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P35234

- PTN5_RAT

UniProt

P35234 - PTN5_RAT

Protein

Tyrosine-protein phosphatase non-receptor type 5

Gene

Ptpn5

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 2 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei265 – 2651SubstrateBy similarity
    Active sitei300 – 3001Phosphocysteine intermediatePROSITE-ProRule annotation
    Binding sitei344 – 3441SubstrateBy similarity

    GO - Molecular functioni

    1. protein tyrosine phosphatase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein phosphatase non-receptor type 5 (EC:3.1.3.48)
    Alternative name(s):
    Neural-specific protein-tyrosine phosphatase
    Striatum-enriched protein-tyrosine phosphatase
    Short name:
    STEP
    Gene namesi
    Name:Ptpn5
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi3448. Ptpn5.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 369369Tyrosine-protein phosphatase non-receptor type 5PRO_0000094757Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei49 – 491Phosphoserine; by PKABy similarity
    Modified residuei59 – 591Phosphothreonine; by MAPKBy similarity
    Modified residuei72 – 721Phosphoserine; by MAPKBy similarity

    Post-translational modificationi

    Phosphorylation at Ser-49 by PKA deactivates PTPN5. Phosphorylation at Thr-59 and Ser-72 by MAPKs stabilizes the phosphatase, dephosphorylation of these sites results in ubiquitin-mediated degradation of the active phosphatase By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP35234.
    PRIDEiP35234.

    PTM databases

    PhosphoSiteiP35234.

    Expressioni

    Tissue specificityi

    Expressed in the central nervous system except in the cerebellum. Enriched within the striatum relative to other brain areas.

    Gene expression databases

    GenevestigatoriP35234.

    Interactioni

    Protein-protein interaction databases

    BioGridi248266. 1 interaction.
    IntActiP35234. 1 interaction.
    MINTiMINT-713354.
    STRINGi10116.ENSRNOP00000018860.

    Structurei

    3D structure databases

    ProteinModelPortaliP35234.
    SMRiP35234. Positions 81-364.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini104 – 359256Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni300 – 3067Substrate bindingBy similarity

    Sequence similaritiesi

    Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5599.
    HOGENOMiHOG000294188.
    HOVERGENiHBG001594.
    InParanoidiP35234.
    KOiK18018.
    PhylomeDBiP35234.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR008356. Tyr_Pase_KIM-con.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view]
    PfamiPF00102. Y_phosphatase. 1 hit.
    [Graphical view]
    PRINTSiPR01778. KIMPTPASE.
    PR00700. PRTYPHPHTASE.
    SMARTiSM00194. PTPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P35234-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEEKVEDDFL DLDAVPETPV FDCVMDIKPE ADPTSLTVKS MGLQERRGSN    50
    VSLTLDMCTP GCNEEGFGYL VSPREESAHE YLLSASRVLR AEELHEKALD 100
    PFLLQAEFFE IPMNFVDPKE YDIPGLVRKN RYKTILPNPH SRVRLTSPDP 150
    EDPLSSYINA NYIRGYNGEE KVYIATQGPI VSTVVDFWRM VWQERTPIIV 200
    MITNIEEMNE KCTEYWPEEQ VVHDGVEITV QKVIHTEDYR LRLISLRRGT 250
    EERGLKHYWF TSWPDQKTPD RAPPLLHLVR EVEEAAQQEG PHCSPIIVHC 300
    SAGIGRTGCF IATSICCQQL RREGVVDILK TTCQLRQDRG GMIQTCEQYQ 350
    FVHHAMSLYE KQLSLQSSE 369
    Length:369
    Mass (Da):42,366
    Last modified:February 1, 1995 - v2
    Checksum:i7CD8A77EE238C64B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S49400 mRNA. Translation: AAB19491.1.
    PIRiA41147.
    RefSeqiNP_062126.3. NM_019253.3.
    UniGeneiRn.10618.

    Genome annotation databases

    GeneIDi29644.
    KEGGirno:29644.
    UCSCiRGD:3448. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S49400 mRNA. Translation: AAB19491.1 .
    PIRi A41147.
    RefSeqi NP_062126.3. NM_019253.3.
    UniGenei Rn.10618.

    3D structure databases

    ProteinModelPortali P35234.
    SMRi P35234. Positions 81-364.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 248266. 1 interaction.
    IntActi P35234. 1 interaction.
    MINTi MINT-713354.
    STRINGi 10116.ENSRNOP00000018860.

    Chemistry

    ChEMBLi CHEMBL2429710.

    PTM databases

    PhosphoSitei P35234.

    Proteomic databases

    PaxDbi P35234.
    PRIDEi P35234.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 29644.
    KEGGi rno:29644.
    UCSCi RGD:3448. rat.

    Organism-specific databases

    CTDi 84867.
    RGDi 3448. Ptpn5.

    Phylogenomic databases

    eggNOGi COG5599.
    HOGENOMi HOG000294188.
    HOVERGENi HBG001594.
    InParanoidi P35234.
    KOi K18018.
    PhylomeDBi P35234.

    Miscellaneous databases

    NextBioi 609910.
    PROi P35234.

    Gene expression databases

    Genevestigatori P35234.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR008356. Tyr_Pase_KIM-con.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view ]
    Pfami PF00102. Y_phosphatase. 1 hit.
    [Graphical view ]
    PRINTSi PR01778. KIMPTPASE.
    PR00700. PRTYPHPHTASE.
    SMARTi SM00194. PTPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of a protein-tyrosine-phosphatase enriched in striatum."
      Lombroso P.J., Murdoch G., Lerner M.
      Proc. Natl. Acad. Sci. U.S.A. 88:7242-7246(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiPTN5_RAT
    AccessioniPrimary (citable) accession number: P35234
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 99 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3