Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P35278 (RAB5C_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ras-related protein Rab-5C
Gene names
Name:Rab5c
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length216 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Protein transport. Probably involved in vesicular traffic By similarity.

Subunit structure

Binds EEA1 By similarity.

Subcellular location

Cell membrane; Lipid-anchor; Cytoplasmic side By similarity. Early endosome membrane; Lipid-anchor By similarity. Melanosome By similarity.

Sequence similarities

Belongs to the small GTPase superfamily. Rab family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 216216Ras-related protein Rab-5C
PRO_0000121111

Regions

Nucleotide binding28 – 358GTP By similarity
Nucleotide binding76 – 805GTP By similarity
Nucleotide binding134 – 1374GTP By similarity
Motif50 – 589Effector region Potential

Amino acid modifications

Lipidation2131S-geranylgeranyl cysteine By similarity
Lipidation2141S-geranylgeranyl cysteine By similarity

Secondary structure

............................ 216
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P35278 [UniParc].

Last modified October 31, 2003. Version 2.
Checksum: AA5658239D8D77ED

FASTA21623,413
        10         20         30         40         50         60 
MAGRGGAARP NGPAAGNKIC QFKLVLLGES AVGKSSLVLR FVKGQFHEYQ ESTIGAAFLT 

        70         80         90        100        110        120 
QTVCLDDTTV KFEIWDTAGQ ERYHSLAPMY YRGAQAAIVV YDITNTDTFA RAKNWVKELQ 

       130        140        150        160        170        180 
RQASPNIVIA LAGNKADLAS KRAVEFQEAQ AYADDNSLLF METSAKTAMN VNEIFMAIAK 

       190        200        210 
KLPKNEPQNA AGAPGRTRGV DLQESNPASR SQCCSN 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye and Retina.
[2]Lubec G., Kang S.U.
Submitted (APR-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 24-34; 83-111; 122-135; 185-196 AND 199-210, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: C57BL/6.
Tissue: Brain.
[3]"The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach."
Chavrier P., Simons K., Zerial M.
Gene 112:261-264(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 33-81.
Tissue: Kidney.
[4]"Structural plasticity of an invariant hydrophobic triad in the switch regions of Rab GTPases is a determinant of effector recognition."
Merithew E., Hatherly S., Dumas J.J., Lawe D.C., Heller-Harrison R., Lambright D.G.
J. Biol. Chem. 276:13982-13988(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 19-182.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC023027 mRNA. Translation: AAH23027.1.
BC027378 mRNA. Translation: AAH27378.1.
BC029678 mRNA. Translation: AAH29678.1.
M79312 mRNA. Translation: AAK14836.1.
PIRJH0641.
RefSeqNP_077776.2. NM_024456.4.
UniGeneMm.29829.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1HUQX-ray1.80A19-182[»]
1Z07X-ray1.81A19-182[»]
1Z0DX-ray2.20A/C19-183[»]
ProteinModelPortalP35278.
SMRP35278. Positions 19-182.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid202549. 5 interactions.
DIPDIP-56521N.
IntActP35278. 4 interactions.
MINTMINT-4996649.

PTM databases

PhosphoSiteP35278.

Proteomic databases

PaxDbP35278.
PRIDEP35278.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000107364; ENSMUSP00000102987; ENSMUSG00000019173.
GeneID19345.
KEGGmmu:19345.
UCSCuc007lme.1. mouse.

Organism-specific databases

CTD5878.
MGIMGI:105306. Rab5c.

Phylogenomic databases

eggNOGCOG1100.
HOGENOMHOG000233968.
HOVERGENHBG009351.
KOK07889.
OrthoDBEOG77DJ7M.

Gene expression databases

ArrayExpressP35278.
BgeeP35278.
CleanExMM_RAB5C.
GenevestigatorP35278.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamPF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP35278.
NextBio296361.
PROP35278.
SOURCESearch...

Entry information

Entry nameRAB5C_MOUSE
AccessionPrimary (citable) accession number: P35278
Secondary accession number(s): Q8R1V8, Q8R2N8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: October 31, 2003
Last modified: April 16, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot