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P35242 (SFTPA_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pulmonary surfactant-associated protein A

Short name=PSAP
Short name=PSP-A
Short name=SP-A
Gene names
Name:Sftpa1
Synonyms:Sftp-1, Sftp1, Sftpa
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length248 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration.

Subunit structure

Oligomeric complex of 6 set of homotrimers.

Subcellular location

Secretedextracellular spaceextracellular matrix. Secretedextracellular spacesurface film.

Miscellaneous

Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).

Sequence similarities

Belongs to the SFTPA family.

Contains 1 C-type lectin domain.

Contains 1 collagen-like domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 By similarity
Chain21 – 248228Pulmonary surfactant-associated protein A
PRO_0000017459

Regions

Domain28 – 10073Collagen-like
Domain132 – 248117C-type lectin

Sites

Metal binding2151Calcium By similarity
Metal binding2171Calcium; via carbonyl oxygen By similarity
Metal binding2341Calcium By similarity
Metal binding2351Calcium By similarity

Amino acid modifications

Modified residue3014-hydroxyproline By similarity
Modified residue3314-hydroxyproline By similarity
Modified residue3614-hydroxyproline By similarity
Modified residue4214-hydroxyproline By similarity
Modified residue5414-hydroxyproline By similarity
Modified residue5714-hydroxyproline By similarity
Modified residue6314-hydroxyproline By similarity
Modified residue6714-hydroxyproline By similarity
Modified residue7014-hydroxyproline By similarity
Modified residue7614-hydroxyproline By similarity
Glycosylation211N-linked (GlcNAc...) Potential
Glycosylation2071N-linked (GlcNAc...) Probable
Disulfide bond26Interchain By similarity
Disulfide bond155 ↔ 246 By similarity
Disulfide bond224 ↔ 238 By similarity

Sequences

Sequence LengthMass (Da)Tools
P35242 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 6688BF070E3EB9AE

FASTA24826,157
        10         20         30         40         50         60 
MSLGSLAFTL FLTVVAGIKC NGTEVCAGSP GIPGTPGNHG LPGRDGRDGI KGDPGPPGPM 

        70         80         90        100        110        120 
GPPGGMPGLP GRDGLPGAPG APGEHGDKGE PGERGLPGFP AYLDEELQTA SYEIKHQILQ 

       130        140        150        160        170        180 
TMGVLSLQGS MLSVGDKVFS TNGQSVNFDT IREMCTRAGG HIAAPRNPEE NEAIASITKK 

       190        200        210        220        230        240 
YNTYPYLGVI EGQTPGDFHY LDGASVNYTN WYPGEPRGRG KEKCVEMYTD GKWNDKGCLQ 


YRLAICEF 

« Hide

References

[1]"Murine pulmonary surfactant SP-A gene: cloning, sequence, and transcriptional activity."
Korfhagen T.R., Bruno M.D., Glasser S.W., Ciraolo P.J., Whitsett J.A., Lattier D.L., Wikenheiser K.A., Clark J.C.
Am. J. Physiol. 263:L546-L554(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: DBA/2J.

Web resources

Functional Glycomics Gateway - Glycan Binding

Pulmonary surfactant protein SP-A

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S48768 Genomic DNA. Translation: AAB24274.1.
CCDSCCDS26960.1.
PIRA48853.
UniGeneMm.46062.

3D structure databases

ProteinModelPortalP35242.
SMRP35242. Positions 104-248.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP35242. 1 interaction.
MINTMINT-4134384.
STRING10090.ENSMUSP00000022314.

PTM databases

PhosphoSiteP35242.

Proteomic databases

MaxQBP35242.
PaxDbP35242.
PRIDEP35242.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:109518. Sftpa1.

Phylogenomic databases

eggNOGNOG315755.
HOGENOMHOG000085660.
HOVERGENHBG108270.
InParanoidP35242.
PhylomeDBP35242.

Gene expression databases

CleanExMM_SFTPA1.
GenevestigatorP35242.

Family and domain databases

Gene3D3.10.100.10. 1 hit.
InterProIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR008160. Collagen.
[Graphical view]
PfamPF01391. Collagen. 2 hits.
PF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMSSF56436. SSF56436. 1 hit.
PROSITEPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROP35242.
SOURCESearch...

Entry information

Entry nameSFTPA_MOUSE
AccessionPrimary (citable) accession number: P35242
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: July 9, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot