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P35242

- SFTPA_MOUSE

UniProt

P35242 - SFTPA_MOUSE

Protein

Pulmonary surfactant-associated protein A

Gene

Sftpa1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi215 – 2151CalciumBy similarity
    Metal bindingi217 – 2171Calcium; via carbonyl oxygenBy similarity
    Metal bindingi234 – 2341CalciumBy similarity
    Metal bindingi235 – 2351CalciumBy similarity

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. respiratory gaseous exchange Source: UniProtKB-KW

    Keywords - Biological processi

    Gaseous exchange

    Keywords - Ligandi

    Calcium, Lectin, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pulmonary surfactant-associated protein A
    Short name:
    PSAP
    Short name:
    PSP-A
    Short name:
    SP-A
    Gene namesi
    Name:Sftpa1
    Synonyms:Sftp-1, Sftp1, Sftpa
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:109518. Sftpa1.

    Subcellular locationi

    GO - Cellular componenti

    1. collagen trimer Source: UniProtKB-KW
    2. extracellular space Source: UniProtKB-SubCell
    3. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted, Surface film

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020By similarityAdd
    BLAST
    Chaini21 – 248228Pulmonary surfactant-associated protein APRO_0000017459Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi26 – 26InterchainPROSITE-ProRule annotation
    Modified residuei30 – 3014-hydroxyprolineBy similarity
    Modified residuei33 – 3314-hydroxyprolineBy similarity
    Modified residuei36 – 3614-hydroxyprolineBy similarity
    Modified residuei42 – 4214-hydroxyprolineBy similarity
    Modified residuei54 – 5414-hydroxyprolineBy similarity
    Modified residuei57 – 5714-hydroxyprolineBy similarity
    Modified residuei63 – 6314-hydroxyprolineBy similarity
    Modified residuei67 – 6714-hydroxyprolineBy similarity
    Modified residuei70 – 7014-hydroxyprolineBy similarity
    Modified residuei76 – 7614-hydroxyprolineBy similarity
    Disulfide bondi155 ↔ 246PROSITE-ProRule annotation
    Glycosylationi207 – 2071N-linked (GlcNAc...)Curated
    Disulfide bondi224 ↔ 238PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Hydroxylation

    Proteomic databases

    MaxQBiP35242.
    PaxDbiP35242.
    PRIDEiP35242.

    PTM databases

    PhosphoSiteiP35242.

    Expressioni

    Gene expression databases

    CleanExiMM_SFTPA1.
    GenevestigatoriP35242.

    Interactioni

    Subunit structurei

    Oligomeric complex of 6 set of homotrimers.

    Protein-protein interaction databases

    IntActiP35242. 1 interaction.
    MINTiMINT-4134384.
    STRINGi10090.ENSMUSP00000022314.

    Structurei

    3D structure databases

    ProteinModelPortaliP35242.
    SMRiP35242. Positions 104-248.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini28 – 10073Collagen-likeAdd
    BLAST
    Domaini132 – 248117C-type lectinPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SFTPA family.Curated
    Contains 1 C-type lectin domain.PROSITE-ProRule annotation
    Contains 1 collagen-like domain.Curated

    Keywords - Domaini

    Collagen, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG315755.
    HOGENOMiHOG000085660.
    HOVERGENiHBG108270.
    InParanoidiP35242.
    PhylomeDBiP35242.

    Family and domain databases

    Gene3Di3.10.100.10. 1 hit.
    InterProiIPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR018378. C-type_lectin_CS.
    IPR016187. C-type_lectin_fold.
    IPR008160. Collagen.
    [Graphical view]
    PfamiPF01391. Collagen. 2 hits.
    PF00059. Lectin_C. 1 hit.
    [Graphical view]
    SMARTiSM00034. CLECT. 1 hit.
    [Graphical view]
    SUPFAMiSSF56436. SSF56436. 1 hit.
    PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
    PS50041. C_TYPE_LECTIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P35242-1 [UniParc]FASTAAdd to Basket

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    MSLGSLAFTL FLTVVAGIKC NGTEVCAGSP GIPGTPGNHG LPGRDGRDGI    50
    KGDPGPPGPM GPPGGMPGLP GRDGLPGAPG APGEHGDKGE PGERGLPGFP 100
    AYLDEELQTA SYEIKHQILQ TMGVLSLQGS MLSVGDKVFS TNGQSVNFDT 150
    IREMCTRAGG HIAAPRNPEE NEAIASITKK YNTYPYLGVI EGQTPGDFHY 200
    LDGASVNYTN WYPGEPRGRG KEKCVEMYTD GKWNDKGCLQ YRLAICEF 248
    Length:248
    Mass (Da):26,157
    Last modified:February 1, 1994 - v1
    Checksum:i6688BF070E3EB9AE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S48768 Genomic DNA. Translation: AAB24274.1.
    CCDSiCCDS26960.1.
    PIRiA48853.
    UniGeneiMm.46062.

    Cross-referencesi

    Web resourcesi

    Functional Glycomics Gateway - Glycan Binding

    Pulmonary surfactant protein SP-A

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S48768 Genomic DNA. Translation: AAB24274.1 .
    CCDSi CCDS26960.1.
    PIRi A48853.
    UniGenei Mm.46062.

    3D structure databases

    ProteinModelPortali P35242.
    SMRi P35242. Positions 104-248.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P35242. 1 interaction.
    MINTi MINT-4134384.
    STRINGi 10090.ENSMUSP00000022314.

    PTM databases

    PhosphoSitei P35242.

    Proteomic databases

    MaxQBi P35242.
    PaxDbi P35242.
    PRIDEi P35242.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:109518. Sftpa1.

    Phylogenomic databases

    eggNOGi NOG315755.
    HOGENOMi HOG000085660.
    HOVERGENi HBG108270.
    InParanoidi P35242.
    PhylomeDBi P35242.

    Miscellaneous databases

    PROi P35242.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_SFTPA1.
    Genevestigatori P35242.

    Family and domain databases

    Gene3Di 3.10.100.10. 1 hit.
    InterProi IPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR018378. C-type_lectin_CS.
    IPR016187. C-type_lectin_fold.
    IPR008160. Collagen.
    [Graphical view ]
    Pfami PF01391. Collagen. 2 hits.
    PF00059. Lectin_C. 1 hit.
    [Graphical view ]
    SMARTi SM00034. CLECT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56436. SSF56436. 1 hit.
    PROSITEi PS00615. C_TYPE_LECTIN_1. 1 hit.
    PS50041. C_TYPE_LECTIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Murine pulmonary surfactant SP-A gene: cloning, sequence, and transcriptional activity."
      Korfhagen T.R., Bruno M.D., Glasser S.W., Ciraolo P.J., Whitsett J.A., Lattier D.L., Wikenheiser K.A., Clark J.C.
      Am. J. Physiol. 263:L546-L554(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: DBA/2J.

    Entry informationi

    Entry nameiSFTPA_MOUSE
    AccessioniPrimary (citable) accession number: P35242
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Pulmonary surfactant consists of 90% lipid and 10% protein. There are 4 surfactant-associated proteins: 2 collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D) and 2 small hydrophobic proteins (SP-B and SP-C).

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3