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P35246

- SFTPD_BOVIN

UniProt

P35246 - SFTPD_BOVIN

Protein

Pulmonary surfactant-associated protein D

Gene

SFTPD

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 2 (27 Jun 2006)
      Previous versions | rss
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    Functioni

    Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro

    GO - Biological processi

    1. innate immune response Source: UniProtKB-KW
    2. lung alveolus development Source: UniProtKB
    3. respiratory gaseous exchange Source: UniProtKB-KW
    4. surfactant homeostasis Source: UniProtKB

    Keywords - Biological processi

    Gaseous exchange, Immunity, Innate immunity

    Keywords - Ligandi

    Calcium, Lectin

    Enzyme and pathway databases

    ReactomeiREACT_215402. Signal regulatory protein (SIRP) family interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pulmonary surfactant-associated protein D
    Short name:
    PSP-D
    Short name:
    SP-D
    Alternative name(s):
    Lung surfactant protein D
    Gene namesi
    Name:SFTPD
    Synonyms:SFTP4
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 28

    Subcellular locationi

    GO - Cellular componenti

    1. collagen trimer Source: UniProtKB-KW
    2. extracellular space Source: UniProtKB-SubCell
    3. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted, Surface film

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020By similarityAdd
    BLAST
    Chaini21 – 369349Pulmonary surfactant-associated protein DPRO_0000017464Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei35 – 351S-nitrosocysteineBy similarity
    Modified residuei40 – 401S-nitrosocysteineBy similarity
    Modified residuei78 – 7814-hydroxyprolineBy similarity
    Modified residuei87 – 8715-hydroxylysineBy similarity
    Glycosylationi90 – 901N-linked (GlcNAc...)Sequence Analysis
    Modified residuei96 – 9614-hydroxyprolineBy similarity
    Modified residuei99 – 9915-hydroxylysineBy similarity
    Modified residuei165 – 16514-hydroxyprolineBy similarity
    Modified residuei171 – 17114-hydroxyprolineBy similarity
    Disulfide bondi275 ↔ 367PROSITE-ProRule annotation
    Disulfide bondi345 ↔ 359PROSITE-ProRule annotation

    Post-translational modificationi

    Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates.By similarity
    S-nitrosylation at Cys-35 and Cys-40 alters the quaternary structure which results in a pro-inflammatory chemoattractive signaling activity with macrophages.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Hydroxylation, S-nitrosylation

    Proteomic databases

    PRIDEiP35246.

    Interactioni

    Subunit structurei

    Oligomeric complex of 4 set of homotrimers.

    Protein-protein interaction databases

    BioGridi159354. 2 interactions.
    STRINGi9913.ENSBTAP00000018649.

    Structurei

    3D structure databases

    ProteinModelPortaliP35246.
    SMRiP35246. Positions 216-369.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini46 – 216171Collagen-likeAdd
    BLAST
    Domaini254 – 369116C-type lectinPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili217 – 24832Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SFTPD family.Curated
    Contains 1 C-type lectin domain.PROSITE-ProRule annotation
    Contains 1 collagen-like domain.Curated

    Keywords - Domaini

    Coiled coil, Collagen, Repeat, Signal

    Phylogenomic databases

    GeneTreeiENSGT00700000104102.
    HOGENOMiHOG000085660.
    HOVERGENiHBG108270.
    KOiK10068.
    OMAiEMKTYSQ.
    OrthoDBiEOG7HXCVB.
    TreeFamiTF330481.

    Family and domain databases

    Gene3Di1.20.5.360. 1 hit.
    3.10.100.10. 1 hit.
    InterProiIPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR018378. C-type_lectin_CS.
    IPR016187. C-type_lectin_fold.
    IPR008160. Collagen.
    IPR015097. Surfac_D-trimer.
    [Graphical view]
    PfamiPF01391. Collagen. 2 hits.
    PF00059. Lectin_C. 1 hit.
    PF09006. Surfac_D-trimer. 1 hit.
    [Graphical view]
    SMARTiSM00034. CLECT. 1 hit.
    [Graphical view]
    SUPFAMiSSF56436. SSF56436. 1 hit.
    PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
    PS50041. C_TYPE_LECTIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P35246-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLLLPLSVLL LLTQPWRSLG AEMKIYSQKT MANACTLVMC SPPEDGLPGR    50
    DGRDGREGPR GEKGDPGSPG PAGRAGMPGP AGPIGLKGDN GSAGEPGPKG 100
    DTGPPGPPGM PGPAGREGPS GKQGSMGPPG TPGPKGDTGP KGGVGAPGIQ 150
    GSPGPAGLKG ERGAPGEPGA PGRAGAPGPA GAIGPQGPSG ARGPPGLKGD 200
    RGTPGERGAK GESGLAEVNA LRQRVGILEG QLQRLQNAFS QYKKAMLFPN 250
    GRSVGEKIFK TEGSEKTFQD AQQICTQAGG QLPSPRSAAE NEALTQLATA 300
    QNKAAFLSMS DTRKEGTFIY PTGEPLVYSN WAPQEPNNDG GSENCVEIFP 350
    NGKWNDKVCG EQRLVICEF 369
    Length:369
    Mass (Da):37,405
    Last modified:June 27, 2006 - v2
    Checksum:i4A74B7593508AE5D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti262 – 2621E → V in CAA53510. (PubMed:8436402)Curated
    Sequence conflicti288 – 2881A → G in CAA53510. (PubMed:8436402)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X75911 mRNA. Translation: CAA53510.1.
    AJ548848, AJ548849, AJ548850 Genomic DNA. Translation: CAD69922.1.
    PIRiS33603.
    RefSeqiNP_851369.1. NM_181026.2.
    UniGeneiBt.33887.

    Genome annotation databases

    EnsembliENSBTAT00000008579; ENSBTAP00000008579; ENSBTAG00000046421.
    GeneIDi282072.
    KEGGibta:282072.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X75911 mRNA. Translation: CAA53510.1 .
    AJ548848 , AJ548849 , AJ548850 Genomic DNA. Translation: CAD69922.1 .
    PIRi S33603.
    RefSeqi NP_851369.1. NM_181026.2.
    UniGenei Bt.33887.

    3D structure databases

    ProteinModelPortali P35246.
    SMRi P35246. Positions 216-369.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 159354. 2 interactions.
    STRINGi 9913.ENSBTAP00000018649.

    Proteomic databases

    PRIDEi P35246.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000008579 ; ENSBTAP00000008579 ; ENSBTAG00000046421 .
    GeneIDi 282072.
    KEGGi bta:282072.

    Organism-specific databases

    CTDi 6441.

    Phylogenomic databases

    GeneTreei ENSGT00700000104102.
    HOGENOMi HOG000085660.
    HOVERGENi HBG108270.
    KOi K10068.
    OMAi EMKTYSQ.
    OrthoDBi EOG7HXCVB.
    TreeFami TF330481.

    Enzyme and pathway databases

    Reactomei REACT_215402. Signal regulatory protein (SIRP) family interactions.

    Miscellaneous databases

    NextBioi 20805922.

    Family and domain databases

    Gene3Di 1.20.5.360. 1 hit.
    3.10.100.10. 1 hit.
    InterProi IPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR018378. C-type_lectin_CS.
    IPR016187. C-type_lectin_fold.
    IPR008160. Collagen.
    IPR015097. Surfac_D-trimer.
    [Graphical view ]
    Pfami PF01391. Collagen. 2 hits.
    PF00059. Lectin_C. 1 hit.
    PF09006. Surfac_D-trimer. 1 hit.
    [Graphical view ]
    SMARTi SM00034. CLECT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56436. SSF56436. 1 hit.
    PROSITEi PS00615. C_TYPE_LECTIN_1. 1 hit.
    PS50041. C_TYPE_LECTIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structural similarity between bovine conglutinin and bovine lung surfactant protein D and demonstration of liver as a site of synthesis of conglutinin."
      Lim B.L., Lu J., Reid K.B.M.
      Immunology 78:159-165(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 208-247.
      Tissue: Lung.
    2. "Bovine surfactant protein D: genomic characterization, chromosomal localization and expression analysis."
      Gjerstorff M., Hansen S., Madsen J., Bendixen C., Holmskov U.
      Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiSFTPD_BOVIN
    AccessioniPrimary (citable) accession number: P35246
    Secondary accession number(s): Q863A1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: June 27, 2006
    Last modified: October 1, 2014
    This is version 112 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3