Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Recoverin

Gene

RCVRN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Seems to be implicated in the pathway from retinal rod guanylate cyclase to rhodopsin. May be involved in the inhibition of the phosphorylation of rhodopsin in a calcium-dependent manner. The calcium-bound recoverin prolongs the photoresponse.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi74 – 851; low affinityPROSITE-ProRule annotationAdd BLAST12
Calcium bindingi110 – 1212; high affinityPROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: ProtInc
  • calcium sensitive guanylate cyclase activator activity Source: ProtInc

GO - Biological processi

  • phototransduction Source: Ensembl
  • regulation of calcium ion transport Source: Ensembl
  • signal transduction Source: ProtInc
  • visual perception Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Sensory transduction, Vision

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000109047-MONOMER.
ReactomeiR-HSA-2514859. Inactivation, recovery and regulation of the phototransduction cascade.
SignaLinkiP35243.

Names & Taxonomyi

Protein namesi
Recommended name:
Recoverin
Alternative name(s):
Cancer-associated retinopathy protein
Short name:
Protein CAR
Gene namesi
Name:RCVRN
Synonyms:RCV1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:9937. RCVRN.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi5957.
OpenTargetsiENSG00000109047.
PharmGKBiPA162400987.

Polymorphism and mutation databases

BioMutaiRCVRN.
DMDMi464600.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00000737592 – 200RecoverinAdd BLAST199

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PaxDbiP35243.
PeptideAtlasiP35243.
PRIDEiP35243.

PTM databases

iPTMnetiP35243.
PhosphoSitePlusiP35243.

Expressioni

Tissue specificityi

Retina and pineal gland.

Gene expression databases

BgeeiENSG00000109047.
CleanExiHS_RCVRN.
GenevisibleiP35243. HS.

Interactioni

Protein-protein interaction databases

BioGridi111890. 14 interactors.
IntActiP35243. 5 interactors.
MINTiMINT-2862634.
STRINGi9606.ENSP00000226193.

Structurei

Secondary structure

1200
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi11 – 20Combined sources10
Helixi25 – 38Combined sources14
Beta strandi42 – 45Combined sources4
Helixi46 – 55Combined sources10
Helixi63 – 73Combined sources11
Beta strandi79 – 82Combined sources4
Helixi83 – 93Combined sources11
Beta strandi96 – 99Combined sources4
Helixi102 – 109Combined sources8
Beta strandi114 – 117Combined sources4
Helixi119 – 132Combined sources14
Helixi135 – 139Combined sources5
Turni143 – 145Combined sources3
Helixi148 – 158Combined sources11
Helixi169 – 178Combined sources10
Helixi180 – 186Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D8NX-ray2.20A1-200[»]
ProteinModelPortaliP35243.
SMRiP35243.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP35243.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 60EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini61 – 96EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini97 – 132EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini147 – 182EF-hand 4PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the recoverin family.Curated
Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0044. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118820.
HOGENOMiHOG000233019.
HOVERGENiHBG108179.
InParanoidiP35243.
KOiK13764.
OMAiKECPSGR.
OrthoDBiEOG091G11T4.
PhylomeDBiP35243.
TreeFamiTF300009.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028846. Recoverin.
[Graphical view]
PANTHERiPTHR23055. PTHR23055. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
PF13833. EF-hand_8. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35243-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNSKSGALS KEILEELQLN TKFSEEELCS WYQSFLKDCP TGRITQQQFQ
60 70 80 90 100
SIYAKFFPDT DPKAYAQHVF RSFDSNLDGT LDFKEYVIAL HMTTAGKTNQ
110 120 130 140 150
KLEWAFSLYD VDGNGTISKN EVLEIVMAIF KMITPEDVKL LPDDENTPEK
160 170 180 190 200
RAEKIWKYFG KNDDDKLTEK EFIEGTLANK EILRLIQFEP QKVKEKMKNA
Length:200
Mass (Da):23,130
Last modified:January 23, 2007 - v2
Checksum:i7B1FA91EF19E6122
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S43855 mRNA. Translation: AAB23163.1.
S45545 mRNA. Translation: AAB23392.1.
S62028 mRNA. Translation: AAB26894.1.
AB001838 mRNA. Translation: BAA19460.1.
BT009838 mRNA. Translation: AAP88840.1.
AK314129 mRNA. Translation: BAG36819.1.
AB593156 mRNA. Translation: BAJ84088.1.
CH471108 Genomic DNA. Translation: EAW90014.1.
BC001720 mRNA. Translation: AAH01720.1.
CCDSiCCDS11151.1.
PIRiJC1227.
RefSeqiNP_002894.1. NM_002903.2.
UniGeneiHs.80539.

Genome annotation databases

EnsembliENST00000226193; ENSP00000226193; ENSG00000109047.
GeneIDi5957.
KEGGihsa:5957.
UCSCiuc002gme.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S43855 mRNA. Translation: AAB23163.1.
S45545 mRNA. Translation: AAB23392.1.
S62028 mRNA. Translation: AAB26894.1.
AB001838 mRNA. Translation: BAA19460.1.
BT009838 mRNA. Translation: AAP88840.1.
AK314129 mRNA. Translation: BAG36819.1.
AB593156 mRNA. Translation: BAJ84088.1.
CH471108 Genomic DNA. Translation: EAW90014.1.
BC001720 mRNA. Translation: AAH01720.1.
CCDSiCCDS11151.1.
PIRiJC1227.
RefSeqiNP_002894.1. NM_002903.2.
UniGeneiHs.80539.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D8NX-ray2.20A1-200[»]
ProteinModelPortaliP35243.
SMRiP35243.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111890. 14 interactors.
IntActiP35243. 5 interactors.
MINTiMINT-2862634.
STRINGi9606.ENSP00000226193.

PTM databases

iPTMnetiP35243.
PhosphoSitePlusiP35243.

Polymorphism and mutation databases

BioMutaiRCVRN.
DMDMi464600.

Proteomic databases

PaxDbiP35243.
PeptideAtlasiP35243.
PRIDEiP35243.

Protocols and materials databases

DNASUi5957.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000226193; ENSP00000226193; ENSG00000109047.
GeneIDi5957.
KEGGihsa:5957.
UCSCiuc002gme.2. human.

Organism-specific databases

CTDi5957.
DisGeNETi5957.
GeneCardsiRCVRN.
HGNCiHGNC:9937. RCVRN.
MIMi179618. gene.
neXtProtiNX_P35243.
OpenTargetsiENSG00000109047.
PharmGKBiPA162400987.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0044. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118820.
HOGENOMiHOG000233019.
HOVERGENiHBG108179.
InParanoidiP35243.
KOiK13764.
OMAiKECPSGR.
OrthoDBiEOG091G11T4.
PhylomeDBiP35243.
TreeFamiTF300009.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000109047-MONOMER.
ReactomeiR-HSA-2514859. Inactivation, recovery and regulation of the phototransduction cascade.
SignaLinkiP35243.

Miscellaneous databases

ChiTaRSiRCVRN. human.
EvolutionaryTraceiP35243.
GenomeRNAii5957.
PROiP35243.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000109047.
CleanExiHS_RCVRN.
GenevisibleiP35243. HS.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028846. Recoverin.
[Graphical view]
PANTHERiPTHR23055. PTHR23055. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
PF13833. EF-hand_8. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRECO_HUMAN
AccessioniPrimary (citable) accession number: P35243
Secondary accession number(s): Q53XL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 156 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Binds two calcium ions; one with high affinity, the other with low affinity.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.