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P35237

- SPB6_HUMAN

UniProt

P35237 - SPB6_HUMAN

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Protein

Serpin B6

Gene

SERPINB6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity). Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss.By similarity5 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei341 – 3422Reactive bond

GO - Molecular functioni

  1. protease binding Source: BHF-UCL
  2. serine-type endopeptidase inhibitor activity Source: BHF-UCL

GO - Biological processi

  1. negative regulation of endopeptidase activity Source: BHF-UCL
  2. regulation of proteolysis Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

ReactomeiREACT_641. Dissolution of Fibrin Clot.

Protein family/group databases

MEROPSiI04.011.

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin B6
Alternative name(s):
Cytoplasmic antiproteinase
Short name:
CAP
Peptidase inhibitor 6
Short name:
PI-6
Placental thrombin inhibitor
Gene namesi
Name:SERPINB6
Synonyms:PI6, PTI
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:8950. SERPINB6.

Subcellular locationi

Cytoplasm 4 Publications

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytosol Source: ProtInc
  3. extracellular space Source: InterPro
  4. extracellular vesicular exosome Source: UniProtKB
  5. protein complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

Deafness, autosomal recessive, 91 (DFNB91) [MIM:613453]: A form of non-syndromic deafness characterized by progressive and age-dependent sensorineural hearing loss. Vestibular function is normal.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.

Keywords - Diseasei

Deafness, Non-syndromic deafness

Organism-specific databases

MIMi613453. phenotype.
Orphaneti90636. Autosomal recessive non-syndromic sensorineural deafness type DFNB.
PharmGKBiPA35516.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 376376Serpin B6PRO_0000094106Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication
Modified residuei195 – 1951N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP35237.
PaxDbiP35237.
PRIDEiP35237.

2D gel databases

OGPiP35237.

PTM databases

PhosphoSiteiP35237.

Expressioni

Tissue specificityi

Expressed in keratinocytes (at protein level). Highest levels in skeletal muscle. Also found in placenta, cardiac muscle, lung, liver, kidney and pancreas. Expressed in the inner ear hair cells. Expressed abundantly by normal mast cells in different tissues and by mast cells in mastocytoma lesions.3 Publications

Gene expression databases

BgeeiP35237.
CleanExiHS_SERPINB6.
ExpressionAtlasiP35237. baseline and differential.
GenevestigatoriP35237.

Organism-specific databases

HPAiHPA009668.
HPA012736.

Interactioni

Subunit structurei

Forms a complex with the monomeric form of beta-tryptase.

Protein-protein interaction databases

BioGridi111287. 9 interactions.
IntActiP35237. 1 interaction.
MINTiMINT-5005332.
STRINGi9606.ENSP00000338358.

Structurei

3D structure databases

ProteinModelPortaliP35237.
SMRiP35237. Positions 1-376.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family. Ov-serpin subfamily.Curated

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00760000118789.
HOGENOMiHOG000238519.
HOVERGENiHBG005957.
InParanoidiP35237.
KOiK13963.
OMAiIEWTRPD.
OrthoDBiEOG7327PB.
PhylomeDBiP35237.
TreeFamiTF352619.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35237-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDVLAEANGT FALNLLKTLG KDNSKNVFFS PMSMSCALAM VYMGAKGNTA
60 70 80 90 100
AQMAQILSFN KSGGGGDIHQ GFQSLLTEVN KTGTQYLLRM ANRLFGEKSC
110 120 130 140 150
DFLSSFRDSC QKFYQAEMEE LDFISAVEKS RKHINTWVAE KTEGKIAELL
160 170 180 190 200
SPGSVDPLTR LVLVNAVYFR GNWDEQFDKE NTEERLFKVS KNEEKPVQMM
210 220 230 240 250
FKQSTFKKTY IGEIFTQILV LPYVGKELNM IIMLPDETTD LRTVEKELTY
260 270 280 290 300
EKFVEWTRLD MMDEEEVEVS LPRFKLEESY DMESVLRNLG MTDAFELGKA
310 320 330 340 350
DFSGMSQTDL SLSKVVHKSF VEVNEEGTEA AAATAAIMMM RCARFVPRFC
360 370
ADHPFLFFIQ HSKTNGILFC GRFSSP
Length:376
Mass (Da):42,622
Last modified:December 4, 2007 - v3
Checksum:i3A06BC26A7510E1A
GO

Sequence cautioni

The sequence BAD92800.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAD98106.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti175 – 1751E → G in CAA80373. (PubMed:8415716)Curated
Sequence conflicti200 – 2001M → V in BAG37155. (PubMed:14702039)Curated
Sequence conflicti362 – 3621S → R in CAA80373. (PubMed:8415716)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti90 – 901M → V.4 Publications
Corresponds to variant rs2295769 [ dbSNP | Ensembl ].
VAR_037295
Natural varianti153 – 1531G → S.
Corresponds to variant rs2295766 [ dbSNP | Ensembl ].
VAR_037296

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z22658 mRNA. Translation: CAA80373.1.
S69272 mRNA. Translation: AAB30320.1.
AK314578 mRNA. Translation: BAG37155.1.
BX538343 mRNA. Translation: CAD98106.1. Different initiation.
AL133351 Genomic DNA. Translation: CAI23292.1.
CH471087 Genomic DNA. Translation: EAW55097.1.
BC001394 mRNA. Translation: AAH01394.1.
BC098564 mRNA. Translation: AAH98564.1.
AB209563 mRNA. Translation: BAD92800.1. Different initiation.
CCDSiCCDS4479.1.
PIRiA48681.
RefSeqiNP_001182220.2. NM_001195291.2.
NP_001258751.1. NM_001271822.1.
NP_001258752.1. NM_001271823.1.
NP_001258753.1. NM_001271824.1.
NP_001258754.1. NM_001271825.1.
NP_004559.4. NM_004568.5.
UniGeneiHs.519523.
Hs.731506.

Genome annotation databases

EnsembliENST00000335686; ENSP00000338358; ENSG00000124570.
ENST00000380520; ENSP00000369891; ENSG00000124570.
ENST00000380524; ENSP00000369896; ENSG00000124570.
ENST00000380529; ENSP00000369901; ENSG00000124570.
ENST00000380539; ENSP00000369912; ENSG00000124570.
ENST00000380546; ENSP00000369919; ENSG00000124570.
GeneIDi5269.
KEGGihsa:5269.
UCSCiuc003muk.3. human.

Polymorphism databases

DMDMi161784343.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z22658 mRNA. Translation: CAA80373.1 .
S69272 mRNA. Translation: AAB30320.1 .
AK314578 mRNA. Translation: BAG37155.1 .
BX538343 mRNA. Translation: CAD98106.1 . Different initiation.
AL133351 Genomic DNA. Translation: CAI23292.1 .
CH471087 Genomic DNA. Translation: EAW55097.1 .
BC001394 mRNA. Translation: AAH01394.1 .
BC098564 mRNA. Translation: AAH98564.1 .
AB209563 mRNA. Translation: BAD92800.1 . Different initiation.
CCDSi CCDS4479.1.
PIRi A48681.
RefSeqi NP_001182220.2. NM_001195291.2.
NP_001258751.1. NM_001271822.1.
NP_001258752.1. NM_001271823.1.
NP_001258753.1. NM_001271824.1.
NP_001258754.1. NM_001271825.1.
NP_004559.4. NM_004568.5.
UniGenei Hs.519523.
Hs.731506.

3D structure databases

ProteinModelPortali P35237.
SMRi P35237. Positions 1-376.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111287. 9 interactions.
IntActi P35237. 1 interaction.
MINTi MINT-5005332.
STRINGi 9606.ENSP00000338358.

Chemistry

DrugBanki DB00055. Drotrecogin alfa.

Protein family/group databases

MEROPSi I04.011.

PTM databases

PhosphoSitei P35237.

Polymorphism databases

DMDMi 161784343.

2D gel databases

OGPi P35237.

Proteomic databases

MaxQBi P35237.
PaxDbi P35237.
PRIDEi P35237.

Protocols and materials databases

DNASUi 5269.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000335686 ; ENSP00000338358 ; ENSG00000124570 .
ENST00000380520 ; ENSP00000369891 ; ENSG00000124570 .
ENST00000380524 ; ENSP00000369896 ; ENSG00000124570 .
ENST00000380529 ; ENSP00000369901 ; ENSG00000124570 .
ENST00000380539 ; ENSP00000369912 ; ENSG00000124570 .
ENST00000380546 ; ENSP00000369919 ; ENSG00000124570 .
GeneIDi 5269.
KEGGi hsa:5269.
UCSCi uc003muk.3. human.

Organism-specific databases

CTDi 5269.
GeneCardsi GC06M002948.
H-InvDB HIX0005534.
HGNCi HGNC:8950. SERPINB6.
HPAi HPA009668.
HPA012736.
MIMi 173321. gene.
613453. phenotype.
neXtProti NX_P35237.
Orphaneti 90636. Autosomal recessive non-syndromic sensorineural deafness type DFNB.
PharmGKBi PA35516.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4826.
GeneTreei ENSGT00760000118789.
HOGENOMi HOG000238519.
HOVERGENi HBG005957.
InParanoidi P35237.
KOi K13963.
OMAi IEWTRPD.
OrthoDBi EOG7327PB.
PhylomeDBi P35237.
TreeFami TF352619.

Enzyme and pathway databases

Reactomei REACT_641. Dissolution of Fibrin Clot.

Miscellaneous databases

ChiTaRSi SERPINB6. human.
GeneWikii SERPINB6.
GenomeRNAii 5269.
NextBioi 20356.
PROi P35237.
SOURCEi Search...

Gene expression databases

Bgeei P35237.
CleanExi HS_SERPINB6.
ExpressionAtlasi P35237. baseline and differential.
Genevestigatori P35237.

Family and domain databases

InterProi IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view ]
PANTHERi PTHR11461. PTHR11461. 1 hit.
Pfami PF00079. Serpin. 1 hit.
[Graphical view ]
SMARTi SM00093. SERPIN. 1 hit.
[Graphical view ]
SUPFAMi SSF56574. SSF56574. 1 hit.
PROSITEi PS00284. SERPIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and molecular characterization of a human intracellular serine proteinase inhibitor."
    Coughlin P., Sun J., Cerruti L., Salem H.H., Bird P.
    Proc. Natl. Acad. Sci. U.S.A. 90:9417-9421(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-90, FUNCTION.
    Tissue: Placenta.
  2. "Complementary DNA cloning and kinetic characterization of a novel intracellular serine proteinase inhibitor: mechanism of action with trypsin and factor Xa as model proteinases."
    Morgenstern K.A., Sprecher C.A., Holth L., Foster D., Grant F.J., Ching A., Kisiel W.
    Biochemistry 33:3432-3441(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 67-73 AND 144-149, VARIANT VAL-90, FUNCTION.
    Tissue: Placenta.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-90.
    Tissue: Testis.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-90.
    Tissue: Small intestine.
  5. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Chondrosarcoma and Colon.
  8. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-372.
    Tissue: Brain.
  9. "Identification and purification of a novel serine proteinase inhibitor."
    Coughlin P.B., Tetaz T., Salem H.H.
    J. Biol. Chem. 268:9541-9547(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 47-60; 63-81 AND 91-98, SUBCELLULAR LOCATION.
    Tissue: Leukemia.
  10. "The intracellular serpin proteinase inhibitor 6 is expressed in monocytes and granulocytes and is a potent inhibitor of the azurophilic granule protease, cathepsin G."
    Scott F.L., Hirst C.E., Sun J., Bird C.H., Bottomley S.P., Bird P.I.
    Blood 93:2089-2097(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  11. "Intracellular serpin SERPINB6 (PI6) is abundantly expressed by human mast cells and forms complexes with beta-tryptase monomers."
    Strik M.C., Wolbink A., Wouters D., Bladergroen B.A., Verlaan A.R., van Houdt I.S., Hijlkema S., Hack C.E., Kummer J.A.
    Blood 103:2710-2717(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, COMPLEX FORMATION WITH BETA-TRYPTASE.
  12. "SerpinB6 is an inhibitor of kallikrein-8 in keratinocytes."
    Scott F.L., Sun J., Whisstock J.C., Kato K., Bird P.I.
    J. Biochem. 142:435-442(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. Cited for: INVOLVEMENT IN DFNB91, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSPB6_HUMAN
AccessioniPrimary (citable) accession number: P35237
Secondary accession number(s): B2RBA8
, Q59F97, Q5TD06, Q7Z2Y7, Q96J44, Q9UDI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: December 4, 2007
Last modified: October 29, 2014
This is version 144 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3