:MNCb-1660
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:894313 Rab6a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi22Q → V: Loss of binding to rabkinesin-6. 1 Publication1
Mutagenesisi27T → N: Loss of binding to rabkinesin-6; when associated with L-73. 1 Publication1
Mutagenesisi46I → E: Loss of binding to rabkinesin-6. 1 Publication1
Mutagenesisi72Q → L: Loss of binding to rabkinesin-6; when associated with N-28. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001211132 – 208Ras-related protein Rab-6AAdd BLAST207

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei184PhosphoserineCombined sources1
Lipidationi206S-geranylgeranyl cysteineBy similarity1
Modified residuei208Cysteine methyl esterBy similarity1
Lipidationi208S-geranylgeranyl cysteineBy similarity1

Post-translational modificationi

Prenylated.By similarity

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

EPDiP35279
PaxDbiP35279
PeptideAtlasiP35279
PRIDEiP35279
TopDownProteomicsiP35279-1 [P35279-1]

PTM databases

iPTMnetiP35279
PhosphoSitePlusiP35279

Expressioni

Gene expression databases

BgeeiENSMUSG00000030704
CleanExiMM_RAB6
ExpressionAtlasiP35279 baseline and differential
GenevisibleiP35279 MM

Interactioni

Subunit structurei

Interacts with RIC1 and RGP1; the interactions are direct with a preference for RAB6A-GDP. Interacts with VSP52 and RABGAP1. Interacts with GCC2 (via its GRIP domain). Interacts with RAB6IP1 (via its RUN 1 domain). Interacts with RAB6KIFL. Interacts with BICD1. Interacts with BICD2. Interacts with TMF1. Interacts (GTP-bound) with DYNLRB1; the interaction is direct (By similarity). Interacts with SCYL1BP1. Interacts with BICDL1; leads to its accumulation in the pericentrosomal region. Interacts with PIFO. Interacts (GTP-bound) with APBA1/MINT1 isoform 3, also called Mint1_826.By similarity4 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202550, 3 interactors
DIPiDIP-120N
IntActiP35279, 26 interactors
MINTiP35279
STRINGi10090.ENSMUSP00000032946

Structurei

3D structure databases

ProteinModelPortaliP35279
SMRiP35279
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 50Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0094 Eukaryota
ENOG410XPBI LUCA
GeneTreeiENSGT00910000144073
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiP35279
KOiK07893
OMAiMYQATIG
PhylomeDBiP35279
TreeFamiTF300803

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P35279-1) [UniParc]FASTAAdd to basket
Also known as: Rab-6a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAGGDFGNP LRKFKLVFLG EQSVGKTSLI TRFMYDSFDN TYQATIGIDF
60 70 80 90 100
LSKTMYLEDR TVRLQLWDTA GQERFRSLIP SYIRDSTVAV VVYDITNVNS
110 120 130 140 150
FQQTTKWIDD VRTERGSDVI IMLVGNKTDL ADKRQVSIEE GERKAKELNV
160 170 180 190 200
MFIETSAKAG YNVKQLFRRV AAALPGMEST QDRSREDMID IKLEKPQEQP

VNEGGCSC
Length:208
Mass (Da):23,590
Last modified:January 23, 2007 - v4
Checksum:iDD08CC2914668FD4
GO
Isoform 2 (identifier: P35279-2) [UniParc]FASTAAdd to basket
Also known as: Rab-6a', Rab6C

The sequence of this isoform differs from the canonical sequence as follows:
     62-88: VRLQLWDTAGQERFRSLIPSYIRDSTV → IRLQLWDTAGQERFRSLIPSYIRDSAA

Show »
Length:208
Mass (Da):23,546
Checksum:iCBE04CA13D0A48C1
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00552862 – 88VRLQL…RDSTV → IRLQLWDTAGQERFRSLIPS YIRDSAA in isoform 2. 2 PublicationsAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041575 mRNA Translation: BAA95059.1
AK051246 mRNA Translation: BAC34572.1
AK083262 mRNA Translation: BAC38834.1
AK084131 mRNA Translation: BAC39121.1
AK160134 mRNA Translation: BAE35649.1
AK160866 mRNA Translation: BAE36058.1
AK169842 mRNA Translation: BAE41406.1
BC019118 mRNA Translation: AAH19118.1
BC026915 mRNA Translation: AAH26915.1
M79313 mRNA Translation: AAK14837.1
CCDSiCCDS21503.1 [P35279-1]
CCDS52323.1 [P35279-2]
PIRiA38883
RefSeqiNP_001157135.1, NM_001163663.1 [P35279-2]
NP_077249.1, NM_024287.4 [P35279-1]
UniGeneiMm.28650

Genome annotation databases

EnsembliENSMUST00000032946; ENSMUSP00000032946; ENSMUSG00000030704 [P35279-1]
ENSMUST00000098252; ENSMUSP00000095852; ENSMUSG00000030704 [P35279-2]
GeneIDi19346
KEGGimmu:19346
UCSCiuc009ini.2 mouse [P35279-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRAB6A_MOUSE
AccessioniPrimary (citable) accession number: P35279
Secondary accession number(s): Q542M6
, Q8R2Z7, Q8VEE5, Q9JJD4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 172 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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