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P35237

- SPB6_HUMAN

UniProt

P35237 - SPB6_HUMAN

Protein

Serpin B6

Gene

SERPINB6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 143 (01 Oct 2014)
      Sequence version 3 (04 Dec 2007)
      Previous versions | rss
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    Functioni

    May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood By similarity. Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss.By similarity5 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei341 – 3422Reactive bond

    GO - Molecular functioni

    1. protease binding Source: BHF-UCL
    2. serine-type endopeptidase inhibitor activity Source: BHF-UCL

    GO - Biological processi

    1. negative regulation of endopeptidase activity Source: BHF-UCL
    2. regulation of proteolysis Source: RefGenome

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Enzyme and pathway databases

    ReactomeiREACT_641. Dissolution of Fibrin Clot.

    Protein family/group databases

    MEROPSiI04.011.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serpin B6
    Alternative name(s):
    Cytoplasmic antiproteinase
    Short name:
    CAP
    Peptidase inhibitor 6
    Short name:
    PI-6
    Placental thrombin inhibitor
    Gene namesi
    Name:SERPINB6
    Synonyms:PI6, PTI
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:8950. SERPINB6.

    Subcellular locationi

    Cytoplasm 4 Publications

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. cytosol Source: ProtInc
    3. extracellular space Source: InterPro
    4. extracellular vesicular exosome Source: UniProt
    5. protein complex Source: BHF-UCL

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Involvement in diseasei

    Deafness, autosomal recessive, 91 (DFNB91) [MIM:613453]: A form of non-syndromic deafness characterized by progressive and age-dependent sensorineural hearing loss. Vestibular function is normal.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Keywords - Diseasei

    Deafness, Non-syndromic deafness

    Organism-specific databases

    MIMi613453. phenotype.
    Orphaneti90636. Autosomal recessive nonsyndromic sensorineural deafness type DFNB.
    PharmGKBiPA35516.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 376376Serpin B6PRO_0000094106Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication
    Modified residuei195 – 1951N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP35237.
    PaxDbiP35237.
    PRIDEiP35237.

    2D gel databases

    OGPiP35237.

    PTM databases

    PhosphoSiteiP35237.

    Expressioni

    Tissue specificityi

    Expressed in keratinocytes (at protein level). Highest levels in skeletal muscle. Also found in placenta, cardiac muscle, lung, liver, kidney and pancreas. Expressed in the inner ear hair cells. Expressed abundantly by normal mast cells in different tissues and by mast cells in mastocytoma lesions.3 Publications

    Gene expression databases

    ArrayExpressiP35237.
    BgeeiP35237.
    CleanExiHS_SERPINB6.
    GenevestigatoriP35237.

    Organism-specific databases

    HPAiHPA009668.
    HPA012736.

    Interactioni

    Subunit structurei

    Forms a complex with the monomeric form of beta-tryptase.

    Protein-protein interaction databases

    BioGridi111287. 6 interactions.
    IntActiP35237. 1 interaction.
    MINTiMINT-5005332.
    STRINGi9606.ENSP00000338358.

    Structurei

    3D structure databases

    ProteinModelPortaliP35237.
    SMRiP35237. Positions 1-376.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the serpin family. Ov-serpin subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG4826.
    HOGENOMiHOG000238519.
    HOVERGENiHBG005957.
    InParanoidiP35237.
    KOiK13963.
    OMAiIEWTRPD.
    OrthoDBiEOG7327PB.
    PhylomeDBiP35237.
    TreeFamiTF352619.

    Family and domain databases

    InterProiIPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    SMARTiSM00093. SERPIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 1 hit.
    PROSITEiPS00284. SERPIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P35237-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDVLAEANGT FALNLLKTLG KDNSKNVFFS PMSMSCALAM VYMGAKGNTA    50
    AQMAQILSFN KSGGGGDIHQ GFQSLLTEVN KTGTQYLLRM ANRLFGEKSC 100
    DFLSSFRDSC QKFYQAEMEE LDFISAVEKS RKHINTWVAE KTEGKIAELL 150
    SPGSVDPLTR LVLVNAVYFR GNWDEQFDKE NTEERLFKVS KNEEKPVQMM 200
    FKQSTFKKTY IGEIFTQILV LPYVGKELNM IIMLPDETTD LRTVEKELTY 250
    EKFVEWTRLD MMDEEEVEVS LPRFKLEESY DMESVLRNLG MTDAFELGKA 300
    DFSGMSQTDL SLSKVVHKSF VEVNEEGTEA AAATAAIMMM RCARFVPRFC 350
    ADHPFLFFIQ HSKTNGILFC GRFSSP 376
    Length:376
    Mass (Da):42,622
    Last modified:December 4, 2007 - v3
    Checksum:i3A06BC26A7510E1A
    GO

    Sequence cautioni

    The sequence BAD92800.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAD98106.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti175 – 1751E → G in CAA80373. (PubMed:8415716)Curated
    Sequence conflicti200 – 2001M → V in BAG37155. (PubMed:14702039)Curated
    Sequence conflicti362 – 3621S → R in CAA80373. (PubMed:8415716)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti90 – 901M → V.4 Publications
    Corresponds to variant rs2295769 [ dbSNP | Ensembl ].
    VAR_037295
    Natural varianti153 – 1531G → S.
    Corresponds to variant rs2295766 [ dbSNP | Ensembl ].
    VAR_037296

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z22658 mRNA. Translation: CAA80373.1.
    S69272 mRNA. Translation: AAB30320.1.
    AK314578 mRNA. Translation: BAG37155.1.
    BX538343 mRNA. Translation: CAD98106.1. Different initiation.
    AL133351 Genomic DNA. Translation: CAI23292.1.
    CH471087 Genomic DNA. Translation: EAW55097.1.
    BC001394 mRNA. Translation: AAH01394.1.
    BC098564 mRNA. Translation: AAH98564.1.
    AB209563 mRNA. Translation: BAD92800.1. Different initiation.
    CCDSiCCDS4479.1.
    PIRiA48681.
    RefSeqiNP_001182220.2. NM_001195291.2.
    NP_001258751.1. NM_001271822.1.
    NP_001258752.1. NM_001271823.1.
    NP_001258753.1. NM_001271824.1.
    NP_001258754.1. NM_001271825.1.
    NP_004559.4. NM_004568.5.
    UniGeneiHs.519523.
    Hs.731506.

    Genome annotation databases

    EnsembliENST00000335686; ENSP00000338358; ENSG00000124570.
    ENST00000380520; ENSP00000369891; ENSG00000124570.
    ENST00000380524; ENSP00000369896; ENSG00000124570.
    ENST00000380529; ENSP00000369901; ENSG00000124570.
    ENST00000380539; ENSP00000369912; ENSG00000124570.
    ENST00000380546; ENSP00000369919; ENSG00000124570.
    GeneIDi5269.
    KEGGihsa:5269.
    UCSCiuc003muk.3. human.

    Polymorphism databases

    DMDMi161784343.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z22658 mRNA. Translation: CAA80373.1 .
    S69272 mRNA. Translation: AAB30320.1 .
    AK314578 mRNA. Translation: BAG37155.1 .
    BX538343 mRNA. Translation: CAD98106.1 . Different initiation.
    AL133351 Genomic DNA. Translation: CAI23292.1 .
    CH471087 Genomic DNA. Translation: EAW55097.1 .
    BC001394 mRNA. Translation: AAH01394.1 .
    BC098564 mRNA. Translation: AAH98564.1 .
    AB209563 mRNA. Translation: BAD92800.1 . Different initiation.
    CCDSi CCDS4479.1.
    PIRi A48681.
    RefSeqi NP_001182220.2. NM_001195291.2.
    NP_001258751.1. NM_001271822.1.
    NP_001258752.1. NM_001271823.1.
    NP_001258753.1. NM_001271824.1.
    NP_001258754.1. NM_001271825.1.
    NP_004559.4. NM_004568.5.
    UniGenei Hs.519523.
    Hs.731506.

    3D structure databases

    ProteinModelPortali P35237.
    SMRi P35237. Positions 1-376.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111287. 6 interactions.
    IntActi P35237. 1 interaction.
    MINTi MINT-5005332.
    STRINGi 9606.ENSP00000338358.

    Chemistry

    DrugBanki DB00055. Drotrecogin alfa.

    Protein family/group databases

    MEROPSi I04.011.

    PTM databases

    PhosphoSitei P35237.

    Polymorphism databases

    DMDMi 161784343.

    2D gel databases

    OGPi P35237.

    Proteomic databases

    MaxQBi P35237.
    PaxDbi P35237.
    PRIDEi P35237.

    Protocols and materials databases

    DNASUi 5269.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000335686 ; ENSP00000338358 ; ENSG00000124570 .
    ENST00000380520 ; ENSP00000369891 ; ENSG00000124570 .
    ENST00000380524 ; ENSP00000369896 ; ENSG00000124570 .
    ENST00000380529 ; ENSP00000369901 ; ENSG00000124570 .
    ENST00000380539 ; ENSP00000369912 ; ENSG00000124570 .
    ENST00000380546 ; ENSP00000369919 ; ENSG00000124570 .
    GeneIDi 5269.
    KEGGi hsa:5269.
    UCSCi uc003muk.3. human.

    Organism-specific databases

    CTDi 5269.
    GeneCardsi GC06M002948.
    H-InvDB HIX0005534.
    HGNCi HGNC:8950. SERPINB6.
    HPAi HPA009668.
    HPA012736.
    MIMi 173321. gene.
    613453. phenotype.
    neXtProti NX_P35237.
    Orphaneti 90636. Autosomal recessive nonsyndromic sensorineural deafness type DFNB.
    PharmGKBi PA35516.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG4826.
    HOGENOMi HOG000238519.
    HOVERGENi HBG005957.
    InParanoidi P35237.
    KOi K13963.
    OMAi IEWTRPD.
    OrthoDBi EOG7327PB.
    PhylomeDBi P35237.
    TreeFami TF352619.

    Enzyme and pathway databases

    Reactomei REACT_641. Dissolution of Fibrin Clot.

    Miscellaneous databases

    ChiTaRSi SERPINB6. human.
    GeneWikii SERPINB6.
    GenomeRNAii 5269.
    NextBioi 20356.
    PROi P35237.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P35237.
    Bgeei P35237.
    CleanExi HS_SERPINB6.
    Genevestigatori P35237.

    Family and domain databases

    InterProi IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view ]
    PANTHERi PTHR11461. PTHR11461. 1 hit.
    Pfami PF00079. Serpin. 1 hit.
    [Graphical view ]
    SMARTi SM00093. SERPIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56574. SSF56574. 1 hit.
    PROSITEi PS00284. SERPIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and molecular characterization of a human intracellular serine proteinase inhibitor."
      Coughlin P., Sun J., Cerruti L., Salem H.H., Bird P.
      Proc. Natl. Acad. Sci. U.S.A. 90:9417-9421(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-90, FUNCTION.
      Tissue: Placenta.
    2. "Complementary DNA cloning and kinetic characterization of a novel intracellular serine proteinase inhibitor: mechanism of action with trypsin and factor Xa as model proteinases."
      Morgenstern K.A., Sprecher C.A., Holth L., Foster D., Grant F.J., Ching A., Kisiel W.
      Biochemistry 33:3432-3441(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 67-73 AND 144-149, VARIANT VAL-90, FUNCTION.
      Tissue: Placenta.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-90.
      Tissue: Testis.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-90.
      Tissue: Small intestine.
    5. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Chondrosarcoma and Colon.
    8. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-372.
      Tissue: Brain.
    9. "Identification and purification of a novel serine proteinase inhibitor."
      Coughlin P.B., Tetaz T., Salem H.H.
      J. Biol. Chem. 268:9541-9547(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 47-60; 63-81 AND 91-98, SUBCELLULAR LOCATION.
      Tissue: Leukemia.
    10. "The intracellular serpin proteinase inhibitor 6 is expressed in monocytes and granulocytes and is a potent inhibitor of the azurophilic granule protease, cathepsin G."
      Scott F.L., Hirst C.E., Sun J., Bird C.H., Bottomley S.P., Bird P.I.
      Blood 93:2089-2097(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    11. "Intracellular serpin SERPINB6 (PI6) is abundantly expressed by human mast cells and forms complexes with beta-tryptase monomers."
      Strik M.C., Wolbink A., Wouters D., Bladergroen B.A., Verlaan A.R., van Houdt I.S., Hijlkema S., Hack C.E., Kummer J.A.
      Blood 103:2710-2717(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, COMPLEX FORMATION WITH BETA-TRYPTASE.
    12. "SerpinB6 is an inhibitor of kallikrein-8 in keratinocytes."
      Scott F.L., Sun J., Whisstock J.C., Kato K., Bird P.I.
      J. Biochem. 142:435-442(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. Cited for: INVOLVEMENT IN DFNB91, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSPB6_HUMAN
    AccessioniPrimary (citable) accession number: P35237
    Secondary accession number(s): B2RBA8
    , Q59F97, Q5TD06, Q7Z2Y7, Q96J44, Q9UDI7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: December 4, 2007
    Last modified: October 1, 2014
    This is version 143 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3