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Protein

Ras-related protein Rab-3D

Gene

Rab3d

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Protein transport. Probably involved in vesicular traffic (By similarity). May be involved in the insulin-induced exocytosis of glut4-containing vesicles in adipocytes.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi29 – 379GTPBy similarity
Nucleotide bindingi48 – 547GTPBy similarity
Nucleotide bindingi77 – 815GTPBy similarity
Nucleotide bindingi135 – 1384GTPBy similarity
Nucleotide bindingi165 – 1673GTPBy similarity

GO - Molecular functioni

  • GTP binding Source: UniProtKB-KW
  • GTP-dependent protein binding Source: MGI
  • myosin V binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Exocytosis, Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-3D
Gene namesi
Name:Rab3d
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:97844. Rab3d.

Subcellular locationi

GO - Cellular componenti

  • cytoplasmic microtubule Source: MGI
  • extracellular exosome Source: MGI
  • mitochondrion Source: MGI
  • plasma membrane Source: UniProtKB-SubCell
  • secretory vesicle Source: MGI
  • transport vesicle Source: Ensembl
  • zymogen granule Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 219218Ras-related protein Rab-3DPRO_0000121089Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Lipidationi217 – 2171S-geranylgeranyl cysteineBy similarity
Modified residuei219 – 2191Cysteine methyl esterBy similarity
Lipidationi219 – 2191S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiP35276.
PaxDbiP35276.
PeptideAtlasiP35276.
PRIDEiP35276.

PTM databases

PhosphoSiteiP35276.

Expressioni

Tissue specificityi

Predominantly expressed in the adipocyte tissue, but is also expressed in several other organs including skin, spleen, heart and lung.

Gene expression databases

BgeeiENSMUSG00000019066.
CleanExiMM_RAB3D.
ExpressionAtlasiP35276. baseline and differential.
GenevisibleiP35276. MM.

Interactioni

Subunit structurei

Interacts with RIMS1, RIMS2, RPH3A, RPH3AL and RAB3IP.2 Publications

GO - Molecular functioni

  • GTP-dependent protein binding Source: MGI
  • myosin V binding Source: MGI

Protein-protein interaction databases

BioGridi202545. 6 interactions.
IntActiP35276. 14 interactions.
STRINGi10090.ENSMUSP00000111008.

Structurei

3D structure databases

ProteinModelPortaliP35276.
SMRiP35276. Positions 20-189.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi51 – 599Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0093. Eukaryota.
ENOG410ZZXQ. LUCA.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP35276.
KOiK07884.
OMAiEPSSCSC.
OrthoDBiEOG091G0J64.
PhylomeDBiP35276.
TreeFamiTF313199.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35276-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASASEPPAS PRDAADQNFD YMFKLLLIGN SSVGKTSFLF RYADDSFTPA
60 70 80 90 100
FVSTVGIDFK VKTVYRHDKR IKLQIWDTAG QERYRTITTA YYRGAMGFLL
110 120 130 140 150
MYDIANQESF TAVQDWATQI KTYSWDNAQV ILVGNKCDLE DERVVPAEDG
160 170 180 190 200
RRLADDLGFE FFEASAKENI NVKQVFERLV DIICDKMNES LEPSSSPGSN
210
GKGPALGDTP PPQPSSCSC
Length:219
Mass (Da):24,416
Last modified:February 1, 1994 - v1
Checksum:i438115B0B5710648
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M89777 mRNA. Translation: AAA40026.1.
AF263365 mRNA. Translation: AAF82769.1.
AF263366 Genomic DNA. Translation: AAF82770.1.
BC010779 mRNA. Translation: AAH10779.1.
BC020010 mRNA. Translation: AAH20010.1.
CCDSiCCDS22912.1.
PIRiA45384.
RefSeqiNP_114080.2. NM_031874.5.
XP_011240724.1. XM_011242422.1.
XP_011240725.1. XM_011242423.1.
UniGeneiMm.260157.

Genome annotation databases

EnsembliENSMUST00000115351; ENSMUSP00000111008; ENSMUSG00000019066.
ENSMUST00000122211; ENSMUSP00000113322; ENSMUSG00000019066.
GeneIDi19340.
KEGGimmu:19340.
UCSCiuc009omu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M89777 mRNA. Translation: AAA40026.1.
AF263365 mRNA. Translation: AAF82769.1.
AF263366 Genomic DNA. Translation: AAF82770.1.
BC010779 mRNA. Translation: AAH10779.1.
BC020010 mRNA. Translation: AAH20010.1.
CCDSiCCDS22912.1.
PIRiA45384.
RefSeqiNP_114080.2. NM_031874.5.
XP_011240724.1. XM_011242422.1.
XP_011240725.1. XM_011242423.1.
UniGeneiMm.260157.

3D structure databases

ProteinModelPortaliP35276.
SMRiP35276. Positions 20-189.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202545. 6 interactions.
IntActiP35276. 14 interactions.
STRINGi10090.ENSMUSP00000111008.

PTM databases

PhosphoSiteiP35276.

Proteomic databases

EPDiP35276.
PaxDbiP35276.
PeptideAtlasiP35276.
PRIDEiP35276.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000115351; ENSMUSP00000111008; ENSMUSG00000019066.
ENSMUST00000122211; ENSMUSP00000113322; ENSMUSG00000019066.
GeneIDi19340.
KEGGimmu:19340.
UCSCiuc009omu.1. mouse.

Organism-specific databases

CTDi9545.
MGIiMGI:97844. Rab3d.

Phylogenomic databases

eggNOGiKOG0093. Eukaryota.
ENOG410ZZXQ. LUCA.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP35276.
KOiK07884.
OMAiEPSSCSC.
OrthoDBiEOG091G0J64.
PhylomeDBiP35276.
TreeFamiTF313199.

Miscellaneous databases

ChiTaRSiRab3d. mouse.
PROiP35276.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019066.
CleanExiMM_RAB3D.
ExpressionAtlasiP35276. baseline and differential.
GenevisibleiP35276. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAB3D_MOUSE
AccessioniPrimary (citable) accession number: P35276
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: September 7, 2016
This is version 152 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.