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Protein

Ras-related protein Rab-5C

Gene

Rab5c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Protein transport. Probably involved in vesicular traffic (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi28 – 36GTPBy similarity9
Nucleotide bindingi47 – 53GTPBy similarity7
Nucleotide bindingi76 – 80GTPBy similarity5
Nucleotide bindingi134 – 137GTPBy similarity4
Nucleotide bindingi164 – 166GTPBy similarity3

GO - Molecular functioni

GO - Biological processi

  • endosome organization Source: MGI
  • plasma membrane to endosome transport Source: MGI
  • protein transport Source: UniProtKB-KW
  • regulation of endocytosis Source: MGI
  • small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-432722. Golgi Associated Vesicle Biogenesis.
R-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-5C
Gene namesi
Name:Rab5c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:105306. Rab5c.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001211111 – 216Ras-related protein Rab-5CAdd BLAST216

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi213S-geranylgeranyl cysteineBy similarity1
Lipidationi214S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Prenylation

Proteomic databases

EPDiP35278.
PaxDbiP35278.
PeptideAtlasiP35278.
PRIDEiP35278.

PTM databases

iPTMnetiP35278.
PhosphoSitePlusiP35278.
SwissPalmiP35278.

Expressioni

Gene expression databases

BgeeiENSMUSG00000019173.
CleanExiMM_RAB5C.
ExpressionAtlasiP35278. baseline and differential.
GenevisibleiP35278. MM.

Interactioni

Subunit structurei

Binds EEA1.By similarity

Protein-protein interaction databases

BioGridi202549. 113 interactors.
DIPiDIP-56521N.
IntActiP35278. 135 interactors.
MINTiMINT-4996649.
STRINGi10090.ENSMUSP00000102987.

Structurei

Secondary structure

1216
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi20 – 29Combined sources10
Helixi34 – 43Combined sources10
Beta strandi54 – 65Combined sources12
Beta strandi68 – 77Combined sources10
Helixi81 – 86Combined sources6
Helixi87 – 91Combined sources5
Beta strandi95 – 102Combined sources8
Helixi106 – 122Combined sources17
Beta strandi128 – 134Combined sources7
Helixi139 – 141Combined sources3
Helixi146 – 155Combined sources10
Beta strandi159 – 162Combined sources4
Turni165 – 167Combined sources3
Helixi171 – 181Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HUQX-ray1.80A19-182[»]
1Z07X-ray1.81A19-182[»]
1Z0DX-ray2.20A/C19-183[»]
ProteinModelPortaliP35278.
SMRiP35278.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP35278.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi50 – 58Effector regionSequence analysis9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0092. Eukaryota.
ENOG410YCCP. LUCA.
GeneTreeiENSGT00760000119101.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP35278.
KOiK07889.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35278-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGRGGAARP NGPAAGNKIC QFKLVLLGES AVGKSSLVLR FVKGQFHEYQ
60 70 80 90 100
ESTIGAAFLT QTVCLDDTTV KFEIWDTAGQ ERYHSLAPMY YRGAQAAIVV
110 120 130 140 150
YDITNTDTFA RAKNWVKELQ RQASPNIVIA LAGNKADLAS KRAVEFQEAQ
160 170 180 190 200
AYADDNSLLF METSAKTAMN VNEIFMAIAK KLPKNEPQNA AGAPGRTRGV
210
DLQESNPASR SQCCSN
Length:216
Mass (Da):23,413
Last modified:October 31, 2003 - v2
Checksum:iAA5658239D8D77ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC023027 mRNA. Translation: AAH23027.1.
BC027378 mRNA. Translation: AAH27378.1.
BC029678 mRNA. Translation: AAH29678.1.
M79312 mRNA. Translation: AAK14836.1.
CCDSiCCDS36333.1.
PIRiJH0641.
RefSeqiNP_077776.2. NM_024456.5.
UniGeneiMm.29829.

Genome annotation databases

EnsembliENSMUST00000107364; ENSMUSP00000102987; ENSMUSG00000019173.
GeneIDi19345.
KEGGimmu:19345.
UCSCiuc007lme.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC023027 mRNA. Translation: AAH23027.1.
BC027378 mRNA. Translation: AAH27378.1.
BC029678 mRNA. Translation: AAH29678.1.
M79312 mRNA. Translation: AAK14836.1.
CCDSiCCDS36333.1.
PIRiJH0641.
RefSeqiNP_077776.2. NM_024456.5.
UniGeneiMm.29829.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HUQX-ray1.80A19-182[»]
1Z07X-ray1.81A19-182[»]
1Z0DX-ray2.20A/C19-183[»]
ProteinModelPortaliP35278.
SMRiP35278.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202549. 113 interactors.
DIPiDIP-56521N.
IntActiP35278. 135 interactors.
MINTiMINT-4996649.
STRINGi10090.ENSMUSP00000102987.

PTM databases

iPTMnetiP35278.
PhosphoSitePlusiP35278.
SwissPalmiP35278.

Proteomic databases

EPDiP35278.
PaxDbiP35278.
PeptideAtlasiP35278.
PRIDEiP35278.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000107364; ENSMUSP00000102987; ENSMUSG00000019173.
GeneIDi19345.
KEGGimmu:19345.
UCSCiuc007lme.2. mouse.

Organism-specific databases

CTDi5878.
MGIiMGI:105306. Rab5c.

Phylogenomic databases

eggNOGiKOG0092. Eukaryota.
ENOG410YCCP. LUCA.
GeneTreeiENSGT00760000119101.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP35278.
KOiK07889.

Enzyme and pathway databases

ReactomeiR-MMU-432722. Golgi Associated Vesicle Biogenesis.
R-MMU-6798695. Neutrophil degranulation.

Miscellaneous databases

EvolutionaryTraceiP35278.
PROiP35278.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019173.
CleanExiMM_RAB5C.
ExpressionAtlasiP35278. baseline and differential.
GenevisibleiP35278. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAB5C_MOUSE
AccessioniPrimary (citable) accession number: P35278
Secondary accession number(s): Q8R1V8, Q8R2N8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: October 31, 2003
Last modified: November 30, 2016
This is version 149 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.