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P35268

- RL22_HUMAN

UniProt

P35268 - RL22_HUMAN

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Protein

60S ribosomal protein L22

Gene

RPL22

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. heparin binding Source: UniProtKB-KW
  2. poly(A) RNA binding Source: UniProtKB
  3. RNA binding Source: ProtInc
  4. structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  1. alpha-beta T cell differentiation Source: Ensembl
  2. cellular protein metabolic process Source: Reactome
  3. gene expression Source: Reactome
  4. mRNA metabolic process Source: Reactome
  5. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  6. RNA metabolic process Source: Reactome
  7. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  8. translation Source: UniProtKB
  9. translational elongation Source: Reactome
  10. translational initiation Source: Reactome
  11. translational termination Source: Reactome
  12. viral life cycle Source: Reactome
  13. viral process Source: Reactome
  14. viral transcription Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

Heparin-binding, RNA-binding

Enzyme and pathway databases

ReactomeiREACT_115902. SRP-dependent cotranslational protein targeting to membrane.
REACT_1404. Peptide chain elongation.
REACT_1797. Formation of a pool of free 40S subunits.
REACT_1986. Eukaryotic Translation Termination.
REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_9491. Viral mRNA Translation.

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L22
Alternative name(s):
EBER-associated protein
Short name:
EAP
Epstein-Barr virus small RNA-associated protein
Heparin-binding protein HBp15
Gene namesi
Name:RPL22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:10315. RPL22.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. cytosol Source: Reactome
  3. cytosolic large ribosomal subunit Source: UniProtKB
  4. extracellular vesicular exosome Source: UniProt
  5. focal adhesion Source: UniProtKB
  6. nucleus Source: UniProt
  7. ribonucleoprotein complex Source: MGI
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34688.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 12812760S ribosomal protein L22PRO_0000215501Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei69 – 691N6-succinyllysineBy similarity

Proteomic databases

MaxQBiP35268.
PaxDbiP35268.
PeptideAtlasiP35268.
PRIDEiP35268.

2D gel databases

SWISS-2DPAGEP35268.

PTM databases

PhosphoSiteiP35268.

Expressioni

Gene expression databases

BgeeiP35268.
CleanExiHS_RPL22.
ExpressionAtlasiP35268. baseline and differential.
GenevestigatoriP35268.

Interactioni

Protein-protein interaction databases

BioGridi112066. 96 interactions.
IntActiP35268. 30 interactions.
MINTiMINT-1149755.
STRINGi9606.ENSP00000346088.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J3Belectron microscopy5.00U1-128[»]
ProteinModelPortaliP35268.
SMRiP35268. Positions 15-126.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi120 – 1289Asp/Glu-rich (highly acidic)

Sequence similaritiesi

Belongs to the ribosomal protein L22e family.Curated

Phylogenomic databases

eggNOGiNOG260326.
GeneTreeiENSGT00390000003719.
HOGENOMiHOG000198396.
HOVERGENiHBG004373.
InParanoidiP35268.
KOiK02891.
OMAiCKQPAND.
PhylomeDBiP35268.
TreeFamiTF313018.

Family and domain databases

InterProiIPR002671. Ribosomal_L22e.
[Graphical view]
PANTHERiPTHR10064. PTHR10064. 1 hit.
PfamiPF01776. Ribosomal_L22e. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35268-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPVKKLVVK GGKKKKQVLK FTLDCTHPVE DGIMDAANFE QFLQERIKVN
60 70 80 90 100
GKAGNLGGGV VTIERSKSKI TVTSEVPFSK RYLKYLTKKY LKKNNLRDWL
110 120
RVVANSKESY ELRYFQINQD EEEEEDED
Length:128
Mass (Da):14,787
Last modified:January 23, 2007 - v2
Checksum:i0F3ED8BE70C9F962
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59357 mRNA. Translation: CAA42007.1.
D17652 mRNA. Translation: BAA04545.1.
AK311749 mRNA. Translation: BAG34692.1.
CR456873 mRNA. Translation: CAG33154.1.
AL031847 Genomic DNA. Translation: CAI19448.1.
CH471130 Genomic DNA. Translation: EAW71518.1.
BC035566 mRNA. Translation: AAH35566.1.
BC058887 mRNA. Translation: AAH58887.1.
BC066314 mRNA. Translation: AAH66314.1.
CCDSiCCDS58.1.
PIRiJC2120.
RefSeqiNP_000974.1. NM_000983.3.
UniGeneiHs.515329.
Hs.554762.

Genome annotation databases

EnsembliENST00000234875; ENSP00000346088; ENSG00000116251.
GeneIDi6146.
KEGGihsa:6146.
UCSCiuc001amd.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59357 mRNA. Translation: CAA42007.1 .
D17652 mRNA. Translation: BAA04545.1 .
AK311749 mRNA. Translation: BAG34692.1 .
CR456873 mRNA. Translation: CAG33154.1 .
AL031847 Genomic DNA. Translation: CAI19448.1 .
CH471130 Genomic DNA. Translation: EAW71518.1 .
BC035566 mRNA. Translation: AAH35566.1 .
BC058887 mRNA. Translation: AAH58887.1 .
BC066314 mRNA. Translation: AAH66314.1 .
CCDSi CCDS58.1.
PIRi JC2120.
RefSeqi NP_000974.1. NM_000983.3.
UniGenei Hs.515329.
Hs.554762.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3J3B electron microscopy 5.00 U 1-128 [» ]
ProteinModelPortali P35268.
SMRi P35268. Positions 15-126.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112066. 96 interactions.
IntActi P35268. 30 interactions.
MINTi MINT-1149755.
STRINGi 9606.ENSP00000346088.

PTM databases

PhosphoSitei P35268.

2D gel databases

SWISS-2DPAGE P35268.

Proteomic databases

MaxQBi P35268.
PaxDbi P35268.
PeptideAtlasi P35268.
PRIDEi P35268.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000234875 ; ENSP00000346088 ; ENSG00000116251 .
GeneIDi 6146.
KEGGi hsa:6146.
UCSCi uc001amd.3. human.

Organism-specific databases

CTDi 6146.
GeneCardsi GC01M006179.
HGNCi HGNC:10315. RPL22.
MIMi 180474. gene.
neXtProti NX_P35268.
PharmGKBi PA34688.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG260326.
GeneTreei ENSGT00390000003719.
HOGENOMi HOG000198396.
HOVERGENi HBG004373.
InParanoidi P35268.
KOi K02891.
OMAi CKQPAND.
PhylomeDBi P35268.
TreeFami TF313018.

Enzyme and pathway databases

Reactomei REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
REACT_1404. Peptide chain elongation.
REACT_1797. Formation of a pool of free 40S subunits.
REACT_1986. Eukaryotic Translation Termination.
REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_9491. Viral mRNA Translation.

Miscellaneous databases

GeneWikii RPL22.
GenomeRNAii 6146.
NextBioi 23879.
PROi P35268.
SOURCEi Search...

Gene expression databases

Bgeei P35268.
CleanExi HS_RPL22.
ExpressionAtlasi P35268. baseline and differential.
Genevestigatori P35268.

Family and domain databases

InterProi IPR002671. Ribosomal_L22e.
[Graphical view ]
PANTHERi PTHR10064. PTHR10064. 1 hit.
Pfami PF01776. Ribosomal_L22e. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "EAP, a highly conserved cellular protein associated with Epstein-Barr virus small RNAs (EBERs)."
    Toczyski D.P.W., Steitz J.A.
    EMBO J. 10:459-466(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-46 AND 108-125.
    Tissue: Placenta.
  2. "A novel heparin-binding protein, HBp15, is identified as mammalian ribosomal protein L22."
    Fujita Y., Okamoto T., Noshiro M., Kato Y., Takada K., Sato J.D., Ozaki T., McKeehan W.L., Crabb J.W., Whitney R.G.
    Biochem. Biophys. Res. Commun. 199:706-713(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Submandibular gland.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Bienvenut W.V., Calvo F., Kolch W.
    Submitted (FEB-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-10; 53-65; 70-81 AND 102-113, CLEAVAGE OF INITIATOR METHIONINE, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Cervix carcinoma.
  6. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain, Cervix and Eye.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS).

Entry informationi

Entry nameiRL22_HUMAN
AccessioniPrimary (citable) accession number: P35268
Secondary accession number(s): B2R495, Q6IBD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Binds to Epstein-Barr virus small RNAs and to heparin.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3