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Protein

60S ribosomal protein L22

Gene

RPL22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Miscellaneous

Binds to Epstein-Barr virus small RNAs and to heparin.

GO - Molecular functioni

  • heparin binding Source: UniProtKB-KW
  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionHeparin-binding, Ribonucleoprotein, Ribosomal protein, RNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
SIGNORiP35268.

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L22
Alternative name(s):
EBER-associated protein
Short name:
EAP
Epstein-Barr virus small RNA-associated protein
Heparin-binding protein HBp15
Large ribosomal subunit protein eL221 Publication
Gene namesi
Name:RPL22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000116251.9.
HGNCiHGNC:10315. RPL22.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi6146.
OpenTargetsiENSG00000116251.
PharmGKBiPA34688.

Polymorphism and mutation databases

BioMutaiRPL22.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00002155012 – 12860S ribosomal protein L22Add BLAST127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei62PhosphothreonineBy similarity1
Modified residuei66PhosphoserineCombined sources1
Modified residuei69N6-succinyllysineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP35268.
MaxQBiP35268.
PaxDbiP35268.
PeptideAtlasiP35268.
PRIDEiP35268.
TopDownProteomicsiP35268.

2D gel databases

SWISS-2DPAGEiP35268.

PTM databases

iPTMnetiP35268.
PhosphoSitePlusiP35268.
SwissPalmiP35268.

Expressioni

Gene expression databases

BgeeiENSG00000116251.
CleanExiHS_RPL22.
ExpressionAtlasiP35268. baseline and differential.
GenevisibleiP35268. HS.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi112066. 205 interactors.
CORUMiP35268.
IntActiP35268. 60 interactors.
MINTiMINT-1149755.
STRINGi9606.ENSP00000346088.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-LU1-128[»]
4V6Xelectron microscopy5.00CU1-128[»]
5AJ0electron microscopy3.50AU1-128[»]
5LKSelectron microscopy3.60LU1-128[»]
5T2Celectron microscopy3.60O1-128[»]
ProteinModelPortaliP35268.
SMRiP35268.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi120 – 128Asp/Glu-rich (highly acidic)9

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3434. Eukaryota.
ENOG4111UVJ. LUCA.
GeneTreeiENSGT00390000003719.
HOGENOMiHOG000198396.
HOVERGENiHBG004373.
InParanoidiP35268.
KOiK02891.
OMAiYQLRFYN.
OrthoDBiEOG091G0POE.
PhylomeDBiP35268.
TreeFamiTF313018.

Family and domain databases

InterProiView protein in InterPro
IPR002671. Ribosomal_L22e.
PANTHERiPTHR10064. PTHR10064. 1 hit.
PfamiView protein in Pfam
PF01776. Ribosomal_L22e. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35268-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPVKKLVVK GGKKKKQVLK FTLDCTHPVE DGIMDAANFE QFLQERIKVN
60 70 80 90 100
GKAGNLGGGV VTIERSKSKI TVTSEVPFSK RYLKYLTKKY LKKNNLRDWL
110 120
RVVANSKESY ELRYFQINQD EEEEEDED
Length:128
Mass (Da):14,787
Last modified:January 23, 2007 - v2
Checksum:i0F3ED8BE70C9F962
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59357 mRNA. Translation: CAA42007.1.
D17652 mRNA. Translation: BAA04545.1.
AK311749 mRNA. Translation: BAG34692.1.
CR456873 mRNA. Translation: CAG33154.1.
AL031847 Genomic DNA. No translation available.
CH471130 Genomic DNA. Translation: EAW71518.1.
BC035566 mRNA. Translation: AAH35566.1.
BC058887 mRNA. Translation: AAH58887.1.
BC066314 mRNA. Translation: AAH66314.1.
CCDSiCCDS58.1.
PIRiJC2120.
RefSeqiNP_000974.1. NM_000983.3.
UniGeneiHs.515329.
Hs.554762.

Genome annotation databases

EnsembliENST00000234875; ENSP00000346088; ENSG00000116251.
GeneIDi6146.
KEGGihsa:6146.
UCSCiuc001amd.4. human.

Similar proteinsi

Entry informationi

Entry nameiRL22_HUMAN
AccessioniPrimary (citable) accession number: P35268
Secondary accession number(s): B2R495, Q6IBD1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 170 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families