SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P35246

- SFTPD_BOVIN

UniProt

P35246 - SFTPD_BOVIN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Pulmonary surfactant-associated protein D
Gene
SFTPD, SFTP4
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro

GO - Biological processi

  1. innate immune response Source: UniProtKB-KW
  2. lung alveolus development Source: UniProtKB
  3. respiratory gaseous exchange Source: UniProtKB-KW
  4. surfactant homeostasis Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Gaseous exchange, Immunity, Innate immunity

Keywords - Ligandi

Calcium, Lectin

Enzyme and pathway databases

ReactomeiREACT_215402. Signal regulatory protein (SIRP) family interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Pulmonary surfactant-associated protein D
Short name:
PSP-D
Short name:
SP-D
Alternative name(s):
Lung surfactant protein D
Gene namesi
Name:SFTPD
Synonyms:SFTP4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 28

Subcellular locationi

GO - Cellular componenti

  1. collagen trimer Source: UniProtKB-KW
  2. extracellular space Source: UniProtKB-SubCell
  3. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted, Surface film

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 By similarity
Add
BLAST
Chaini21 – 369349Pulmonary surfactant-associated protein D
PRO_0000017464Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei35 – 351S-nitrosocysteine By similarity
Modified residuei40 – 401S-nitrosocysteine By similarity
Modified residuei78 – 7814-hydroxyproline By similarity
Modified residuei87 – 8715-hydroxylysine By similarity
Glycosylationi90 – 901N-linked (GlcNAc...) Reviewed prediction
Modified residuei96 – 9614-hydroxyproline By similarity
Modified residuei99 – 9915-hydroxylysine By similarity
Modified residuei165 – 16514-hydroxyproline By similarity
Modified residuei171 – 17114-hydroxyproline By similarity
Disulfide bondi275 ↔ 367 By similarity
Disulfide bondi345 ↔ 359 By similarity

Post-translational modificationi

Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates By similarity.
S-nitrosylation at Cys-35 and Cys-40 alters the quaternary structure which results in a pro-inflammatory chemoattractive signaling activity with macrophages By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation, S-nitrosylation

Proteomic databases

PRIDEiP35246.

Interactioni

Subunit structurei

Oligomeric complex of 4 set of homotrimers.

Protein-protein interaction databases

BioGridi159354. 2 interactions.
STRINGi9913.ENSBTAP00000018649.

Structurei

3D structure databases

ProteinModelPortaliP35246.
SMRiP35246. Positions 216-369.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 216171Collagen-like
Add
BLAST
Domaini254 – 369116C-type lectin
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili217 – 24832 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Belongs to the SFTPD family.

Keywords - Domaini

Coiled coil, Collagen, Repeat, Signal

Phylogenomic databases

GeneTreeiENSGT00700000104102.
HOGENOMiHOG000085660.
HOVERGENiHBG108270.
KOiK10068.
OMAiEMKTYSQ.
OrthoDBiEOG7HXCVB.
TreeFamiTF330481.

Family and domain databases

Gene3Di1.20.5.360. 1 hit.
3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR008160. Collagen.
IPR015097. Surfac_D-trimer.
[Graphical view]
PfamiPF01391. Collagen. 2 hits.
PF00059. Lectin_C. 1 hit.
PF09006. Surfac_D-trimer. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35246-1 [UniParc]FASTAAdd to Basket

« Hide

MLLLPLSVLL LLTQPWRSLG AEMKIYSQKT MANACTLVMC SPPEDGLPGR    50
DGRDGREGPR GEKGDPGSPG PAGRAGMPGP AGPIGLKGDN GSAGEPGPKG 100
DTGPPGPPGM PGPAGREGPS GKQGSMGPPG TPGPKGDTGP KGGVGAPGIQ 150
GSPGPAGLKG ERGAPGEPGA PGRAGAPGPA GAIGPQGPSG ARGPPGLKGD 200
RGTPGERGAK GESGLAEVNA LRQRVGILEG QLQRLQNAFS QYKKAMLFPN 250
GRSVGEKIFK TEGSEKTFQD AQQICTQAGG QLPSPRSAAE NEALTQLATA 300
QNKAAFLSMS DTRKEGTFIY PTGEPLVYSN WAPQEPNNDG GSENCVEIFP 350
NGKWNDKVCG EQRLVICEF 369
Length:369
Mass (Da):37,405
Last modified:June 27, 2006 - v2
Checksum:i4A74B7593508AE5D
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti262 – 2621E → V in CAA53510. 1 Publication
Sequence conflicti288 – 2881A → G in CAA53510. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X75911 mRNA. Translation: CAA53510.1.
AJ548848, AJ548849, AJ548850 Genomic DNA. Translation: CAD69922.1.
PIRiS33603.
RefSeqiNP_851369.1. NM_181026.2.
UniGeneiBt.33887.

Genome annotation databases

EnsembliENSBTAT00000008579; ENSBTAP00000008579; ENSBTAG00000046421.
GeneIDi282072.
KEGGibta:282072.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X75911 mRNA. Translation: CAA53510.1 .
AJ548848 , AJ548849 , AJ548850 Genomic DNA. Translation: CAD69922.1 .
PIRi S33603.
RefSeqi NP_851369.1. NM_181026.2.
UniGenei Bt.33887.

3D structure databases

ProteinModelPortali P35246.
SMRi P35246. Positions 216-369.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 159354. 2 interactions.
STRINGi 9913.ENSBTAP00000018649.

Proteomic databases

PRIDEi P35246.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000008579 ; ENSBTAP00000008579 ; ENSBTAG00000046421 .
GeneIDi 282072.
KEGGi bta:282072.

Organism-specific databases

CTDi 6441.

Phylogenomic databases

GeneTreei ENSGT00700000104102.
HOGENOMi HOG000085660.
HOVERGENi HBG108270.
KOi K10068.
OMAi EMKTYSQ.
OrthoDBi EOG7HXCVB.
TreeFami TF330481.

Enzyme and pathway databases

Reactomei REACT_215402. Signal regulatory protein (SIRP) family interactions.

Miscellaneous databases

NextBioi 20805922.

Family and domain databases

Gene3Di 1.20.5.360. 1 hit.
3.10.100.10. 1 hit.
InterProi IPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR008160. Collagen.
IPR015097. Surfac_D-trimer.
[Graphical view ]
Pfami PF01391. Collagen. 2 hits.
PF00059. Lectin_C. 1 hit.
PF09006. Surfac_D-trimer. 1 hit.
[Graphical view ]
SMARTi SM00034. CLECT. 1 hit.
[Graphical view ]
SUPFAMi SSF56436. SSF56436. 1 hit.
PROSITEi PS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structural similarity between bovine conglutinin and bovine lung surfactant protein D and demonstration of liver as a site of synthesis of conglutinin."
    Lim B.L., Lu J., Reid K.B.M.
    Immunology 78:159-165(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 208-247.
    Tissue: Lung.
  2. "Bovine surfactant protein D: genomic characterization, chromosomal localization and expression analysis."
    Gjerstorff M., Hansen S., Madsen J., Bendixen C., Holmskov U.
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiSFTPD_BOVIN
AccessioniPrimary (citable) accession number: P35246
Secondary accession number(s): Q863A1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: June 27, 2006
Last modified: September 3, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi