Reviewed, UniProtKB/Swiss-Prot P35268 (RL22_HUMAN)

Names and origin

Protein names

Recommended name:
    60S ribosomal protein L22
Alternative name(s):
    Epstein-Barr virus small RNA-associated protein
    EBER-associated protein
      Short name=EAP
    Heparin-binding protein HBp15

Gene names

Name:

RPL22

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	128 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Miscellaneous	Binds to Epstein-Barr virus small RNAs and to heparin.
Sequence similarities	Belongs to the ribosomal protein L22e family.

Ontologies

Keywords
Ligand	Heparin-binding RNA-binding
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	translational elongation Inferred from Experiment. Source: Reactome
Cellular component	cytosolic large ribosomal subunit Ref.2 Traceable author statement. Source: ProtInc
Molecular function	RNA binding Ref.2 Traceable author statement. Source: ProtInc heparin binding Inferred from electronic annotation. Source: UniProtKB-KW structural constituent of ribosome Ref.2 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.1 Ref.5
	Chain	2 – 128	127	60S ribosomal protein L22		PRO_0000215501
Regions
	Compositional bias	120 – 128	9	Asp/Glu-rich (highly acidic)

Sequences

	Sequence		Length	Mass (Da)
	P35268-1 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 0F3ED8BE70C9F962	FASTA	128	14,787
	10 20 30 40 50 60 MAPVKKLVVK GGKKKKQVLK FTLDCTHPVE DGIMDAANFE QFLQERIKVN GKAGNLGGGV 70 80 90 100 110 120 VTIERSKSKI TVTSEVPFSK RYLKYLTKKY LKKNNLRDWL RVVANSKESY ELRYFQINQD EEEEEDED

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"EAP, a highly conserved cellular protein associated with Epstein-Barr virus small RNAs (EBERs)." Toczyski D.P.W., Steitz J.A. EMBO J. 10:459-466(1991) [PubMed: 1846807] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-46 AND 108-125. Tissue: Placenta.
[2]	"A novel heparin-binding protein, HBp15, is identified as mammalian ribosomal protein L22." Fujita Y., Okamoto T., Noshiro M., Kato Y., Takada K., Sato J.D., Ozaki T., McKeehan W.L., Crabb J.W., Whitney R.G. Biochem. Biophys. Res. Commun. 199:706-713(1994) [PubMed: 8135813] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Submandibular gland.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	Bienvenut W.V., Calvo F., Kolch W. Submitted (FEB-2008) to UniProtKB Cited for: PROTEIN SEQUENCE OF 2-10; 53-65; 70-81 AND 102-113, CLEAVAGE OF INITIATOR METHIONINE, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[6]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed: 16641997] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain, Cervix and Eye.
[9]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X59357 mRNA. Translation: CAA42007.1. D17652 mRNA. Translation: BAA04545.1. AK311749 mRNA. Translation: BAG34692.1. CR456873 mRNA. Translation: CAG33154.1. AL031847 Genomic DNA. Translation: CAI19448.1. CH471130 Genomic DNA. Translation: EAW71518.1. BC035566 mRNA. Translation: AAH35566.1. BC058887 mRNA. Translation: AAH58887.1. BC066314 mRNA. Translation: AAH66314.1.
IPI	IPI00219153.
PIR	JC2120.
RefSeq	NP_000974.1.
UniGene	Hs.515329 Hs.554762
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P35268. 16 interactions.
2-D gel databases
SWISS-2DPAGE	P35268.
Proteomic databases
PeptideAtlas	P35268.
PRIDE	P35268.
Genome annotation databases
Ensembl	ENSG00000116251. Homo sapiens. [Contig view]
GeneID	6146.
KEGG	hsa:6146.
Organism-specific databases
GeneCards	GC01M006179.
H-InvDB	HIX0000074. HIX0003853. HIX0030593. HIX0030647.
HGNC	HGNC:10315. RPL22.
MIM	180474. gene.
PharmGKB	PA30952.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P35268.
HOVERGEN	P35268.
OMA	P35268. ASYAKYL.
Enzyme and pathway databases
Reactome	REACT_1762. 3' -UTR-mediated translational regulation. REACT_6167. Influenza Infection. REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	P35268.
Bgee	P35268.
CleanEx	HS_RPL22.
GermOnline	ENSG00000116251. Homo sapiens.
Family and domain databases
InterPro	IPR002671. Ribosomal_L22e. [Graphical view]
PANTHER	PTHR10064. Ribosomal_L22e. 1 hit.
Pfam	PF01776. Ribosomal_L22e. 1 hit. [Graphical view]
ProDom	PD007306. Ribosomal_L22e. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...
Other Resources
NextBio	23879.
SOURCE	Search...

Entry information

Entry name

RL22_HUMAN

Accession

Primary (citable) accession number: P35268
Secondary accession number(s): B2R495, Q6IBD1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	January 23, 2007
Last modified:	June 16, 2009
This is version 80 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)