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Protein

Ras-related protein Rab-3D

Gene

Rab3d

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Protein transport. Probably involved in vesicular traffic (By similarity). May be involved in the insulin-induced exocytosis of glut4-containing vesicles in adipocytes.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi29 – 37GTPBy similarity9
Nucleotide bindingi48 – 54GTPBy similarity7
Nucleotide bindingi77 – 81GTPBy similarity5
Nucleotide bindingi135 – 138GTPBy similarity4
Nucleotide bindingi165 – 167GTPBy similarity3

GO - Molecular functioni

  • GTPase activity Source: InterPro
  • GTP binding Source: UniProtKB-KW
  • GTP-dependent protein binding Source: MGI
  • myosin V binding Source: MGI

GO - Biological processi

  • bone resorption Source: MGI
  • exocytosis Source: UniProtKB-KW
  • peptidyl-cysteine methylation Source: MGI
  • positive regulation of regulated secretory pathway Source: MGI
  • protein transport Source: UniProtKB-KW
  • regulation of exocytosis Source: MGI

Keywordsi

Biological processExocytosis, Protein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-3D
Gene namesi
Name:Rab3d
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:97844. Rab3d.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001210892 – 219Ras-related protein Rab-3DAdd BLAST218

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei190PhosphoserineBy similarity1
Lipidationi217S-geranylgeranyl cysteineBy similarity1
Modified residuei219Cysteine methyl esterBy similarity1
Lipidationi219S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

EPDiP35276.
PaxDbiP35276.
PeptideAtlasiP35276.
PRIDEiP35276.

PTM databases

PhosphoSitePlusiP35276.

Expressioni

Tissue specificityi

Predominantly expressed in the adipocyte tissue, but is also expressed in several other organs including skin, spleen, heart and lung.

Gene expression databases

BgeeiENSMUSG00000019066.
CleanExiMM_RAB3D.
ExpressionAtlasiP35276. baseline and differential.
GenevisibleiP35276. MM.

Interactioni

Subunit structurei

Interacts with RIMS1, RIMS2, RPH3A, RPH3AL and RAB3IP.2 Publications

GO - Molecular functioni

  • GTP-dependent protein binding Source: MGI
  • myosin V binding Source: MGI

Protein-protein interaction databases

BioGridi202545. 6 interactors.
IntActiP35276. 14 interactors.
STRINGi10090.ENSMUSP00000111008.

Structurei

3D structure databases

ProteinModelPortaliP35276.
SMRiP35276.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi51 – 59Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0093. Eukaryota.
ENOG410ZZXQ. LUCA.
GeneTreeiENSGT00890000139330.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP35276.
KOiK07884.
OMAiEPSSCSC.
OrthoDBiEOG091G0J64.
PhylomeDBiP35276.
TreeFamiTF313199.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
PfamiView protein in Pfam
PF00071. Ras. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51419. RAB. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35276-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASASEPPAS PRDAADQNFD YMFKLLLIGN SSVGKTSFLF RYADDSFTPA
60 70 80 90 100
FVSTVGIDFK VKTVYRHDKR IKLQIWDTAG QERYRTITTA YYRGAMGFLL
110 120 130 140 150
MYDIANQESF TAVQDWATQI KTYSWDNAQV ILVGNKCDLE DERVVPAEDG
160 170 180 190 200
RRLADDLGFE FFEASAKENI NVKQVFERLV DIICDKMNES LEPSSSPGSN
210
GKGPALGDTP PPQPSSCSC
Length:219
Mass (Da):24,416
Last modified:February 1, 1994 - v1
Checksum:i438115B0B5710648
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M89777 mRNA. Translation: AAA40026.1.
AF263365 mRNA. Translation: AAF82769.1.
AF263366 Genomic DNA. Translation: AAF82770.1.
BC010779 mRNA. Translation: AAH10779.1.
BC020010 mRNA. Translation: AAH20010.1.
CCDSiCCDS22912.1.
PIRiA45384.
RefSeqiNP_001311460.1. NM_001324531.1.
NP_114080.2. NM_031874.5.
XP_011240724.1. XM_011242422.2.
XP_011240725.1. XM_011242423.2.
UniGeneiMm.260157.

Genome annotation databases

EnsembliENSMUST00000115351; ENSMUSP00000111008; ENSMUSG00000019066.
ENSMUST00000122211; ENSMUSP00000113322; ENSMUSG00000019066.
GeneIDi19340.
KEGGimmu:19340.
UCSCiuc009omu.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiRAB3D_MOUSE
AccessioniPrimary (citable) accession number: P35276
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: August 30, 2017
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families