Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ras-related protein Rab-5C

Gene

Rab5c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Protein transport. Probably involved in vesicular traffic (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi28 – 369GTPBy similarity
Nucleotide bindingi47 – 537GTPBy similarity
Nucleotide bindingi76 – 805GTPBy similarity
Nucleotide bindingi134 – 1374GTPBy similarity
Nucleotide bindingi164 – 1663GTPBy similarity

GO - Molecular functioni

GO - Biological processi

  • endosome organization Source: MGI
  • plasma membrane to endosome transport Source: MGI
  • protein transport Source: UniProtKB-KW
  • regulation of endocytosis Source: MGI
  • small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-5C
Gene namesi
Name:Rab5c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:105306. Rab5c.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 216216Ras-related protein Rab-5CPRO_0000121111Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi213 – 2131S-geranylgeranyl cysteineBy similarity
Lipidationi214 – 2141S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Prenylation

Proteomic databases

EPDiP35278.
PaxDbiP35278.
PRIDEiP35278.

PTM databases

iPTMnetiP35278.
PhosphoSiteiP35278.
SwissPalmiP35278.

Expressioni

Gene expression databases

BgeeiP35278.
CleanExiMM_RAB5C.
ExpressionAtlasiP35278. baseline and differential.
GenevisibleiP35278. MM.

Interactioni

Subunit structurei

Binds EEA1.By similarity

Protein-protein interaction databases

BioGridi202549. 113 interactions.
DIPiDIP-56521N.
IntActiP35278. 135 interactions.
MINTiMINT-4996649.
STRINGi10090.ENSMUSP00000102987.

Structurei

Secondary structure

1
216
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi20 – 2910Combined sources
Helixi34 – 4310Combined sources
Beta strandi54 – 6512Combined sources
Beta strandi68 – 7710Combined sources
Helixi81 – 866Combined sources
Helixi87 – 915Combined sources
Beta strandi95 – 1028Combined sources
Helixi106 – 12217Combined sources
Beta strandi128 – 1347Combined sources
Helixi139 – 1413Combined sources
Helixi146 – 15510Combined sources
Beta strandi159 – 1624Combined sources
Turni165 – 1673Combined sources
Helixi171 – 18111Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1HUQX-ray1.80A19-182[»]
1Z07X-ray1.81A19-182[»]
1Z0DX-ray2.20A/C19-183[»]
ProteinModelPortaliP35278.
SMRiP35278. Positions 19-182.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP35278.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi50 – 589Effector regionSequence analysis

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0092. Eukaryota.
ENOG410YCCP. LUCA.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP35278.
KOiK07889.
OrthoDBiEOG77DJ7M.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35278-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGRGGAARP NGPAAGNKIC QFKLVLLGES AVGKSSLVLR FVKGQFHEYQ
60 70 80 90 100
ESTIGAAFLT QTVCLDDTTV KFEIWDTAGQ ERYHSLAPMY YRGAQAAIVV
110 120 130 140 150
YDITNTDTFA RAKNWVKELQ RQASPNIVIA LAGNKADLAS KRAVEFQEAQ
160 170 180 190 200
AYADDNSLLF METSAKTAMN VNEIFMAIAK KLPKNEPQNA AGAPGRTRGV
210
DLQESNPASR SQCCSN
Length:216
Mass (Da):23,413
Last modified:October 31, 2003 - v2
Checksum:iAA5658239D8D77ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC023027 mRNA. Translation: AAH23027.1.
BC027378 mRNA. Translation: AAH27378.1.
BC029678 mRNA. Translation: AAH29678.1.
M79312 mRNA. Translation: AAK14836.1.
CCDSiCCDS36333.1.
PIRiJH0641.
RefSeqiNP_077776.2. NM_024456.5.
UniGeneiMm.29829.

Genome annotation databases

EnsembliENSMUST00000107364; ENSMUSP00000102987; ENSMUSG00000019173.
GeneIDi19345.
KEGGimmu:19345.
UCSCiuc007lme.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC023027 mRNA. Translation: AAH23027.1.
BC027378 mRNA. Translation: AAH27378.1.
BC029678 mRNA. Translation: AAH29678.1.
M79312 mRNA. Translation: AAK14836.1.
CCDSiCCDS36333.1.
PIRiJH0641.
RefSeqiNP_077776.2. NM_024456.5.
UniGeneiMm.29829.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1HUQX-ray1.80A19-182[»]
1Z07X-ray1.81A19-182[»]
1Z0DX-ray2.20A/C19-183[»]
ProteinModelPortaliP35278.
SMRiP35278. Positions 19-182.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202549. 113 interactions.
DIPiDIP-56521N.
IntActiP35278. 135 interactions.
MINTiMINT-4996649.
STRINGi10090.ENSMUSP00000102987.

PTM databases

iPTMnetiP35278.
PhosphoSiteiP35278.
SwissPalmiP35278.

Proteomic databases

EPDiP35278.
PaxDbiP35278.
PRIDEiP35278.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000107364; ENSMUSP00000102987; ENSMUSG00000019173.
GeneIDi19345.
KEGGimmu:19345.
UCSCiuc007lme.2. mouse.

Organism-specific databases

CTDi5878.
MGIiMGI:105306. Rab5c.

Phylogenomic databases

eggNOGiKOG0092. Eukaryota.
ENOG410YCCP. LUCA.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP35278.
KOiK07889.
OrthoDBiEOG77DJ7M.

Miscellaneous databases

EvolutionaryTraceiP35278.
NextBioi296361.
PROiP35278.
SOURCEiSearch...

Gene expression databases

BgeeiP35278.
CleanExiMM_RAB5C.
ExpressionAtlasiP35278. baseline and differential.
GenevisibleiP35278. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye and Retina.
  2. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 24-34; 83-111; 122-135; 185-196 AND 199-210, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6J.
    Tissue: Brain.
  3. "The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach."
    Chavrier P., Simons K., Zerial M.
    Gene 112:261-264(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 33-81.
    Tissue: Kidney.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.
  5. "Structural plasticity of an invariant hydrophobic triad in the switch regions of Rab GTPases is a determinant of effector recognition."
    Merithew E., Hatherly S., Dumas J.J., Lawe D.C., Heller-Harrison R., Lambright D.G.
    J. Biol. Chem. 276:13982-13988(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 19-182.

Entry informationi

Entry nameiRAB5C_MOUSE
AccessioniPrimary (citable) accession number: P35278
Secondary accession number(s): Q8R1V8, Q8R2N8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: October 31, 2003
Last modified: May 11, 2016
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.