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P35234

- PTN5_RAT

UniProt

P35234 - PTN5_RAT

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Protein

Tyrosine-protein phosphatase non-receptor type 5

Gene

Ptpn5

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei265 – 2651SubstrateBy similarity
Active sitei300 – 3001Phosphocysteine intermediatePROSITE-ProRule annotation
Binding sitei344 – 3441SubstrateBy similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 5 (EC:3.1.3.48)
Alternative name(s):
Neural-specific protein-tyrosine phosphatase
Striatum-enriched protein-tyrosine phosphatase
Short name:
STEP
Gene namesi
Name:Ptpn5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi3448. Ptpn5.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 369369Tyrosine-protein phosphatase non-receptor type 5PRO_0000094757Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei49 – 491Phosphoserine; by PKABy similarity
Modified residuei59 – 591Phosphothreonine; by MAPKBy similarity
Modified residuei72 – 721Phosphoserine; by MAPKBy similarity

Post-translational modificationi

Phosphorylation at Ser-49 by PKA deactivates PTPN5. Phosphorylation at Thr-59 and Ser-72 by MAPKs stabilizes the phosphatase, dephosphorylation of these sites results in ubiquitin-mediated degradation of the active phosphatase By similarity.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP35234.
PRIDEiP35234.

PTM databases

PhosphoSiteiP35234.

Expressioni

Tissue specificityi

Expressed in the central nervous system except in the cerebellum. Enriched within the striatum relative to other brain areas.

Gene expression databases

GenevestigatoriP35234.

Interactioni

Protein-protein interaction databases

BioGridi248266. 1 interaction.
IntActiP35234. 1 interaction.
MINTiMINT-713354.
STRINGi10116.ENSRNOP00000018860.

Structurei

3D structure databases

ProteinModelPortaliP35234.
SMRiP35234. Positions 81-364.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini104 – 359256Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni300 – 3067Substrate bindingBy similarity

Sequence similaritiesi

Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5599.
HOGENOMiHOG000294188.
HOVERGENiHBG001594.
InParanoidiP35234.
KOiK18018.
PhylomeDBiP35234.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR008356. Tyr_Pase_KIM-con.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR01778. KIMPTPASE.
PR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P35234-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEEKVEDDFL DLDAVPETPV FDCVMDIKPE ADPTSLTVKS MGLQERRGSN
60 70 80 90 100
VSLTLDMCTP GCNEEGFGYL VSPREESAHE YLLSASRVLR AEELHEKALD
110 120 130 140 150
PFLLQAEFFE IPMNFVDPKE YDIPGLVRKN RYKTILPNPH SRVRLTSPDP
160 170 180 190 200
EDPLSSYINA NYIRGYNGEE KVYIATQGPI VSTVVDFWRM VWQERTPIIV
210 220 230 240 250
MITNIEEMNE KCTEYWPEEQ VVHDGVEITV QKVIHTEDYR LRLISLRRGT
260 270 280 290 300
EERGLKHYWF TSWPDQKTPD RAPPLLHLVR EVEEAAQQEG PHCSPIIVHC
310 320 330 340 350
SAGIGRTGCF IATSICCQQL RREGVVDILK TTCQLRQDRG GMIQTCEQYQ
360
FVHHAMSLYE KQLSLQSSE
Length:369
Mass (Da):42,366
Last modified:February 1, 1995 - v2
Checksum:i7CD8A77EE238C64B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S49400 mRNA. Translation: AAB19491.1.
PIRiA41147.
RefSeqiNP_062126.3. NM_019253.3.
UniGeneiRn.10618.

Genome annotation databases

GeneIDi29644.
KEGGirno:29644.
UCSCiRGD:3448. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S49400 mRNA. Translation: AAB19491.1 .
PIRi A41147.
RefSeqi NP_062126.3. NM_019253.3.
UniGenei Rn.10618.

3D structure databases

ProteinModelPortali P35234.
SMRi P35234. Positions 81-364.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 248266. 1 interaction.
IntActi P35234. 1 interaction.
MINTi MINT-713354.
STRINGi 10116.ENSRNOP00000018860.

Chemistry

ChEMBLi CHEMBL2429710.

PTM databases

PhosphoSitei P35234.

Proteomic databases

PaxDbi P35234.
PRIDEi P35234.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 29644.
KEGGi rno:29644.
UCSCi RGD:3448. rat.

Organism-specific databases

CTDi 84867.
RGDi 3448. Ptpn5.

Phylogenomic databases

eggNOGi COG5599.
HOGENOMi HOG000294188.
HOVERGENi HBG001594.
InParanoidi P35234.
KOi K18018.
PhylomeDBi P35234.

Miscellaneous databases

NextBioi 609910.
PROi P35234.

Gene expression databases

Genevestigatori P35234.

Family and domain databases

Gene3Di 3.90.190.10. 1 hit.
InterProi IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR008356. Tyr_Pase_KIM-con.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00102. Y_phosphatase. 1 hit.
[Graphical view ]
PRINTSi PR01778. KIMPTPASE.
PR00700. PRTYPHPHTASE.
SMARTi SM00194. PTPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular characterization of a protein-tyrosine-phosphatase enriched in striatum."
    Lombroso P.J., Murdoch G., Lerner M.
    Proc. Natl. Acad. Sci. U.S.A. 88:7242-7246(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiPTN5_RAT
AccessioniPrimary (citable) accession number: P35234
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1995
Last modified: October 29, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3