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Protein

Pulmonary surfactant-associated protein A

Gene

Sftpa1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi215 – 2151CalciumBy similarity
Metal bindingi217 – 2171Calcium; via carbonyl oxygenBy similarity
Metal bindingi234 – 2341CalciumBy similarity
Metal bindingi235 – 2351CalciumBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Gaseous exchange

Keywords - Ligandi

Calcium, Lectin, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Pulmonary surfactant-associated protein A
Short name:
PSAP
Short name:
PSP-A
Short name:
SP-A
Gene namesi
Name:Sftpa1
Synonyms:Sftp-1, Sftp1, Sftpa
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:109518. Sftpa1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted, Surface film

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020By similarityAdd
BLAST
Chaini21 – 248228Pulmonary surfactant-associated protein APRO_0000017459Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi26 – 26InterchainPROSITE-ProRule annotation
Modified residuei30 – 3014-hydroxyprolineBy similarity
Modified residuei33 – 3314-hydroxyprolineBy similarity
Modified residuei36 – 3614-hydroxyprolineBy similarity
Modified residuei42 – 4214-hydroxyprolineBy similarity
Modified residuei54 – 5414-hydroxyprolineBy similarity
Modified residuei57 – 5714-hydroxyprolineBy similarity
Modified residuei63 – 6314-hydroxyprolineBy similarity
Modified residuei67 – 6714-hydroxyprolineBy similarity
Modified residuei70 – 7014-hydroxyprolineBy similarity
Modified residuei76 – 7614-hydroxyprolineBy similarity
Disulfide bondi155 ↔ 246PROSITE-ProRule annotation
Glycosylationi207 – 2071N-linked (GlcNAc...)Curated
Disulfide bondi224 ↔ 238PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

MaxQBiP35242.
PaxDbiP35242.
PRIDEiP35242.

PTM databases

PhosphoSiteiP35242.

Expressioni

Gene expression databases

CleanExiMM_SFTPA1.

Interactioni

Subunit structurei

Oligomeric complex of 6 set of homotrimers.

Protein-protein interaction databases

IntActiP35242. 1 interaction.
MINTiMINT-4134384.
STRINGi10090.ENSMUSP00000022314.

Structurei

3D structure databases

ProteinModelPortaliP35242.
SMRiP35242. Positions 104-248.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 10073Collagen-likeAdd
BLAST
Domaini132 – 248117C-type lectinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the SFTPA family.Curated
Contains 1 C-type lectin domain.PROSITE-ProRule annotation
Contains 1 collagen-like domain.Curated

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiNOG315755.
HOGENOMiHOG000085660.
HOVERGENiHBG108270.
InParanoidiP35242.
PhylomeDBiP35242.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR008160. Collagen.
[Graphical view]
PfamiPF01391. Collagen. 2 hits.
PF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35242-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLGSLAFTL FLTVVAGIKC NGTEVCAGSP GIPGTPGNHG LPGRDGRDGI
60 70 80 90 100
KGDPGPPGPM GPPGGMPGLP GRDGLPGAPG APGEHGDKGE PGERGLPGFP
110 120 130 140 150
AYLDEELQTA SYEIKHQILQ TMGVLSLQGS MLSVGDKVFS TNGQSVNFDT
160 170 180 190 200
IREMCTRAGG HIAAPRNPEE NEAIASITKK YNTYPYLGVI EGQTPGDFHY
210 220 230 240
LDGASVNYTN WYPGEPRGRG KEKCVEMYTD GKWNDKGCLQ YRLAICEF
Length:248
Mass (Da):26,157
Last modified:February 1, 1994 - v1
Checksum:i6688BF070E3EB9AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S48768 Genomic DNA. Translation: AAB24274.1.
CCDSiCCDS26960.1.
PIRiA48853.
UniGeneiMm.46062.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Pulmonary surfactant protein SP-A

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S48768 Genomic DNA. Translation: AAB24274.1.
CCDSiCCDS26960.1.
PIRiA48853.
UniGeneiMm.46062.

3D structure databases

ProteinModelPortaliP35242.
SMRiP35242. Positions 104-248.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP35242. 1 interaction.
MINTiMINT-4134384.
STRINGi10090.ENSMUSP00000022314.

PTM databases

PhosphoSiteiP35242.

Proteomic databases

MaxQBiP35242.
PaxDbiP35242.
PRIDEiP35242.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:109518. Sftpa1.

Phylogenomic databases

eggNOGiNOG315755.
HOGENOMiHOG000085660.
HOVERGENiHBG108270.
InParanoidiP35242.
PhylomeDBiP35242.

Miscellaneous databases

PROiP35242.
SOURCEiSearch...

Gene expression databases

CleanExiMM_SFTPA1.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR008160. Collagen.
[Graphical view]
PfamiPF01391. Collagen. 2 hits.
PF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Murine pulmonary surfactant SP-A gene: cloning, sequence, and transcriptional activity."
    Korfhagen T.R., Bruno M.D., Glasser S.W., Ciraolo P.J., Whitsett J.A., Lattier D.L., Wikenheiser K.A., Clark J.C.
    Am. J. Physiol. 263:L546-L554(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: DBA/2J.

Entry informationi

Entry nameiSFTPA_MOUSE
AccessioniPrimary (citable) accession number: P35242
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: June 24, 2015
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.