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P35234 (PTN5_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein phosphatase non-receptor type 5

EC=3.1.3.48
Alternative name(s):
Neural-specific protein-tyrosine phosphatase
Striatum-enriched protein-tyrosine phosphatase
Short name=STEP
Gene names
Name:Ptpn5
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length369 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Subcellular location

Cytoplasm By similarity.

Tissue specificity

Expressed in the central nervous system except in the cerebellum. Enriched within the striatum relative to other brain areas.

Post-translational modification

Phosphorylation at Ser-49 by PKA deactivates PTPN5. Phosphorylation at Thr-59 and Ser-72 by MAPKs stabilizes the phosphatase, dephosphorylation of these sites results in ubiquitin-mediated degradation of the active phosphatase By similarity.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.

Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionHydrolase
Protein phosphatase
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processpeptidyl-tyrosine dephosphorylation

Inferred from electronic annotation. Source: GOC

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionprotein tyrosine phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 369369Tyrosine-protein phosphatase non-receptor type 5
PRO_0000094757

Regions

Domain104 – 359256Tyrosine-protein phosphatase
Region300 – 3067Substrate binding By similarity

Sites

Active site3001Phosphocysteine intermediate By similarity
Binding site2651Substrate By similarity
Binding site3441Substrate By similarity

Amino acid modifications

Modified residue491Phosphoserine; by PKA By similarity
Modified residue591Phosphothreonine; by MAPK By similarity
Modified residue721Phosphoserine; by MAPK By similarity

Sequences

Sequence LengthMass (Da)Tools
P35234 [UniParc].

Last modified February 1, 1995. Version 2.
Checksum: 7CD8A77EE238C64B

FASTA36942,366
        10         20         30         40         50         60 
MEEKVEDDFL DLDAVPETPV FDCVMDIKPE ADPTSLTVKS MGLQERRGSN VSLTLDMCTP 

        70         80         90        100        110        120 
GCNEEGFGYL VSPREESAHE YLLSASRVLR AEELHEKALD PFLLQAEFFE IPMNFVDPKE 

       130        140        150        160        170        180 
YDIPGLVRKN RYKTILPNPH SRVRLTSPDP EDPLSSYINA NYIRGYNGEE KVYIATQGPI 

       190        200        210        220        230        240 
VSTVVDFWRM VWQERTPIIV MITNIEEMNE KCTEYWPEEQ VVHDGVEITV QKVIHTEDYR 

       250        260        270        280        290        300 
LRLISLRRGT EERGLKHYWF TSWPDQKTPD RAPPLLHLVR EVEEAAQQEG PHCSPIIVHC 

       310        320        330        340        350        360 
SAGIGRTGCF IATSICCQQL RREGVVDILK TTCQLRQDRG GMIQTCEQYQ FVHHAMSLYE 


KQLSLQSSE 

« Hide

References

[1]"Molecular characterization of a protein-tyrosine-phosphatase enriched in striatum."
Lombroso P.J., Murdoch G., Lerner M.
Proc. Natl. Acad. Sci. U.S.A. 88:7242-7246(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S49400 mRNA. Translation: AAB19491.1.
PIRA41147.
RefSeqNP_062126.3. NM_019253.3.
UniGeneRn.10618.

3D structure databases

ProteinModelPortalP35234.
SMRP35234. Positions 81-364.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP35234. 1 interaction.
MINTMINT-713354.
STRING10116.ENSRNOP00000018860.

PTM databases

PhosphoSiteP35234.

Proteomic databases

PaxDbP35234.
PRIDEP35234.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID29644.
KEGGrno:29644.
UCSCRGD:3448. rat.

Organism-specific databases

CTD84867.
RGD3448. Ptpn5.

Phylogenomic databases

eggNOGCOG5599.
HOGENOMHOG000294188.
HOVERGENHBG001594.
InParanoidP35234.
KOK04458.

Gene expression databases

GenevestigatorP35234.

Family and domain databases

InterProIPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR008356. Tyr_Pase_KIM-con.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSPR01778. KIMPTPASE.
PR00700. PRTYPHPHTASE.
SMARTSM00194. PTPc. 1 hit.
[Graphical view]
PROSITEPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio609910.
PROP35234.

Entry information

Entry namePTN5_RAT
AccessionPrimary (citable) accession number: P35234
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1995
Last modified: January 22, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families