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P35247

- SFTPD_HUMAN

UniProt

P35247 - SFTPD_HUMAN

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Protein
Pulmonary surfactant-associated protein D
Gene
SFTPD, COLEC7, PSPD, SFTP4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.1 Publication

GO - Molecular functioni

  1. carbohydrate binding Source: UniProtKB
  2. protein binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. defense response to bacterium Source: UniProtKB
  2. innate immune response Source: UniProtKB
  3. lung alveolus development Source: UniProtKB
  4. macrophage chemotaxis Source: UniProtKB
  5. negative regulation of T cell proliferation Source: UniProtKB
  6. negative regulation of interleukin-2 biosynthetic process Source: UniProtKB
  7. positive regulation of phagocytosis Source: UniProtKB
  8. reactive oxygen species metabolic process Source: UniProtKB
  9. receptor-mediated endocytosis Source: UniProtKB
  10. regulation of cytokine production Source: UniProtKB
  11. respiratory gaseous exchange Source: UniProtKB-KW
  12. surfactant homeostasis Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Gaseous exchange, Immunity, Innate immunity

Keywords - Ligandi

Calcium, Lectin

Enzyme and pathway databases

ReactomeiREACT_23916. Signal regulatory protein (SIRP) family interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Pulmonary surfactant-associated protein D
Short name:
PSP-D
Short name:
SP-D
Alternative name(s):
Collectin-7
Lung surfactant protein D
Gene namesi
Name:SFTPD
Synonyms:COLEC7, PSPD, SFTP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:10803. SFTPD.

Subcellular locationi

GO - Cellular componenti

  1. collagen trimer Source: UniProtKB-KW
  2. endocytic vesicle Source: UniProtKB
  3. extracellular region Source: UniProtKB
  4. extracellular space Source: UniProtKB-SubCell
  5. lysosome Source: UniProtKB
  6. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted, Surface film

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35715.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 By similarity
Add
BLAST
Chaini21 – 375355Pulmonary surfactant-associated protein D
PRO_0000017465Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei35 – 351S-nitrosocysteine By similarity
Modified residuei40 – 401S-nitrosocysteine By similarity
Modified residuei78 – 7814-hydroxyproline By similarity
Modified residuei87 – 8715-hydroxylysine By similarity
Glycosylationi90 – 901N-linked (GlcNAc...) Reviewed prediction
Modified residuei96 – 9614-hydroxyproline By similarity
Modified residuei99 – 9915-hydroxylysine By similarity
Modified residuei171 – 17114-hydroxyproline By similarity
Modified residuei177 – 17714-hydroxyproline By similarity
Disulfide bondi281 ↔ 373
Disulfide bondi351 ↔ 365

Post-translational modificationi

The N-terminus is blocked.
Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates By similarity.
S-nitrosylation at Cys-35 and Cys-40 alters the quaternary structure which results in a pro-inflammatory chemoattractive signaling activity with macrophages By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation, S-nitrosylation

Proteomic databases

PaxDbiP35247.
PRIDEiP35247.

Expressioni

Tissue specificityi

Expressed in lung, brain, pancreas and adipose tissue (mainly mature adipocytes).1 Publication

Gene expression databases

ArrayExpressiP35247.
BgeeiP35247.
CleanExiHS_SFTPD.
GenevestigatoriP35247.

Organism-specific databases

HPAiCAB004578.
HPA044582.

Interactioni

Subunit structurei

Oligomeric complex of 4 set of homotrimers.

Protein-protein interaction databases

BioGridi112339. 3 interactions.
STRINGi9606.ENSP00000361366.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi226 – 25328
Turni254 – 2563
Beta strandi257 – 2604
Beta strandi263 – 27311
Helixi274 – 28310
Beta strandi286 – 2883
Helixi294 – 30714
Beta strandi311 – 3166
Beta strandi318 – 3203
Beta strandi323 – 3253
Helixi345 – 3473
Beta strandi351 – 3544
Beta strandi360 – 3634
Beta strandi367 – 3759

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1B08X-ray2.30A/B/C218-375[»]
1M7LNMR-A/B/C220-257[»]
1PW9X-ray1.60A/B/C199-375[»]
1PWBX-ray1.40A/B/C199-375[»]
2GGUX-ray1.90A/B/C223-375[»]
2GGXX-ray1.90A/B/C223-375[»]
2ORJX-ray1.80A/B/C223-375[»]
2ORKX-ray1.89A/B/C223-375[»]
2OS9X-ray1.70A/B/C223-375[»]
2RIAX-ray1.80A/B/C223-375[»]
2RIBX-ray1.80A/B/C223-375[»]
2RICX-ray1.80A/B/C223-375[»]
2RIDX-ray1.80A/B/C223-375[»]
2RIEX-ray1.60A/B/C223-375[»]
3DBZX-ray1.80A/B/C223-375[»]
3G81X-ray1.80A/B/C223-375[»]
3G83X-ray1.90A/B/C223-375[»]
3G84X-ray2.30A/B/C223-375[»]
3IKNX-ray1.60A/B/C199-375[»]
3IKPX-ray1.75A/B/C199-375[»]
3IKQX-ray2.25A/B/C199-375[»]
3IKRX-ray1.65A/B/C199-375[»]
4E52X-ray1.70A/B/C201-375[»]
4M17X-ray2.10A/B/C/D/E/F/G/H/I/J/K/L229-375[»]
4M18X-ray3.20A/B/C/D/E/F/G/H/I/J/K/L229-375[»]
ProteinModelPortaliP35247.
SMRiP35247. Positions 224-375.

Miscellaneous databases

EvolutionaryTraceiP35247.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 222177Collagen-like
Add
BLAST
Domaini260 – 375116C-type lectin
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili223 – 25230 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Belongs to the SFTPD family.

Keywords - Domaini

Coiled coil, Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiNOG267163.
HOVERGENiHBG108270.
InParanoidiP35247.
KOiK10068.
OMAiEMKTYSQ.
OrthoDBiEOG7HXCVB.
PhylomeDBiP35247.
TreeFamiTF330481.

Family and domain databases

Gene3Di1.20.5.360. 1 hit.
3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR008160. Collagen.
IPR015097. Surfac_D-trimer.
[Graphical view]
PfamiPF01391. Collagen. 2 hits.
PF00059. Lectin_C. 1 hit.
PF09006. Surfac_D-trimer. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35247-1 [UniParc]FASTAAdd to Basket

« Hide

MLLFLLSALV LLTQPLGYLE AEMKTYSHRT MPSACTLVMC SSVESGLPGR    50
DGRDGREGPR GEKGDPGLPG AAGQAGMPGQ AGPVGPKGDN GSVGEPGPKG 100
DTGPSGPPGP PGVPGPAGRE GPLGKQGNIG PQGKPGPKGE AGPKGEVGAP 150
GMQGSAGARG LAGPKGERGV PGERGVPGNT GAAGSAGAMG PQGSPGARGP 200
PGLKGDKGIP GDKGAKGESG LPDVASLRQQ VEALQGQVQH LQAAFSQYKK 250
VELFPNGQSV GEKIFKTAGF VKPFTEAQLL CTQAGGQLAS PRSAAENAAL 300
QQLVVAKNEA AFLSMTDSKT EGKFTYPTGE SLVYSNWAPG EPNDDGGSED 350
CVEIFTNGKW NDRACGEKRL VVCEF 375
Length:375
Mass (Da):37,728
Last modified:January 11, 2011 - v3
Checksum:i298917699FC40F6A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti31 – 311M → T.4 Publications
Corresponds to variant rs721917 [ dbSNP | Ensembl ].
VAR_020937
Natural varianti123 – 1231L → V.2 Publications
Corresponds to variant rs17878336 [ dbSNP | Ensembl ].
VAR_020938
Natural varianti180 – 1801T → A.4 Publications
Corresponds to variant rs2243639 [ dbSNP | Ensembl ].
VAR_020939
Natural varianti290 – 2901S → T.2 Publications
Corresponds to variant rs3088308 [ dbSNP | Ensembl ].
VAR_020940
Natural varianti309 – 3091E → K.1 Publication
Corresponds to variant rs4469829 [ dbSNP | Ensembl ].
VAR_020941

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti22 – 221E → G in AAH22318. 1 Publication
Sequence conflicti59 – 591P → F AA sequence 1 Publication
Sequence conflicti122 – 1221P → A in AAB59450. 1 Publication
Sequence conflicti240 – 2401H → P AA sequence 1 Publication
Sequence conflicti341 – 3411E → K in AAH22318. 1 Publication
Sequence conflicti369 – 3691R → S in CAG46746. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X65018 mRNA. Translation: CAA46152.1.
L05485, L05483, L05484 Genomic DNA. Translation: AAB59450.1.
CR541948 mRNA. Translation: CAG46746.1.
AY216721 Genomic DNA. Translation: AAO22991.1.
AL512662 Genomic DNA. Translation: CAI14436.1.
BC022318 mRNA. Translation: AAH22318.1.
CCDSiCCDS7362.1.
PIRiA45225.
RefSeqiNP_003010.4. NM_003019.4.
UniGeneiHs.253495.

Genome annotation databases

EnsembliENST00000372292; ENSP00000361366; ENSG00000133661.
GeneIDi6441.
KEGGihsa:6441.
UCSCiuc001kbh.3. human.

Polymorphism databases

DMDMi317373510.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs
Functional Glycomics Gateway - Glycan Binding

Pulmonary surfactant protein SP-D

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X65018 mRNA. Translation: CAA46152.1 .
L05485 , L05483 , L05484 Genomic DNA. Translation: AAB59450.1 .
CR541948 mRNA. Translation: CAG46746.1 .
AY216721 Genomic DNA. Translation: AAO22991.1 .
AL512662 Genomic DNA. Translation: CAI14436.1 .
BC022318 mRNA. Translation: AAH22318.1 .
CCDSi CCDS7362.1.
PIRi A45225.
RefSeqi NP_003010.4. NM_003019.4.
UniGenei Hs.253495.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1B08 X-ray 2.30 A/B/C 218-375 [» ]
1M7L NMR - A/B/C 220-257 [» ]
1PW9 X-ray 1.60 A/B/C 199-375 [» ]
1PWB X-ray 1.40 A/B/C 199-375 [» ]
2GGU X-ray 1.90 A/B/C 223-375 [» ]
2GGX X-ray 1.90 A/B/C 223-375 [» ]
2ORJ X-ray 1.80 A/B/C 223-375 [» ]
2ORK X-ray 1.89 A/B/C 223-375 [» ]
2OS9 X-ray 1.70 A/B/C 223-375 [» ]
2RIA X-ray 1.80 A/B/C 223-375 [» ]
2RIB X-ray 1.80 A/B/C 223-375 [» ]
2RIC X-ray 1.80 A/B/C 223-375 [» ]
2RID X-ray 1.80 A/B/C 223-375 [» ]
2RIE X-ray 1.60 A/B/C 223-375 [» ]
3DBZ X-ray 1.80 A/B/C 223-375 [» ]
3G81 X-ray 1.80 A/B/C 223-375 [» ]
3G83 X-ray 1.90 A/B/C 223-375 [» ]
3G84 X-ray 2.30 A/B/C 223-375 [» ]
3IKN X-ray 1.60 A/B/C 199-375 [» ]
3IKP X-ray 1.75 A/B/C 199-375 [» ]
3IKQ X-ray 2.25 A/B/C 199-375 [» ]
3IKR X-ray 1.65 A/B/C 199-375 [» ]
4E52 X-ray 1.70 A/B/C 201-375 [» ]
4M17 X-ray 2.10 A/B/C/D/E/F/G/H/I/J/K/L 229-375 [» ]
4M18 X-ray 3.20 A/B/C/D/E/F/G/H/I/J/K/L 229-375 [» ]
ProteinModelPortali P35247.
SMRi P35247. Positions 224-375.
ModBasei Search...

Protein-protein interaction databases

BioGridi 112339. 3 interactions.
STRINGi 9606.ENSP00000361366.

Chemistry

ChEMBLi CHEMBL2176857.

Polymorphism databases

DMDMi 317373510.

Proteomic databases

PaxDbi P35247.
PRIDEi P35247.

Protocols and materials databases

DNASUi 6441.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000372292 ; ENSP00000361366 ; ENSG00000133661 .
GeneIDi 6441.
KEGGi hsa:6441.
UCSCi uc001kbh.3. human.

Organism-specific databases

CTDi 6441.
GeneCardsi GC10M081687.
H-InvDB HIX0008974.
HGNCi HGNC:10803. SFTPD.
HPAi CAB004578.
HPA044582.
MIMi 178635. gene.
neXtProti NX_P35247.
PharmGKBi PA35715.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG267163.
HOVERGENi HBG108270.
InParanoidi P35247.
KOi K10068.
OMAi EMKTYSQ.
OrthoDBi EOG7HXCVB.
PhylomeDBi P35247.
TreeFami TF330481.

Enzyme and pathway databases

Reactomei REACT_23916. Signal regulatory protein (SIRP) family interactions.

Miscellaneous databases

EvolutionaryTracei P35247.
GeneWikii Surfactant_protein_D.
GenomeRNAii 6441.
NextBioi 25031.
PROi P35247.
SOURCEi Search...

Gene expression databases

ArrayExpressi P35247.
Bgeei P35247.
CleanExi HS_SFTPD.
Genevestigatori P35247.

Family and domain databases

Gene3Di 1.20.5.360. 1 hit.
3.10.100.10. 1 hit.
InterProi IPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR008160. Collagen.
IPR015097. Surfac_D-trimer.
[Graphical view ]
Pfami PF01391. Collagen. 2 hits.
PF00059. Lectin_C. 1 hit.
PF09006. Surfac_D-trimer. 1 hit.
[Graphical view ]
SMARTi SM00034. CLECT. 1 hit.
[Graphical view ]
SUPFAMi SSF56436. SSF56436. 1 hit.
PROSITEi PS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Purification, characterization and cDNA cloning of human lung surfactant protein D."
    Lu J., Willis A.C., Reid K.B.M.
    Biochem. J. 284:795-802(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 214-243, VARIANTS THR-31 AND ALA-180.
    Tissue: Amniotic fluid and Lung.
  2. "Genomic organization of human surfactant protein D (SP-D). SP-D is encoded on chromosome 10q22.2-23.1."
    Crouch E., Rust K., Veile R., Donis-Keller H., Grosso L.
    J. Biol. Chem. 268:2976-2983(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Placenta.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS THR-31 AND ALA-180.
  4. SeattleSNPs variation discovery resource
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-31; VAL-123; ALA-180; THR-290 AND LYS-309.
  5. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  7. "Accumulation of surfactant protein D in human pulmonary alveolar proteinosis."
    Crouch E., Persson A., Chang D.
    Am. J. Pathol. 142:241-248(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 46-72 AND 223-260.
  8. "Human surfactant protein D: SP-D contains a C-type lectin carbohydrate recognition domain."
    Rust K., Grosso L., Zhang V., Chang D., Persson A., Longmore W., Cai G.-Z., Crouch E.
    Arch. Biochem. Biophys. 290:116-126(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 60-375, PARTIAL PROTEIN SEQUENCE.
    Tissue: Lung.
  9. "The lung innate immune gene surfactant protein-D is expressed in adipose tissue and linked to obesity status."
    Ortega F.J., Pueyo N., Moreno-Navarrete J.M., Sabater M., Rodriguez-Hermosa J.I., Ricart W., Tinahones F.J., Fernandez-Real J.M.
    Int. J. Obes. Relat. Metab. Disord. 37:1532-1538(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  10. "Crystal structure of the trimeric alpha-helical coiled-coil and the three lectin domains of human lung surfactant protein D."
    Hakansson K., Lim N.K., Hoppe H.-J., Reid K.B.M.
    Structure 7:255-264(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).
  11. "Genetic defects in surfactant protein A2 are associated with pulmonary fibrosis and lung cancer."
    Wang Y., Kuan P.J., Xing C., Cronkhite J.T., Torres F., Rosenblatt R.L., DiMaio J.M., Kinch L.N., Grishin N.V., Garcia C.K.
    Am. J. Hum. Genet. 84:52-59(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS THR-31; VAL-123; ALA-180 AND THR-290.

Entry informationi

Entry nameiSFTPD_HUMAN
AccessioniPrimary (citable) accession number: P35247
Secondary accession number(s): Q5T0M3
, Q6FH08, Q86YK9, Q8TCD8, Q9UCJ2, Q9UCJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 11, 2011
Last modified: September 3, 2014
This is version 158 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi