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Protein

Tyrosine-protein phosphatase non-receptor type 5

Gene

Ptpn5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei265SubstrateBy similarity1
Active sitei300Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei344SubstrateBy similarity1

GO - Molecular functioni

  • protein tyrosine phosphatase activity Source: RGD

GO - Biological processi

  • exploration behavior Source: RGD
  • negative regulation of MAP kinase activity Source: RGD
  • peptidyl-tyrosine dephosphorylation Source: RGD
  • positive regulation of long-term synaptic potentiation Source: RGD
  • positive regulation of neuron death Source: RGD
  • positive regulation of neuron projection development Source: RGD
  • positive regulation of protein import into nucleus, translocation Source: RGD
  • positive regulation of protein phosphorylation Source: RGD
  • positive regulation of protein targeting to mitochondrion Source: RGD
  • positive regulation of receptor internalization Source: RGD
  • positive regulation of response to drug Source: RGD
  • response to acetylsalicylate Source: RGD
  • response to amphetamine Source: RGD
  • response to drug Source: RGD
  • response to immobilization stress Source: RGD

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 5 (EC:3.1.3.48)
Alternative name(s):
Neural-specific protein-tyrosine phosphatase
Striatum-enriched protein-tyrosine phosphatase
Short name:
STEP
Gene namesi
Name:Ptpn5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3448 Ptpn5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2429710

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000947571 – 369Tyrosine-protein phosphatase non-receptor type 5Add BLAST369

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei49Phosphoserine; by PKABy similarity1
Modified residuei59Phosphothreonine; by MAPKBy similarity1
Modified residuei72Phosphoserine; by MAPKBy similarity1

Post-translational modificationi

Phosphorylation at Ser-49 by PKA deactivates PTPN5. Phosphorylation at Thr-59 and Ser-72 by MAPKs stabilizes the phosphatase, dephosphorylation of these sites results in ubiquitin-mediated degradation of the active phosphatase (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP35234
PRIDEiP35234

PTM databases

iPTMnetiP35234
PhosphoSitePlusiP35234

Expressioni

Tissue specificityi

Expressed in the central nervous system except in the cerebellum. Enriched within the striatum relative to other brain areas.

Interactioni

Protein-protein interaction databases

BioGridi248266, 4 interactors
IntActiP35234, 1 interactor
MINTiP35234
STRINGi10116.ENSRNOP00000018860

Structurei

3D structure databases

ProteinModelPortaliP35234
SMRiP35234
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini104 – 359Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST256

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni300 – 306Substrate bindingBy similarity7

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0789 Eukaryota
COG5599 LUCA
HOGENOMiHOG000294188
HOVERGENiHBG001594
InParanoidiP35234
KOiK18018
PhylomeDBiP35234

Family and domain databases

Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR008356 Tyr_Pase_KIM-con
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00102 Y_phosphatase, 1 hit
PRINTSiPR01778 KIMPTPASE
PR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

Sequencei

Sequence statusi: Complete.

P35234-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEKVEDDFL DLDAVPETPV FDCVMDIKPE ADPTSLTVKS MGLQERRGSN
60 70 80 90 100
VSLTLDMCTP GCNEEGFGYL VSPREESAHE YLLSASRVLR AEELHEKALD
110 120 130 140 150
PFLLQAEFFE IPMNFVDPKE YDIPGLVRKN RYKTILPNPH SRVRLTSPDP
160 170 180 190 200
EDPLSSYINA NYIRGYNGEE KVYIATQGPI VSTVVDFWRM VWQERTPIIV
210 220 230 240 250
MITNIEEMNE KCTEYWPEEQ VVHDGVEITV QKVIHTEDYR LRLISLRRGT
260 270 280 290 300
EERGLKHYWF TSWPDQKTPD RAPPLLHLVR EVEEAAQQEG PHCSPIIVHC
310 320 330 340 350
SAGIGRTGCF IATSICCQQL RREGVVDILK TTCQLRQDRG GMIQTCEQYQ
360
FVHHAMSLYE KQLSLQSSE
Length:369
Mass (Da):42,366
Last modified:February 1, 1995 - v2
Checksum:i7CD8A77EE238C64B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S49400 mRNA Translation: AAB19491.1
PIRiA41147
RefSeqiNP_062126.3, NM_019253.3
UniGeneiRn.10618

Genome annotation databases

GeneIDi29644
KEGGirno:29644
UCSCiRGD:3448 rat

Similar proteinsi

Entry informationi

Entry nameiPTN5_RAT
AccessioniPrimary (citable) accession number: P35234
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1995
Last modified: May 23, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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