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Protein

Pulmonary surfactant-associated protein D

Gene

SFTPD

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Gaseous exchange, Immunity, Innate immunity

Keywords - Ligandi

Calcium, Lectin

Enzyme and pathway databases

ReactomeiR-BTA-166016. Toll Like Receptor 4 (TLR4) Cascade.
R-BTA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-BTA-391160. Signal regulatory protein (SIRP) family interactions.
R-BTA-5683826. Surfactant metabolism.
R-BTA-5686938. Regulation of TLR by endogenous ligand.

Names & Taxonomyi

Protein namesi
Recommended name:
Pulmonary surfactant-associated protein D
Short name:
PSP-D
Short name:
SP-D
Alternative name(s):
Lung surfactant protein D
Gene namesi
Name:SFTPD
Synonyms:SFTP4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 28

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted, Surface film

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20By similarityAdd BLAST20
ChainiPRO_000001746421 – 369Pulmonary surfactant-associated protein DAdd BLAST349

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei35S-nitrosocysteineBy similarity1
Modified residuei40S-nitrosocysteineBy similarity1
Modified residuei784-hydroxyprolineBy similarity1
Modified residuei875-hydroxylysineBy similarity1
Glycosylationi90N-linked (GlcNAc...)Sequence analysis1
Modified residuei964-hydroxyprolineBy similarity1
Modified residuei995-hydroxylysineBy similarity1
Modified residuei1654-hydroxyprolineBy similarity1
Modified residuei1714-hydroxyprolineBy similarity1
Disulfide bondi275 ↔ 367PROSITE-ProRule annotation
Disulfide bondi345 ↔ 359PROSITE-ProRule annotation

Post-translational modificationi

Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates.By similarity
S-nitrosylation at Cys-35 and Cys-40 alters the quaternary structure which results in a pro-inflammatory chemoattractive signaling activity with macrophages.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation, S-nitrosylation

Proteomic databases

PaxDbiP35246.
PRIDEiP35246.

Expressioni

Gene expression databases

BgeeiENSBTAG00000046421.

Interactioni

Subunit structurei

Oligomeric complex of 4 set of homotrimers.

Protein-protein interaction databases

BioGridi159354. 2 interactors.
STRINGi9913.ENSBTAP00000008579.

Structurei

3D structure databases

ProteinModelPortaliP35246.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 216Collagen-likeAdd BLAST171
Domaini254 – 369C-type lectinPROSITE-ProRule annotationAdd BLAST116

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili217 – 248Sequence analysisAdd BLAST32

Sequence similaritiesi

Belongs to the SFTPD family.Curated
Contains 1 C-type lectin domain.PROSITE-ProRule annotation
Contains 1 collagen-like domain.Curated

Keywords - Domaini

Coiled coil, Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00700000104102.
HOGENOMiHOG000085660.
HOVERGENiHBG108270.
InParanoidiP35246.
KOiK10068.
OMAiAENCVEI.
OrthoDBiEOG091G0MYV.
TreeFamiTF330481.

Family and domain databases

Gene3Di1.20.5.360. 1 hit.
3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR008160. Collagen.
IPR016187. CTDL_fold.
IPR015097. Surfac_D-trimer.
[Graphical view]
PfamiPF01391. Collagen. 2 hits.
PF00059. Lectin_C. 1 hit.
PF09006. Surfac_D-trimer. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35246-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLLPLSVLL LLTQPWRSLG AEMKIYSQKT MANACTLVMC SPPEDGLPGR
60 70 80 90 100
DGRDGREGPR GEKGDPGSPG PAGRAGMPGP AGPIGLKGDN GSAGEPGPKG
110 120 130 140 150
DTGPPGPPGM PGPAGREGPS GKQGSMGPPG TPGPKGDTGP KGGVGAPGIQ
160 170 180 190 200
GSPGPAGLKG ERGAPGEPGA PGRAGAPGPA GAIGPQGPSG ARGPPGLKGD
210 220 230 240 250
RGTPGERGAK GESGLAEVNA LRQRVGILEG QLQRLQNAFS QYKKAMLFPN
260 270 280 290 300
GRSVGEKIFK TEGSEKTFQD AQQICTQAGG QLPSPRSAAE NEALTQLATA
310 320 330 340 350
QNKAAFLSMS DTRKEGTFIY PTGEPLVYSN WAPQEPNNDG GSENCVEIFP
360
NGKWNDKVCG EQRLVICEF
Length:369
Mass (Da):37,405
Last modified:June 27, 2006 - v2
Checksum:i4A74B7593508AE5D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti262E → V in CAA53510 (PubMed:8436402).Curated1
Sequence conflicti288A → G in CAA53510 (PubMed:8436402).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75911 mRNA. Translation: CAA53510.1.
AJ548848, AJ548849, AJ548850 Genomic DNA. Translation: CAD69922.1.
PIRiS33603.
RefSeqiNP_851369.1. NM_181026.2.
UniGeneiBt.33887.

Genome annotation databases

EnsembliENSBTAT00000008579; ENSBTAP00000008579; ENSBTAG00000046421.
GeneIDi282072.
KEGGibta:282072.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75911 mRNA. Translation: CAA53510.1.
AJ548848, AJ548849, AJ548850 Genomic DNA. Translation: CAD69922.1.
PIRiS33603.
RefSeqiNP_851369.1. NM_181026.2.
UniGeneiBt.33887.

3D structure databases

ProteinModelPortaliP35246.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi159354. 2 interactors.
STRINGi9913.ENSBTAP00000008579.

Proteomic databases

PaxDbiP35246.
PRIDEiP35246.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000008579; ENSBTAP00000008579; ENSBTAG00000046421.
GeneIDi282072.
KEGGibta:282072.

Organism-specific databases

CTDi6441.

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00700000104102.
HOGENOMiHOG000085660.
HOVERGENiHBG108270.
InParanoidiP35246.
KOiK10068.
OMAiAENCVEI.
OrthoDBiEOG091G0MYV.
TreeFamiTF330481.

Enzyme and pathway databases

ReactomeiR-BTA-166016. Toll Like Receptor 4 (TLR4) Cascade.
R-BTA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-BTA-391160. Signal regulatory protein (SIRP) family interactions.
R-BTA-5683826. Surfactant metabolism.
R-BTA-5686938. Regulation of TLR by endogenous ligand.

Gene expression databases

BgeeiENSBTAG00000046421.

Family and domain databases

Gene3Di1.20.5.360. 1 hit.
3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR008160. Collagen.
IPR016187. CTDL_fold.
IPR015097. Surfac_D-trimer.
[Graphical view]
PfamiPF01391. Collagen. 2 hits.
PF00059. Lectin_C. 1 hit.
PF09006. Surfac_D-trimer. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSFTPD_BOVIN
AccessioniPrimary (citable) accession number: P35246
Secondary accession number(s): Q863A1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: June 27, 2006
Last modified: November 30, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.